Specific interactions between proteins are essential for life. Protein-protein interactions (PPIs) dictate signal transduction, biochemical processes, cell replication, the immune system, and more. Since 2005, the Molecular Perspectives in Protein-Protein Interactions Conference has been the leading forum for presenting and discussing research on PPIs. The scope of the conference includes fundamental molecular and biophysical principles, as well as connections to and integration with biology and medicine. Topics of interest include the integration of computational and directed evolution methods to predict and engineer PPIs, mechanisms and manipulation of allosteric effects, characterization of multi-component protein assemblies and nano-machines, and multi-scale integration of structural, computational, and biological methods. In addition to basic research, the conference aims to address the translation of knowledge about PPIs to the development of protein-based tools and therapeutics, including not only recombinant therapeutics, but developing cell therapies that incorporate PPIs. This scope – broad and interdisciplinary but with a core focus on protein interactions – has allowed the conference to develop into a highly intellectual meeting with considerable impact. The conference gathers leading experts in molecular interactions and allied fields for intellectual exchange and networking, engages next generation and early career scientists, and provides an exciting forum for new trainees to enter the field.