The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancerAndrea Murmann, Abdul Qadir, Austin Stults, and Marcus Peter
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Novel approaches to target STAT3 in cancerHua Yu
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Can your intimate partner’s bad mood make you sick?Jennifer Steel1,2,3, Youngmee Kim4, Yoram Vodovotz1, Vincent Reyes5, Michael Antoni4, Jonas Johnson5, Gauri Kiefer5, Christopher Marsh5, Jason Bierenbaum5, Nishant Tageja5, Michael Krauze5, Robert Van Der Weele5, Gaurav Goel5, Dan Zandberg5, Marci Nilsen6, and David Geller1
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STAT5 is a novel downstream effector in PDGFRB positive Anaplastic Large Cell LymphomaInes Garces de los Fayos Alonso1,2, Lamija Zujo1,3, Ivana Krsmanovic1,3, Petra Kodojova2, Michaela Schlederer1, Gerald Timelthaler4, Sophie Edtmayer5, Catello Giordano1, Michael Kothmayer1,2,6, Heidi Neubauer7, Saptaswa Dey8, Oliver Pusch6, Sandra Hoegler2, Simone Tangermann2, Ana-Iris Schiefer1,10,11, Christoph Kornauth1,10,11, Peter Wolf8, Dagmar Stoiber5, Philipp Staber10,11, Wolfram Klapper12, Wilhelm Woessmann13, Patrick Gunning14,15, Suzanne Turner16,17, Richard Moriggl7, Sabine Lagger2, and Lukas Kenner 1,2,3,9,18
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TGF-beta1 induced S100 family protein expression is associated with epithelial to mesenchymal transition states and poor survival in pancreatic cancer Ronnie Ren Jie Low1,2,3, Ka Yee Fung1,2, Hugh Gao3,4, Adele Preaudet1,2, Laura Dagley6, Jumana Yousef6, Rune Larsen6, Belinda Lee1,2, Peter Gibbs1,2, Nadia Kershaw7, Antony Burgess1,2, Frédéric Hollande3,4, Michael Griffin5, Sean Grimmond3,4, and Tracy Putoczki1,2
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The anti-inflammatory activity of a novel diisoquinoline derivative in combination with anti-MUC1 antibody in MCF-7 breast cancer cells
Krzysztof Bielawski1, Agnieszka Gornowicz2, Wojciech Szymanowski2, Karolina Lendzion2, and Anna Bielawska2
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The influence of etoposide in combination with anti-MUC1 antibody on TNF-α and COX-2 concentrations in MCF-7 breast cancer cells.Anna Bielawska1, Agnieszka Gornowicz1, Wojciech Szymanowski1, Karolina Lendzion1, and Krzysztof Bielawski2
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Eosinophils decrease pulmonary metastatic mammary tumor growthRachel Cederberg1,2 and Kevin Bennewith1,2
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Intercellular communication in melanoma microenvironment via exosomesKarolína Strnadová1,2, Petr Přikryl5, Jiří Novotný3,4, Martin Vokurka5, Jan Brábek, Michal Kolář3,4, Karel Smetana1,2, and Lukáš Lacina1,2,6
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Targeting hypoxia improves the benefit of immunotherapy in melanoma by regulating the pro-inflammatory cytokine/chemokine network and inducing immune cell infiltration.Audrey Lequeux1, Muhammad Zaeem Noman1, Alice Benoit1, Salem Chouaib2,3, and Bassam Janji1
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A single Cannabinoid reduces Melanoma secretion of CSF-1 leading to decreased MDSC immunosuppressive ActivityIris Wyrobnik, Hila Novak-Kotzer, and David Meiri
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Unraveling the interplay of CDK6 and STAT5B in NPM/ALK-driven transformation
Jonatan Kendler, Sebastian Kollmann, Barbara Maurer, Klavdija Bastl, Sophia Hofmann, and Veronika Sexl
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Exploring the role of cytokines in promoting the development of Squamous Cell Carcinoma in Epidermolysis BullosaAnshu Sharma1, Sarra Zaafouri1, Maria Klicznik1, Suraj Varkhande1, Giorgia Nasi1, Kathrina Umundum1, Eva Murauer2, Sophie Kitzmueller2, Verena Wally2, Josefina Piñón Hofbauer2, Christina Guttmann-Gruber2, Daniel Campbell3, and Iris Gratz1,2,3
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Non-canonical STAT3 function reduces REDD1 transcriptionNadine Köhler1, Fred Schaper1,2,3, and Anna Dittrich1,2,3
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New roles of pattern recognition receptor-induced transcription factor signalling in monocyte responsesIvana Andrejcinova1,2, Marcela Hortova Kohoutkova1, Veronika Bosakova1,2, Kamila Bendickova1, and Jan Fric1,3
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Gradient of cytokines associated with bone remodelling might indicate early biochemical recurrence in d'Amico high risk prostate cancer patients - a pilot study Julia Smentoch1, Tomasz Kryczka3, Anna Żaczek1, Marek Sowa2, Kevin Miszewski2, Marcin Matuszewski2, and Natalia Bednarz-Knoll1
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SBNO2 is a specific dependency of STAT3-driven T-cell malignancies Tania Brandstoetter1, Barbara Maurer1, Johannes Schmoellerl2, Sebastian Kollmann1, Jani Huuhtanen3, Reinhard Grausenburger1, Satu Mustjoki3, Johannes Zuber2, and Veronika Sexl1
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The interaction of CDK6 and STAT5 in CALR-mutant MPNsBrian Ringhofer, Wolfram Polzer, Sebastian Kollmann, Veronika Sexl, and Karoline Kollmann
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Interferon-deficiency modulates granulopoiesis and neutrophil activity in cancer Jadwiga Jablonska, Ekaterina Pylaeva, and Elena Siakaeva
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Targeting RING-finger E3 ligases PRAJA1 and 2 in GliomasKazufumi Ohshiro1 and Bibhuti Mishra2
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Super-enhancer-based identification of a BATF3/IL-2R module reveals vulnerabilities in anaplastic large cell lymphomaHuan-Chang Liang1, Mariantonia Costanza2, Nicole Prutsch4, Mark Zimmerman4, Elisabeth Gurnhofer1, Ivonne Montes-Mojarro5, Brian Abraham6, Nina Prokoph7, Stefan Stoiber1, Simone Tangermann8, Cosimo Lobello10, Jan Oppelt10, Ioannis Anagnostopoulos11, Thomas Hielscher16, Shahid Pervez12, Wolfram Klapper13, Francesca Zammarchi16, Daniel-Adriano Silva14, Christopher Garcia15, David Baker14, Martin Janz2, Nicolai Schleussner2, Falko Fend5, Sarka Posposilova9, Andrea Janikova9, Jacqueline Wallwitz18, Dagmar Stoiber18, Ingrid Simonitsch-Klupp1, Lorenzo Cerroni19, Stefano Pileri20, Laurence deLeval21, David Sibon22, Virginie Fataccioli23, Philippe Gaulard23, Chalid Assaf24, Fabian Knörr24, Christine Damm-Welk24, Wilhelm Woessmann24, Suzanne Turner7, Thomas Look4, Stephan Mathas3, Lukas Kenner1, and Olaf Merkel1
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The dual role of TYK2 as tumor driver and modulator of anti-tumor immune response in Anaplastic Large Cell LymphomaCatello Giordano1, Nicole Prutsch1,4, Elisabeth Gurnhofer1, Judith Leitner3, Peter Steinberger1,2, Lukas Kenner1, and Olaf Merkel1
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Characterization of Metformin's Repression of Chemokine Production in Triple-Negative Breast Cancer CellsDrake Alton and Barb Trask
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Expression of elongases ELOVL 2, ELOVL5 and ELOVL 6 in glioblastoma multiforme tumors Irena Baranowska-Bosiacka1, Jan Korbecki1, Donata Simińska1, Mateusz Bosiacki1, Ryta Łagocka1, Patrycja Kupnicka1, and Dariusz Chlubek1
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CCL18 expression in a tumor of glioblastoma multiforme and migration of hypoxia sensitized neoplastic cellsPatrycja Kupnicka1, Irena Baranowska-Bosiacka1, Szymon Grochans1, Jan Korbecki1, Mateusz Bosiacki2, Anna Baranowska1, Donata Simińska1, Wojciech Żwierełło1, and Dariusz Chlubek1
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Spatiotemporal regulation of differential type I interferon signaling in a multicellular contextEkaterina Novichkova and Gideon Schrieber
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Sex-biased development of LKB1-mutant lung adenocarcinoma correlates with differences in plasma cytokine levelsYijian Fan1, Rui Jin1, Xiuju Liu1, Yuan Liu2, Chunzi Huang1, Melissa-Gilbert Ross1, Adam Marcus1, and Wei Zhou1
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Loss of tumour-intrinsic type I IFN signalling predicts and facilitates bone-metastatic outgrowth in advanced prostate cancerKatie Owen1,7, Linden Gea2, Aaron Meyers1, Niall Corcoran4, Paul Hertzog2,3, Chris Hovens4, Shahneen Sandhu6,7, and Belinda Parker1,7
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SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferonMaya Shemesh1, Turgut Esad Aktepe2, Joshua Deerain2, Julie McAuley2, Michelle Audsley3, Cassandra David3, Damian Purcell2, Victoria Urin1, Rune Hartmann4, Gregory Moseley3, Jason Mackenzie2, Gideon Schreiber1, and Daniel Harari1
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Chronic and cycling hypoxia: triggers of cancer chronic inflammation through HIF-1 and NF-κB activation. Katarzyna Barczak1, Jan Korbecki3, Patrycja Kupnicka3, Mateusz Bosiacki2, Dariusz Chlubek3, and Irena Baranowska-Bosiacka3
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