Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastomaNicola Tumino1, Gerrit Weber2,3, Francesca Besi1, Francesca Del Bufalo2, Valentina Bertaina2, Paola Paci4, Linda Quatrini1, Laura Antonucci2, Matilde Sinibaldi2, Concetta Quintarelli2, Enrico Maggi1, Biagio De angelis2, Franco Locatelli2, Lorenzo Moretta1, Paola Vacca1, and Ignazio Caruana2,3
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Lost and found: inhibitors of NF-kappaB signalling in fishDoret van Muilekom1, Fabio Sarais1, Henrike Rebl2, Tom Goldammer1, and Alexander Rebl1
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Cytokine responses to LPS in reprogrammed monocytes are associated with the transcription factor PU.1Kedeye Tuerxun1, Kristine Midtbö1, Eva Särndahl1, Egor Vorontsov2, Roger Karlsson3, Alexander Persson1, and Daniel Eklund1
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High-yield influenza A vaccine virus production in MDCK cell lines by CRISPR/Cas9 technologyPriya Ranjan1, Zhu Guo1, Amrita Kumar1, Zachary Ende1, Kayla Griffith1, Caitlin Bohannon1, Weiping Cao1, Karen Valdez2, Shivaprakash Gangappa1, James Stevens1, and Suryaprakash Sambhara1
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Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell deathJazlyn Borges1, Ragnhild Sætra2, Allen Volchuk3, Marit Bugge2, Pascal Devant4, Bjørnar Sporsheim2, Bridget Kilburn1, Charles Evavold5, Jonathan Kagan4, Neil Goldenberg3,6,7, Trude Helen Flo2,4, and Benjamin Ethan Steinberg1,6,7
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Dimethyl itaconate induces long-term innate immune responses and confers protection against infection. Anaísa Ferreira1, Sarantos Kostidis3, Laszlo Groh1, Valerie Koeken1, Mariolina Bruno1, Ilayda Baydemir1, Gizem Kilic1, Özlem Bulut1, Theano Andriopoulou5, Victoria Spanou5, Kalliopi Synodinou5, Theologia Gkavogianni5, Simone Moorlag1, Charlotte de Bree1, Vera Mourits1, Vasiliki Matzaraki1, Werner Koopman6, Frank van de Veerdonk1, Georgios Renieris5, Martin Giera3, Evangelos Giamarellos-Bourboulis5, Boris Novakovic, and Jorge Domínguez-Andrés1
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Glucose rewires neutrophil metabolism and promotes host injuryTyler Morrison1, Pranvera Sadiku1, Patricia Coelho1, Manuel Garcia1, Leila Reyes1, Emily Watts1, Ailiang Zhang1, Caroline Bruce1, Ananda Mirchandani1, Giovanni Rodriguez-Blanco2, Alex Von Kriegsheim2, Andrew Howden3, Fraser Gibb4, Moira Whyte1, Shareen Forbes5, and Sarah Walmsley1
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Candidalysin variants possess different potencies of immune activation in oral epithelial cellsDon Navod Wickramasinghe, Jonathan Richardson, and Julian Naglik
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Innate immunity and bone infections: emerging roles of PTX3 in Staphylococcus aureus-dependent osteomyelitisRaffaella Parente1, Valentina Possetti1,2, Valentina Granata1, Ciro Menale6, Eleonora Palagano7, Dario Strina3, Maria Schiavone1,3, Francesca Davi1, Maša Filipović4,5, Danka Grčević4,5, Barbara Bottazzi1, Alberto Mantovani1,8, Cristina Sobacchi1,3, and Antonio Inforzato1,2
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SLAMF1-derived peptide could limit the inflammatory signaling downstream several Toll-like receptorsKaja Nilsen1, Boyao Zhang3, Astrid Skjesol1, Siril Bakke1, Caroline Gravastrand1, Liv Ryan1, Ingvild Mestvedt1, Harald Husebye1, Egil Lien3, Terje Espevik1, and Maria Yurchenko1,2
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EGR1 and EGR2 regulate opposite transcriptional programs in human macrophages
Marten Hoeksema
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Signaling windows concept of innate immune responses – Francisella as a modelKlara Kubelkova and Ales Macela
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Synthetic Microbiota and Colonization Resistance in Gnotobiotic PigletsAlla Splichalova1, Kristyna Horvathova2, Eva Vlkova2, Zdislava Kindlova1, Vera Neuzil Bunesova2, and Igor Splichal1
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Alterations in lipidome profiles distinguish early-onset hyperuricemia and goutBlanka Stiburkova1, Katerina Pavelcova1, Jana Masinova1, Lenka Hasikova1, Karel Pavelka1, Ales Kvasnicka3, David Friedecky3, Radana Brumarova3, and Marketa Pavlikova
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HMGB1 and TLR4 in Gnotobiotic Piglets Associated with Probiotics and Defined Oligo MicrobiotaIgor Splichal1, Eva Vlkova2, Zdislava Kindlova1, Vera Neuzil Bunesova2, Kristyna Horvathova2, and Alla Splichalova1
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Characterization of non-coding RNAs and related target proteins in monocytes and macrophages of chronic lymphocytic leukemiaRonghua Zhang1, Priyanka Khare1, Priyanka Banerjee1, Cristina Ivan1, Sarah Schneider4, Federica Barbaglio3, Karen Clise-Dwyer5,10, Vanessa Jensen6, Erika Thompson7, Marisela Mendoza7, Nicholas Chiorazzi2, Shih-Shih Chen2, Xiao-Jie Yan2, Nitin Jain8, Paolo Ghia3, Federico Caligaris-Cappio3, William Wierda8, Varsha Gandhi1, George Calin9, Michael Keating8, and Maria Teresa Bertilaccio1
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Macrophages regulate ILC2 immune checkpoints expression and responsiveness to tissue-derived signals Cecilia Ciancaglini, Paola Vacca, Lorenzo Moretta, and Linda Quatrini
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Immunity to Influenza A Virus during Pregnancy: An unexpected Mechanism of ResistanceJulia Chronopoulos1,2, Erwan Pernet2, Toby McGovern1, Arina Morozan1,2, James Martin1,2, and Maziar Divangahi1,2
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Enhanced activation of IL-6/JAK2 axis confers neonatal susceptibility to GBS infections via inhibition of LC3 Associated Phagocytosis (LAP)Ourania Kolliniati1, Ioanna Lapi1, Ioanna Pantazi1, Stergios hatzisevastos1, Christos Tsatsanis1, and Eleni Vergadi3
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Rab37 fosters M2 polarization of tumor-associated macrophages via autophagyChih-Peng Chang1 and Wan-Ting Kuo2
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Different effects of NK cells and NK-derived soluble factors on cell lines derived from primary or metastatic pancreatic cancersPiera Fiore1, Nicola Tumino1, Enrico Munari2, Lorenzo Moretta1, and Paola Vacca1
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Ex vivo lung model to elucidate host-pathogen interactions in TuberculosisIda Fjellvær1,2, Marit Bugge1,2, and Trude Flo1,2
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Mechanisms regulating soluble PD-1 production and function in human NK cellsFrancesca Romana Mariotti1, Tiziano Ingegnere1, Nadine Landolina1, Paola Vacca2, and Loenzo Moretta1
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Breaking the link: Disentangling inflammasome activation and glycolytic reprogramming in Mycobacterium tuberculosis infected macrophagesAna Fernandes1,2, Diogo Silvério1,2, Marta Silva1,2, Rute Gonçalves1,2, Matias Cardoso3, Carolina Ferreira4,5, Ulrike Zedler6, Iola Duarte3, Ricardo Silvestre4,5, Anca Dorhoi6, and Margarida Saraiva1
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Building a scRNAseq Macrophage Atlas: A Comprehensive View of Cellular Heterogeneity and FunctionKlara Ruppova1, Pavel Honsa1, Alon Shaiber2, Shikha Nayar2, Scott Gigante2, Jana Sponarova3, and Adeeb Rahman2
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Aberrant tolerogenic functions and proinflammatory skew of dendritic cells
in STAT1 gain-of-function patients may contribute to autoimmunity and
fungal susceptibilityZuzana Parackova, Irena Zentsova, Petra Vrabcova, Anna Sediva, and Marketa Bloomfield
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The role of the scavenger receptor MARCO in Group B Streptococcus (GBS) clearance in neonatal and adult macrophages.Ioanna Lapi1,2,3, Ourania Kolliniati1,2,3, Ioanna Pantazi1,2,3, Stergios Chatzisevastos1,2,3, Christos Tsatsanis1,2, and Eleni Vergadi3
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PB2 and NS1 genes of 2009 pandemic H1N1 virus are associated with proinflammatory innate responses in human airway epithelial cellsHui Zeng, Claudia Pappas, Jessica Belser, and Taronna Maines
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Echinococcus granulosus antigen B: an immunomodulatory lipid-binding protein at the host-parasite interfaceSofía Lagos 1, Ana Folle1, Martín Fló2, Federico Carrión2, Otto Pritsch2, Jeremias Dutto 3, Mariana Maccioni3, Josep Julve4, and Ana Ferreira1
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The histone demethylase PHF8 regulates macrophage activation and metabolismMaria Daskalaki1, Ismini Marava1, Konstantinos Axarlis1, Eleni Vergadi1, Sotirios Kampranis2, and Christos Tsatsanis1
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evolution of virus-host interactions in SARS-CoV-2 VOCsJyoti Vishwakarma1, Melissa Verin1, Vincent Grass1, Antonio Piras1, Sussane Maidl1, Valter Bergant1, Carsten Schmidt-Weber2, Constanze Jakwerth2, and Andreas Pichlmair1
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Metabolic Reprogramming to Warburg Metabolism Enables Macrophages to Withstand FerroptosisCarolin Watson1, Jasmina Dukic1, Julia Unsöld1, Julia Sauer1, Daniela Schlösser1, Peter Murray2, and Karim El Kasmi1
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An orthogonal Approach to test the Relevance of ADP-ribosylation in Antiviral ImmunityDorsa Farhadnia1, Sabri Hamad1, Julia Mergner2, Carina Baer de Oliveira Mann1, and Andreas Pichlmair1
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Evolution of blood monocyte landscape during human NSCLC reveals their functional plasticity: Insights into pro-tumor activity, treatment response and mechanisms of resistance.Romana Vidergar1, Yunqin Lee1, Manprit Dhillon1, Jyue Yuan Lim1, Sze Sing Lee2, Wai Fook Leong1, Fara Regis2, Bernett Lee1, Shyam Prabhakar3, Balram Chowbay2, Ross Soo4, and Subhra Biswas1
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Macrophage cell state demonstrates limited plasticity under certain gene expression programsJacob Hochfelder
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Studying the complement system of the ancient chondrostean fish Acipenser gueldenstaedtii (Russian sturgeon) Ana Ferreira2, Alicia Costábile3, Marcio Aversa-Marnai1, Mauricio Castellano3, Ignacio Quartiani4, Alejandro Perreta4, Andrea Villarino3, and Valeria Silva-Alvarez1
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IL-1β ubiquitylation and turnover suppresses inflammation Vishwas Mishra, Anna Crespo Puig, Callum McCarthy, Tereza Masonou, Izabela Glegola-Madejska, Alice Dejoux , Gabriella Dow, Matthew Eldridge, Luciano Marinelli, MEIHAN MENG, Shijie Wang, Daniel Bennison, and Avinash Shenoy
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Mining pathway-based molecular networks to integrate and interpret multi-omics dataSara Patti, Cecilia Wieder, and Tim Ebbels
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The role of fibroblasts in initiation and maintenance of inflammation in the context of insulin resistance in ligamentum flavum hypertrophyEleni Paflioti, Evangelia Kandylaki, Georgios Kontakis, and Christos Tsatsanis
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Modulation of STING signaling changes outcomes of acute kidney injuryWulf Tonnus, Anne Brucker, Jorunn Becker, Karolin Flade, and Andreas Linkermann
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Resolution of inflammation is impaired in Parkinson’s disease and is rescued by specialized pro-resolving lipid mediator RvD1 through targeting microglia and brain-infiltrating macrophagesValerio Chiurchiu1,2, Marta Tiberi2, Alessandro Matteocci2, Mariangela Massaro Cenere3, and Nicola Mercuri4
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The glucocorticoid dexamethasone impairs antiviral effects of interferon-beta in an in vitro model of SARS-CoV-2 infection.Oliwia Bolimowska1, Aekkachai Tuekprakhon2, John O'Neil1, Zania Stamataki2, and Andrew Clark1
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Type I IFNs exacerbates Mycobaterium tuberbulosis induced cell death of human monocyte-derived macrophagesAngela Lee and Carl Nathan
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A single cell epigenomic atlas of adjuvant-mediated innate immune responsesYutaka Negishi1, Mumin Ozturk1, Andrea Lee2,5, Teja Celhar 2,5, Josephine Lum 2, Takeshi Takahashi3, Shanshan Howland 2,5, Akiko Minoda 1, Musa Mhlanga1,4, and Amit Singhal2,5
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Targeted removal of macrophage-secreted interleukin-1 receptor antagonist protects against lethal Candida albicans sepsisHang Gander-Bui1, Joëlle Schläfli1, Johanna Baumgartner1, Sabrina Walthert1, Vera Genitsch1, Geert van Geest2, Jose Galvan1, Carmen Cardozo1, Cristina Graham Martinez1, Mona Grans3, Sabine Muth3, Remy Bruggmann2, Hans Christian Probst3, Cem Gabay4, and Stefan Freigang1
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Neutrophils mediate protection against colitis and carcinogenesis by controlling bacterial invasion and driving IL-22 production by gamma delta T cells.Silvia Carnevale1, Andrea Ponzetta1, Anna Rigatelli1, Roberta Carriero1, Simone Puccio1, Domenico Supino1, Giovanna Grieco2, Fabio Pasqualini2, Camilla Recordati3, Claudio Tripodo4, Beatrice Belmonte4, Andrea Mariancini1, Francesco Scavello1, Irene Di Ceglie1, Paolo Kunderfranco1, Enrico Lugli1, Eduardo Bonavita1, Elena Magrini1, Cecilia Garlanda1, Alberto Mantovani1, and Sebastien Jaillon1
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Discovery of a forkhead box protein transcriptional network in human neutrophils following exposure to inflammatory stimuliAiten Ismailova, Reyhaneh Salehi-Tabar, Vassil Dimitrov, Babak Memari, Camille Barbier, and John White
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The long pentraxin PTX3 protects against invasive pneumococcal infection through regulation of the inflammatory response.Rémi Porte1, Rita Silva-Gomes1,2, Charlotte Theroude3, Raffaella Parente1, Fatemeth Asgari1,2, Marina Sironi1, Fabio Pasqualini1, Sonia Valentino1, Rosanna Asselta1,2, Camilla Recordati4,5, Marta Monari6, Andrea Doni1, Antonio Inforzato1,2, Jose Rodriguez-Gallego7, Ignacio Obando8, Barbara Bottazzi1, and Alberto Mantovani1,2,9
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MyD88-dependent activation of innate immune defense rules the Bordetella pertussis infection of nasal cavityPeter SEBO
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Balance between TNFα and type I IFN in JIA patients during anti TNFα therapyIrena Zentsova1, Petra Vrabcova1, Adam Klocperk1, Hanna Malcova2, Dita Cebecauerova2, Rudolf Horvath2, Anna Sediva1, and Zuzana Parackova1
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Flip side of the coin: IFN-induced trained immunity in non-immune cellsPawel Mikulski1, Sahar Tehrani1, Wojciech Siwek2, and Lars Jansen1
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Gut microbiota promotes mesenchymal niche development in early postnatal period by inducing macrophage Wnt secretion
Ji-Eun Kim and Tae-Hee Kim
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Live cell imaging delineating the kinetic correlation between ASC-speck formation and cytokine release in the NLRP3 inflammasome. One course of action or dependent on initiating trigger?Matthew Herring1,2, Alexander Persson1, Ryan Potter2, Roger Karlsson3, Eva Särndahl1, and Mikael Ejdebäck2
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