First International Conference of Liver Pathobiology: From Bench to Bedside

Program - Friday, October 13

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences


    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.


    Please note that Crete has two airports. You want to arrive at the Chania International Airport (code: CHQ) and take a taxi from the airport to the hotel (~60 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively the other airport (HER) is a two-hour drive to the Conference Center.

    Accommodation Tax

    An accommodation tax of € 4.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 


    Accommodations for the conference are at the Avra Imperial Hotel.  The hotel is located in Kolymbari, 39 km from Chania International Airport, 23 km from the Souda Harbor, and 23 km west of Chania town center.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Avra Imperial Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 


    Breakfast for registered participants and registered accompanying persons will be served at the Avra Imperial Hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Friday, October 13

08:00 AM - 09:00 AM
Transcriptional regulation, identity, cell-cell communication and connective tissue biology in hepatic health and disease
Chairs: Kirsten Sadler and Mikko Karpale
09:00 AM - 09:30 AM
Epigenetic mechanisms of tissue aging
Payel Sen
09:30 AM - 10:00 AM
Game of zones: WNTer is coming
Jan Tchorz
10:00 AM - 10:30 AM
Regulation of hepatocyte functions by hepatic stellate cells in health and disease
Robert Schwabe1 and Aveline Filliol2
10:30 AM - 10:45 AM
Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies
Vincent Merens, Stefaan Verhulst, and Leo van Grunsven
10:45 AM - 11:00 AM
Multicellular liver organoids recapitulate homeostatic and fibrotic peri-portal liver tissue architecture and cellular interactions in vitro.
Anna Dowbaj1, Aleksandra Sljukic1, Armin Niksic1, Cedric Landerer1, Julien Delpierre1, Ariane Kuehn1, Marino Zerial1,2, and Meritxell Huch1,2,3
11:00 AM - 11:15 AM
Understanding the Role of HNF1B in the Transition of the Endoderm to a Hepatic Fate
Carla Martinez-Morant and Stephen Duncan
11:15 AM - 11:45 AM
Coffee Break and Poster Viewing
Transcriptional regulation, identity, cell-cell communication and connective tissue biology in hepatic health and disease
Chairs: Jan Tchorz and Anna Dowbaj
11:45 AM - 12:15 PM
Translational control in liver disease
Mercedes Fernandez
12:15 PM - 12:45 PM
How programmed cell death and cell death responses control HCC development
Tom Luedde and Anne Schneider
12:45 PM - 01:15 PM
The development of ex vivo models of hepatocellular carcinoma for therapeutic screening and as a precision medicine tool.
Amy Collins1,2, Jack Leslie1,2, Maja Laszczewska1,2, Erik Ramon-Gil1,2, Daniel Geh1,2, Glyn Nelson3, Rainie Cameron1, Kenny Dalgarno4, Helen Reeves2,5, Derek Mann1,2, and Fiona Oakley1,2
01:15 PM - 01:30 PM
The distinct effects of oxygen shortage, Roxadustat and HIF-P4H-2 inhibition on mouse embryonic fibroblasts and hepatic stellate cell activation
Mikko Karpale, Atte Tapiola, Sofia Siermala, and Peppi Koivunen
01:30 PM - 01:45 PM
Disease-specific human ECM composition and bioactivity in NASH liver fibrosis
Alan` Holmes
01:45 PM - 03:00 PM
Lunch and Informal Discussion
03:00 PM - 07:00 PM
Informal Discussinos
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)