First International Conference on Mesenchymal Cells in Health & Disease

Program

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences

    Registration 

    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.

    Airport

    Please note that Crete has two airports. You want to arrive at the Chania International Airport (code: CHQ) and take a taxi from the airport to the hotel (~60 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively the other airport (HER) is a two-hour drive to the Conference Center.

    Accommodation Tax

    An accommodation tax of € 4.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 

     Accommodations

    Accommodations for the conference are at the Avra Imperial Hotel.  The hotel is located in Kolymbari, 39 km from Chania International Airport, 23 km from the Souda Harbor, and 23 km west of Chania town center.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Avra Imperial Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 

    Breakfast

    Breakfast for registered participants and registered accompanying persons will be served at the Avra Imperial Hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Friday, June 03

07:00 PM - 08:00 PM
Conference Registration
08:00 PM - 10:30 PM
Welcome Reception and Dinner

Saturday, June 04

08:00 AM - 09:00 AM
Breakfast
09:00 AM - 09:15 AM
Welcome and Opening Remarks (Organizing Committee)
Mesenchymal cells in Immunity
Chairs: Christopher Buckley and Burkhard Ludewig
09:15 AM - 09:45 AM
Lymphoid organ fibroblasts
Burkhard Ludewig
09:45 AM - 10:15 AM
Active Notch signaling is critical for lymph node fibroblast development and function
Nagham Alouche1, Hélene Cannelle1, Hsin-Ying Huang1, Burkhard Ludewig2, Freddy Radtke3, and Sanjiv Luther1
10:15 AM - 10:30 AM
Notch signaling in lymph node fibroblasts shapes the T cell zone and regulates its functions
Nagham Alouche1, Hélène Cannelle1, Hsin-Ying Huang1, Stéphanie Favre1, Seyran Mutlu1, Burkhard Ludewig2, Freddy Radtke3, and Sanjiv Luther1
10:30 AM - 10:45 AM
Conserved stromal–immune cell interactions secure B cell follicle homeostasis
Mechthild Lütge1, Angelina De Martin1, Yves Stanossek1, Lucas Onder1, Hung-Wei Cheng1, Lisa Kurz1, Charlotte Soneson3, Mark Robinson4, Sandro Stöckli2, Burkhard Ludewig1, and Natalia Pikor1
10:45 AM - 11:30 AM
Coffee Break and Poster Viewing
Mesenchymal cells in Immunity
Chairs: Christopher Buckley and Burkhard Ludewig
11:30 AM - 12:00 PM
Diverse spleen mesenchymal cell populations direct tissue homeostasis and immunity.
Scott Mueller
12:00 PM - 12:30 PM
Stroma of lymphoid organs: from development to infection
Christopher Mueller
12:30 PM - 12:45 PM
Impact of RANKL on the hematopoietic stem cells in the bone marrow and CD169+ macrophages in the spleen
Alice Lavanant and Christopher Mueller
12:45 PM - 01:00 PM
Podoplanin maintains lymph node tissue integrity and is required for acute lymph node expansion
Spyridon Makris1, Yukti Gupta1, Jesus Cantoral-Rebordinos4, Victor Martinez3, Charlotte de Winde2, Harry Horsnell1, Agnesska Benjamin1, and Sophie Acton1
01:00 PM - 01:15 PM
ZEB1+AML orchestrate the bone marrow immune suppressive microenvironment via Th17 and stromal CD40 up-regulation.
Bassani Barbara1, Claudio Tripodo2, Paola Portararo1, Laura Botti1, Valeria Cancila2, Antonio Curti3, Marilena Ciciarello3,4, Mario Colombo1, and Sabina Sangaletti1
01:15 PM - 02:30 PM
Lunch and Informal Discussions
07:30 PM - 10:30 PM
Dinner and Informal Discussions

Sunday, June 05

08:00 AM - 09:00 AM
Breakfast
Mesenchymal cells in Inflammation and Fibrosis
Chairs: George Kollias and Robert Schwabe
09:00 AM - 09:30 AM
Fibroblast subsets in arthritis
Christopher Buckley
09:30 AM - 10:00 AM
Title TBA
Fiona Oakley
10:00 AM - 10:15 AM
Cellular networks established during human development drive propensity for arthritic disease
Mark Coles, Sarah Davidson, and Christopher Buckley
10:15 AM - 10:30 AM
Single-cell chromatin and transcriptome dynamics of Synovial Fibroblasts transitioning from homeostasis to pathology in TNF-driven arthritis
Maria Sakkou1,2, Dimitris Konstantopoulos3, Christos Tzaferis4, Matthieu D Lavigne3, Anastasios Liakos3, Petros P Sfikakis1,5,6, Meletios A Dimopoulos1,7, Maria Fousteri3, Marietta Armaka3, and George Kollias1,2,4
10:30 AM - 10:45 AM
Repurposing of a known antipsychotic drug to target arthritogenic synovial fibroblasts
Dimitra Papadopoulou1,2, Fani Roumelioti1,6, Vasiliki Mavrikaki1,5, Christos Tzaferis1,2, Filippos Charalampous1, Niki Karagianni4, Maria Denis4, Alexis Matralis1, and George Kollias1,2,3
10:45 AM - 11:00 AM
PI-16+ reticular cells in human palatine tonsils generate a distinct subepithelial niche for activated T and B cells
Angelina De Martin1, Yves Stanossek1,2, Mechthild Lütge1, Lucas Onder1, Hung-Wei Cheng1, Sandro Stöckli2, Natalia Pikor1, and Burkhard Ludewig1
11:00 AM - 11:30 AM
Coffee Break and Poster Viewing
Mesenchymal cells in Inflammation and Fibrosis
Chairs: George Kollias and Robert Schwabe
11:30 AM - 12:00 PM
Hepatic stellate in liver fibrosis and cancer
Robert Schwabe
12:00 PM - 12:30 PM
Core regulators of Fibroblast Polarization and Organ Damage
Andreas Ramming
12:30 PM - 12:45 PM
Restoration of WT1/miR-769-5p axis by HDAC1-3 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells.
Giulio Bontempi1, Michela Terri1, Cecilia Battistelli1, Sabrina Garbo1, Veronica Bordoni3, Chiara Agrati3, Sergio Valente4, Clemens Zwergel4, Antonello Mai5, Alessandro Domenici5, Paolo Menè5, Marco Tripodi1, and Raffaele Strippoli1
12:45 PM - 02:30 PM
Lunch and Informal Discussions
07:30 PM - 10:30 PM
Dinner and Informal Discussions

Monday, June 06

08:00 AM - 09:00 AM
Breakfast
Mesenchymal cells in cancer
Chairs: Gian Paolo Dotto and Sara Zanivan
09:00 AM - 09:30 AM
Androgen signaling as negative determinant of cancer associated fibroblast (CAF) activation at the interface between gene transcription and DNA stability
Gian-Paolo Dotto
09:30 AM - 10:00 AM
The peripheral adaptive immune mesenchyme in cancer
Maria Tsoumakidou
10:00 AM - 10:15 AM
Tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer
Julia Houthuijzen1, Roebi de Bruijn1, Anne-Paulien Drenth1, Eline van der Burg1, Ellen Wientjens1, Mirjam Boelens1, Marja Nieuwland, Iris de Rink, Frank van Diepen5, Colinda Scheele3, Sjoerd Klarenbeek4, Ron Kerkhoven, and Jos Jonkers1
10:15 AM - 10:30 AM
Stromal cell - neutrophil interactions are driving a pro-tumor microenvironment in multiple myeloma
Madelon de Jong1, Cathelijne Fokkema1, Teddie van Heusden1, Natalie Papazian1, Michael Vermeulen1, Sabrin Tahri1, Pieter van de Woestijne2, Mark van Duin1, Annemiek Broijl1, Pieter Sonneveld1, and Tom Cupedo1
10:30 AM - 11:30 AM
Coffee Break and Poster Viewing
Mesenchymal cells in cancer
Chairs: Gian Paolo Dotto and Sara Zanivan
11:30 AM - 12:00 PM
CAF metabolism drives pro-tumorigenic remodelling of the tumour microenvironment
Sara Zanivan
12:00 PM - 12:30 PM
THE EMBO LECTURE: Cell mechanotransduction and ECM remodeling in health and disease
Miguel Del Pozo Barriuso
12:30 PM - 12:45 PM
Targeting mesothelial-to-mesenchymal transition in ovarian cancer peritoneal metastasis
Pilar Sandoval1, Lucía Pascual-Antón1, Henar Tomero-Sanz1, Ricardo Sainz de la Cuesta2, Lucía González-Cortijo3, José Antonio Jiménez-Heffernan4, Myriam Fabre5, and Manuel López-Cabrera1
12:45 PM - 01:00 PM
INTERCONNECTION OF EPITHELIAL-MESENCHYMAL TRANSITION AND SENESCENCE IN PANCREATIC NEUROENDOCRINE LESIONS
Ioanna Angelioudaki1, Agapi Kataki2, Efthymios Koniaris3, Alexandros Tzingounis1, Alexandros Mitrousias1, Loukas Stoupis1, and Manousos Konstadoulakis1
01:00 PM - 02:30 PM
Lunch and Informal Discussions
03:00 PM - 07:30 PM
City Tour
07:30 PM - 10:30 PM
Dinner and Informal Discussions

Tuesday, June 07

08:00 AM - 09:00 AM
Breakfast
Mesenchymal cells in Homeostasis and Tissue Regeneration
Chairs: Vasiliki Koliaraki and Giovanni D'Angelo
09:00 AM - 09:30 AM
Stromal lineages crosstalk in postnatal intestinal homeostasis and repair
Lucie Peduto
09:30 AM - 10:00 AM
Col6a1+/CD201+ mesenchymal cells regulate intestinal morphogenesis and homeostasis
Vasiliki Koliaraki
10:00 AM - 10:15 AM
Intestinal fibroblasts display transcriptional and spatial heterogeneity in the TnfΔΑRE model of ileitis.
Lida Iliopoulou1, Alejandro Prados1, Christos Tzaferis1, Dimitris Konstantopoulos1, Vasiliki Koliaraki1, and George Kollias1,2
10:15 AM - 10:30 AM
Fetal/regenerative reprogramming of intestinal epithelium by fibroblast derived Neuregulin-1
Toni Lemmetyinen1, Emma Viitala1, Linnea Wartiovaara1, Eva Domenech Moreno2, Timothy Wang3, and Saara Ollila1
10:30 AM - 10:45 AM
Primed to resolve: the shoulder capsule informs a cellular basis for resolving inflammatory fibrosis
Michael Ng1, Steven Sansom1, Moustafa Attar1, Hamez Gacaferi1, Caio McHaido1, Sarah Davidson1, Rowie Borst1, Micon Garvilles1, Ian Reekie1, Dylan Windell1, Ananya Bhalla1, Kate Powell4, Paul Klenerman4, Andrew Titchener1, Steve Gwilym1, Chris Little1, Jonathan Rees1, Salma Chaudhury1, Rajat Chaudhury1, Amar Rangan2, Phil Holland2, Dominic Furniss1, Kathrin Jansen1, James Charlesworth1, Andrew Carr1, Derek Gilroy3, Mark Coles1, Christopher Buckley1, and Stephanie Dakin1
10:45 AM - 11:00 AM
Coffee Break and Poster Viewing
Mesenchymal cells in Homeostasis and Tissue Regeneration
Chairs: Vasiliki Koliaraki and Giovanni D'Angelo
11:00 AM - 11:30 AM
Rigid anatomies
Yuval Rinkevich
11:30 AM - 12:00 PM
Sphingolipids Control Dermal Fibroblast Heterogeneity
Laura Capolupo1, Irina Khven2, Alex R. Lederer2, Luigi Mazzeo3, Galina Glousker4, Sylvia Ho1, Francesco Russo5, Jonathan Montoya1, Dhaka R. Bhandari6, Andrew P. Bowman7, Shane R. Ellis7,8, Romain Guiet9, Olivier Burri9, Johanna Detzner10, Johannes Muthing10, Krisztian Homicsko11,12,13, François Kuonen14, Michel Gilliet14, Bernhard Spengler6, Ron M.A. Heeren7, Paolo Dotto15,16, Gioele La Manno2, and Giovanni D’Angelo 1,5
12:00 PM - 12:30 PM
Fibroblast heterogeneity and versatility in skin homeostasis and wound repair
Xiaoyan Sun, Karl Annusver, Tim Dalessandri, and Maria Kasper
12:30 PM - 12:45 PM
Mesenchymal Osr1 cells orchestrate lymph node initiation
Pedro Vallecillo Garcia, Glenda Comai, Claudia Giesecke-Thiel, Uta Höpken, Mickael Orgeur, and Sigmar Stricker
12:45 PM - 01:15 PM
Round table “The future of mesenchymal research”
01:15 PM - 02:45 PM
Lunch and Informal Discussions
08:00 PM - 11:00 PM
Farewell Dinner

Wednesday, June 08

08:00 AM - 10:00 AM
Breakfast
10:00 AM - 12:00 PM
Departure