First International Conference on Tissue Repair, Regeneration, and Fibrosis

Program

Wednesday, September 21

     

6:00 PM

 

Conference Registration

     

8:00 PM

 

Welcome Reception/Dinner

     

Thursday, September 22

     

7:30 AM

 

Breakfast

     

8:25 AM

 

Welcome and Opening Remarks

   

 

SESSION I

 

Chronic tissue Injury and repair

Chairs: Thomas Wynn and Stefan Wollin

8:30 AM

1

Myeloid cell regulation of adult lung alveologenesis post-pneumonectomy

Andrew Lechner and Jason Rock

8:55 AM

2

TBA

Paul Noble

9:20 AM

3

Immunoregulation of liver fibrosis: novel pathways

Sophie Lotersztajn

9:45 AM

4

Contribution of hepatic stellate cells to hepatic wound healing and carcinogenesis

Robert Schwabe

10:10 AM

5

Novel pharmacological approaches for the treatment of Non-Alcoholic Steatohepatitis (NASH)

James Trevaskis, Silvia Guionaud, Hani Jouihan, Michelle  Beaton, Peter Ravn, Sarah Will, Michael Feigh, Sanne Skovgaard Veidal, Matthew Coghlan, Joseph Grimsby, Anish Konkar, Cristina Rondinone, and Lutz Jermutus

10:35 AM

6

Type 2 immunity protects against obesity-induced metabolic disease but exacerbates NAFLD collaboratively with TGF-β1

Kevin Hart, Thomas Fabre, Richard Gieseck, Lee Borthwick, Kevin Vannella, Robert Thompson, Sandra White, Genevieve Soucy, Marc Bilodeau, Thirumalai Ramalingam, Naglaa Shoukry, and Thomas Wynn

10:50 AM

7

Anti-LOXL2 treatment paves the way for macrophage-mediated collagen degradation in liver fibrosis

Mordehay Klepfish, Milena Vugman, Chen Varol, and Irit Sagi

     

11:05 AM

 

Coffee Break/Poster Viewing

     

SESSION II

 

Focus on liver regeneration and fibrosis

Chairs: Ludovic Vallier and Lee A Borthwick

12:00 PM

8

Targeting rebound inflammation to improve anti-fibrotic therapy

Thiru Ramalingam, Richard (Trey) Gieseck, Tommy Acciani, Kevin Hart, Allen Cheever, Margaret Mentink-Kane, Kevin Vannella, and Thomas A Wynn

12:25 PM

9

Intravital imaging of liver regeneration and repair

Neil Henderson

12:50 PM

10

Epigenetic control of wound healing and tissue fibrosis

Derek Mann

1:15 PM

11

Hepatic stellate cells, hedgehog and hepatocyte reprogramming

Ana Mae Diehl

1:40 PM

12

Interleukin-13 drives distinct cellular pathways directing regeneration and fibrosis

Richard Gieseck, Thirumulai Ramalingam, Kevin Hart, Kevin Vannella, David Cantu, Wei-Yu Lu, Sofia Ferreira-Gonzalez, Stuart Forbes, Ludovic Vallier, and Thomas Wynn

1:55 PM

13

Sortilin deficiency attenuates ductular reaction and bile duct morphogenesis following cholestasis-induced liver injury

Einav Hubel, Elise Lavoie, Roy Avraham, Sigal Fishman, Jonathan Dranoff, Oren Shibolet, and Isabel Zvibel

     

2:10 PM

 

Lunch and Informal Discussions

     

7:30 PM

 

Dinner and Informal Discussions

         

Friday, September 23

     

7:30 AM

 

Breakfast

     

SESSION III

 

Progenitor cells and regeneration

Chairs: Neil Henderson and Paola Romagnani

8:30 AM

14

Human induced pluripotent stem cells to model inherited metabolic disorders

Ludovic Vallier

8:55 AM

15

Liver regeneration from hepatic progenitor cells

Stuart Forbes

9:20 AM

16

Generation of functional islets of langerhans from human exocrine pancreas

Kevin Docherty

9:45 AM

17

Dissecting the molecular and cellular mechanisms responsible for tissue repair in inflammatory bowel disease

Shiro Yui, Jordi  Guiu, Pawel Schweiger, and Kim Jensen

10:10 AM

18

Regeneration of the biliary tree using primary extra-hepatic cholangiocyte organoids

Fotios Sampaziotis, Richard Gieseck, Natalie Lie Berntsen, Miguel Cardoso de Brito, Steve Sawiak, María Gómez-Vázquez, Olivia Tysoe, Daniel Ortmann, Alessandro Bertero, Johannes Bargehr, Mariëlle  Zonneveld, Loukia Yiangou, Negar Pirmadjid, Marianne   Pedersen, Matthias  Pawlowski, Nikitas Georgakopoulos, Edmund  Godfrey, Sara Upponi, Casey  Rimland, Ingrid  Simonic, Susan Davies, Kim Jensen, William Gelson, Sanjay Sinha, Graeme Alexander, Nicholas Hannan, Espen Melum, Tom Wynn, Kourosh Saeb-Parsy, and Ludovic Vallier

10:25 AM

19

Type I, III collagen and elastin remodeling is elevated in the precision-cut lung slice model of IPF and can be restored back to vehicle levels using a PDE inhibitor

Niels Hansen, Morten Karsdal, Sarah Brockbank, Simon Cruwys, Alan Young, Puneeta Nath, and Diana Leeming

     

10:40 AM

 

Coffee Break/Poster Viewing

     

SESSION IV

 

Myofibroblasts and Biomarkers

Chairs: Joseph Arron and Bryan Fuchs

11:40 AM

20

Biomarkers of fibrosis progression; a route to shorter and smaller clinical trials

Toby Maher

12:00 PM

21

Novel biomarkers and mechanisms of lung fibrosis

Oliver Eickelberg

12:25 PM

22

Periplakin: a target for autoimmunity in lung fibrosis

Bruno Crestani

12:50 PM

23

Myofibroblast mechanical memory

Boris Hinz

1:15 PM

24

Alveolar regulation of TGFβ activation

Gisli Jenkins

1:40 PM

25

Redox regulation of cardiomyocyte renewal

Hesham Sadek

     

2:05 PM

 

Lunch and Informal Discussions

     

7:30 PM

 

Dinner and Informal Discussions

         

Saturday, September 24

     

7:30 AM

 

Breakfast

     

SESSION V

 

Therapeutic strategies

Chairs: Stuart Forbes and Paul Noble

8:30 AM

26

Fingerprints of Fibrosis: Tracing pathogenic mechanisms in human tissue

Carmel Nanthakumar, Adam Taylor, Lindsay Edwards, Susan Boyce, Richard Marshall, Andrew Fisher, Toby Maher, Gino Miele, Hannah Woodcock, Rachel Chambers, and Andy Blanchard

8:55 AM

27

Biomarker-Guided Therapeutic Strategies in IPF

Joseph Arron

9:20 AM

28

Anti-inflammatory, anti-angiogenic, anti-fibrotic! The mode of action of nintedanib in fibrosing interstitial lung diseases.

Lutz Wollin, Elizabeth Redente, David Riches, Joerg Distler, and Cara Williams

9:45 AM

29

Molecular pathways in kidney fibrosis

Carol Moreno Quinn

10:10 AM

30

TBA

Lynne Murray

     

10:35 AM

 

Coffee Break/Poster Viewing

     

SESSION VI

 

Immune mechanisms of repair and fibrosis

Chairs: Sophie Lotersztajn and Jason Rock

11:30 AM

31

Myeloid cells in regeneration and fibrosis: dynamics, regulation and function

Sabine Eming

11:55 AM

32

Translating scleroderma: pathogenic mechanisms and recent clinical trials

Christopher Denton

12:20 PM

33

Purinergic Signaling in Fibrosis

Bruce Cronstein and Gibran Sheikh

12:45 PM

34

From vasculopathy to immune activation and fibrosis - A Fli1 Odyssey

Maria Trojanowska

1:10 PM

35

A retinoic acid dependent stroma-leukemia crosstalk promotes tissue remodeling and chronic lymphocytic leukemia progression

Andrea Brendolan

     

1:35 PM

 

Lunch and Informal Discussions

     

3:30 PM

 

City Tour

     

7:30 PM

 

Dinner and Informal Discussions

       

Sunday, September 25

     

7:30 AM

 

Breakfast

 
     

SESSION VII

Fibrosis and regeneration across organ systems I

Chairs: Lynne Murray and Sabine Eming

 

8:30 AM

36

Molecular magnetic resonance imaging of fibrosis in animal models

Bryan Fuchs, Christian  Farrar, Philip  Waghorn, Lan Wei, Pauline Desogere, Bo Zhu, Michael  Lanuti, Kenneth Tanabe, and Peter Caravan

 

8:55 AM

37

The renal progenitor system in kidney homeostasis, injury and regeneration

Paola Romagnani

 

9:20 AM

38

Causes and effects of fibrosis in chronic muscle damage

Marcela Low, Christine Eisner, Farshad Babaijhandagi, and Fabio Rossi

 

9:45 AM

39

Autotaxin distorts lipid homeostasis promoting and interconnecting fibrosis and cancer

Vassilis Aidinis

 

10:10 AM

40

A Recombinant Antibody to Siglec-8 Inhibits Lung and Skin Fibrosis

Rustom Falahati, Bradford Youngblood, John Leung, Alejandro Dorenbaum, Leonard Shultz, Dale Greiner, Michael Brehm, Christopher Bebbington, and Nenad  Tomasevic

 

10:25 AM

41

c-Rel is a master regulator of innate immunity and multi-organ fibrosis.

Jack Leslie, Saimir Luli, Julie Worrell, Jonathan Scott, John Simpson, Neil Sheerin, Lee Borthwick, Derek Mann, and Fiona Oakley

 

10:40 AM

42

The role of p21 activated kinase 1 (PAK1) in liver fibrosis

Aoibheann Mullan, James Pritchett, Katherine Martin, Jessica Llewellyn, Varinder Athwal, Neil Hanley, and Karen Piper Hanley

 
     

10:55 AM

 

Coffee Break/Poster Viewing

 
     

SESSION VIII

Fibrosis and regeneration across organ systems II

Chairs: Derek Mann and Carol Moreno Quinn

 

12:00 PM

43

Immune Surveillance, Wound Repair and Fibrosis of the Salivary Gland

Maria Kukuruzinska

 

12:25 PM

44

Muscle stem cell regenerative decline in aging

Laura García-Prat, Marta  Martinez-Vicente, Marta Flandez, Sonia Alonso-Martín, Javier Rodríguez-Ubreva, Esteban  Ballestar, Antonio Serrano, Marco Sandri, and Pura Muñoz-Cánoves

 

12:50 PM

45

Building Better Bone: Biologic and Engineering Strategies for Managing Traumatic Bone Loss

Robert Guldberg, Albert Cheng, Nick Willett, Mara Schenker, and Laxminarayanan Krishnan

 

1:15 PM

46

Organ specific roles for FPR-1 in fibrosis

Benjamin Millar, Jack Leslie, Alan Carruthers, John Ferguson, Matthew Sleeman, Saimir Luli, Rachel Howarth, Chris Fox, Lynne Murray, Donna Finch, Derek Mann, Andrew  Fisher, and Lee A Borthwick

 

1:40 PM

47

Yes Associated Protein 1 (YAP1) and Integrin α 11 β1 promote organ fibrosis

James Pritchett, Katherine Martin, Jessica Llewellyn, Aoibheann Mullan, Emma Harvey, Sayyid Raza, Varinder Athwal, Neil Hanley, and Karen Piper Hanley

 

1:55 PM

48

Rhamm deficiency impairs normal liver wound healing after acute hepatotoxin exposure

Michele Pritchard and Jennifer McCracken

 
       

2:10 PM

 

Closing Remarks

 
       

2:15 PM

 

Lunch and Informal Discussions

 
       

8:00 PM

 

Farewell Dinner

 
             

Monday, September 26

     

7:30 AM

 

Breakfast

     

10:30 AM

 

Departure

         

 

POSTERS

49

Protective role of the novel modulator spermidine in alcoholic liver injury, fibrosis, and liver regeneration

Raj Lakshman, Ruchi Shah, and Karina Reyes-Gordillo

50

Integrin alpha 11 as a novel therapeutic target in tissue fibrosis in multiple organs

Ruchi Bansal, Shigeki Nakagawa, Scott Friedman, and Yujin Hoshida

51

Development of injectable high molecular weight hyaluronic acid hydrogels for cartilage regeneration

Shraddha Mondal

52

Sortilin deficiency reduces ductular reaction, hepatocyte apoptosis and liver fibrosis in cholestatic-induced liver injury

Einav Hubel, Ashish Saroha, Yael Pewzner-Jung, Anthony Futerman, Sigal Fishman, Jonathan Dranoff, Oren Shibolet, and Isabel Zvibel

53

Intravital imaging of the hepatocyte regenerative niche following acetaminophen-induced liver injury

Kylie Conroy, Alexandra Thompson, Stephen Greenhalgh, Martin Lee, John Iredale, Kenneth Simpson, Matthew Ford, Richard Mort, Alan Serrels, and Neil Henderson

54

Dynamic fluid flow induces the osteogenic differentiation of human bone-derived mesenchymal stem cells

Bumgeun Choi, Kang Yoon Kim, Tosol Yu, and Ki-Taek Lim

55

Neutrophil extracellular traps components and mare endometrium fibrosis: are they related?

Maria Rebordão, Ana Amaral, Karolina Lukasik, Anna Szostek, Antonio Galvão, Pedro Pinto-Bravo, Dariusz Skarzynski, and Graça Ferreira-Dias

56

Role of Connective Tissue Growth Factor (CTGF/CCN2) in the fibrosis associated to denervated skeletal muscle and ALS disease progression

Enrique Brandan, Daniela Rebolledo, David Gonzalez, Kenneth Lipson, Gail  Walkinshaw, Waldo Cerpa, Felipe Court, and Brigitte Van Zundert

57

Myeloid cell-produced p38a MAP kinase regulates the resolving phase of the tissue wound healing process

Yacine Kharraz, Patrizia Pessina, Vanessa Ruiz-Bonilla, Mercè Jardi, and Pura Muñoz-Cánoves

58

Prophylactic treatment with ALK5 inhibitor SB525334 significantly improves lung function tests and reduces accumulation of myofibroblasts in the mouse model of bleomycin induced pulmonary fibrosis

Željka  Anzulović, Maja Antolić, Snježana Čužić, Ines Glojnarić, and Boška Hrvačić

59

A bleomycin in-vivo and an ex-vivo model combined with clinically validated serum extracellular matrix turnover markers of IPF may be used as an intelligent drug screening tool

Diana Leeming, Sarah Brockbank, Niels Hansen, Morten Karsdal, Puneeta Nath, David Rider, Alan Young, and Simon Cruwys

60

The assessment of clinically relevant extracellular matrix markers in a bleomycin-induced mouse model of lung fibrosis

Alan Young, Puneeta Nath, Diana Leeming, Nils Ulrik Hansen, Morten Karsdal, Sarah Brockbank, David Rider, and Simon Cruwys

61

Identification of differentially expressed long non-coding RNAs in human lung fibroblasts during idiopathic pulmonary fibrosis

Marina Hadjicharalambous, Mark Lindsay, and Deborah Clarke

62

Dissection of hedgehog and IL-13 pathways in liver fibrosis

Thiago de Almeida Pereira, Lee Borthwick, Mariana Machado, Guanhua Xie, Paula Vidigal, Izabela Voieta, Vivian Rezende, Rafal Witek, José Lambertucci, Anna  Diehl, and Thomas Wynn

63

Disease relevant in vitro and in vivo models for lung fibrosis

Jeroen DeGroot, Alan Young, Mary McElroy, Krista Ouwehand, and Loubna Chadli

64

Progenitor cells in the human extrahepatic biliary tree and gallbladder

Casey Rimland, Fotios Sampaziotis, Nikitas Georgakopoulos, Nicholas  Hannan, Kourosh Saeb-Parsy, Thomas Wynn, and Ludovic Vallier

65

The role of mast cells in thymic recovery after involution

Valeriia Guselnikova

66

New treatment option for children with encephalopathy

Marcin Majka, Olga Milczarek, Bogna Badyra, and Stanislaw Kwiatkowski

67

A novel biomarker of collagen type VII degradation is elevated in serum of patients with chronic obstructive pulmonary disease

Jannie Sand, Patricia Lamy, Morten Karsdal, and Diana Leeming

68

Versican degradation is associated with acute exacerbations of idiopathic interstitial pneumonia

Jannie Sand, Yoshinori Tannino, T Nikaido, K Misa, Y Sato, R Togawa, X Wang, Diana Leeming, and M Munakata

69

Objective quantitative evaluation of anti-fibrotic agents in animal models

Kenneth Zhang, Li Chen, Bertha Xue, Chen Hu, Laurent Gole, and Chuan-Chu Chou

70

Wnt-β catenin, a molecular mechanism of the anal sphincter injury induced fibrosis and sphincter dysfunction

Ravinder Mittal and M. Raj Rajasekaran

71

c-Rel is a critical regulator of epithelial cell fate during renal  fibrosis

Saimir Luli, Julie Worrell, Neil Sheerin, Lee Borthwick, Derek Mann, and Fiona Oakley

72

Myf5+ stem cells of ventral dermis are dedifferentiated Schwann cells

Haizea Iribar, Araika Gutierrez-Rivera, Virginia Perez-Lopez, and ander Izeta

73

TGFβ-induced mitochondrial stress in lung fibroblasts and evidence to support extracellular mitochondrial DNA as a predictor of disease severity in IPF patients

Glenda Trujillo, Changwan Ryu, Wajahat Mehal, Yonglin Chen, Huanxing  Sun, Jose Herazo-Maya, Naftali Kaminski, Daniel Bogenhagen, and Erica Herzog

74

Idiopathic pulmonary fibrosis fibroblasts in culture as a model system to generate extracellular matrix responses

Breda Twomey and Tim Johnson

75

AP-1/Fra-2 activation in macrophages is necessary for lung fibrosis development

Alvaro Ucero, Latifa Bakiri, Masakatsu Suzuki, and Erwin Wagner