Aegean Conferences

8th International Conference on Molecular Perspectives in Protein-Protein Interactions

Program

Important: The program online is copyrighted to each author and should not be copied and pasted!

General Information

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Friday, October 17

06:30 PM - 07:30 PM

Conference Registration

07:30 PM - 10:00 PM

Welcome Reception and Dinner

Saturday, October 18

08:00 AM - 08:50 AM

Breakfast

08:50 AM - 09:00 AM

Welcome and Opening Remarks - Brian Baker

Protein interactions in signaling I

Chair: Jacob Piehler

09:00 AM - 09:25 AM

Structure Dictates Co-Translational Assembly, Evolution Follows
Emmanuel Levy

09:25 AM - 09:50 AM

Mutational profiling of SARS-CoV-2 PLpro in human cells reveals requirements for function, structure, and drug escape
Xinyu Wu^1,², Margareta Go¹, Julie V Nguyen¹, Matthew E Call^1,², and Melissa J Call^1,²

09:50 AM - 10:15 AM

Re-designing Gα proteins with altered multi-specific partner interactions
Mickey Kosloff, Meirav Avital-Shacham, Anna Bakhman, Rojeh Eid, Lyudmila Getmanenko, Sabreen Higazy‑Mreih, Noor Natour, Irina Nekrasova, Isra Sadiya, and Ahmad Zedany

10:15 AM - 10:40 AM

Activation of the RXFP1 relaxin receptor by diverse agonists
Andrew Kruse

10:40 AM - 11:05 AM

A new role for SOCS2 in the DNA damage response
Sandra Nicholson

11:05 AM - 11:35 AM

Coffee Break and Poster Viewing (Odd Numbers)

Proteins in action: dynamics, allostery and cooperative interactions

Chair: Beatriz Trastoy Bello

11:35 AM - 12:00 PM

Protein-Protein Interactions in the Periplasmic Biogenesis Pathway
Karen Fleming

12:00 PM - 12:25 PM

Revealing protein dynamics by tuning relative humidity in X-ray crystallography
Sebastian Guenther, Patrick YA Reinke, Marina Galchenkova, Sven Falke, Pontus Fischer, Sreevidya Theeku Veedu, Jan Meyer, Miriam Barthelmess, and Alke Meents

12:25 PM - 12:50 PM

TBA - Xavier Salvatella
Xavier Salvatella

12:50 PM - 01:15 PM

The atypical filament assembly underpins the inflammasome-independent functions of IFI16.
Jungsan Sohn

01:15 PM - 01:40 PM

Inhibition of herpesvirus capsid packaging through small molecules
Elizabeth Draganova¹, Shea Lowery¹, Rachel Hill¹, and Ananya Paul

01:45 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:00 PM

Informal Discussions

07:30 PM - 11:00 PM

Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Sunday, October 19

08:00 AM - 09:00 AM

Breakfast

Manipulating, engineering, and modeling interactions

Chair: Melissa Call

09:00 AM - 09:25 AM

Stringent, but not relaxed yeast display evolution closely follows omicron evolution, providing molecular insight on how protein-protein interactions drive real-life virus evolution
Gideon Schreiber¹, Aviv Shoshany¹, Ruojin Tian², Miguel Padilla-Blanco², Marin Mokrejs², and Jiri Zahradnik²

09:25 AM - 09:50 AM

Small scaffold-derived protein binders effective in neutralizing of Candida albicans mediated infection
Maros Huliciak, Sohail Khoshnevis, and Eric John Sundberg

09:50 AM - 10:15 AM

Cyclotides as scaffolds for blocking intracellular protein:protein interactions
David J Craik

10:15 AM - 10:40 AM

Shared and distinct sequence-function signatures define different modes of hTpoR activation
Xinyu Wu^1,², Piers Blombery³, Melissa J Call^1,², and Matthew E Call^1,²

10:40 AM - 11:10 AM

Coffee Break and Poster Viewing (Even Numbers)

Protein interactions in infection and immunity

Chair: Mickey Kosloff

11:10 AM - 11:35 AM

The association and molecular mechanism behind asymptomatic SARS-CoV-2 infection
Dimitra Chatzileontiadou

11:35 AM - 12:00 PM

Uncovering How Chikungunya Virus Proteins Orchestrate Infection Through Dynamic Complexes
Juan Reguera and Rhian Jones

12:00 PM - 12:25 PM

Dynamic aspects of antigen presentation and T cell activation
Alexandra Mitlehner, Jana Sticht, Franziska Budig, and Christian Freund

12:25 PM - 12:50 PM

Using small molecules to regulate adaptive immune responses
Efstratios Stratikos

12:50 PM - 01:15 PM

Prediction and design of T cell receptor interactions with structural models
Phil Bradley

01:15 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:00 PM

Informal Discussions

07:30 PM - 11:00 PM

Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Monday, October 20

08:00 AM - 09:00 AM

Breakfast

Biophysics and mechanics

Chair: Efstratios Stratikos

09:00 AM - 09:25 AM

Biomolecular condensates: molecular insights and implications for disease intervention
Simon Alberti

09:25 AM - 09:50 AM

Virulent and antimicrobial amyloids
Meytal Landau

09:50 AM - 10:15 AM

Charged for action: how Basic residue Rich Sequence (BRS) regulates immunoreceptor signaling
Chenqi Xu

10:15 AM - 10:40 AM

How nature harnesses entropy to tune protein function
Zachary Wood

10:40 AM - 11:10 AM

Coffee Break and Poster Viewing (Odd Numbers)

Antibodies and other receptors

Chair: Eric Sundberg

11:10 AM - 11:35 AM

The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases
Diego Sastre

11:35 AM - 12:00 PM

Mechanisms of IgA1 cleavage by gut bacterial M64 Proteases
Beatriz Trastoy

12:00 PM - 12:25 PM

HLA-A*03:01 association with COVID-19 vaccine side effect is T cell independent
Stephanie Gras

12:25 PM - 12:50 PM

Mechanistic and structural insights into IgA1 recognition by the bacterial protease ThomasA
María Ángeles Márquez-Moñino¹, Ana Martínez-Gascueña¹, Tala Azzam², Aitor Manzanares-Gomez¹, Marina Aguillo-Urarte¹, Diego E. Sastre², Eric J. Sundberg², and Beatriz Trastoy¹

12:50 PM - 01:15 PM

TBA - Leo James
Leo James

01:15 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:00 PM

City Tour of Chania (Buses Depart Hotel Lobby)

08:00 PM - 11:00 PM

Dinner and Informal Discussions (Buses do not return or pickup from the hotel prior to dinner)

Tuesday, October 21

08:00 AM - 09:00 AM

Breakfast

Protein interactions in signaling II

Chair: Dimitra Chatzileontiadou

09:00 AM - 09:25 AM

The regulatory cortactin-WIP complex: structure and pharmaceutical applications
Chana G Sokolik¹, Miriam Gulman¹, Inna Mininberg¹, Inbal Sher¹, Shams Twafra², Hava Gil-Henn², and Jordan H Chill¹

09:25 AM - 09:50 AM

Protein complexes downstream of Parkinson’s disease associated LRRK2 kinase
Dieter Waschbuesch², Prosenjit Pal², Raja S Nirujogi², Melanie Cavin², Dario R Alessi², and Amir R Khan¹

09:50 AM - 10:15 AM

Structural and functional plasticity of cytokine receptor signaling complexes
Jacob Piehler

10:15 AM - 10:40 AM

Ionic protein interaction perspectives in immune receptor signaling
Hua Li

10:40 AM - 11:10 AM

Coffee Break and Poster Viewing (Even Numbers)

Imaging and mapping of PPIs

Chair: Brian Baker

11:10 AM - 11:35 AM

Bayesian metamodeling of early T-cell antigen receptor signaling accounts for its nanoscale activation patterns
Barak Raveh

11:35 AM - 12:00 PM

The Cys sense: Regulation of cellular proliferation and protein homeostasis through redox-switch proteins
Dana Reichmann¹, Meytal Radzinski¹, Tal Oppenheim¹, Tommer Ravid¹, Merav Braitbard², and Dina Schneidman²

12:00 PM - 12:25 PM

The SPID Platform: Navigating the Antibody Sequence Space at a Warp Speed
Tae-Young Yoon

12:25 PM - 12:50 PM

Mapping binding landscapes of Ras-effector interactions in health and disease
Atilio Tomazini, Sagara Gurusinghe, and Julia Shifman

12:50 PM - 01:15 PM

Live-cell quantitation of GPCR conformational ensembles that encode PPI selectivity and drug efficacy
Dimitrios Stamou

01:15 PM - 01:30 PM

Closing Remarks - Eric Sundberg

01:30 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:00 PM

Informal Discussions

07:30 PM - 11:00 PM

Farewell Dinner

Wednesday, October 22

08:00 AM - 10:00 AM

Breakfast

10:00 AM - 12:00 PM

Departure