First International Conference of Liver Pathobiology: From Bench to Bedside


Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences


    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.


    Please note that Crete has two airports. You want to arrive at the Chania International Airport (code: CHQ) and take a taxi from the airport to the hotel (~60 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively the other airport (HER) is a two-hour drive to the Conference Center.

    Accommodation Tax

    An accommodation tax of € 4.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 


    Accommodations for the conference are at the Avra Imperial Hotel.  The hotel is located in Kolymbari, 39 km from Chania International Airport, 23 km from the Souda Harbor, and 23 km west of Chania town center.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Avra Imperial Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 


    Breakfast for registered participants and registered accompanying persons will be served at the Avra Imperial Hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Wednesday, October 11

06:30 PM - 07:30 PM
Conference Registration
07:30 PM - 10:30 PM
Welcome Reception and Dinner

Thursday, October 12

08:00 AM - 08:50 AM
08:50 AM - 09:00 AM
Welcome and Opening Remarks
Novel approaches in liver biology and pathobiology
Chairs: Holger Willenbring and Carla Martinez Morant
09:00 AM - 09:30 AM
Multimodal decoding of human liver regeneration
Neil Henderson and Kylie Matchett
09:30 AM - 10:00 AM
Approaches to extending the reach of liver gene therapy
Holger Willenbring
10:00 AM - 10:30 AM
Epigenetic regulation of liver development, cancer & regeneration
Kirsten Sadler
10:30 AM - 10:45 AM
Mechanosensitive self-fueling vascular Wnt controls liver function
Ki Hong Lee1,2 and Hellmut Augustin1,2
10:45 AM - 11:00 AM
the niche map of ductular reaction-driven regeneration
Rita Manco, Gauthier Neirynck, and Isabelle Leclercq
11:00 AM - 11:30 AM
Coffee Break and Poster Viewing
Novel approaches in liver biology and pathobiology
Chairs: Rita Manco and Charlotte Scott
11:30 AM - 12:00 PM
Injury-induced hepatocyte dedifferentiation in liver regeneration and tumorigenesis
Lijian Hui and Zhen Chen
12:00 PM - 12:30 PM
Visualizing Kupffer cell adaptations in liver fibrosis
Moritz Peiseler
12:30 PM - 01:00 PM
Deep Learning-Based Phenotyping Reclassifies Combined Hepatocellular-Cholangiocarcinoma
Narmin Ghaffari Laleh3, Julien Calderaro1, Qinghe Zeng4, Stefano Caruso5, and Jakob Kather
01:00 PM - 01:30 PM
Efferocytosis regulates phenotypes of resident and recruited macrophages in distinct models of hepatic injury.
Federico De Ponti, Ania Bujko, Tinne Thone, Liesbet Martens, Kathryn Waller, Fleur Parmentier, Bavo Vanneste, and Charlotte Scott
01:30 PM - 02:00 PM
Poster session I (even posters)
02:00 PM - 03:30 PM
Lunch. and Informal Discussions
03:30 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses depart from hotel lobby)

Friday, October 13

08:00 AM - 09:00 AM
Transcriptional regulation, identity, cell-cell communication and connective tissue biology in hepatic health and disease
Chairs: Kirsten Sadler and Mikko Karpale
09:00 AM - 09:30 AM
Epigenetic mechanisms of tissue aging
Payel Sen
09:30 AM - 10:00 AM
Game of zones: WNTer is coming
Jan Tchorz
10:00 AM - 10:30 AM
Regulation of hepatocyte functions by hepatic stellate cells in health and disease
Robert Schwabe1 and Aveline Filliol2
10:30 AM - 10:45 AM
Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies
Vincent Merens, Stefaan Verhulst, and Leo van Grunsven
10:45 AM - 11:00 AM
Multicellular liver organoids recapitulate homeostatic and fibrotic peri-portal liver tissue architecture and cellular interactions in vitro.
Anna Dowbaj1, Aleksandra Sljukic1, Armin Niksic1, Cedric Landerer1, Julien Delpierre1, Ariane Kuehn1, Marino Zerial1,2, and Meritxell Huch1,2,3
11:00 AM - 11:15 AM
Understanding the Role of HNF1B in the Transition of the Endoderm to a Hepatic Fate
Carla Martinez-Morant and Stephen Duncan
11:15 AM - 11:45 AM
Coffee Break and Poster Viewing
Transcriptional regulation, identity, cell-cell communication and connective tissue biology in hepatic health and disease
Chairs: Jan Tchorz and Anna Dowbaj
11:45 AM - 12:15 PM
Translational control in liver disease
Mercedes Fernandez
12:15 PM - 12:45 PM
How programmed cell death and cell death responses control HCC development
Tom Luedde and Anne Schneider
12:45 PM - 01:15 PM
The development of ex vivo models of hepatocellular carcinoma for therapeutic screening and as a precision medicine tool.
Amy Collins1,2, Jack Leslie1,2, Maja Laszczewska1,2, Erik Ramon-Gil1,2, Daniel Geh1,2, Glyn Nelson3, Rainie Cameron1, Kenny Dalgarno4, Helen Reeves2,5, Derek Mann1,2, and Fiona Oakley1,2
01:15 PM - 01:30 PM
The distinct effects of oxygen shortage, Roxadustat and HIF-P4H-2 inhibition on mouse embryonic fibroblasts and hepatic stellate cell activation
Mikko Karpale, Atte Tapiola, Sofia Siermala, and Peppi Koivunen
01:30 PM - 01:45 PM
Disease-specific human ECM composition and bioactivity in NASH liver fibrosis
Alan` Holmes
01:45 PM - 03:00 PM
Lunch and Informal Discussion
03:00 PM - 07:00 PM
Informal Discussinos
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Saturday, October 14

08:00 AM - 09:00 AM
Metabolic liver disease
Chairs: Vangelis Kondylis and Chantal Desdouets
09:00 AM - 09:30 AM
Maladaptive re-activation of morphogenic signaling in liver as causal to NASH-induced fibrosis
Utpal Pajvani
09:30 AM - 10:00 AM
Correcting metabolic liver disease by gene therapy
Karl-Dimiter Bissig
10:00 AM - 10:15 AM
Hepatic specific ablation of PGC-1α drives fibrosis in MASH model
Maria Arconzo1, Elena Piccinin1,2, Maria Laura Matrella2, Gaetano Villani2, and Antonio Moschetta1
10:15 AM - 10:30 AM
Vascular Control of Liver Pathobiology
Donato Inverso
10:30 AM - 11:30 AM
Coffee Break and Poster Viewing
Metabolic liver disease
Chairs: Neil Henderson and Peter Campbell
11:30 AM - 12:00 PM
Polyploidy, DNA damage response driver or gatekeeper of chronic liver diseases
Chantal Desdouets and Pierre Cordier
12:00 PM - 12:30 PM
Somatic mutations in steatotic liver disease lead to hepatic metabolic remodelling
Peter Campbell and Natalia Brzozwoska
12:30 PM - 01:00 PM
NASH has a tumor-suppressive effect through Yap driven cell competition
Ana Algueró Nadal, Georg Halder, Elena Zoppolato, and Hasse Mol
01:00 PM - 01:15 PM
A Mavs-dependent type I IFN pathway contributes to non-viral liver injury upon hepatic autophagy impairment
Vangelis Kondylis1,2,4, Farina Schneider4, and Manolis Pasparakis3
01:15 PM - 01:45 PM
Multiancestry genome-wide studies in nonalcoholic fatty liver disease studies
Marijana Vujkovic
01:45 PM - 02:15 PM
Poster Session II (odd posters)
02:15 PM - 03:15 PM
Lunch and Informal Discussion
03:30 PM - 07:00 PM
Olde Town Chania Tour
07:30 PM - 11:00 PM
Dinner and Informal Discussion

Sunday, October 15

08:00 AM - 09:00 AM
Hepatic carcinogenesis and therapeutic vulnerabilities
Chairs: Jessica Zucman-Rossi and Amaia Lujambio
09:00 AM - 09:30 AM
Genetic predisposition to liver cancer
Jessica Zucman-Rossi
09:30 AM - 10:00 AM
Targeting senescence mechanisms in liver fibrosis and cancer
Scott Lowe
10:00 AM - 10:30 AM
Novel mechanisms regulating cancer risk revealed by CRISPR screening in vivo
Dingzi Yin, Kirk Wangensteen, and Alexandra Vazquez Salgado
10:30 AM - 10:45 AM
Intermittent fasting promotes immune escape in hepatocellular carcinoma.
Anthony Lozano1,2,3, Kathrenine Lindblad1,2,3,4, Ian Liebling1,2,3, Marina Barcena-Varela1,2,3, Romain Donne1,2,3, and Amaia Lujambio1,2,3
10:45 AM - 11:00 AM
Novel pre-malignant hepatocyte state (daHep) accumulates in liver disease and predicts HCC risk
Rodrigo Carlessi and Nina Tirnitz-Parker
11:00 AM - 11:15 AM
Diet-induced steatosis is a driver of liver metastasis from pancreatic cancer
Changyu Zhu1, Kaloyan Tsanov1, Yu-jui Ho1, Richard Koche2, Rajmohan Murali3, and Scott Lowe1,4
11:15 AM - 11:45 AM
Coffee Break and Poster Viewing
Hepatic carcinogenesis and therapeutic vulnerabilities
Chairs: Rodrigo Maron Carlessi and Changyu Zhu
11:45 AM - 12:15 PM
Development and characterization of kinase sparing TPX2-tethering Aurora Kinase A ligands for cancer therapy
Lars Zender and Athina Moschopoulou
12:15 PM - 12:45 PM
Characterization of a novel Er stress inducing oncoprotein that restricts immunosurveillance
Mathias, Heikenwälder
12:45 PM - 01:15 PM
Notch1 promotes sexually dimorphic immune responses in HCC
Amaia Lujambio
01:15 PM - 01:45 PM
Deciphering Mucosal-Associated Invariant T (MAIT) Cell Regulation Networks in Liver Cancer
Benjamin ruf
01:45 PM - 02:15 PM
The oncogenic function of Smyd3 histone methyltransferase in liver and colon cancer
Iannis Talianidis
02:15 PM - 03:15 PM
Lunch and Informal Discussion
03:15 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:30 PM
Farewell Dinner

Monday, October 16

08:00 AM - 10:00 AM
10:00 AM - 12:00 PM