15th International Conference on Complement Therapeutics

Program - Sunday, May 28

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences


    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.


    Please note that Crete has two airports. You want to arrive at the Chania International Airport (code: CHQ) and take a taxi from the airport to the hotel (~60 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively the other airport (HER) is a two-hour drive to the Conference Center.

    Accommodation Tax

    An accommodation tax of € 4.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 


    Accommodations for the conference are at the Avra Imperial Hotel.  The hotel is located in Kolymbari, 39 km from Chania International Airport, 23 km from the Souda Harbor, and 23 km west of Chania town center.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Avra Imperial Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 


    Breakfast for registered participants and registered accompanying persons will be served at the Avra Imperial Hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Sunday, May 28

08:00 AM - 09:00 AM
Targeting complement in neurological diseases
Chairs: Andrea Tenner and Wioleta Zelek
09:00 AM - 09:20 AM
Complement in neuroinflammatory and neurodegenerative diseases.
Paul Morgan
09:20 AM - 09:40 AM
progressive neurological injury, early neurological deterioration and microvascular dysfunction following endovascular thrombectomy for larger vessel stroke: a target for anti-complement therapeutics
E Connolly
09:40 AM - 10:00 AM
A detrimental role for complement C5aR1 activation in Huntington’s disease
John Lee, Jenny Fung, Jianina Marallag, Ning Liu, and Trent Woodruff
10:00 AM - 10:20 AM
New Shot on Goal: Targeting Inflammation and Synapse Loss to Suppress Alzheimer’s Disease
Andrea Tenner1,2, Nicole Schartz1, Heidi Liang3, Shu-Hui Chu1, Angela Gomez-Arboledas1, and Ali Mortazavi3
10:20 AM - 10:40 AM
Generation and characterization of C3 inducible conditional KO Alzheimer’s-like mice
Brijendra Singh1, Andre Batista1, Maren Schroeder1, Khyrul Khan1, Emma Spooner1, Takashi Saito5, Hiroki Sasaguri4, Takaomi Saido4, Michael Carroll3, and Cynthia Lemere1
10:40 AM - 11:00 AM
The therapeutic potential of C3aR agonists in the post-acute phase after stroke
Marcela Pekna
11:00 AM - 11:20 AM
The role of terminal pathway in driving pathology in dementia.
Wioleta Zelek, Ryan Bevan, and Paul Morgan
11:20 AM - 11:40 AM
Aberrant protein S-nitrosylation of C3 activates phagocytosis of neuronal synapses by microglia in Alzheimer's disease
Hongmei Yang1,2, Chang-ki Oh1,2, Haitham Amal1,2, John S. Wishnok1,2, Sarah Lewis1,2, Emily Schahrer1,2, Dorit Trudler1,2, Tomohiro Nakamura1,2, Steven R. Tannenbaum1,2, and Stuart A. Lipton1,2
11:40 AM - 12:15 PM
Coffee Break and Poster Viewing
Complement in thromboinflammation
Chairs: Lubka Roumenina and Mikkel-Ole Skjoedt
12:15 PM - 12:35 PM
The complement regulator MAP-1 interacts with activated FXII and attenuates the coagulation system
Mikkel-Ole Skjoedt
12:35 PM - 12:55 PM
An alternative binding and activation mechanism of native C3 induced by contact with biosurfaces without involvement of the thioester
Bo Nilsson, Anna Adler, Osama Hamad, Claudia Dührkop, Roland Ebert, Yuji Teramura, Kristina Ekdahl, and Karin Fromell
12:55 PM - 01:10 PM
The Escherichia coli-induced platelet aggregation in human whole blood is inhibited by compstatin and is C3b dependent
Anne Landsem1, Åse Emblem1, Corinna Lau1, Dorte Christiansen1, Alexandra Gerogianni2, Bård Karlsen1, Tom Mollnes1,3, Per Nilsson2, and Ole Brekke1,4
01:10 PM - 01:25 PM
A MaGical cASe: a story on the cell-specific effects of C3-mediated neurodegeneration
Maria-Tzousi Papavergi1,2, Brijendra Singh1,3, Andre Batista1,3, Praveen Bathini1,3, Emma Spooner1, Shaomin Li1,3, and Cynthia Lemere1,3
01:25 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:30 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions