4th International Conference on Cytokines in Cancer


Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences


    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.


    Please note that Crete has two airports. You want to arrive at the Chania International Airport (code: CHQ) and take a taxi from the airport to the hotel (~60 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively the other airport (HER) is a two-hour drive to the Conference Center.

    Accommodation Tax

    An accommodation tax of € 4.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 


    Accommodations for the conference are at the Avra Imperial Hotel.  The hotel is located in Kolymbari, 39 km from Chania International Airport, 23 km from the Souda Harbor, and 23 km west of Chania town center.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Avra Imperial Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 


    Breakfast for registered participants and registered accompanying persons will be served at the Avra Imperial Hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Thursday, May 19

07:00 PM - 08:00 PM
Conference Registration
08:00 PM - 10:30 PM
Welcome Reception and Dinner

Friday, May 20

07:30 AM - 08:30 AM
08:20 AM - 08:30 AM
Introductory Remarks - Leonidas Platanias
Pro-oncogenic mechanisms
Chairs: Lopa Mishra and Diana Saleiro
08:30 AM - 08:55 AM
Novel tumor promoting activities of CD95/Fas in breast cancer
Abdul S. Qadir11, Jean Philippe Guégan3, Christophe Ginestier4, Assia Chaibi3, Alban Bessede3, Emmanuelle Charafe-Jauffret4, Manon Macario4, Vincent Lavoué5, Thibault de la Motte Rouge6, Hongbin Wang7, Emily Stroup7, Andrea E. Murmann1, Zhe Ji7, Patrick Legembre, and Marcus E. Peter1
08:55 AM - 09:20 AM
A TGFβ-ALDH2 Axis controls Obesity-Associated Liver Disease and Cancer
Shuyun Rao1, Xiaochun Yang9, Xiyan Xiang9, Kazufumi Ohshiro1, Sobia Zaidi9, Krishanu Bhowmick9, Richard Amdur3, Ben Da1, James Crawford4, Bibhuti Mishra5, Herbert Yu6, Patricia Latham7, Xin Wang8, Adrian Krainer2, Nancy Gough1, and Lopa Mishra9
09:20 AM - 09:45 AM
The role of long noncoding lincRNA Platr18 in TGFbeta-mediated breast cancer progression.
Philip Howe
09:45 AM - 10:10 AM
PTPs and STATs in Cancer Immunotherapy
Tony Tiganis
10:10 AM - 10:30 AM
How Transforming Growth Factor beta (TGF-β) is Activated in the Tumors ?
Alexandra Lainé1, Ossama labiad1, Hector Hernandez-Vargas1, Helena Paidassi3, Mark Travis4, Dean Sheppard2, and Julien Marie1
10:30 AM - 11:00 AM
Coffee Break and Posters Viewing
Fundamentals and unexpected angles
Chairs: Jadwiga Jablonska and Elena Voronov
11:00 AM - 11:25 AM
Cytokine receptor Stoichiometry regulates cell signalling and function
Angel F Lopez
11:25 AM - 11:50 AM
Structural Rearrangements of Chromatin during Transcriptional Activation of Interferon-Induced Genes
Thomas Decker
11:50 AM - 12:15 PM
Exploring shared immune mechanisms in cancer and COVID-19
Ludmila Prokunina-Olsson
12:15 PM - 12:40 PM
SARS-CoV-2: variant predictions and antiviral drug design are enabled by in vitro evolution
Gideon Schreiber
12:40 PM - 01:05 PM
IFNs-α, COVID-19 and cancer
Eleanor Fish
01:05 PM - 01:25 PM
IL-1α secreted by subcapsular sinus macrophages promotes melanoma metastasis in the sentinel lymph node by upregulating STAT3 signaling in the tumor.
Tommaso Virgilio1, Alberto Arribas2, Robert Hunger3, Antonino Bruno6, Lorenzo Mortara5, Elena Voronov4, Silvia Monticelli1, Ron Apte4, Francesco Bertoni2, and Santiago Gonzalez1
01:25 PM - 01:45 PM
Effects of clonal hematopoiesis on anti-tumor immunity: PPM1D-driven clonal hematopoiesis
Oleg Demidov
01:45 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:30 PM
Informal Discussions
07:30 PM - 10:30 PM
Dinner and Informal Discussions

Saturday, May 21

07:30 AM - 08:20 AM
08:20 AM - 08:30 AM
Housekeeping Notes
Inflammation & Cancer- 1
Chairs: Elenore Fish and Ana Gamero
08:30 AM - 08:55 AM
Cytokines and microbiota in inflammation, cancer progression and metastasis
Sergei Grivennikov
08:55 AM - 09:20 AM
Activation of cyclin D1-NF-kB and inactivation of PTEN drives development of endometrial carcinoma
J. Alan Diehl
09:20 AM - 09:45 AM
Growth Hormone Receptor (GHR) signalling in melanoma progression and immune evasion
Andrew Brooks
09:45 AM - 10:10 AM
Pro-inflammatory activity of STAT2 in the gastrointestinal tract
Ana Gamero
10:10 AM - 10:30 AM
A STAT5B–CD9 axis determines self-renewal in hematopoietic and leukemic stem cells
Sebastian Kollmann
10:30 AM - 11:00 AM
Coffee Break and Poster Viewing
Inflammation & Cancer- 2
Chairs: Katherine Borden and Iris Behrman
11:00 AM - 11:25 AM
Interferon-gamma promotes melanoma progression and metastasis
Bo Zhou, Jayati Basu, Hasan Kazmi, Sarah Preston-Alp, Xuan Mo, and M. Raza Zaidi
11:25 AM - 11:50 AM
STAT1 signalling in myeloid cells regulates hematopoietic progenitors in the spleen during infection and inflammation
Tanja Bulat1, Svetlana Pahernik1, Caroline Lassnig1,3, Jelena Josipović1, Lena Amenitsch1, Dagmar Gotthardt2, Veronika Sexl2, Mathias Müller1,3, and Birgit Strobl1
11:50 AM - 12:15 PM
The role of tumor-related and microenvironment IL-1α in TNBC progression
Mathumathi Krishnamohan, Sapir Maudi Boker, Irena Kaplanov, Esther Noy Machluf, Marina Bersudsky, Ron Apte, Alex Braiman, and Elena Voronov
12:15 PM - 12:40 PM
Signal transduction of IL-6-type cytokines: involvement of (short and long) non-coding RNAs
Nadège Minoungou1, Mélanie Kirchmeyer1, Florence Servais1, Petr Nazarov2, Aurélien Ginolhac1, Stephanie Kreis1, Claude Haan1, and Iris Behrmann1
12:40 PM - 01:05 PM
Role of SOCS3 and SHP2 for the Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling
Anna Dittrich1, Jessica Fiebelkow1, Beate Gündel1, André Gündel2, Nora Mehwald1, Ulrike Billing1, Tomasz Jetka3, Lukas Nordmann1, Nicole Wundrack1, Michal Komorowski3, Steffen Waldherr4, and Fred Schaper1
01:05 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
City Tour and Discussions
07:00 PM - 10:00 PM
Dinner and Informal Discussions

Sunday, May 22

07:30 AM - 08:20 AM
08:20 AM - 08:30 AM
Housekeeping Notes
Tumor microenvironment and immune responses-1
Chairs: Stephanie Watowich and Anna Bielawska
08:30 AM - 08:55 AM
Co-opting the innate and adaptive immune system for potent antitumor and antiviral activity
Bryan Williams1, Himanshu Brahmbhatt, and Jennifer MacDiarmid
08:55 AM - 09:20 AM
Interferons generate a distinct subset of activated dendritic cells in the tumor microenvironment.
Malay Haldar and Tsun Ki Jerrick To
09:20 AM - 09:45 AM
IFN-deficiency modulates neutrophil development and tumorigenic properties
Jadwiga Jablonska
09:45 AM - 10:10 AM
BTN2A1 is essential for the activation of Vγ9Vδ2+ T cells
Andreas Behren1,2, Marc Rigau3,4,5, Simone Ostrouska1,2, Darryl Johnson3,5, Hamish McWilliam3,6, Jose Villadangos3,6, Andrew Hammet7, Anne Verhagen7, Eugene Maraskovsky7, Con Panousis7, Jonathan Cebon1,2, Dale Godfrey3,5, Adam Uldrich3,5, and Thomas Fulford3
10:10 AM - 10:30 AM
Interleukin-11 as a therapeutic target to control oncogenic Stat3 signaling
Matthias Ernst
10:30 AM - 11:00 AM
Coffee Break and Poster Viewing
Tumor microenvironment and immune responses-2
Chairs: Veronika Sexl and Tanja Bulat
11:00 AM - 11:25 AM
Inactivation of the Type I IFN pathway in the intratumoral cytotoxic T lymphocytes
Serge Fuchs
11:25 AM - 11:50 AM
The role of cytokines bound to extracellular vesicles in cancer and metastasis
Andreas Moeller
11:50 AM - 12:15 PM
Towards an understanding of the STAT5BN642H driver mutation in blood cancers and how to eliminate it
Richard Moriggl
12:15 PM - 12:40 PM
The diverse oncogenic impact of STAT3 in cancer
Jesse Balic, Mohamed Saad, Louise McLeod, Beena Kumar, Sultan Alhayyani, Prithi Bhathal, Richard Ferrero, Dan Gough, and Brendna Jenkins
12:40 PM - 01:05 PM
STAT3 deletion increases metastatic dissemination of Small Cell Lung Cancer
Daniel Gough
01:05 PM - 01:25 PM
Continuous sensing of IFNα by liver sinusoidal endothelial cells shapes a vascular antimetastatic barrier
Giovanni Sitia1, Ngoc Tran1, Lorena Ferreira1, Blanca Alvarez-Moya1, Valentina Buttiglione1, Barbara Ferrini1, Paola Zordan1, Eugenia Bezzecchi2, Giulia Scotti2, Antonio Esposito3, Riccardo Leone3, Andrea Monestiroli1, Claudio Fagioli1, Andrea Brendolan4, and Luca Guodotti1
01:25 PM - 01:50 PM
Boosting metastatic cell immunogenicity via therapeutic restoration of intratumoral IFNs
Belinda Parker
01:50 PM - 03:30 PM
Lunch and Informal Discussions
03:30 PM - 07:30 PM
Informal Discussions
07:30 PM - 10:30 PM
Dinner and Informal Discussions

Monday, May 23

07:30 AM - 08:20 AM
08:20 AM - 08:30 AM
Housekeeping Notes
Pathogenesis and therapies-1
Chairs: Hua Yu and Natalia Bednarz-Knoll
08:30 AM - 08:55 AM
Prolactin-humanized NSG mice for improved in vivo modeling of human cancer and tissues
Hallgeir Rui
08:55 AM - 09:20 AM
Melanoma Addiction to GCDH
ZEEV RONAI and Sachin Verma
09:20 AM - 09:45 AM
STAT3 and STAT5 gain-of-function mutations in hematopoietic malignancies
Veronika Sexl
09:45 AM - 10:10 AM
STAT3: from fundamental discoveries to clinical translation
Hua Yu
10:10 AM - 10:30 AM
ULK1 as a novel therapeutic target in melanoma
Diana Saleiro, Sarah Fenton, Liliana Ilut, Mariafausta Fischietti, Markella Zannikou, Chidera Oku, and Leonidas Platanias
10:30 AM - 11:00 AM
Coffee Break and Poster Viewing
Pathogenesis and therapies-2
Chairs: Bryan Williams and Ludmila Prokunina-Olsson
11:00 AM - 11:25 AM
Mechanisms of immune toxicity in checkpoint blockade therapy
Stephanie Watowich
11:25 AM - 11:50 AM
Cancer cells hijack RNA processing to transform cell architecture inside and out
Mehdi Ghram, Jean-Clement Mars, Gavin Morris, Biljana Culjkovic, and Katherine Borden
11:50 AM - 12:15 PM
Interferon signaling circuits as targets in the treatment of malignancies
Leonidas Platanias
12:15 PM - 12:35 PM
STAT3 signaling as a checkpoint for epigenetic reprogramming of acute myeloid leukemia into antigen-presenting cells
Marcin Kortylewski
12:35 PM - 12:55 PM
Loss of tumour-intrinsic type I IFN signalling predicts and facilitates bone-metastatic outgrowth in advanced prostate cancer
Katie Owen1,7, Linden Gea2, Aaron Meyers1, Niall Corcoran4,5, Paul Hertzog2,3, Chris Hovens4, Shahneen Sandhu6,7, and Belinda Parker1,7
12:55 PM - 01:15 PM
Clinical Development of heterodimeric IL-15 for Cancer Immunotherapy
George Pavlakis
01:15 PM - 01:20 PM
Concluding Remarks - Serge Fuchs
01:15 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 08:00 PM
Informal Discussions
08:00 PM - 11:30 PM
Farewell Dinner - Leonidas Platanias - Travel awards presentation

Tuesday, May 24

08:00 AM - 10:00 AM
10:00 AM - 12:00 PM