Unveiling autoimmune adrenal disease with imaging mass cytometry André Sulen1, Kathrine Skarstein2, Bergithe Oftedal1, Eystein Husebye1,3, and Eirik Bratland1
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Meningeal lymphatics and immunity in brain function and dysfunctionJonathan Kipnis
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IL-12-driven intrinsic neuroepithelial cells attenuate CNS inflammationMyrto Andreadou1, Ekaterina Friebel1, Teresa Cramer2, Pascale Eede3, Donatella De Feo1, Selma Tuzlak1, Christina Welsh1, Shirin Schneeberger3, Shiva Tyagarajan2, Melanie Greter1, Frank Heppner3, Sarah Mundt1, and Burkhard Becher1
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IL-17 regulates EAE severity through the intestinal environmentKatlynn Carter, Tommy Regen, and Ari Waisman
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Role of the phosphate exporter Xpr1 in myeloid cell developmentSebastian Stifter1, Ekaterina Petrova1, Selma Tuzlak2, Annika Keller3, Burkhard Becher2, and Melanie Greter1
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New molecular methods in the diagnosis of rheumatoid arthritisRanda Issa
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Does cancer masquerade as sarcoidosisDaniel Albert
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Enrichment of serum IgG4 in MuSK myasthenia gravis patientsDana Vergoossen1, Annabel Ruiter2, Kevin Keene2, Erik Niks2, Martijn Tannemaat2, Ellen Strijbos2, Alexander Lipka2, Els Jol-van der Zijde3, Jaap Bakker4, Brigitte Wevers4, Maarten van Tol3, Elisabet Westerberg5, Lucia Borges6, Olivia Tong6, David Richman6, Isabel Illa7, Anna Punga5, Amelia Evoli8, Silvere van der Maarel1, Jan Verschuuren2, and Maartje Huijbers1
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Uncovering how GM-CSF rejuvenates the Alzheimer brainRachel Lindemann1, Maria Geesdorf2, Wiebke Mildenberger1, Elsa Roussel1, Myrto Andreadou1, Philipp Häne1, Frank Heppner2, Donatella De Feo1, and Burkhard Becher1
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Constitutive RIG-I Activation Causes Skin Lesion Resembling Psoriasis in MiceAhmed Abu Tayeh and Takashi Fujita
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Nrf2 regulates redox metabolism of CD4+T cells in chronic inflammatory conditions like childhood arthritisAnandhi Rajendiran, Sudheendra Subramanyam, Klaus Tenbrock, and Kim Ohl
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PD-1/PD-L1 co-inhibition and its multiplexed impact on neuroinflammationChristian Ashworth1, Florian Ingelfinger1, Lothar Dieterich3, Bettina Schreiner3, Burkhard Becher1, and Sarah Mundt1
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Joint-tissue sensing drives TLR4+ Tfh-like cells cytotoxic activityDaniela Amaral-Silva, Jaime Branco, and Helena Soares
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Single cell sequencing of antigen-specific autoreactive B cells in MuSK myasthenia gravisLaurent Paardekooper1, Jessica van Bokkum1, Yvonne Fillié-Grijpma1, Theresa Kissel3, Susan Kloet1, Martijn Tannemaat2, Jan Verschuuren2, Silvère van der Maarel1, and Maartje Huijbers1
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Macrophage-derived human resistin promotes perivascular adipose tissue (PVAT) dysfunction in a rheumatoid arthritis mouse model.
Aline Fedoce1, Marcos Rosa1, Flávio Veras1, Ayda Schnaider1, Josiane Silva1, Isadora Paiva1, Mirele Machado1, Leandra Ramalho2, José Carlos Alves-Filho1, Fernando Cunha1, Anthony Bonavia3, Mitchell Lazar3, and Rita Tostes1
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NCF1-dependent low induction of reactive oxygen species in plasmacytoid dendritic cells exacerbates lupusHuqiao Luo1, Vilma Urbonaviciute1, Amir Saei1,2, and Rikard Holmdahl1
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Foxp3 expression on regulatory T cells is regulated by acetyl-coa availabilityPhilipp Stueve2, Janet Godoy2, Tim Sparwasser2, and Luciana Berod1
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An animal model of cortical grey matter inflammation resembling progressive MS pathologyEmily Ullrich Gavilanes1,2,3, Aleksandra Mezydlo1,2, Clara de la Rosa del Val1,2,3, Nils Treiber1,2, Virag Kocsis-Jutka1,2, and Martin Kerschensteiner1,2
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Astrocyte-derived HB-EGF promotes recovery from autoimmune CNS inflammation and is a potential target in progressive diseaseMathias Linnerbauer
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The RNA sensor TLR7 mediates immune cells, promoting autoimmunity and kidney disease during chronic RNA-viral infection in mouse and humanChristabel Kho1, Sümeyye Ertugrul1, Patrick Droste2, Alexandra Brand1, Satoru Kudose3, Konstantinos Symeonidis1, Sara Khorasani1, Hella Luksch4, Claudia Günther5, Vivette D'Agati3, Peter Boor2, Christian Kurts1, and Zeinab Abdullah1
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The role of cytokine-producing B cells in initiation of EAEAnna Thomann1, Courtney McQuade1, Katarina Pinjušić2, and Anneli Peters1,2
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The role of MMP-12 in MS-associated neuroinflammationLaura Oberbichler, Sara da Costa Pereira, Rachel Lindemann, Donatella de Feo, and Burkhard Becher
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Neutrophil extracellular traps (NET) trigger an enhanced pro-inflammatory response in macrophage subpopulations in rheumatoid arthritis patients via the aryl hydrocarbon receptor (AhR) pathwayDyhia Melbouci1, Sarra Seninet1, Marie-Christophe Boissier1,2, Elodie Segura3, and Patrice Decker1
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Intranasal delivery of TGFα – a novel therapeutic approach for lesion resolution in Multiple Sclerosis?Lena Loesslein
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Role of CNS-infiltrating immune cells in mice undergoing experimental autoimmune encephalomyelitis after asymptomatic HSV-1 infectionLuisa Duarte1, Mónica Farías2, Almendra Castillo 1, Felipe Cancino2, Claudia Riedel1, and Pablo González2
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The T cell HECT type ubiquitin ligase HECTd1 is a potential therapeutic target for multiple sclerosisAmy Tang and Deyu Fang
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TRAF6 counteracts MALT1 protease function to prevent autoimmune inflammationThomas O'Neill, Andreas Gewies, Carina Graß, Thomas Seeholzer, and Daniel Krappmann
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Serum and CSF protein profiles associated with severity of relapsing-remitting multiple sclerosis Carolina Moraes-Cabe1, Vincent Bondet1, Darragh Duffy1, Priyanka Devi-Marulkar1, Caroline Papeix2, Sandra Pellegrini1, and Frédérique Michel1
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Antigen-specific nanoparticle tolerance treatment actively induces regulatory mechanisms via the STING pathwayJoseph Podojil1,2, Tobias Neef1, Tushar Murthy2, Michael Boyne1,2, Ming-Yi Chiang1, Andrew Cogswell1, Adam Elhofy2, and Stephen Miller1
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GM-CSF drives multi-organ autoimmunity upon loss of peripheral toleranceSara Costa Pereira1, Margit Lanzinger2, Dona de Feo1, Nico Nunez1, Myrto Andreadou1, Sinduya Krishnarajah1, Elsa Roussel1, Frederike Ridder1, Juan Villar-Vesga1, Philipp Häne1, Rachel Lindemann1, Aakriti Sethi1, André Fonseca da Silva1, Mirjam Lutz1, Andrew Croxford3, Melanie Greter1, and Burkhard Becher1
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Identification of BPT264 - a potent alpha-enhanced/beta-dead and half-life-extended IL-2 Treg enhancer for treatment of autoimmune diseasesAdrian Walmsley, Magali Muller, Ruben Alvarez, Fabian Junker, Benoit Hornsperger, Roy Meoded, Jean-Philippe Carralot, Vijay Pattabiraman, and Bertolt Kreft
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Active translation control of CD4 T cell activation by regulatory T cellsSteven Ziegler1, Lomon So1, Kazushige Obata-Ninomiya1, Alex Hu1, and Ram Savan2
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Retroviral glycoprotein-mediated immune suppression via the potassium Channel KCa3.1- A new strategy for amelioration of Inflammatory Bowel Diseases (IBD).Magdalena Laska1, Jesper Bonnet Møller2, Jonas Heilskov Graversen3, Dorthe Strøbæk4, Linda Blomster5, Palle Christophersen4, and Shervin Bahrami6
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A minimal intracellular domain of CD5 allows a negative regulator of T cell activation to operate positivelyZachary Fasana1, Courtney Matson1, Erika Carmody1, Paul Love2, and Nevil Singh1
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Recent thymic emigrants require Notch signaling to transition into functionally mature naïve T cellsJC Zuniga-Pflucker
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Microglia ontogeny and phenotype is influenced by the unique micro-environment of the circumventricular organsHannah Van Hove1,2,3,5, Jonathan Bastos1,2,3, Isabelle Scheyltjens1,2,3, Karen De Vlaminck1,2,3, Ana Rita Pombo Antunes1,2,3, Daliya Kancheva1,2,3, Lukas Amann4, Wiebke Mildenberger5, Diego Gomez-Nicola6, Ilse Smolders7, Luc Bouwens8, Marco Prinz4,9,10, Melanie Greter5, Jo Van Ginderachter1,2, and Kiavash Movahedi1,2,3
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Identification of essential modules regulating T cell migration to the central nervous system in multiple sclerosisArek Kendirli, Clara de la Rosa, Katrin Lämmle, Isabel Bauer , Martin Kerschensteiner, and Naoto Kawakami
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Deficiency of NIK in CX3CR1 expressing cells protects from autoimmune neuroinflammationNishada Ramphal and Ari Waisman
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The emerging role of autoreactive T cells in Guillain-Barré syndromeLenka Súkeníková1, Anna Mallone1, Federica Sallusto1,2, Paolo Ripellino3, Bettina Schreiner4, and Daniela Latorre1
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B cells contribute to splenic CD8 T cell response through communication with marginal metallophilic macrophages and splenic cDC1 in murine Cytomegalovirus infectionXinyuan Liu, Ronald Backer, and Ari Waisman
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Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravisDana L.E. Vergoossen1, Jaap J. Plomp2, Christoph Gstöttner3, Yvonne E. Fillié-Grijpma1, Roy Augustinus1, Robyn Verpalen1, Manfred Wuhrer3, Paul W.H.I. Parren4,5, Elena Dominguez-Vega3, Silvère M. van der Maarel1, Jan J. Verschuuren2, and Maartje G. Huijbers2
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Identification of BPT323 - An immunocytokine for treatment of autoimmune diseases combining orthogonal modes of action of TNFa blockade and selective Treg expansionAdrian Walmsley, Magali Muller, Natalie Wickli, Sandra Klein, Ruben Alvarez, Robert Tam, Vijay Pattabiraman, and Bertolt Kreft
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