15th International Conference on Complement Therapeutics

Program - Saturday, May 27

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences


    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.


    Please note that Crete has two airports. You want to arrive at the Chania International Airport (code: CHQ) and take a taxi from the airport to the hotel (~60 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively the other airport (HER) is a two-hour drive to the Conference Center.

    Accommodation Tax

    An accommodation tax of € 4.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 


    Accommodations for the conference are at the Avra Imperial Hotel.  The hotel is located in Kolymbari, 39 km from Chania International Airport, 23 km from the Souda Harbor, and 23 km west of Chania town center.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Avra Imperial Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 


    Breakfast for registered participants and registered accompanying persons will be served at the Avra Imperial Hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Saturday, May 27

08:00 AM - 08:50 AM
08:50 AM - 09:00 AM
Welcome & Opening Remarks - John Lambris (on behalf of the Organizing Committee)
Structural insights and mechanisms of activation, regulation and crosstalk
Chairs: Anna Blom and Brian Geisbrecht
09:00 AM - 09:20 AM
structural insight on the function of properdin in the alternative pathway
Josefine Lorentzen, Dennis V Pedersen, Trine AF Gadeberg, and Gregers R Andersen
09:20 AM - 09:40 AM
A review of the double inhibition of complement and TLRs - from the origin on the bench through animal studies and possible clinical applications.
Tom E Mollnes
09:40 AM - 10:00 AM
FcγR-mediated Trogocytosis 2.0: Revisiting History gives rise to a Unifying Hypothesis
Ronald P Taylor
10:00 AM - 10:20 AM
Cytosolic C3 in cellular homeostasis and defence
Ben C King
10:20 AM - 10:35 AM
Granzyme K activates a new complement pathway
Carlos Donado1,2, Helena Jonsson1,2, and Erin Theisen1,2
10:35 AM - 11:15 AM
Coffee Break and Poster Viewing
Therapeutic development: novel complement inhibitors
Chairs: Monica Olcina and Daniel Ricklin
11:15 AM - 11:35 AM
The dawn of clinical C3 inhibition: the story, its milestones and what lies ahead
John D Lambris & collaborators
11:35 AM - 11:55 AM
Mechanistic and therapeutic aspects in complement-driven periodontal disease
George Hajishengallis1, Hatice Hasturk2, Dimitrios Mastellos3, Despina Yancopoulou4, and John D Lambris5
11:55 AM - 12:15 PM
A new treatment paradigm for Paroxysmal Nocturnal Hemoglobinuria: the era of proximal complement inhibitors
Antonio M. Risitano1,2, Camilla Frieri1, Luana Marano1, Despina Yancopoulou3, Dimitris Mastellos5, and John D. Lambris4
12:15 PM - 12:35 PM
Drug and Druggability: A new era in complement-targeted therapeutics and novel approaches off the conventional path
Daniel Ricklin1, Said Rabbani1, Oliver Schwardt1, Rachel Hevey1, Ekaterina Umnyakova1, Peter Rüthemann1, Clément Bechtler1, Kevin Widmer1, Aleksandra Blagojevic1, Stephanie Vogt1, Jannes Felsch1, Murielle Golomingi2, Christina Lamers1, Richard B Pouw1, Martin Smiesko1, Markus Lill1, Verena Schroeder2, Christoph Q Schmidt3, and John D Lambris4
12:35 PM - 12:55 PM
Continued investigations of modified DNA aptamers as inhibitors of complement proteins and their complexes
Brian V Geisbrecht, Huiquan Duan, and Ying Zhang
12:55 PM - 01:10 PM
An Oral C5aR receptor antagonist blocks disease in the C3 gain-of-function mouse model of aHUS.
Kate Smith-Jackson1,3, Isabel Y. Pappworth1,3, Beth G. Gibson1,3, Thomas Hoyler2, Marianne Martinic2, Mark Murphy 2, and Kevin J Marchbank1,3
01:10 PM - 01:25 PM
Complement inhibition prevents paranodal loop injury in an anti-GM1 antibody-mediated paranodal demyelinating mouse model.
Inge Van de Walle1, Clare I Campbell2, Rhona McGonigal2, Jennifer A Barrie2, Jolien Delaere1, Laura Bracke1, Madelaine E Cunningham2, Denggao Yao2, Tim Delahaye2, and Hugh J Willison2
01:25 PM - 01:40 PM
Probing C3 modulation in the intracellular space: Cellular internalization of compstatin-based C3 inhibitors and its functional implications
Dimitrios C. Mastellos1, Rebecca Lee2, Merita Rumano2, George Hajishengallis3, Despina Yancopoulou4, and John D. Lambris2
01:40 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions