3rd International Conference on Tissue Repair, Regeneration, and Fibrosis


Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences


    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.


    Please note that Crete has two airports. You want to arrive at the Chania International Airport (code: CHQ) and take a taxi from the airport to the hotel (~60 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively the other airport (HER) is a two-hour drive to the Conference Center.

    Accommodation Tax

    An accommodation tax of € 4.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 


    Accommodations for the conference are at the Avra Imperial Hotel.  The hotel is located in Kolymbari, 39 km from Chania International Airport, 23 km from the Souda Harbor, and 23 km west of Chania town center.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Avra Imperial Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 


    Breakfast for registered participants and registered accompanying persons will be served at the Avra Imperial Hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Monday, October 10

05:30 PM - 07:00 PM
Conference Registration
07:00 PM - 10:00 PM
Welcome Reception and Dinner

Tuesday, October 11

08:00 AM - 09:00 AM
08:55 AM - 09:00 AM
Welcome and Opening Remarks - Robert Martinez
Cell types, mechanisms, and therapeutic targets in lung repair and fibrosis
Chair: Federica Genovese
09:00 AM - 09:25 AM
Fibroblasts and alveolar macrophages make a fibrotic handshake following lung injury
Boris Hinz
09:25 AM - 09:50 AM
Dopamine signaling in fibrosis resolution
Daniel Tschumperlin
09:50 AM - 10:15 AM
Reducing fibrosis by targeting extracellular matrix formation with small molecules: a promising clinical approach
Wolfgang Jarolimek
10:15 AM - 10:30 AM
Exploring tissue heterogeneity: A new approach to understand fibrosis progression in IPF
Rachel A Burgoyne1, Sandra Murphy1, Ben S Barksby1, Joaquim Majo2, Andrew J Fisher3,4, and Lee A Borthwick1,5
10:30 AM - 10:45 AM
Alternation of NAD+ metabolism in an aged bleomycin-induced lung fibrosis mouse model
Mohammed Alsuraih1, Ju Wang2, Guan-Yu Lin1, Brendon Kapinos3, Jessie Qian3, Tom Lanz3, Shangzhong Li1, Franklin Schlerman2, Robert Martinez1, and Shian-Huey Chiang1
10:45 AM - 11:45 AM
Coffee Break and Poster Viewing
Cell types, mechanisms, and therapeutic targets in lung repair and fibrosis
11:45 AM - 12:10 PM
TBA - Noble
Paul Noble
12:10 PM - 12:35 PM
Targeting BRD4 is effective in regulating the activation and function of pathogenic cells in idiopathic pulmonary fibrosis
Milena S. Espindola1, Miriam S. Hohmann1, Stephanie Garcia1, Brecht Creyns1, Yago Jannini-Sá1, Ana Lucia Coelho1, Mark T. Marino2, Michael Hy2, and Cory M. Hogaboam1
12:35 PM - 12:50 PM
Epithelial Hippo signaling in bleomycin-induced pulmonary fibrosis.
stijn De Langhe, Rachel Warren, and Handeng Lyu
12:50 PM - 01:05 PM
Are all Fibroblasts created equal?! Collagen type-I mRNA translation inhibitor reduces fibrosis specifically in the lungs
Ofer Bihari, Mordehay Klepfish, Wissam Mansour, Yoni Sheinberger, Aurora Paola Borroni, Ephrem Kassa, Inbal Shapira Lots, Neta Barashi1, and Iris Alroy
01:05 PM - 01:30 PM
Endotrophin: a crystal ball for risk of mortality in chronic diseases.
Federica Genovese
01:30 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 10:30 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Wednesday, October 12

08:00 AM - 09:00 AM
Cell types, mechanisms, and therapeutic targets in liver repair and fibrosis
Chair: Robert Martinez
09:00 AM - 09:25 AM
Hepatic Stellate Cells in Nonalcoholic Steatohepatitis (NASH).
Sara Brin Rosenthal1,2, Xiao Liu2,3, Cuijuan Han2,3, Tatiana Kisseleva3, and David Brenner2
09:25 AM - 09:50 AM
Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis
Thomas Fabre1, Alexander M. S. Barron1, Stephen M. Christensen1, Shoh Asano1, Marc Wadsworth1, Ju Wang1, James McMahon1, Franklin Schlerman1, Alexis White1, Kellie M. Kravarik1, Andrew J. Fisher2, Lee A. Borthwick2, Kevin M. Hart1, Neil C. Henderson3, Tom A. Wynn1, and Ken Dower1
09:50 AM - 10:15 AM
IL-17 Signaling Facilitates Progression of Alcohol-Associated Liver Disease in Mice.
Raquel Carvalho-Gontijo11,2, Gen Yamamoto4, Vivian Zhang1,2, Ju Youn Kim3, Ji Young Kim1,2, Na Li5, Michael Karin3, David Brenner2, and Tatiana Kisseleva1
10:15 AM - 10:30 AM
Chronic liver disease induces plasticity between cholangiocytes and hepatocytes in the human liver
Vasileios Galanakis1, Christopher Gribben1, Alexander Calderwood1, Ilias Moutsopoulos1, Katarzyna Kania3, Emmanouil Athanasiadis4, Michael Allison2, Irina Mohorianu1, and Ludovic Vallier1
10:30 AM - 10:45 AM
Granzyme B: An Important Mediator of Age-Impaired Wound Healing
David Granville1,3,, Chris Turner3, and Hongyan Zhao1,3,
10:45 AM - 11:45 AM
Coffee Break and Poster Viewing
Cell types, mechanisms, and therapeutic targets in liver repair and fibrosis
Chair: Tatiana Kisseleva
11:45 AM - 12:10 PM
Using multimodal single cell genomics to decode human liver disease
Neil C Henderson
12:10 PM - 12:35 PM
Spatial compartmentalization of signalling imparts source-specific functions on secreted factors
Elena Groppa, Marine Theret, Morten Ritso, Will Wang, Hesham Soliman, Helen Blau, Martini Paolo, and Fabio Rossi
12:35 PM - 12:50 PM
Multimodal decoding of the mesenchymal landscape of human biliary fibrosis.
David H Wilson and Neil C Henderson
12:50 PM - 01:05 PM
Pig adipose-derived stem cells (pASCs) pre-conditioned with hypoxia. Characterization and validation for wound healing therapy
Joanna Wiśniewska1, Magda Słyszewska4, Marta Kopcewicz1, Katarzyna Walendzik1, Sylwia Machcińska-Zielińska1, Patrycja Dudek4, Karolina Stałanowska3, and Barbara Gawrońska-Kozak1
01:05 PM - 01:30 PM
TPL2 as a Therapeutic Target in NASH
Grant Budas
01:30 PM - 01:55 PM
Novel Systems Biology Approaches to Determine Targetable Master Regulators Contributing to Hepatic Stellate Cell Activation and Liver Fibrosis
Robert F Schwabe
01:55 PM - 03:15 PM
Lunch and Informal Discussions
03:15 PM - 07:00 PM
Informal Discussions
07:30 PM - 10:30 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Thursday, October 13

08:00 AM - 09:00 AM
Mechanisms in Fibrosis
Chair: Kevin Hart
09:00 AM - 09:25 AM
Connective Tissue Movements and Organ Repair
Yuval Rinkevich
09:25 AM - 09:50 AM
Progress in Therapeutic Combinations for the Treatment of NASH and Liver Fibrosis
James L. Trevaskis
09:50 AM - 10:15 AM
Using precision cut tissue slices to study tissue fibrosis, senescence and cancer
Fiona Oakley
10:15 AM - 10:30 AM
Renal fibrosis associated with the three liver trematodiases in an experimental hamster model.
Oxana Zaparina, Yaroslav K Kapushchak, Viatcheslav A Mordvinov, and Maria Y Pakharukova
10:30 AM - 10:55 AM
Spatial transcriptomics defines impaired mechanisms driving liver fibrosis with implications across organs
Karen Piper Hanley
10:55 AM - 11:45 AM
Coffee Break and Poster Viewing
Cell types, mechanisms, and therapeutic targets in renal and skin repair and fibrosis
Chair: Karen Piper-Hanley
11:45 AM - 12:10 PM
Mapping kidney and cardiovascular fibrosis using single cell and spatial genomics.
Rafael Kramann
12:10 PM - 12:35 PM
A pro-fibrotic activin A- mDia2 axis in cancer-associated fibroblasts promotes skin tumorigenesis
Sabine Werner
12:35 PM - 12:50 PM
Human skin explants as a model for inflammation and wound healing
Adriana Petrinić Grba1, Dora Štefok1, Matea Cedilak1, Andrea Paravić Radičević1, Maja Antolić2, Anja Ognjenović2, Sonja Vidović Iviš2, Vuk Milutinović2, Snježana Čužić2, Martina Bosnar1, and Vesna Eraković Haber1
12:50 PM - 01:05 PM
In contrast to its pro-fibrotic effects in mammals, Lysyl Hydroxylase 2 does not affect granulation tissue resolution during zebrafish cutaneous wound healing
Ismail Kucukaylak1, Manuel Metzger1, Sabine Eming2, and Matthias Hammerschmidt1
01:05 PM - 01:20 PM
Sex, individual age and transcription factor Foxn1 affect the condition of healthy and post injured mice and human skin
Marta Kopcewicz1, Sylwia Machcińska-Zielińska1, Katarzyna Walendzik1, Joanna Wiśniewska1, Joanna Rutkowska3, Piotr Malinowski4, Tomasz Waśniewski2, Justyna Drukała5, and Barbara Gawrońska-Kozak1
01:20 PM - 01:45 PM
Live imaging and modelling of wound repair and inflammation
Paul B Martin
01:45 PM - 03:00 PM
Lunch and Informal Discussions
03:30 PM - 07:30 PM
City Tour (Buses Depart from Hotel Lobby)
07:30 PM - 10:30 PM
Dinner and Informal Discussions (Buses do not return to the hotel prior to dinner)

Friday, October 14

08:00 AM - 09:00 AM
Model Systems to Enhance Development of Anti-Fibrotic Agents
Chair: Fiona Oakley
09:00 AM - 09:25 AM
TBA - Vallier
Ludovic Vallier
09:25 AM - 09:50 AM
Dynamic fibrogenesis in human precision cut heart slices: a novel platform for target identification and validation in the heart
Lee Borthwick
09:50 AM - 10:15 AM
DEMISTIFI'ing Fibrosis
Gisli Jenkins
10:15 AM - 10:30 AM
Establishment and Characterization of Two Immortalized Fibroblast Lines from the Regenerative Spiny Mouse
Michele N Dill1 and Chelsey S Simmons2
10:30 AM - 10:45 AM
Tissue regeneration and liver flukes biomolecules: new approaches to wound healing therapy
Anna V. Kovner, Oxana G. Zaparina, Viatcheslav A. Mordvinov, and Maria Y. Pakharukova
10:45 AM - 11:45 AM
Coffee Break and Poster Viewing
Interrogating fibroblast heterogeneity and cross-talk in health and disease
Chair: Neil Henderson
11:45 AM - 12:10 PM
Targeting the cross-talk of heterogeneous bone marrow stromal cells and malignant hematopoietic cells in bone marrow fibrosis
Rebekka K Schneider
12:10 PM - 12:35 PM
The Impact of Fibroblast Heterogeneity on the Immune Infiltrate
Jamie G Bates
12:35 PM - 12:50 PM
Development and characterization of an ex vivo model of the human bone marrow vascular niche
Maria Mitsi and Benjamin Simona
12:50 PM - 01:05 PM
Circulating levels of endotrophin are associated with worse health conditions in a self-reported health questionnaire
Clara F. G. Laursen, Rosa C. Christiansen, Federica Genovese, Morten Karsdal, and Cecilie Bager
01:05 PM - 01:30 PM
The human microbiome in tissue repair: a bacterial protein modulates PAI-1 to drive intestinal barrier restoration
Karim Dabbagh
01:30 PM - 01:55 PM
TBA - Yaworsky
Paul Yaworsky
01:55 PM - 02:00 PM
Closing Remarks
02:00 PM - 03:30 PM
Lunch and Informal Discussions
03:30 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Farewell Dinner