7th International Conference on Molecular Perspectives on Protein-Protein Interactions


Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences

    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.

    Please note that Crete has two airports. You want to arrive at the Heraklion International Airport (code: HER) and take a taxi from the airport to the hotel (~60 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively Chania International Airport (CHQ) is a two-hour drive to the Conference Center.

    Accommodation Tax
    An accommodation tax of € 4.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 

    Accommodations for the conference are at the Aldemar Hotel.  The hotel is located in Hersonissos, 27 km from Heraklion International Airport.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in 
    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue
    The Aldemar Conference Center is located at the hotel. 

    Handicapped Accessibility
    The site is fully handicapped accessible.

    Oral Presentations
    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    Archaeological Site of Knossos and City Tour
    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 

    Breakfast for registered participants and registered accompanying persons will be served at the Aldemar Knossos Royal Village main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions
    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions
    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer 
    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation
    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information
    Animals are not permitted on site.
    Badges are required for admission to all events.
    All Aegean Conferences events are non-smoking. 

    No Photographs and Recording Devices 
    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 
    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 


Friday, October 06

06:30 PM - 07:30 PM
Conference Registration
07:30 PM - 10:30 PM
Welcome Reception and Dinner

Saturday, October 07

08:00 AM - 08:50 AM
08:50 AM - 09:00 AM
Welcome and Opening Remarks - Eric Sundberg and Brian Baker
Design and engineering of protein-protein interactions
Chair: Jamie Spangler
09:00 AM - 09:25 AM
De novo-designed transmembrane domains tune chimeric antigen receptor function
Melissa J Call1, Matthew E Call1, Sarel J Fleishman2, Nicholas J Chandler1, Ashleigh S Davey1, and Assaf Elazar2
09:25 AM - 09:50 AM
Creating protein-protein interactions
Shohei Koide
09:50 AM - 10:15 AM
Computational design and experimental optimization of PPI inhibitors from natural effectors
Alessandro Bonadio, Sergey Bogomolov, Jason Shirian, and Julia Shifman
10:15 AM - 10:40 AM
De novo engineering of cytokine/receptor interactions to study and manipulate the immune response
Jamie B Spangler
10:40 AM - 11:05 AM
A protocol for the design of peptidic PPI inhibitors integrating machine learning based generative peptide design, molecular docking and high-throughput binding assay screening
Jerome Tubiana1, Lucia Adriana-Lifshits2, Michael Nissan1, Matan Gabay2, Inbal Sher2, Marina Sova2, Maayan Gal2, and Haim J Wolfson1
11:05 AM - 11:30 AM
Coffee Break and Poster Viewing
Proteins in action: dynamics, allostery, and cooperative interactions
Chair: Eric Sundberg
11:30 AM - 12:30 PM
The soul of the integrin machine
Timothy A Springer
12:30 PM - 12:55 PM
Powered PPIs: How bacteria use energised protein-protein interactions to coordinate outer membrane constriction with cell division
12:55 PM - 01:20 PM
Understanding Protein Motion and Protein Disorder Using All-Atom Simulation
Sarah Rauscher
01:20 PM - 01:45 PM
Order and disorder in protein complexes
Birthe B. Kragelund
01:45 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 10:30 PM
Dinner and Informal Discussions - Buses Depart Hotel Lobby

Sunday, October 08

08:00 AM - 09:00 AM
Protein interactions in infection and immunity
Chair: Nikolaos Sgourakis
09:00 AM - 09:25 AM
Mech(n)anoimmunology: podosome architecture and dynamics in 2D and 3D environments.
Alessandra Cambi
09:25 AM - 09:50 AM
Understanding chaperone interactions with HLA molecules through the lens of molecular evolution and protein engineering
Nikolaos Sgourakis
09:50 AM - 10:15 AM
How MHC proteins sample the antigenic universe to inform the immune system in human health and disease
Erin Adams
10:15 AM - 10:40 AM
Host genetics is linked with asymptomatic profile of COVID-19
Stephanie Gras
10:40 AM - 11:05 AM
SARS-CoV-2 evolution is driven by parallel forces altering the sequence of the Spike-ACE2 protein-protein interaction
Gideon Schreiber and Jiri Zahradnik
11:05 AM - 11:30 AM
Coffee Break and Poster Viewing
Chemical and synthetic biology and protein-protein interactions
11:30 AM - 11:55 AM
A tale of two EVH1 domains
Amy Keating
11:55 AM - 12:20 PM
Engineering minimal TIMP-based inhibitors using DNA shuffling and yeast display
Maryam Raeeszadeh Sarmazdeh
12:20 PM - 12:45 PM
Non-adaptive processes contribute to the organization of cellular networks.
Christian Landry
12:45 PM - 01:10 PM
Stabilization of the 14-3-3/CRAF interaction for inhibition of the MAPK pathway
Holly R Vickery1, Johanna M Virta1, Markella Konstantinidou1, Marloes Pennings2, Maxime van den Oetelaar2, Emira Visser2, Dyana N Kenanova1, Christian Ottmann2, Luc Brunsveld2, and Michelle R Arkin1
01:10 PM - 01:35 PM
Lipids Mediate Promiscuous Supramolecular Protein Assemblies in the Bacterial Outer Membrane
Melissa N Webby1, Abraham O Oluwole2, Conrado Pedebos1, Anna Olerinyova2, Dheeraj Prakaash1, Patrick G Inns1, Shabaz Mohammed2, Syma Khalid1, and Colin Kleanthous1
01:35 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 10:30 PM
Dinner and Informal Discussions - Buses Depart Hotel Lobby

Monday, October 09

08:00 AM - 09:00 AM
Physics and mechanics: condensates, aggregates, and forces
09:00 AM - 09:25 AM
Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
Tejbir Kandola1, Shriram Venkatesan1, Jiahui Zhang3, Celeste Sagui3, and Randal Halfmann1,2
09:25 AM - 09:50 AM
Catch bonds: Twenty years after their experimental demonstration
Cheng Zhu and Hyun-Kyu Choi
09:50 AM - 10:15 AM
Mechanistic view of α-synuclein pathological aggregation in Parkinson's disease
Cong Liu
10:15 AM - 10:40 AM
How RecA nucleoprotein filaments respond to internal mechanical stress: a molecular dynamics simulation study
Afra Sabei1, Claudia Danilowicz2, Mara Prentiss2, and Chantal Prévost1
10:40 AM - 11:05 AM
Effect of the plasma membrane on local ligand concentration
Ágnes Szabó, Tímea Szatmári, and Peter Nagy
11:05 AM - 11:30 AM
Coffee Break and Poster Viewing
Antibodies and other receptors
Chair: Beatriz Trastoy
11:30 AM - 11:55 AM
Synthetic antibodies targeting EPHA2 induce diverse signalling-competent clusters
Jarrett John Adams and Sachdev S Sidhu
11:55 AM - 12:20 PM
Non-canonical substrate recognition and processivity define the interaction between HtrA2 and its antiapoptotic binding partner Pea15
Kakoli BOSE, Aasna L Parui, Shubhankar Dutta, Kalyani Natu, and Rashmi Puja
12:20 PM - 12:45 PM
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases
Beatriz Trastoy1, Jonathan J. Du6, Javier O. Cifuente8, Lorena Rudolph3, Erik H. Klontz5, Daniel Deredge4, Lai-Xi Wang6, Francisco Corzana7, Alvaro Mallagaray3, Eric J. Sundberg2, and Marcelo E. Guerin8
12:45 PM - 01:10 PM
unravelling IRE1α interactions in the UPRosome
Tess Rogier, Kaat Leroy, Elianne Burg, Veronic De Puysseleyr, Irma Lemmens, Jan Tavernier, Patrick Sips, and Sarah Gerlo
01:10 PM - 01:35 PM
Fusion of proteins is simple so the properties of the resulted proteins, or is it otherwise? How protein protein- interactions drive structure and properties of a multi-domain protein.
Jiri Vondrasek, Kristyna Vydra Bousova, and Konstantinos Tripsianes
01:35 PM - 03:00 PM
Lunch and Informal Discussions
03:30 PM - 07:30 PM
City Tour (Buses Depart Hotel Lobby)
07:30 PM - 10:30 PM
Dinner and Informal Discussions (Buses do not return to hotel prior to dinner)

Tuesday, October 10

08:00 AM - 09:00 AM
Protein interactions in signaling
Chair: Bostjan Kobe
09:00 AM - 09:25 AM
Structural Pharmacology of TRPV channels
Vera Moiseenkova-Bell
09:25 AM - 09:50 AM
Specificity and promiscuity of members of the Janus Kinase family binding cytokine receptors, and its implications towards signaling
Eyal Zoler1, Thomas Meyer2, Junel Sotolongo Bellon2, Boyue Sun 1, Jacob Piehler2, and Gideon Schreiber1
09:50 AM - 10:15 AM
Structural elements in Gα proteins integrate multi-specific partner interactions and inactivation
Mickey Kosloff
10:15 AM - 10:40 AM
Signaling and regulation mechanisms of the AIM2-ASC Inflammasome.
Jungsan Sohn
10:40 AM - 11:05 AM
Open-ended signalling assemblies formed by TIR domains
Bostjan Kobe
11:05 AM - 12:00 PM
Coffee Break and Poster Viewing
Imaging of PPIs
Chair: Diane Lidke
12:00 PM - 12:25 PM
Assembly and dynamics of cytokine receptor signaling complexes in the plasma membrane
Jacob Piehler
12:25 PM - 12:50 PM
High-density single molecule maps to resolve transient multi-molecular receptor interactions in living cells.
Nicolas Mateos1, Parijat Sil3, Carlo Manzo2, Juan Torreno-Pina1, Satyajit Mayor3, and Maria F. Garcia-Parajo1
12:50 PM - 01:15 PM
Adaptive Smart Microscopy for Quantitative Imaging of Protein-Protein Interactions
Keith A Lidke
01:15 PM - 01:40 PM
Nanoscale imaging of the FcεRI signalosome
Diane Lidke
01:40 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Farewell Dinner

Wednesday, October 11

08:00 AM - 10:00 AM
10:00 AM - 12:00 PM