6th International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems



Friday, June 17






6:00 PM


Conference Registration






8:00 PM


Welcome Reception/Dinner






Saturday, June 18






7:30 AM








9:00 AM


Welcome and Opening Remarks






Session I:


Myelopoiesis and Innate Immunity


9:15 AM


Functional diversity of macrophage/monocyte subsets

Shizuo Akira


9:45 AM


Apoptotic cell engulfment machinery and Rheumatoid Arthritis

Kodi Ravichandran and Sanja Arandjelovic


10:15 AM


Dickkopf-related protein 1 (Dkk1) exerts immune suppressive effects in cancer by regulating accumulation and function of myeloid derived suppressor cells

Roberta Faccio






10:45 AM


Coffee Break and Poster Viewing






Session II:




12:00 PM


Argininosuccinate lyase is required for nitric oxide synthase-dependent NO production in coupling osteoblast-osteoclast function

Zixue Jin, Jordan Kho, Monica Grover, Brian Dawson, Ming-Ming Jiang, Yuqing Chen, Terry Bertin, and Brendan Lee


12:30 PM


Growth-associated skeletal progenitor cells

Henry Kronenberg


1:00 PM


Bone marrow niche and hematopoietic stem cell differentiation are regulated by the microbiota

Yubin Luo, Guang-liang Chen, Nicole Hannemann, Natacha Ipseiz, Gerhard Kroenke, Stefan Wirtz, Georg Schett, and Aline Bozec






1:30 PM


Lunch/Informal Discussions






7:30 PM


Dinner/Informal Discussions at a local Greek Restaurant

Buses depart from the hotel lobby at 7:30 PM






Sunday, June 19






7:30 AM








Session III:


Immune –Bone Interactions


9:00 AM


Gamma delta T cells in bone fracture and new insights into the osteoimmune system

Hiroshi Takayanagi


9:30 AM


Pathways that suppress osteoclastogenesis

Lionel Ivashkiv


10:00 AM


Enhancement of bone destruction and tumor growth by Myeloma-Bone interaction

Toshio Matsumoto






10:30 AM


Coffee Break and Poster Viewing






Session IV:


Bone Marrow Niche


12:00 PM


Eosinophils and the bone marrow niche

Claudia Berek


12:30 PM


Development of the fetal bone marrow niche

Suleyman Coskun


1:00 PM


Searching for a lymphopoietic niche in bone marrow

João Pereira






1:30 PM


Lunch/Informal Discussions






7:30 PM


Dinner/Informal Discussions at a local Greek Restaurant

Buses depart from the hotel lobby at 7:30 PM






Monday, June 20





7:30 AM






Session V:



9:00 AM


Epigenetic regulation of RANKL-induced osteoclastogenesis

Sakae Tanaka

9:30 AM


High fat diet-induced osteoarthritis is mediated by innate immune receptors

Evangelia Kalaitzoglou, Jacquelyn  Herron, Yao Hu, Erika  Barboza, Joanna  Hudson, Timothy Griffin, and Mary Beth Humphrey

10:00 AM


Intracellular replication of staphylococcus aureus in osteoclasts

Jennifer Krauss and Deborah Novack

10:15 AM


The novel role of MICD as a transcriptional regulator in osteoclasts

Se Hwan Mun and Kyung-Hyun Park-Min




10:30 AM


Coffee Break and Poster Viewing




Session VI:



11:30 AM


Orchestrating the symphony of osteoclastogenesis

Yihong Wan

12:30 PM


The role of the iron-sensing receptor Tfr2 in bone homeostasis

Martina Rauner, Ulrike Baschant, Antonella Roetto, Uwe Platzbecker, and Lorenz Hofbauer

1:00 PM


exFoxp3Th17 cells, a pathogenic CD4+ T cell subset in periodontal disease

Masayuki Tsukasaki, Noriko Komatsu, and Hiroshi Takayanagi

1:15 PM


Alterations in the adaptive immune system correlate with fracture healing outcome

Christian Bucher, Claudia Schlundt, Hans-Dieter Volk, Georg Duda, and Katharina Schmidt-Bleek




1:30 PM


Lunch/Informal Discussions




3:00 PM


City Tour

Buses depart from hotel lobby at 3:00 PM




7:30 PM


Dinner/Informal Discussions at a local Greek Restaurant

Please note buses do not pick-up at the hotel prior to dinner.

Dinner proceeds right after the tour




Tuesday, June 21





7:30 AM






Session VII:


Up And Coming

9:00 AM


Microbial signals calibrate mononuclear phagocyte function via modifying the bone marrow niche

Andreas Diefenbach

9:30 AM


The impact of TREM2 in macrophage biology and human diseases

Marco Colonna

10:00 AM


The diversity of antibody effector functions

Stylianos Bournazos and Jeffrey Ravetch




10:30 AM


Coffee Break and Poster Viewing




Session VIII:


Short Presentations

11:15 AM


Sepsis-induced osteoblast ablation causes immunosuppression

Asuka Terashima, Kazuo Okamoto, Tomoki Nakashima, Shizuo Akira, Koichi Ikuta and Hiroshi Takayanagi

11:30 AM


Rankl-/- Mesenchymal Stromal Cells have an unexpected osteogenic differentiation defect which is improved by a RANKL-expressing lentiviral vector

Ciro Menale, Francesca Schena, Lorenzo Diomede, Lucia Sergi Sergi, Lucia Susani, Antonio Inforzato, Eleonora Palagano, Elisabetta Traggiai, Paolo Vezzoni, Cristina Sobacchi, and Anna Villa

11:45 AM


Light/TNFSF14 in vivo affects bone remodeling through the regulation osteoprotegerin expression

Giacomina Brunetti, Isabella Gigante, Angela Oranger, Graziana Colaianni, Adriana Di Benedetto, Roberto Tamma, Luciana Lippo, Paolo Pignataro, Mariasevera Di Comite, Giorgio Mori, Tamada Koji, Carl Ware, Silvia Colucci, and Maria Grano

12:00 PM


Low-dose RANKL as a potential therapeutic for postmenopausal osteoporosis

Anna Cline-Smith, Elena Shashkova, Jesse Gibbs, Deborah Novack, and Rajeev Aurora

12:15 PM


Exploring the role of interleukin-18 in bone loss associated with chronic inflammatory bowel disease

Corinne Metzger, Anand Narayanan, David Zawieja, and Susan Bloomfield

12:30 PM


Activation of neutrophils by components of the extracellular polymeric substance of bacterial biofilms

Ulrike Dapunt, Matthias Gaida, Susanne Maurer, Eva Meyle, Philippe Fouchard, Birgit Prior, and Gertrud Hänsch

12:45 PM


Lysyl oxidase promotes osteoclastogenesis via RANKL-dependent pathway

Koki Hamada, Masayuki Tsukasaki, Kazuo Okamoto, Noriko Komatsu, and Hiroshi Takayanagi

1:00 PM


Sclerostin expression in distinct osteolineage cell types differentially regulates hematopoietic stem cell and B lymphocyte development

Gabriela Loots, Jamila Bajwa, Deepa Murugesh, Cristal Yee, Aris Economides, and Jennifer Manilay




1:15 PM


Closing Remarks




1:30 PM


Lunch/Informal Discussions




8:00 PM


Farewell Dinner





Wednesday, June 22





7:30 AM








12:00 PM










Poster Presentations


Alterations of VEGF and CSF-1 expression following orthodontic biophysical force loading in hyperglycemic diabetic rats

Jungsun Moon, Yoon-Ho  Choi, Hongil Yoo, Hyun-Mi Ko, Jeong-Tae Koh, Min-Seok Kim, Eun-Joo Lee, and Sun-Hun Kim


Autophagy-linked FYVE containing protein Wdfy3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis

Dennis Wu, Blaine Christiansen, Ran Gu, Ritu Sarin, Regina Zavodovskaya, Chia-Pei  Chen, Konstantinos Zarbalis, and Iannis Adamopoulos


Bone marrow adipogenesis in transgenic mice expression human RANKL

Vagelis Rinotas, Maria Papadaki, and Eleni Douni


Can we predict fracture healing outcome early? -Evaluation of Osteoprotegerin, an early inflammatory marker

Sabir Ali, Ajai  ingh, and Abbas Mahdi


Comparing Orthopaedic Surgical Suture Material Immunogenicity In Vitro

Jill Cornish, Alistair Lock, MeiLin Tay, Karen Callon, Dorit Naot, Brendan Coleman, and David Musson


Direct and indirect effects of monosodium urate crystals on osteocyte cell viability and gene expression; is there a role for osteocytes in erosive gout?

Ashika Chhana, David Musson, Karen Callon, Dorit Naot, Greg Gamble, Geraldine McCarthy, Jillian Cornish, and Nicola Dalbeth


Dual Role of Cyanidin-3-glucoside on the differentiation of bone cells

Seoung Hoon Lee


Dysregulation of ERK signaling leads to the development of osteochondroma-like lesions

Marie Wehenkel, Maripat Corr, Clifford Guy, Benjamin Edwards, Spencer Richardson, Christopher Calabrese, Gilles Pagès, Jacques Pouysségur, Peter Vogel, and Maureen McGargill


Ebselen is a potential anti-osteoporosis agent by suppressing receptor activator of nuclear factor kappa-b ligand-induced osteoclast differentiation in vitro and lipopolysaccharide-induced inflammatory bone destruction in vivo

Chang Hoon Lee, Jaemin Oh, Jong Min Baek, Ju-Young Kim, and Myeung Su Lee


Ex vivo preservation of drug-resistant patient multiple myeloma cells at the osteoblastic niche

Wenting Zhang, Woo Lee, and Jenny Zilberberg


Expression of protease-activated receptor-2 by oral epithelial cells is required for bone loss in Porphyromonas gingivalis-induced periodontitis

Nidhish Francis, Charles Pagel, Rob Pike, and Eleanor Mackie


Functional analysis of the gene involved in epigenetic regulation during osteoclastogenesis

Shinya Nakamura, Sakae Tanaka, Takeshi Miyamoto, Naohiro Izawa, and Hiroyuki Aburatani


IL-11 acts as an autocrine stimulus during osteoclastogenesis

Ulrike Harre, Manuel Gado, and Georg Schett


In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice

Stephanie Win, Anja Kühl, Tim Sparwasser, Thomas Hünig,and Thomas Kamradt


Inhibitory effect of CXCL 14 in the osteogenic differentiation of periodontal ligament cells

Jungsun Moon, Sun-Hun Kim, and Hyun-Mi Ko


Inhibitory Effects of Tacrolimus on the IL-1- and endoplasmic reticulum (ER) stress-mediated osteoclastogenesis and inflammation

Han-Gyul Yoo, Wan Hee Yoo, MyeungSu Lee, Yong-Wook Park, and Hanbin Yoo


Interaction between magnesium-based implant and cells of the musculoskeletal system

Bérengère Luthringer, Maria Costantino, Lili Wu, and Regine Willumeit-Römer


Leptin protects  articular chondrocytes from cytotoxic cytokine induced by TNF-a in vivo animal model

Sang Yeob Lee, Sung Won Lee, and Won Tae Chung


microRNA profiles in ankylosing spondylitis

Taejong Kim, Hye-Mi Jin, Young-Nan Cho, Seung-Jung Kee, and Yong-Wook Park


Non-enzymatic omega-3-fatty acid breakdown products are differentially expressed in rheumatoid arthritis and suppress NFκB activity to inhibit osteoclast formation

Lynett Danks, Seint T Lwin, Joshua Brooks, Karin E Lundberg, Ginger Milne, and James R Edwards


NR4a1 is a crucial regulator of bone homeostasis and osteoclast motility

Carina Scholtysek, Natach Ipseiz, Brenda Krishnacoumar, Katrin Palumbo-Zerr, Jan Tuckermann, Martin Hermann, Georg Schett, and Gerhar Krönke


Osteocyte-specific ablation of the hypoxia inducible factor regulator VHL alters hematopoiesis in the bone marrow

Jennifer Manilay, Jamila Bajwa, Cameron  Carlisle, Deepa Murugesh, Cristal Yee, Gabriela Loots, Damian Genetos, and Clare Yellowley


Osteoimmunological interactions and expression profile in osteoporotic transgenic mice overexpressing human RANKL

Maria Papadaki, Vagelis Rinotas, Lenka Plestilova, George Kollias, Astrid  Jüngel, and Eleni Douni


Ratio of CD8+ effector T cells and regulatory T cells determines the outcome in fracture healing

Claudia Schlundt, Hanna Schell, Christian Bucher, Hans-Dieter Volk, Georg Duda, and Katharina Schmidt-Bleek


Relationship between Periodontal Disease and Rheumatoid Arthritis of the bone

Surena Vahabi and Abdorahman Gazaleh Rostamian Baniebrahimi


Role of CrkII signaling in RANKL-induced osteoclast differentiation and function

Seung-Jung Kee, Jung Ha Kim, Semun Seong, Yong-Wook Park, and Nacksung Kim


Role of dipeptidyl peptidase 3 in bone and immune system: a new osteoimmunological player

Ciro Menale, Eleonora Palagano, Harry Blair, Antonella Forlino, Rosita Rigoni, Stefano Mantero, Marta Monari, Paolo Vezzoni, Barbara Cassani, Anna Villa, and Cristina Sobacchi


Screening novel bone graft scaffolds for immunogenicity in vitro

David Musson, Alistair Lock, Karen Callon, Dorit Naot, and Jill Cornish


Sirtuin 3 maintains bone homeostasis by regulating AMPK-PGC-1b axis in mice

Jeong-Eun Huh, Seoung Hoon Lee, Yongwon Choi, Hyun Seok Kim, and Soo Young Lee


Suppression of inflammation and bone destruction in collagen induced arthritis mice by aGalCer-stimulated natural killer T cells

Seung-Jung Kee, Nacksung Kim, Wan-Hee Yoo, Hye-Mi Jin, Young-Nan Cho, and Yong-Wook Park


The effects of switching from teriparatide to anti-RANKL antibody on bone metabolism

Toshinobu Omiya, Jun Hirose, Yuho Kadono, Yasunori Omata, Kumiko Ono, Naohiro Izawa, Takeshi Miyamoto, and Sakae Tanaka


The iron sensing receptor Tfr2 regulates the osteohematopoietic niche

Ulrike Baschant, Martina Rauner, Uwe Platzbecker, and Lorenz Hofbauer


The role of the oxidative burst in bone remodeling during chronic inflammation

Christine Czegley, Christine Schauer, Carina Scholtysek, Gerhard Krönke, Georg Schett, Martin Herrmann, and Markus Hoffmann


The Syk tyrosine kinase regulates in vivo bone homeostasis

Daniel Csete, David Győri, Shigeaki Kato, Alexander Tarakhovsky, and Attila Mócsai


Utility of Toll-like receptor pattern as biomarkers for deep joint infection in total joint arthroplasty

Regina Fillerova, Anna  Petrackova, Petr  Gajdos, Milos Kudelka, Jiri Gallo, and Eva Kriegova


WNT signaling inhibitors as promising diagnostic serum markers of osteolytic bone metastasis

Emanuela Galliera, Monica Marazzi, Lorenzo Drago, Giuseppe Banfi, Alessandro Luzzati, and Massimiliano Corsi Romanelli