9th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets


Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences 


    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.


    You want to arrive at the Kalamata International Airport (code: KLX) and take a taxi from the airport to the hotel (~25 EUR). 

    Accommodation Tax

    An accommodation tax of € 4.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 


    Accommodations for the conference are at the Grecotel Filoxenia.  The hotel is located in the city of Kalamata, 13 km from  Airport.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in 

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements. 

    Conference Venue

    The Grecotel Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible. 

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 


    Breakfast for registered participants and registered accompanying persons will be served at the Grecotel Filoxenia main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer 

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date. 

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking. 

    No Photographs and Recording Devices 

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations.  

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 


    Aegean Conferences expects attendees to conform their conduct at these meetings to the policies and procedures of their employing institution or company. If we learn of improper conduct by an attendee, we will take appropriate action, including reporting such conduct to the attendee's employing institution or company and barring the attendee from participation in our meetings. 

    The Aegean Conferences is committed to protecting the privacy of its visitors. Information that our meeting participants provide or that is derived from internal website tracking is not sold, rented or shared with any individual or organization.  You can let us know that you would prefer not to receive information by e-mail at any time, simply by sending an e-mail to unsubscribe@aegeanconferences.org. If you do so, we will not use your personal information for informing you on our future meetings and other services. 


Sunday, September 17

06:30 PM - 07:30 PM
Conference Registration
07:30 PM - 10:30 PM
Welcome Reception and Dinner

Monday, September 18

08:00 AM - 09:00 AM
09:00 AM - 09:05 AM
Welcome and Opening Remarks - Costas Koumenis
Age-related changes in the TME and cancer cells
Chair: Costas Koumenis
09:05 AM - 09:30 AM
Age Against the Machine: How the aging microenvironment drives tumor progression
Ashani Weeraratna
09:30 AM - 09:55 AM
Age-related stromal changes drive breast cancer progression
Sheila Stewart
09:55 AM - 10:20 AM
UGCG inhibition augments anti-tumor immunity in melanoma
Vaibhav Jain1, Monika Bhardwaj1, Amanda Versace1, Shujing Liu2, Sandra Harper3, Mary Ann S Crissey1, Aaron R. Goldman3, Xiaowei Xu2, David Speicher3, and Ravi Amaravadi1
10:20 AM - 10:45 AM
Unraveling the Complexities of the Aging Breast Cancer Microenvironment for Improved Treatment Strategies
Sandra S. McAllister
10:45 AM - 11:20 AM
Coffee Break-Discussions and Poster Viewing
The immune landscape of tumors, cancer cell plasticity & immune evasion
Chair: Sandra Ryeom
11:20 AM - 11:45 AM
Glutamine metabolism regulates dendritic cell distribution in the tumor microenvironment.
Malay Haldar and Graham Lobel
11:45 AM - 12:10 PM
The lymph node microenvironment induces cancer cell plasticity and evasion of anticancer immunity
Timothy Padera
12:10 PM - 12:35 PM
Metabolic reprogramming of endothelial cells for cancer immunotherapy
Yi Fan and Yanqing Gong
12:35 PM - 01:00 PM
NFE2L2 mutation enhances radioresistance in head and neck cancer by modulating intratumoral myeloid cells
Quynh-Thu Le
01:00 PM - 01:15 PM
Investigating the bidirectional interaction of tumor cells and the bone marrow (BM) microenvironment.
Richard WJ Groen
01:15 PM - 01:30 PM
Enhanced Acod1 expression in cancer cells promotes immune evasion
James Schofield1, Joseph Longo2, Sean Murphy1, Ryan Sheldon2, Emma Albano1, Russell Jones2, Xin Lu1, and Zachary Schafer1
01:30 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 10:30 PM
Dinner and Informal Discussions - Buses Depart Hotel Lobby

Tuesday, September 19

07:30 AM - 08:30 AM
TME stress responses I: UPR and ISR
Chair: Albert Koong
08:30 AM - 08:55 AM
IRE1 Regulates Ferroptosis through Regulation of Glutathione Synthesis: Implications for Cancer Therapy
Albert Koong
08:55 AM - 09:20 AM
Endoplasmic Reticulum proteostasis in brain cancer
Eric Chevet
09:20 AM - 09:45 AM
Metabolic stress in the tumor microenvironment and the Integrated Stress Response
Cristina Muñoz-Pinedo
09:45 AM - 10:10 AM
Stressing Out Therapy-Resistant Cancers
Xi Chen
10:10 AM - 10:25 AM
PKR-like endoplasmic reticulum kinase is a marker and target to enhance immune checkpoint therapy response
Katherine Cook, Adam Wilson, Mitra Kooshki, Pierre Triozzi, and David Soto-Pantoja
10:25 AM - 10:40 AM
PRDX4 loss triggers antitumor immune responses through DNA damage in pancreatic cancer
Lucie Malbeteau1, Emily Poulton1,3, Vishal Pandya1,4, Alina Jaglanian1, Shane Harding1,2,3, and Marianne Koritzinsky1,2,3,4
10:40 AM - 11:30 AM
Coffee Break and Poster Viewing
TME Stress responses II: Autophagy, differentiation & senescence
Chair: Ashani Weeraratna
11:30 AM - 11:55 AM
Identifying and disabling lysosome dependent adaptive programs in primary and metastatic pancreatic cancer
Rushika Perera
11:55 AM - 12:20 PM
Autophagy and metastatic differentiation
Jay Debnath
12:20 PM - 12:45 PM
Therapy-Induced Senescence Landscape
Pataje Prasanna
12:45 PM - 01:15 PM
Senescence and senolytic strategies to enhance the response to standard of care in preclinical cancer models
David Gewirtz, Hisashi Harada, Fereshteh Ahmadinejad, Valerie Carpenter, Natalie Luffman, Ahmed Elshazly, and Tareq Saleh
01:15 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 10:30 PM
Dinner and Informal Discussions - Buses Depart Hotel Lobby

Wednesday, September 20

07:30 AM - 08:30 AM
Metabolism in primary and metastatic tumors
Chair: Yi Fan
08:30 AM - 08:55 AM
Dissecting the crosstalk of nutrient sensing, stress response signalling and immune evasion
Thales Papagiannakopoulos
08:55 AM - 09:20 AM
Selective remodeling of the translatome underlies ketogenesis and diet associated tumor growth
Davide Ruggero
09:20 AM - 09:45 AM
Deciphering the Warburg effect: mitochondrial uncoupling reprograms cancer metabolism and epigenome to induce differentiation
Jiangbin Ye
09:45 AM - 10:10 AM
Understanding the role of Mitochondria in Cancer and Age
Marcia Haigis
10:15 AM - 11:15 AM
Coffee Break and Poster Viewing
Tumor-stroma interactions
Chair: Ioannis Verginadis
11:15 AM - 11:40 AM
Tumor-stroma coevolution
Ruth Scherz-Shouval
11:40 AM - 12:05 PM
Tumor innervation in cancer progression
Sandra Ryeom
12:05 PM - 12:30 PM
Cell - cell interactions in regulation of lung homeostasis, disease and cancer
Carla Kim
12:30 PM - 12:45 PM
Tumor-stroma assembloids of lung adenocarcinoma reveal the spatial cell-cell "colocatome”
Gina Bouchard1, Weiruo Zhang1, Irene Li1, Ilayda Ilerten1, Asmita Bhattacharya3, Yuanyuan Li1, Winston Trope4, Joseph Shrager4, Calvin Kuo3, Lu Tian1, Amato Giaccia5,, and Sylvia Plevritis1
12:45 PM - 01:00 PM
Hypoxia shapes the chromatin accessibility changes in glioma-reprogrammed microglial cells
Monika Dzwigonska1, Jakub Mieczkowski2, Bozena Kaminska1, and Katarzyna Leszczynska1
01:00 PM - 01:15 PM
Exploring the relationship between the epigenome and metabolism in MYCN-amplified neuroblastoma
Krista Dalton1, Timothy Lochmann1, Colin Coon1, Marissa Calbert1, Mikhail Dozmorov2, Lisa Shock4, Madhu Gowda3, Masoud Manjili4, and Jennifer Koblinski5
01:15 PM - 01:30 PM
Dissecting the role of redox homeostasis and ferroptosis in lung adenocarcinoma
Katherine Wu1,2, Jozef Bossowski1,3, Toshitaka Nakamura4, Hongyu Ding1,3, Marcus Conrad4, and Thales Papagiannakopoulos1,3
01:30 PM - 01:45 PM
The inflammatory signals produced by fatty bone marrow promote clonal hematopoiesis driven by DNMT3a
Nathali kaushansky, Naama Zioni, and Liran Shlush
01:45 PM - 03:00 PM
Lunch and Informal Discussions
03:30 PM - 07:30 PM
Cultural Tour - Buses Depart Hotel Lobby
07:30 PM - 10:30 PM
Dinner and Informal Discussions (Buses do not return to hotel prior to dinner)

Thursday, September 21

07:30 AM - 08:30 AM
Tumor stem cells, cell-autonomous signaling
Chair: Maria Tsiarli
08:30 AM - 08:55 AM
Cell Stress, Cell Death and Inflammation: What doesn’t Kill you Makes you Stranger
Seamus Martin
08:55 AM - 09:20 AM
Loss of PP2A activity drive prostate cancer progression and therapy resistance
Irfan Asagnani
09:20 AM - 09:45 AM
Targeting lipid metabolic vulnerabilities in chemotherapy-tolerant persister cells
Lenka Munoz
09:45 AM - 10:10 AM
Chromatin regulation and cancer
Yang Shi
10:10 AM - 10:25 AM
Short Coffee break
Latest developments in Radiotherapy-FLASH Radiation I
Chair: Michele Kim
10:25 AM - 10:50 AM
Overcoming radiation resistance of tumors with FLASH?
Marie-Catherine Vozenin
10:50 AM - 11:15 AM
Elucidating the protective neurological mechanisms of hypofractionated FLASH radiotherapy in pediatric and adult mouse models
Charles Limoli
11:15 AM - 11:45 AM
Coffee Break and Poster Viewing
Latest developments in Radiotherapy-FLASH Radiation II
Chair: Erato Stylianou Markidou
11:45 AM - 12:10 PM
Physics considerations for clinical translations of proton FLASH radiotherapy
Michele Kim
12:10 PM - 12:35 PM
Effects of FLASH proton radiotherapy on bone/soft tissue and tumor growth using single dose and fractionated regimens
Anastasia Velalopoulou1, Ilias V. Karagounis2, Kyle Kim1, Jiawei Lu3, Ken Chen3, Ioannis I. Verginadis1, Gwendolyn M. Cramer1, Michele Kim1, Eric Diffenderfer1, Lei Dong1, Michele M. Kim1, Ling Qin3, James Metz1, Costantinos Koumenis1, Keith A. Cenge1, Theresa M. Busch1, and Amit Maity2
12:35 PM - 01:00 PM
A surprising role for IFN signaling behind the FLASH sparing effect in normal intestinal tissues
Costas Koumenis
01:00 PM - 01:25 PM
Investigating the Effects of FLASH Radiotherapy Using Large Animal Models: The Issue at Hand is the Tissue at Hand
Cengel Keith
01:25 PM - 01:40 PM
FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease.
Ioannis (Yiannis) Verginadis1, Kyle Kim1, Michele Kim1, Giorgos Skoufos3, Eric Diffenderfer1, Joanna Griffin4, Artemis Hatzigeorgiou3,5, James Metz1, Alexander Lin1, Steven Feigenberg1, Keith Cengel1, Bonnie Ky, and Constantinos Koumenis1
01:40 PM - 01:45 PM
Closing Remarks
01:45 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Farewell Dinner

Friday, September 22

08:00 AM - 10:00 AM
10:00 AM - 12:00 PM