5th International Conference on Cytokines in Cancer


Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences


    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.


    You want to arrive at the Kos International Airport "Hippocrates" (IATAKGSICAOLGKOand take a taxi from the airport to the hotel (~55 EUR). To book a transfer you may use https://www.kostaxi.eu

    Accommodation Tax

    An accommodation tax of € 4.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 


    Accommodations for the conference are at the Grecotel Kos Imperial. The hotel is located 30 km from the airport.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 pm. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 


    Breakfast for registered participants and registered accompanying persons will be served at the hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Sunday, May 14

06:00 PM - 07:00 PM
Conference Registration
07:00 PM - 10:00 PM
Welcome Reception & Dinner

Monday, May 15

07:15 AM - 08:20 AM
08:20 AM - 08:30 AM
Welcome & Opening Remarks (Belinda Parker & Eleanor Fish)
Inflammation and Cancer
Chair: Andreas Behren
08:30 AM - 09:00 AM
Targeting NASH and HCC through intrinsically disordered proteins
Lopa Mishra
09:00 AM - 09:30 AM
Cytokines bound to cancer-derived extracellular vesicles impact immune cell phenotypes and metastasis
Andreas Möller
09:30 AM - 10:00 AM
Accelerated experimental cancer growth and altered tumour-host interactions in mice with ACKR1-deficient erythroid cells
Antal Rot
10:00 AM - 10:30 AM
Re-evaluating the tumour vasculature to improve cancer outcomes
Claudine Bonder
10:30 AM - 11:00 AM
Unravelling the contribution of TNF to pancreatic cancer
Tracy Putoczki
11:00 AM - 11:45 AM
Coffee Break
Cancer initiation and senescence
Chair: Stephanie Watowich
11:45 AM - 12:15 PM
Leveraging senescence-associated cytokine signaling for pancreatic cancer immunotherapy
Marcus Ruscetti
12:15 PM - 12:45 PM
The role of the immune system in breast cancer risk and early tumour formation
Kara Britt
12:45 PM - 01:15 PM
Investigating disease mechanisms and targetable dependencies in γδ T cell lymphoma using novel STAT5B-driven pre-clinical models
Susann Schönefeldt*1, Myint Aung* 1, Sophie Kraupp1, Tamara Wais1, Tobias Suske1, Safia Zahma1, Helena Sorger5, Christina Wagner1, Christine Pirker2, Walter Berger2, Julia List7, Dagmar Gotthardt7, Luis Montaño-Gutierrez6, Florian Halbritter6, Marco Herling3, Vasileios Bekiaris4, Richard Moriggl1, and Heidi Neubauer1
01:15 PM - 01:45 PM
The gp130 signaling-cascade provides therapeutic vulnerabilities for solid malignancies
Matthias Ernst
01:45 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 06:30 PM
Informal Discussions
07:00 PM - 10:30 PM
Dinner and Informal Discussions

Tuesday, May 16

07:30 AM - 08:30 AM
Cytokine signaling and epigenetics
Chair: Paul Hertzog
08:30 AM - 09:00 AM
Cancer cells subvert the RNA metabolism machinery to re-write the message and reprogramme the cell
Katherine Borden
09:00 AM - 09:30 AM
Principles of epigenetics and chromatin in development and human disease
Ali Shilatifard
09:30 AM - 10:00 AM
USP18 in regulation of cancer immune responses
Dong-Er Zhang
10:00 AM - 10:30 AM
STAT3 as a collateral dependency in KRAS mutant pancreatic cancer
Stephen D'Amico, Varvara Kirillov, Fang Hao, Oleksi Petrenko, and Nancy Reich Marshall
10:30 AM - 11:00 AM
Role of CHAF1B in interferon responses in myeloproliferative neoplasms
Diana Saleiro1, Ewa Kosciuczuk1, Mariafausta Fischietti1, Ricardo Perez1, G. Sohae Yang1, Frank Eckerdt1, Elspeth Beauchamp1, Ye Hou3, Qixuan Wang3, Rona Singer Weinberg5, Eleanor Fish4, Feng Yue3, Ronald Hoffman, and Leonidas Platanias1
11:00 AM - 11:45 AM
Coffee Break & Poster Viewing
Cytokines as predictors of therapeutic response
Chair: Kara Britt
11:45 AM - 12:15 PM
Restraint of early T cell activation by the tolerance checkpoint
Ian Parish
12:15 PM - 12:45 PM
CD4 T cell immunity in cutaneous melanoma
Thomas Gebhardt
12:45 PM - 01:15 PM
Unleashing TNF cytotoxicity to enhance cancer immunotherapy
Conor Kearney1,2, Stephin Vervoort1,2, Andrew Freeman1,2, John Silke3, Ricky Johnstone1,2, and Jane Oliaro1,2
01:15 PM - 01:45 PM
PTPs and STATs in cancer immunotherapy
Tony Tiganis
01:45 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 06:30 PM
Informal Discussions
07:00 PM - 10:30 PM
Dinner and Informal Discussions

Wednesday, May 17

07:30 AM - 08:30 AM
Cancer immunotherapy and autoimmunity
Chair: Nancy Reich Marshall
08:30 AM - 09:00 AM
Association of the microbiome with response and toxicity to immune checkpoint inhibitors
Stephanie Watowich
09:00 AM - 09:30 AM
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity
Yong Wan
09:30 AM - 10:00 AM
Localized type I interferon therapy improves immune infiltration and PD-blockade in a mouse melanoma model
Gideon Schreiber and Daniel Harari
10:00 AM - 10:30 AM
Interferon epsilon has tumour suppressor activities in ovarian cancer.
Paul Hertzog
10:30 AM - 11:00 AM
Uncovering opportunities for immune targeting of bone metastases
Belinda Parker
11:00 AM - 11:45 AM
Coffee Break
Cytokines in cancer
Chairs: Eleanor Fish and Belinda Parker
11:45 AM - 12:00 PM
JAK/BCL2 inhibition acts synergistically with LSD1 inhibitors to selectively target ETP-ALL.
Jody Haigh
12:00 PM - 12:15 PM
Characterization of the SLFN5 Role in the Regulation of Immune Cells and Natural Killer (NK) Cells Anti-Tumor Activity
Markella Zannikou1, Mariafausta Fischietti1, Ricardo Perez1, Elspeth Beauchamp1, Diana Saleiro1, Frank Eckerdt1, Eleanor Fish2, and Leonidas Platanias1
12:15 PM - 12:30 PM
A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development
Ryan N O’Keefe1, Annalisa LE Carli1, David Baloyan1, David Chisanga1, Wei Shi1, Shoukat Afshar-Sterle 1, Moritz Eissmann1, Ashleigh Poh1, Bhupinder Pal1, Cyril Seillet2, Richard M Locksley3, Matthias Ernst1, and Michael Buchert1
12:30 PM - 12:45 PM
CD103-expressing CD56+ regulatory ILCs suppresses intratumoural T cells and are associated with poor clinical outcomes
Douglas Chung1,3, Jehan Vakharia2, Kathrin Warner2, Nicolas Jacquelot2, Azin Sayad2, SeongJun Han1,2, Maryam Ghaedi2, Carlos Garcia-Batres2, Alisha Elford2, Jessica Matthews4,5, Ben Wang2, Linh Nguyen2, Patricia Shaw6, Blaise Clarke6,7, Marcus Bernardini6,7, Sarah Ferguson6, Sarah Crome1,4,5, and Pamela Ohashi1,2
12:45 PM - 01:00 PM
Cancer cell SMAD4 mutations drive increased myeloid cell infiltration in the tumor microenvironment of pancreatic ductal adenocarcinoma
Robbie Jin1,2, Maria Teresa Ciudad2, Zhe Qi Liu1,2, Xin Zhang2, Matthew Bianca1,2, and Tracy McGaha1,2
01:00 PM - 01:15 PM
Interferon epsilon limits ovarian cancer metastasis via regulation of peritoneal immune cells
Nicole Campbell1,2, Linden Gearing1,2, Jodee Gould1,2, Georgie Wray-McCann1, Nicole de Weerd1, and Paul Hertzog1,2
01:15 PM - 01:30 PM
Enhanced IFN sensing by aggressive chronic lymphocytic leukemia cells
Yu Xuan Luo, David Spaner, Yonghong Shi, and Guizhi Wang
01:30 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
City Tour
07:00 PM - 10:30 PM
Dinner and Informal Discussions

Thursday, May 18

07:30 AM - 08:30 AM
Immune cell populations in cancer
Chair: Ian Parish
08:30 AM - 09:00 AM
Combination immunotherapy in patients with rare cancers
Andreas Behren
09:00 AM - 09:30 AM
Immunoregulatory functions of neutrophils in cancer
Jadwiga Jablonska
09:30 AM - 10:00 AM
A new effector T cell subset leading to cancer
Julien Marie, Olivier Fesneau, Valentin Thevin, Hector Hernandez-Vargas, and Nicolas Benech
10:00 AM - 10:30 AM
PTP1B deficiency alleviates T cell exhaustion by promoting JAK/STAT signalling
Florian Wiede1,2, Nicole Amiet1,2, Kevin Sek4, Mathias Mueller3, Phil Darcy4, and Tony Tiganis1,2
10:30 AM - 11:15 AM
Coffee Break & Poster Viewing
One Health: lessons from cytokines in other diseases
Chair: Gideon Schreiber
11:15 AM - 11:45 AM
Interferon-mediated regulation of T cell function and immunotherapy in cancer
David Brooks
11:45 AM - 12:15 PM
STAT1 gain-of-function DNA-binding-domain mutations cause immune dysregulation in humans and mice
Ori Scott1,2, Ronald Cohn2,4, Evgueni Ivakine3, Cynthia Guidos2, and Chaim Roifman2
12:15 PM - 12:45 PM
Remodelling the interferon and chemokine activity landscape in COVID-19 and inflammatory responses by immune cell proteases and SARS-CoV-2 3Clpro main protease precision proteolysis reveals chinks in the cell's armour
Christopher Overall
12:45 PM - 01:15 PM
IFN-ß ring prophylaxis to reduce SARS-CoV-2 transmission
Eleanor Fish and CONCORD-19 Consortium
01:15 PM - 01:20 PM
Closing Remarks
01:20 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Farewell Dinner

Friday, May 19

07:30 AM - 10:00 AM
10:00 AM - 12:00 PM