First International Conference on Obesity - Biological Drivers and Therapeutic Approaches

Program

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences

    Registration 
    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.

    Airport
    Please note that Crete has two airports. You want to arrive at the Heraklion International Airport (code: HER) and take a taxi from the airport to the hotel (~65 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively Chania International Airport (CHQ) is a two-hour drive to the Conference Center.

    Accommodation Tax
    An accommodation tax of € 15.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 

    Accommodations
    Accommodations for the conference are at the Kalimera Kriti Hotel.  The hotel is located in Sissi, 40 km from Heraklion International Airport.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in 
    It is expected that attendees will arrive/check-in after 2:00 PM. Anyone arriving after 10:00 pm on the first day should make alternative dinner arrangements.

    Conference Venue
    The Kalimera Kriti Conference Center is located at the hotel. 

    Handicapped Accessibility
    The site is fully handicapped accessible.

    Oral Presentations
    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    Archaeological Site of Knossos and City Tour
    Buses for the city tour will depart from the hotel front lobby at 3:00 pm. Badges are required for participation. 

    Breakfast
    Breakfast for registered participants and registered accompanying persons will be served at the Kalimera Kriti main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions
    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions
    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer 
    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation
    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa/ETIAS
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date. Starting 2025 you may need to apply for an ETIAS.
    https://www.etiaseu.com/us-citizens/etias-greece

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information
    Animals are not permitted on site.
    Badges are required for admission to all events.
    All Aegean Conferences events are no smoking, no e-cigarretes, no vaping, etc. 

    No Photographs and Recording Devices 
    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 
    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

     

Tuesday, May 20

06:30 PM - 07:30 PM
Conference Registration
07:30 PM - 10:30 PM
Welcome Reception and Dinner

Wednesday, May 21

08:00 AM - 09:00 AM
Breakfast
09:00 AM - 09:05 AM
Welcome and Opening Remarks
Session I Plenary: Tissue crosstalk in energy balance and glucoregulation
Chairs: Jacqueline Stoeckli and Tony Tiganis
09:05 AM - 09:30 AM
1
Cellular energy sensing & implications for obesity
Greg Steinberg
09:30 AM - 09:55 AM
2
The impact of obesity in pregnancy on offspring hypothalamic feeding pathways: the role of insulin
Laura Dearden
09:55 AM - 10:20 AM
3
Inter-organ communication of active kinases: Implications for metabolic obesity related diseases
Mark A Febbraio
10:20 AM - 10:45 AM
4
Weight Loss & Systemic Improvements in the Cardiorenal Metabolic Syndrome: The Central Role of the Adipocyte
Philipp Scherer
10:45 AM - 11:00 AM
5
In Vivo Targeting of an Alternate Metabolism Pathway in Mice Protects Against Obesity
Simon T Bond, Michael F Keating, Yingying Liu, Christine Yang, Kevin H Liu, Anna C Calkin, and Brian G Drew
11:00 AM - 11:15 AM
6
The Alzheimer’s disease protein amyloid beta 42 links obesity with impaired cardiac energetics and function and development of heart failure
Liam Hall, Juliane Czeczor, Timothy Connor, and Sean McGee
11:15 AM - 11:30 AM
7
Enhancing the efficacy of incretin-based therapies
Tony Tiganis
11:30 AM - 12:00 PM
Coffee Break and Poster Viewing (Odd Numbers)
Session II Plenary: Genetics, ageing & mitochondria in obesity & metabolic disease
Chairs: Brian Drew and Tony Tiganis
12:00 PM - 12:25 PM
8
An Activation Mechanism of Ucp1-Independent Thermogenesis
Lawrence Kazak
12:25 PM - 12:50 PM
9
Fueling metabolic flexibility & mitochondrial lipid tolerance
Deborah Muoio
12:50 PM - 01:15 PM
10
Selective Insulin Resistance
David James
01:15 PM - 01:40 PM
11
Novel Small Molecule Approaches for Treatment of Obesity
Umut Ozcan
01:40 PM - 01:55 PM
12
Loss of adipocyte KAT8 uncouples adiposity and metabolic health
David Mendoza, Tamra Mendoza, Allison J Richard, and Jacqueline M Stephens
01:55 PM - 02:10 PM
13
Identification of a GxE health variant that protects against metabolic disease
Jacqueline Stoeckli
02:10 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:30 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Thursday, May 22

08:00 AM - 09:00 AM
Breakfast
Session III Plenary: Adipose Tissue Crosstalk
Chairs: Maria Chondronikola and Endre Kristóf
09:00 AM - 09:25 AM
14
Role of adipose tissue in interorgan crosstalk
Paul Cohen
09:25 AM - 09:50 AM
15
Circadian and thermogenic control of adipocyte metabolism and implications for inter-organ crosstalk
Zachary Gerhart-Hines
09:50 AM - 10:15 AM
16
Novel secreted peptides from human thermogenic adipocytes
Camilla Schéele
10:15 AM - 10:40 AM
17
Oxytocin: new metabolic roles for an ancient hormone
Evan D Rosen
10:40 AM - 10:55 AM
18
Modeling adipose tissue dysfunction in polycystic ovary syndrome in vitro using 2D and 3D cell culture systems
Anja Dekanski1, Congru Li1, Lena Emilia Schobloch1, Eva Lindgren1, Shane Wright1, Angelica Linden Hirschberg2, Duarte Ferreira1, Volker Lauschke1, Nayere Taebnia1, and Elisabet Stener-Victorin1
10:55 AM - 11:10 AM
19
Single cell transcriptomics of adipose tissue in weight loss reveals a role of NPY1R
Julius E.R. Grothen1,2, Jaime M. Martinez3, Nikos Sidiropoulos3, Lucas Massier4, Danae Zareifi4, Jiawei Zhong4, Jette W. Platou1, Henning Hvid1, Jette Mandelbaum1, Pia Rothe1, Jens M. Bruun 5,6,7, Bjørn Richelsen5,6,8, Bente Stallknecht9, Mikael Rydén4, Niklas Mejhert4, Jørn W. Helge9, Zach Gerhart-Hines2, and Thomas Å. Pedersen1
11:10 AM - 11:25 AM
20
Control of systemic glucose fluxes by atrial natriuretic peptide signaling in brown adipose tissue
Cedric Moro
11:25 AM - 11:55 AM
Coffee Break and Poster Viewing (Even Numbers)
Session IV Plenary: Adipocyte Growth, Differentiation & Subtypes
Chairs: Elisabet Stener-Victorin and Congru Li
11:55 AM - 12:20 PM
21
Cell cycle in mature human adipocytes
Kirsty Spalding
12:20 PM - 12:45 PM
22
Long non-coding RNAs regulating thermogenic function of human adipocytes
Søren Nielsen
12:45 PM - 01:10 PM
23
TBA - Alexander Bartelt
Alexander Bartelt
01:10 PM - 01:35 PM
24
Human adipose tissue development and therapeutic potential
Silvia Corvera
01:35 PM - 01:50 PM
25
Plasticity and heterogeneity of human adipose tissue in response to cold exposure in women with overweight and obesity
Isabel Reinisch1, Adhideb Ghosh1,2, Noe Falko2, Christian Wolfrum1, and Maria Chondronikola3
01:50 PM - 02:05 PM
26
TMEM16F-mediated phosphatidylserine exposure as a key contributor to adipogenesis
Rochelle M Ellison1, Brady J Barron1, Marta E Stremska1, Yitan Chen1, Sofia Gasperino1, Chanchal S Chowdhury1, Jerry Sun1, Laura Karvelyte1, Turan Tufan1, Shannon Kelley1, Rachael L Field1, John R Moley1, Christian Maueroder2, Jonathan R Brestoff1, and Kodi S Ravichandran1
02:05 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:30 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Friday, May 23

08:00 AM - 09:00 AM
Breakfast
Session V Plenary: Hypothalamic and brainstem modulators of energy homeostasis
Chairs: Nilufer Sayar and Cait Beddows
09:00 AM - 09:25 AM
27
Targeting the hypothalamus with small extracellular vesicles to prevent antipsychotic-induced weight gain
Johan Fernø
09:25 AM - 09:50 AM
28
Cortical-hypothalamic circuit mediating body weight
Zane Andrews
09:50 AM - 10:15 AM
29
Stress and appetite: a role for corticotropin-releasing hormone inputs to the brainstem
Marie K Holt
10:15 AM - 10:40 AM
30
Mapping the feeding circuitry in the human brain.
Giles Yeo
10:40 AM - 10:55 AM
31
A hypothalamic pathway for hunger induced reward sensitization
Deniz Atasoy and Hyojin Kim
10:55 AM - 11:10 AM
32
The Hypothalamic Extracellular Matrix: A New Player in the Fight Against Metabolic Disease
Cait A Beddows1, Feiyue Shi1, Anna Horton2,3, Sagar Dalal4, Ping Zhang5, Chang-Chun Ling5, V.Wee Yong6, Kim Loh7, Ellie Cho8, Adam J Rose9, Magdalene K Montgomery1, Nicki Packer4, Matthew Watt1, Benjamin J Parker1, Edward SX Moh4, and Garron T Dodd1
11:10 AM - 11:25 AM
33
Semaglutide effects on energy balance are mediated by Adcyap1+ neurons in the dorsal vagal complex
Linda Engström Ruud
11:25 AM - 11:55 AM
Coffee Break and Poster Viewing (Odd Numbers)
Session VI Plenary: GPCRs modulating ingestive behavior, energy expenditure & adiposity accumulation
Chairs: Katrine Galsgaard and Deniz Atasoy
11:55 AM - 12:20 PM
34
Dire fly, Dire mouse, Dire wolf: Regulation of Metabolism and Growth
Joel Elmquist
12:20 PM - 12:45 PM
35
Brain GPCR Circuits Controlling Energy Balance
Lora Heisler
12:45 PM - 01:10 PM
36
Temporal control of snacking and body weight by GHSR-expressing suprachiasmatic nucleus neurons
Omprakash Singh, Sepideh Sheybani-Deloui, Soumya Kulkarni, Moyu Lyu, Bingbing Li, Salil Varshney, Kripa Shankar, Deepali Gupta, Luis Leon Mercado, Avi W Burstein, Corine P Richard, Connor Lawrence, Sherri Osborne-Lawrence, and Jeffrey M Zigman
01:10 PM - 01:35 PM
37
Translational mechanisms for GPR75 loss-of-function and protection from obesity
Judith Altarejos
01:35 PM - 01:50 PM
38
Inhibition of a serotonergic brain circuit reverses middle aged decline in physical activity.
Pablo B Martinez de Morentin2, Alasdair Leeson-Payne1, Shuwen Mu1, and Lora K Heisler1
01:50 PM - 02:05 PM
39
Appetite for discovery: scalable human platforms for GLP-1 biology and novel discovery
Florian Merkle
02:05 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 08:00 PM
Archaeological Tour of Knossos and the Museum (Buses Depart Hotel Lobby)
08:00 PM - 11:00 PM
Dinner and Informal Discussions (Buses do not return or pickup from the hotel prior to dinner)

Saturday, May 24

08:00 AM - 09:00 AM
Breakfast
Session VII Plenary: GLP-1, amylin & emerging energy expending therapies
09:00 AM - 09:25 AM
40
Therapeutic strategies targeting energy expenditure
Michael P Czech
09:25 AM - 09:50 AM
41
Does it really take two to tango? GLP-1 vs. amylin therapies for obesity.
James L Trevaskis
09:50 AM - 10:15 AM
42
Known knowns and known unknowns of amylin biology
Thomas Lutz
10:15 AM - 10:40 AM
43
Characterization of selective amylin receptor agonists in rat models of aversion and obesity
David Hornigold
10:40 AM - 10:55 AM
44
targeting Neurofibrosis to potentiate Incretin Therapies
Feiyue Shi1, Cait A Beddows1, Emily A Canner1, Garron T Dodd1, Sagar Dalal2, Nicolle H Packer2, and Edward SX Moh2
10:55 AM - 11:10 AM
45
Pharmacological Activation of GPR139 by TAK-041 Modulates Energy Balance and Provides Insights into GPR139 Signaling
Ester Dos Santos Alves1, Gabriela Batitucci1, Nicolly Porto Marin2, Igor Vinicius Sousa Cavalheiro2, Shannon O'Brien3, Natália Ferreira Mendes2, Davide Calebiro3, and Licio Augusto Velloso1
11:10 AM - 11:25 AM
46
Fluoroquinolone-like compounds promote weight loss and improve glycemic control in obese mice
Niedson Correia de Lima Junior1, Gerson Profeta de Souza2, Linnéa Bergenholm3, Henver Simionato Brunetta4, Jessica Aparecida da Silva Pereira2, Fernanda Luísa Basei1, João Pedro Mazzi1, Letícia de Souza Figueiredo1, Gabriel Palermo Ruiz1, Deisi Braga Shimo1, Andrea Livia Silva Rocha5, Raul Gobato Costa1, Kauê de Oliveira Chinaglia1, José Luiz da Costa1, Jeremie Boucher3, Gavin O'Mahony3, and Marcelo Alves da Silva Mori1
11:25 AM - 11:55 AM
Coffee Break and Poster Viewing (Even Numbers)
Session VIII Plenary: Combination approaches, muscle function & future patient needs
11:55 AM - 12:20 PM
47
Antagonism vs. agonism for GIPR added to GLP-1 for weight loss
Murielle Veniant-Ellison
12:20 PM - 12:45 PM
48
GLP-1 combinations for obesity therapy
Manu Chakravarthy
12:45 PM - 01:10 PM
49
Activin blockade approaches to improve muscle function during weight loss
Mark Sleeman
01:10 PM - 01:35 PM
50
Clinical Obesity (Lancet Commission); From Definition, Diagnosis, to Preliminary Prevalence Rates
Eric Ravussin
01:35 PM - 01:50 PM
51
Identification of novel regulators of mitochondrial function and energy metabolism in adipose tissue
Chunyan Wu1, Tongtong Wang1, Miroslav Balaz2, and Christian Wolfrum1
01:50 PM - 02:05 PM
52
Chronic urocortin 2 administration improves exercise capacity and metabolism in diet-induced obese mice
Joe Brozinick, Andrew Ryan, Steve Bauer, Mark Wade, Natalie Janzen, and Pablo Vidal-Souza
02:05 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:30 PM
Informal Discussions
07:30 PM - 11:00 PM
Farewell Dinner

Sunday, May 25

07:30 AM - 10:00 AM
Breakfast
10:00 AM - 12:00 PM
Departure