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Thursday, June 23 |
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6:00 PM |
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Conference Registration |
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8:00 PM |
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Welcome Reception/Dinner |
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Friday, June 24 |
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7:30 AM |
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Breakfast |
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8:45 AM |
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Welcome & Opening Remarks |
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Session I |
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Innate immune cells Chairs: Alberto Mantovani and Triantafyllos Chavakis |
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9:00 AM |
1 |
Dendritic cell and macrophage ontogeny Florent Ginhoux |
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9:25 AM |
2 |
Advances on the biology of 6-sulfo LacNAc (slan)/M-DC8+ cells Alessandra Micheletti, Federica Calzetti, Giulia Finotti, Silvia Lonardi, William Vermi, and Marco Cassatella |
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9:50 AM |
3 |
Immune suppressive and immune stimulating monocytes in cancer Vincenzo Bronte |
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10:15 AM |
4 |
Establishment of non-resolving low-grade inflammatory polarization of monocytes during impaired wound healing Liwu Li, Ruoxi Yuan, and Shuo Geng |
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10:40 AM |
5 |
The social network of immune cells defined by quantitative proteomics Jan Rieckmann, Roger Geiger, Daniel Hornburg, Tobias Wolf, Federica Sallusto, Antonio Lanzavecchia, Matthias Mann, and Felix Meissner |
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10:55 AM |
6 |
C1q and HMGB1 reciprocally regulate human macrophage polarization Myoungsun Son, Amit Porat, Mingzhu He, Frances Santiago-Schwarz, Ulf Andersson, Kevin Tracey, Yousef Al-Aed, and Betty Diamond |
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11:10 AM |
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Coffee Break/Poster Viewing |
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Session II |
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Host-microbe interactions Chairs: Peter Murray and Mihai Netea |
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12:00 PM |
7 |
Linking pathogen virulence, host immunity and the microbiota at the intestinal barrier Gabriel Nunez |
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12:25 PM |
8 |
The novel role of constitutive AHR-signaling in type I IFN response to viral infection Akinori Takaoka |
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12:50 PM |
9 |
Mechanisms of innate immune responses against viral nucleic-acids Jeongmin Ryoo and Kwangseog Ahn |
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1:15 PM |
10 |
Exploiting host innate immune defense for pre-symptomatic diagnosis and therapy of infectious disease Hau Nguyen, Supratim Basu, Paige Pardington, Melinda Wren, Guixia Hoo, Ed Stover, David Lee, and Goutam Gupta |
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1:30 PM |
11 |
Suppressive neutrophils are induced by dysbiotic bacteria in the colon in chronic HIV Tiffany Hensley-McBain, Jennifer Manuzak, Alexander Zevin, Ryan Cheu, Charlene Miller, Eric Lee, Cara Wilson, Adam Burgener, and Nichole Klatt |
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1:45 PM |
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The end of modern medicine? Can drugs that modulate innate immunity save our essential antibiotics? David Brown |
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2:00 PM |
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Lunch/Informal Discussions |
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7:30 PM |
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Dinner/Informal Discussions at a local Greek Restaurant Buses depart from the hotel lobby at 7:30 PM |
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Saturday, June 25 |
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7:30 AM |
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Breakfast |
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Session III |
Regulation of host immune responses Chairs: Marco Cassatella and Mark Febbraio |
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9:00 AM |
13 |
Role of atypical chemokine receptors in autoimmunity Silvano Sozzani |
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9:25 AM |
14 |
Expression and function of atypical chemokine receptor 4 in salivary glands Antal Rot |
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9:50 AM |
15 |
Functional and genetic architecture of cytokine responses in humans Mihai Netea |
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10:15 AM |
16 |
The functional specificity of RNA controllers in inflammation Dimitris Kontoyiannis |
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10:40 AM |
17 |
Neuropilin-1 is a high affinity receptor for extracellular miRNA and AGO2/miRNA complexes and mediates miRNA internalization and their productive activity Gerald Prud'homme, Yelena Glinka, and George Yousef |
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10:55 AM |
18 |
Del-1 is a component of the hematopoietic stem cell niche that regulates steady-state and emergency myelopoiesis Ioannis Mitroulis, Lan-Sun Chen, Rashim Pal Singh, Matina Economopoulou, Tetsuhiro Kajikawa, Ioannis Kourtzelis, Athanasios Ziogas, Kavita Hosur, Klara Kotlabova, Marianna Di Scala, Pallavi Subramanian, Andres Hidalgo, Ben Wielockx, George Hajishengallis, and Triantafyllos Chavakis |
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11:10 AM |
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Coffee Break/Poster Viewing |
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Session IV |
Immunomodulation and therapeutic intervention Chairs: Laurie Dempsey and George Hajishengallis |
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12:00 PM |
19 |
Compstatin Cp40 (AMY-101): a C3-targeted complement inhibitor reaching its prime for bedside intervention John D Lambris, Edimara Reis, Alexandra Primikyri, Yiannis Sarigiannis, Sofia Koutsogiannaki, Malvina Papanastasiou, Hongbin Wang, Markus Huber-Lang, Martijn van Griensven, Bo Nilsson, Kristina Nilsson-Ekdahl, Richard J Smith, Dimitrios Mastellos, Margaret A Lindorfer, Ronald P Taylor, Laura Evgin, John Bell, Gang Chen, Evlambia Hajishengallis, George Hajishengallis, Despina Yancopoulou, Antonio M Risitano, and Daniel Ricklin |
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12:25 PM |
20 |
Targeting tumor-associated macrophages in combination with cancer immunotherapy Carola Ries, Sabine Hoves, Michael Cannarile, Dominik Rüttinger, Carlos Gomez-Roca, Philippe Cassier, Jean-Yves Blay, and Jean-Pierre Delord |
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12:50 PM |
21 |
Human NK cells: from surface receptors to the cure of high-risk leukemias Lorenzo Moretta, Franco Locatelli, Daniela Pende, Maria Cristina Mingari, and Alessandro Moretta |
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1:15 PM |
22 |
Therapeutic targeting of the IL-23/IL-17 axis in leukocyte adhesion deficiency Niki Moutsopoulos, George Hajishengallis, and Steven Holland |
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1:30 PM |
23 |
Targeting oxidant-dependent mechanisms to treat acute and chronic lung diseases Ross Vlahos |
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1:45 PM |
24 |
The Agaricus blazei-based mushroom extract, AndosanTM, protects against development of intestinal cancer in the A/J Min/+ mouse model for colorectal adenocarcinoma Geir Hetland, Dag Eide, Jon Tangen, Mads Haugen, Mohamad Mirlashari, and Jan Paulsen |
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2:00 PM |
25 |
An obligate role for innate immunity and Activin A in the development of heterotopic ossification in Fibrodysplasia Ossificans Progressiva Aris N Economides |
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2:25 PM |
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Lunch/Informal Discussions |
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7:30 PM |
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Dinner/Informal Discussions at a local Greek Restaurant Buses depart from the hotel lobby at 7:30 PM |
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Sunday, June 26 |
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7:30 AM |
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Breakfast |
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Session V |
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Mechanisms of immune-mediated diseases Chairs: Giuseppe Matarese and Thomas Van Dyke |
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9:00 AM |
26 |
Humoral innate immunity and macrophages in tumor-promoting inflammation Alberto Mantovani |
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9:25 AM |
27 |
Genetic dissection of innate immunity in cancer Peter Murray |
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9:50 AM |
28 |
Cytosolic sensing of endogenous nucleic acids as a trigger for autoimmunity Rayk Behrendt, Katrin Peschke, Martin Achleitner, BjörnHiller, Anja Hoppe, Tina Schumann, Martin Kleefisch, and Axel Roers |
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10:15 AM |
29 |
Fibrin and the activation of CNS innate immunity Katerina Akassoglou |
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10:40 AM |
30 |
Innate lymphoid cells in leukocyte adhesion deficiency-associated mucosal inflammation Baomei Wang, Tetsuhiro Kajikawa, Xiaofei Li, Niki Moutsopoulos, Triantafyllos Chavakis, and George Hajishengallis |
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10:55 AM |
31 |
Human endogenous retroviral genetic element with immune suppressive activity in both human autoimmune diseases and experimental arthritis Magdalena Laska, Anne Troldborg, Ellen Hauge, Shervin Bahrami, and Kristian Stengaard-Pedersen |
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11:10 AM |
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Coffee Break/Poster Viewing |
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Session VI |
Inflammation and Metabolic Disease Chair: Katerina Akassoglou and Axel Roers |
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12:00 PM |
32 |
Macrophage retention inhibits beige adipogenesis in obesity Kyoung-Jin Chung, Antonios Chatzigeorgiou, Ioannis Mitroulis, Vasileia Alexaki, George Hajishengallis, and Triantafyllos Chavakis |
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12:25 PM |
33 |
The chameleon role TLR4 in lipid-induced macrophage inflammation Graeme Lancaster, Katherine Langley, and Mark Febbraio |
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12:50 PM |
34 |
Distinct transcriptional signatures define conventional T versus regulatory T cell responses to leptin and mTOR inhibition: the molecular basis for metabolic manipulation of innate ad adaptive immunity Giuseppe Matarese, Paola De Candia, and Veronica De Rosa |
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1:15 PM |
35 |
RvE1 reverses neutrophil phenotypic changes induced by type 2 diabetes Thomas Van Dyke |
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1:40 PM |
36 |
Novel insights into a shared pathophysiology in type I diabetes and Crohn’s Disease Saleh Naser |
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1:55 PM |
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Lunch/Informal Discussions |
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3:30 PM |
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City Tour |
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Buses depart from hotel lobby at 3:30 PM
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7:30 PM |
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Dinner/Informal Discussions at a local Greek Restaurant Please note buses do not pick-up at the hotel prior to dinner. Dinner proceeds right after the tour. |
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Monday, June 27 |
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7:30 AM |
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Breakfast |
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Session VII |
Innate and adaptive immunity Chair: Dimitris Kontoyiannis and Antal Rot |
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9:00 AM |
37 |
Innate and adaptive immune mechanisms in inflammatory bone loss George Hajishengallis and Jonathan Korostoff |
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9:25 AM |
38 |
Differential requirement of Let-7 MicroRNAs for control of pulmonary TH17 responses Hui-Ying Tung, Farrah Kheradmand, and David Corry |
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9:50 AM |
39 |
Innate and adaptive natural killer cell responses to HIV/SIV R Keith Reeves |
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10:15 AM |
40 |
Intact innate immunity requires the distal complement pathway Peter Ward, Fatemeh Fattahi, Claudia Kemper, and Firas Zetoune |
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10:40 AM |
41 |
The PI3K/PTEN signaling pathway at the crossroads of innate and adaptive immunity Gernot Schabbauer |
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10:55 AM |
42 |
Decreased Dicer expression is linked to increased expression of co-stimulatory molecule CD80 on B cells in Multiple Sclerosis Latt Latt Aung and Konstantin Balashov |
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11:10 AM |
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Coffee Break/Poster Viewing |
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Session VIII |
Disease mechanisms and therapeutic intervention Chairs: Peter Ward and Liwu Li |
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11:40 AM |
43 |
Neutralization of Lupus autoantibodies with small molecule decoys; HIV protease inhibitor derivatives block autoantibody binding Yousef Al-Abed, Sonya vanpatten, Shan Sun, Mingzhu He, Kai Fan Cheng, Ahmad Altiti, Ona bloom, Angelo Papatheodorou, Nathalie Meurice, Thomas Coleman, and Betty Diamond |
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11:55 AM |
44 |
Therapeutic inhibition of C3 promotes wound healing Edimara S Reis, Sophia Koutsogiannaki, Alexandra Primikyri, Ranillo RG Resuello, Joel V Tuplano, Bo Nilsson, Kristina Nilsson-Ekdahl,Despina Yancopoulou, Daniel Ricklin, and John D Lambris |
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12:10 PM |
45 |
Macrophage death following influenza vaccination promotes IL-1α-dependent dendritic cell function and induces B cell response in draining lymph nodes Chatziandreou Nikolaos, Farsakoglu Yagmur, D’Antuono Rocco, Palomino-Segura Miguel, Pizzagalli Diego, Sallusto Federica, Lukacs-Kornek Veronika, Turley Shannon, Lanzavecchia Antonio, Carroll Michael, and Santiago Gonzalez |
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12:25 PM |
46 |
Vγ9Vδ2 T-Cell polyfunctionality is differently modulated in HAART-Treated HIV+ patients according to CD4 T-cell count Rita Casetti, Gabriele De Simone, Alessandra Sacchi, Alessandra Rinaldi, Domenico Viola, Chiara Agrati, Veronica Bordoni, Eleonora Cimini, Nicola Tumino, Francesca Besi, and Federico Martini |
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12:40 PM |
47 |
The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways Franck Rodet, Marie Duhamel, Adriana Natalia Murgoci, Roxane Desjardins, Hugo Gagnon, Maxence Wisztorski, Isabelle Fournier, Robert Day, and Michel Salzet |
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12:55 PM |
48 |
Neutrophils are protective in carcinogenesis by altering tumor microenvironment and controlling intestinal microbiota Andrea Ponzetta, Marialuisa Barbagallo, Maria Rosaria Galdiero, Martina Molgora, Elena Magrini, Eduardo Bonavita, Nadia Polentarutti, Cecilia Garlanda, Alberto Mantovani, and Sebastièn Jaillon |
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1:10 PM |
49 |
Innate Regeneration Panagiotis A Tsonis |
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1:35 PM |
50 |
Mechanics of the innate immune reaction to a traumatic brain injury Dorian B McGavern |
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2:00 PM |
51 |
Funding translational research and development of pharmaceutical innovation – sources and strategies to create novel therapeutics Charles Baltic |
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2:25 PM |
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Closing Remarks |
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2:30 PM |
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Lunch/Informal Discussions |
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8:00 PM |
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Farewell Dinner |
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Tuesday, June 28 |
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7:30 AM |
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Breakfast |
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9:00 AM |
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Departure |
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POSTERS |
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52 |
Association of antibodies to oxidative-LDL with intima media thickness in presence of periodontal pathogen P. gingivalis Ramin Akhi, Sohvi Hörkkö, and Pirkko Pussinen |
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53 |
B lymphocytes participate on innate immune response against intracellular bacterial pathogen Francisella tularensis Zuzana Krocova, Klara Kubelkova, Lenka Plzakova, and Ales Macela |
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54 |
C3-deficiency is associated with reduced tumor growth in carcinogen-induced epithelial and mesenchymal murine cancer models Elena Magrini, Sabrina Di Marco, Maria Luisa Barbagallo, Eduardo Bonavita, Stefania Gentile, Andrea Ponzetta, Alberto Mantovani, and Cecilia Garlanda |
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55 |
CSF1R-dependent monocytes are required for NK-mediated control of metastasis Michal Beffinger, Yannick Montagnolo, Isabel Ohs, Sonia Tugues, Aron Gagliardi, Nikola Misljencevic, James Sutton, Roman Spörri, Burkhard Becher, Anurag Gupta, and Maries van den Broek |
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56 |
Cytokine profiles of Korean patients with adult onset Still’s disease treated with tumor necrosis factor inhibitors Dae Hyun Yoo, Seung Taek Song, and Soo Man Kang |
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57 |
Efflux protein complexes are more than pumps: a case study of Pseudomonas aeruginosa Melinda Wren, Kumkum Ganguly, Paige Pardington, Mira Dimitrijevic, Benjamin Mcmahon, Norman Doggett, Herbert Schweizer, and Goutam Gupta |
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58 |
Extracellular RNA degradation as well as VEGF-receptor inhibition counteracts arteriogenesis by interfering with mast cell degranulation Manuel Lasch, Eike Kleinert, Thomas Lautz, Amelia Caballero-Martinez, and Elisabeth Deindl |
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59 |
Functional activity of gut CX3CR1+ macrophages in colitis-induced cancer Giulia Marelli, Marco Erreni, Cristina Belgiovine, Alberto Mantovani, and Paola Allavena |
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60 |
Growing complexity of the invertebrate complement system: evidences from colonial tunicates Nicola Franchi and Loriano Ballarin |
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61 |
GRPR antagonist protects from drug-induced liver injury by impairing neutrophils chemotraxis and motility Natália Jaeger, Rafael Czepielewski, Pedro Marques, Rafaela Pereira, Rodrigo da Silva, Tiago Lopes, Vinícius da Silva, Bárbara Porto, Gustavo Menezes, and Cristina Bonorino |
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62 |
HIV infection of monocytes-derived dendritic cells inhibits Vγ9Vδ2 T cells functions Alessandra Sacchi, Nicola Tumino, Rita Casetti, Chiara Agrati, Federica Turchi, Veronica Bordoni, Eleonora Cimini, and Federico Martini |
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63 |
Hypoxia attenuates the inflammatory response during endotoxemia, in mice and man Dorien Kiers, Jelle Gerretsen, Emmy Janssen, Aaron John, Rianne Groeneveld, Lars Damen, Johannes van der Hoeven, Gert-Jan Scheffer, Peter Pickkers, and Matthijs Kox |
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64 |
Innate immune responses to Marek's disease vaccine Mohammad Heidari |
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65 |
Interleukin-1 receptor 8 (IL-1R8) plays a crucial role in Natural Killer cell differentiation and function Martina Molgora, Eduardo Bonavita, Andrea Ponzetta, Marialuisa Barbagallo, Nadia Polentarutti, Sebastien Jaillon, Federica Riva, Elena Magrini, Giorgia Benigni, Giovanni Bernardini, Angela Santoni, Alberto Mantovani, and Cecilia Garlanda |
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66 |
Natural killer lymphocytes in HIV and multiple sclerosis Tatiana Koudriavtseva, Domenico Plantone, Alessandra Latini, Manuela Colafigli, Chiara Mandoj, Rosaria Renna, Elisabetta Trento, and Fulvia Pimpinelli |
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67 |
Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors Gudrun Weiss, Cheryl Lai, Bernadett Tildy, Robert Snelgrove, Gang Xin, Clare Lloyd, and Tracy Hussell |
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68 |
Roles of nitric oxide in the aggregation of resident adherent peritoneal cells in C57BL/6 mice Dipankar Nandi |
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69 |
Studies on the expression and functional characterization of hemoglobin in human vaginal cells Debarchana Saha, Shashank Parulekar, and KVR Reddy |
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70 |
Suppressor of Cytokine Signaling-3 (SOCS-3) regulates alveolar bone loss in experimental periodontitis and the anti-inflammatory actions of Resolvin E1 (RvE1) Evangelos Papathanasiou, Alpdogan Kantarci, Antonios Konstantinidis, Hongwei Gao, and Thomas Van Dyke |
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71 |
Sustained virological response to first generation DAA treatment of chronic HCV-infected patients is associated with the activation of circulating dendritic cells Nicola Tumino, Federica Turchi, Eleonora Cimini, Chiara Agrati, Giulia Refolo, Gian Maria Fimia, Fabiola Ciccosanti, Raffaella Lionetti, Marzia Montalbano, Gianpiero D'Offizi, Rita Casetti, Veronica Bordoni, Antonella Romanelli, Federico Martini, and Alessandra Sacchi |
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72 |
The cellular and molecular aspects of early immune responses of immunocompromised host against intracellular bacterium Klara Kubelkova and Ales Macela |
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73 |
The ex vivo tolerance induction to Toll-like receptor 7 in donor lymphocytes prevents murine acute Graft-versus-Host Disease Nikolaos Zogas, Garyfalia Karponi, Fotios Iordanidis, Vasilios Paraskevas, Eleni Siotou, Anastasia Papadopoulou, Zaharias Scouras, Achilles Anagnostopoulos, and Evangelia Yannaki |
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74 |
Silencing of natural killer cells in the human lung tumor microenvironment by microRNA183 Melba Tejera, Jun-Min Zhou, Danielle L Gilvary,and Julie Y Djeu |
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75 |
Cell type-specific role of ATX in nonalcoholic steatohepatitis (NASH) Pallavi Subramanian, Nora Techritz, Marta Prucnal, Vassilis Aidinis, andTriantafyllos Chavakis |
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76 |
IL17B, a novel member of the IL17 cytokine family, promotes Type-2 immune responses through the receptors IL-17RA and IL17RB Rajita Pappu, Vladimir Ramirez-Carrozzi, Arivazhagan Sambandam, Naruhisa Ota, and Wenjun Ouyang |
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