Aegean Conferences

First International Conference on Obesity - Biological Drivers and Therapeutic Approaches

Program

Important: The program online is copyrighted to each author and should not be copied and pasted!

General Information

No details.

Tuesday, May 20

06:30 PM - 07:30 PM

Conference Registration

07:30 PM - 10:30 PM

Welcome Reception and Dinner

Wednesday, May 21

07:30 AM - 08:30 AM

Breakfast

08:30 AM - 08:35 AM

Welcome and Opening Remarks

Session I Plenary: Tissue crosstalk in energy balance and glucoregulation

Chairs: Jacqueline Stephens and Tony Tiganis

08:35 AM - 09:00 AM

Cellular energy sensing & implications for obesity
Greg Steinberg

09:00 AM - 09:25 AM

The impact of obesity in pregnancy on offspring hypothalamic feeding pathways: the role of insulin
Laura Dearden

09:25 AM - 09:50 AM

Inter-organ communication of active kinases: Implications for metabolic obesity related diseases
Mark A Febbraio

09:50 AM - 10:15 AM

Weight Loss & Systemic Improvements in the Cardiorenal Metabolic Syndrome: The Central Role of the Adipocyte
Philipp Scherer

10:15 AM - 10:30 AM

In Vivo Targeting of an Alternate Metabolism Pathway in Mice Protects Against Obesity
Simon T Bond, Michael F Keating, Yingying Liu, Christine Yang, Kevin H Liu, Anna C Calkin, and Brian G Drew

10:30 AM - 10:45 AM

The Alzheimer’s disease protein amyloid beta 42 links obesity with impaired cardiac energetics and function and development of heart failure
Liam Hall, Juliane Czeczor, Timothy Connor, and Sean McGee

10:45 AM - 11:00 AM

TBA - Tony Tiganis
Tony Tiganis

11:00 AM - 12:00 PM

Coffee Break and Poster Viewing (Odd Numbers)

Session II Plenary: Genetics, ageing & mitochondria in obesity & metabolic disease

Chairs: Brian Drew and Tony Tiganis

12:00 PM - 12:25 PM

An Activation Mechanism of Ucp1-Independent Thermogenesis
Lawrence Kazak

12:25 PM - 12:50 PM

Fueling metabolic flexibility & mitochondrial lipid tolerance
Deborah Muoio

12:50 PM - 01:15 PM

Selective Insulin Resistance
David James

01:15 PM - 01:40 PM

Novel Small Molecule Approaches for Treatment of Obesity
Umut Ozcan

01:40 PM - 01:55 PM

Loss of adipocyte KAT8 uncouples adiposity and metabolic health
David Mendoza, Tamra Mendoza, Allison J Richard, and Jacqueline M Stephens

01:55 PM - 02:10 PM

Identification of a GxE health variant that protects against metabolic disease
Jacqueline Stoeckli

02:10 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:30 PM

Informal Discussions

07:30 PM - 11:00 PM

Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Thursday, May 22

07:30 AM - 08:30 AM

Breakfast

Session III Plenary: Adipose Tissue Crosstalk

08:30 AM - 08:55 AM

Role of adipose tissue in interorgan crosstalk
Paul Cohen

08:55 AM - 09:20 AM

Circadian and thermogenic control of adipocyte metabolism and implications for inter-organ crosstalk
Zachary Gerhart-Hines

09:20 AM - 09:45 AM

Novel secreted peptides from human thermogenic adipocytes
Camilla Schéele

09:45 AM - 10:10 AM

Oxytocin: new metabolic roles for an ancient hormone
Evan D Rosen

10:10 AM - 10:25 AM

Modeling adipose tissue dysfunction in polycystic ovary syndrome in vitro using 2D and 3D cell culture systems
Anja Dekanski¹, Congru Li¹, Lena Emilia Schobloch¹, Eva Lindgren¹, Shane Wright¹, Angelica Linden Hirschberg², Duarte Ferreira¹, Volker Lauschke¹, Nayere Taebnia¹, and Elisabet Stener-Victorin¹

10:25 AM - 10:40 AM

Single cell transcriptomics of adipose tissue in weight loss reveals a role of NPY1R
Julius E.R. Grothen^1,², Jaime M. Martinez³, Nikos Sidiropoulos³, Lucas Massier⁴, Danae Zareifi⁴, Jiawei Zhong⁴, Jette W. Platou¹, Henning Hvid¹, Jette Mandelbaum¹, Pia Rothe¹, Jens M. Bruun ^5,^6,⁷, Bjørn Richelsen^5,^6,⁸, Bente Stallknecht⁹, Mikael Rydén⁴, Niklas Mejhert⁴, Jørn W. Helge⁹, Zach Gerhart-Hines², and Thomas Å. Pedersen¹

10:40 AM - 10:55 AM

Control of systemic glucose fluxes by atrial natriuretic peptide signaling in brown adipose tissue
Cedric Moro

10:55 AM - 11:55 AM

Coffee Break and Poster Viewing (Even Numbers)

Session IV Plenary: Adipocyte Growth, Differentiation & Subtypes

11:55 AM - 12:20 PM

Cell cycle in mature human adipocytes
Kirsty Spalding

12:20 PM - 12:45 PM

Long non-coding RNAs regulating thermogenic function of human adipocytes
Søren Nielsen

12:45 PM - 01:10 PM

TBA - Alexander Bartelt
Alexander Bartelt

01:10 PM - 01:35 PM

Human adipose tissue development and therapeutic potential
Silvia Corvera

01:35 PM - 01:50 PM

Plasticity and heterogeneity of human adipose tissue in response to cold exposure in women with overweight and obesity
Isabel Reinisch¹, Adhideb Ghosh^1,², Noe Falko², Christian Wolfrum¹, and Maria Chondronikola³

01:50 PM - 02:05 PM

TMEM16F-mediated phosphatidylserine exposure as a key contributor to adipogenesis
Rochelle M Ellison¹, Brady J Barron¹, Marta E Stremska¹, Yitan Chen¹, Sofia Gasperino¹, Chanchal S Chowdhury¹, Jerry Sun¹, Laura Karvelyte¹, Turan Tufan¹, Shannon Kelley¹, Rachael L Field¹, John R Moley¹, Christian Maueroder², Jonathan R Brestoff¹, and Kodi S Ravichandran¹

02:05 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:30 PM

Informal Discussions

07:30 PM - 11:00 PM

Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Friday, May 23

07:30 AM - 08:30 AM

Breakfast

Session V Plenary: Hypothalamic and brainstem modulators of energy homeostasis

Chairs: Nilufer Sayar and Cait Beddows

08:30 AM - 08:55 AM

Targeting the hypothalamus with small extracellular vesicles to prevent antipsychotic-induced weight gain
Johan Fernø

08:55 AM - 09:20 AM

Cortical-hypothalamic circuit mediating body weight
Zane Andrews

09:20 AM - 09:45 AM

Stress and appetite: a role for corticotropin-releasing hormone inputs to the brainstem
Marie K Holt

09:45 AM - 10:10 AM

Mapping the feeding circuitry in the human brain.
Giles Yeo

10:10 AM - 10:25 AM

A hypothalamic pathway for hunger induced reward sensitization
Deniz Atasoy and Hyojin Kim

10:25 AM - 10:40 AM

The Hypothalamic Extracellular Matrix: A New Player in the Fight Against Metabolic Disease
Cait A Beddows¹, Feiyue Shi¹, Anna Horton^2,³, Sagar Dalal⁴, Ping Zhang⁵, Chang-Chun Ling⁵, V.Wee Yong⁶, Kim Loh⁷, Ellie Cho⁸, Adam J Rose⁹, Magdalene K Montgomery¹, Nicki Packer⁴, Matthew Watt¹, Benjamin J Parker¹, Edward SX Moh⁴, and Garron T Dodd¹

10:40 AM - 10:55 AM

Semaglutide effects on energy balance are mediated by Adcyap1+ neurons in the dorsal vagal complex
Linda Engström Ruud

10:55 AM - 11:55 AM

Coffee Break and Poster Viewing (Odd Numbers)

Session VI Plenary: GPCRs modulating ingestive behavior, energy expenditure & adiposity accumulation

Chairs: Katrine Galsgaard and Deniz Atasoy

11:55 AM - 12:20 PM

Dire fly, Dire mouse, Dire wolf: Regulation of Metabolism and Growth
Joel Elmquist

12:20 PM - 12:45 PM

Brain GPCR Circuits Controlling Energy Balance
Lora Heisler

12:45 PM - 01:10 PM

Temporal control of snacking and body weight by GHSR-expressing suprachiasmatic nucleus neurons
Omprakash Singh, Sepideh Sheybani-Deloui, Soumya Kulkarni, Moyu Lyu, Bingbing Li, Salil Varshney, Kripa Shankar, Deepali Gupta, Luis Leon Mercado, Avi W Burstein, Corine P Richard, Connor Lawrence, Sherri Osborne-Lawrence, and Jeffrey M Zigman

01:10 PM - 01:35 PM

Translational mechanisms for GPR75 loss-of-function and protection from obesity
Judith Altarejos

01:35 PM - 01:50 PM

Inhibition of a serotonergic brain circuit reverses middle aged decline in physical activity.
Pablo B Martinez de Morentin², Alasdair Leeson-Payne¹, Shuwen Mu¹, and Lora K Heisler¹

01:50 PM - 02:05 PM

Appetite for discovery: scalable human platforms for GLP-1 biology and novel discovery
Florian Merkle

02:05 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 08:00 PM

Archaeological Tour of Knossos and the Museum (Buses Depart Hotel Lobby)

08:00 PM - 11:00 PM

Dinner and Informal Discussions (Buses do not return or pickup from the hotel prior to dinner)

Saturday, May 24

07:30 AM - 08:30 AM

Breakfast

Session VII Plenary: GLP-1, amylin & emerging energy expending therapies

08:30 AM - 08:55 AM

Therapeutic strategies targeting energy expenditure
Michael P Czech

08:55 AM - 09:20 AM

Does it really take two to tango? GLP-1 vs. amylin therapies for obesity.
James L Trevaskis

09:20 AM - 09:45 AM

Known knowns and known unknowns of amylin biology
Thomas Lutz

09:45 AM - 10:10 AM

Amylin-based therapies for treatment of obesity
David Hornigold

10:10 AM - 10:25 AM

targeting Neurofibrosis to potentiate Incretin Therapies
Feiyue Shi¹, Cait A Beddows¹, Emily A Canner¹, Garron T Dodd¹, Sagar Dalal², Nicolle H Packer², and Edward SX Moh²

10:25 AM - 10:40 AM

Pharmacological Activation of GPR139 by TAK-401 Modulates Energy Balance and Provides Insights into GPR139 Signaling
Ester Dos Santos Alves¹, Gabriela Batitucci¹, Nicolly Porto Marin², Igor Vinicius Sousa Cavalheiro², Shannon O'Brien³, Natália Ferreira Mendes², Davide Calebiro³, and Licio Augusto Velloso¹

10:40 AM - 10:55 AM

Fluoroquinolone-like compounds promote weight loss and improve glycemic control in obese mice
Niedson Correia de Lima Junior¹, Gerson Profeta de Souza², Linnéa Bergenholm³, Henver Simionato Brunetta⁴, Jessica Aparecida da Silva Pereira², Fernanda Luísa Basei¹, João Pedro Mazzi¹, Letícia de Souza Figueiredo¹, Gabriel Palermo Ruiz¹, Deisi Braga Shimo¹, Andrea Livia Silva Rocha⁵, Raul Gobato Costa¹, Kauê de Oliveira Chinaglia¹, José Luiz da Costa¹, Jeremie Boucher³, Gavin O'Mahony³, and Marcelo Alves da Silva Mori¹

10:55 AM - 11:55 AM

Coffee Break and Poster Viewing (Even Numbers)

Session VIII Plenary: Combination approaches, muscle function & future patient needs

11:55 AM - 12:20 PM

Antagonism vs. agonism for GIPR added to GLP-1 for weight loss
Murielle Veniant-Ellison

12:20 PM - 12:45 PM

GLP-1 combinations for obesity therapy
Manu Chakravarthy

12:45 PM - 01:10 PM

Activin blockade approaches to improve muscle function during weight loss
Mark Sleeman

01:10 PM - 01:35 PM

Clinical Obesity (Lancet Commission); From Definition, Diagnosis, to Preliminary Prevalence Rates
Eric Ravussin

01:35 PM - 01:50 PM

Identification of novel regulators of mitochondrial function and energy metabolism in adipose tissue
Chunyan Wu¹, Tongtong Wang¹, Miroslav Balaz², and Christian Wolfrum¹

01:50 PM - 02:05 PM

Chronic urocortin 2 administration improves exercise capacity and metabolism in diet-induced obese mice
Joe Brozinick, Andrew Ryan, Steve Bauer, Mark Wade, Natalie Janzen, and Pablo Vidal-Souza

02:05 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:30 PM

Informal Discussions

07:30 PM - 11:00 PM

Farewell Dinner

Sunday, May 25

07:30 AM - 10:00 AM

Breakfast

10:00 AM - 12:00 PM

Departure