6:00 PM |
Conference Registration |
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8:00 PM |
Welcome Reception/Dinner |
7:30 AM |
Breakfast |
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8:25 AM |
Welcome and opening remarks |
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Session I |
Inflammatory Cytokines in Cancer Chairs: Iris Behrman and Hallgeir Rui |
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8:30 AM |
1 |
Inflammation, macrophage polarization and cancer Alberto Mantovani |
9:15 AM |
2 |
Novel Technologies to Target STAT3: Transition into the Clinic Hua Yu |
9:40 AM |
3 |
Tumor elicited inflammation and cytokines in tumor progression Sergei Grivennikov |
10:30 AM |
4 |
The Interleukin-11/gp130/Stat3 signaling cascade serves as a therapeutically targetable rheostat during regeneration and tumorigenesis of the gastrointestinal epithelium Matthias Ernst, Tracy Putoczki, Michael Buchert and Toby Phesse |
10:45 AM |
Coffee break and poster viewing |
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Session II |
Mechanisms of molecular regulation Chairs: Yu Hua and Mathias Ernst |
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12:00 PM |
5 |
MicroRNAs as modulators of cytokine responses in cancer Iris Behrmann, Susanne Reinsbach, Martina Schmitt, Petr Nazarov, Demetra Philippidou, Florence Servais, Matthias Hamdorf, Laurent Vallar, Christiane Margue and Stephanie Kreis |
12:25 PM |
6 |
TTP-dependent mRNA decay guards immune homeostasis: implications for inflammation and cancer Pavel Kovarik |
12:50 PM |
7 |
Modulation of the innate immune response by BTB-ZF transcriptional regulator PLZF Bryan Williams, Anthony Sadler and Dakang Xu |
1:15 PM |
8 |
Post-Transcriptional Regulation of Cytokine Signaling by AU-Rich and GU-Rich Elements MaiLee Moua, Amanda Zeisels, Paul Bohjanen and Irina St. Louis |
1:30 PM |
Lunch/Informal Discussions |
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7:30 PM |
Dinner/Informal Discussions at a local Greek Restaurant Meet at the hotel lobby at 7:30 PM |
7:30 AM |
Breakfast |
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Session III |
Interferon signaling in cancer Chairs: Nikola Baschuk and Fred Schaper |
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8:30 AM |
9 |
Functional plasticity in type I interferon signaling Gideon Schreiber |
8:55 AM |
10 |
ISG15 Deconjugating Enzyme USP18/UBP43 in IFN signaling, Blood Stem Cells, and Cancer Kei-Ichiro Arimoto, Sayuri Miyauchi, Junbao Fan, Christopher Burkart and Dong-Er Zhang |
9:20 AM |
11 |
Canonical and non-canonical Tyk2 functions in cytokine signalling and cancer Agnieszka Witalisz-Siepracka, Michaela Prchal-Murphy, Karoline Bednarik, Eva-Maria Putz, Dagmar Gotthardt, Kartin Meissl, Nicole Leitner, Dagmar Stoiber-Skaguchi, Veronika Sexl, Mathias Müller and Birgit Strobl |
9:45 AM |
12 |
STAT1 isoforms in cytokine signalling and tumour surveillance Mathias Parrini, Christian Semper, Nicole Leitner, Caroline Lassnig, Agnieszka Witalisz-Siepracka, Sebastian Wienerroither, Ana Puga, Katrin Meissl, Pavel Kovarik, Veronika Sexl, Thomas Decker, Mathias Müller and Birgit Strobl |
10:10 AM |
13 |
Tumor microenvironment downregulates IFNAR1 in the lymphoid immune cells to promote development and progression of colorectal cancer Kanstantsin Katlinski, Christopher Carbone, Sabyasachi Bhattacharya, Melanie Girondo, Hallgeir Rui and Serge Fuchs |
10:25 AM |
Coffee break and poster viewing |
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Session IV |
Anti-tumorigenic signaling and transactivation Chairs: Marja Nevalainen and Belinda Parker |
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11:00 AM |
14 |
Activities of Stat1 in absence of its tyrosine phosphorylation Eva Maria Putz, Andrea Majoros, Dagmar Gotthardt, Mathias Müller, Veronika Sexl and Thomas Decker |
11:25 AM |
15 |
IFN-signaling pathways and their roles in malignancies Leonidas Platanias |
11:50 AM |
16 |
Cytokine-induced tumor suppression: a GRIM lesson Dhan Kalvakolanu, Sudhakar Kalakonda and Shreeram Nallar |
12:15 PM |
17 |
ISG15, a balancing factor between autoimmunity and antiviral protection Scott Speer, Zhi Li, Mathilde Vinet, Béatrice Payelle-Brogard, Sofija Buta, Dusan Bogunovic and Sandra Pellegrini |
12:40 PM |
18 |
Gene cooperativity in a mouse model of childhood precursor B cell malignancy Dagmar Stoiber |
1:05 PM |
19 |
A novel recombinant interferon sIFN-I elicits potent signaling and anti-tumor effect Kangjian Zhang, Xiaofei Yin, Yuanqing Yang, Rongbing Guo, Guanwen Wei, Dacheng Wang and Xinyuan Liu |
1:20 PM |
Lunch/Informal Discussions |
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7:30 PM |
Dinner/Informal Discussions at a local Greek Restaurant Buses depart from the hotel lobby at 7:30 PM |
7:30 AM |
Breakfast |
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Session V |
Alteration of cytokine signaling in cancer Chairs: Yu Hua and Pavel Kovarik |
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8:30 AM |
20 |
Elimination of the IFNAR1 chain of Type 1 interferons as a mechanism to overcome cell senescence and anti-tumor immunity Serge Fuchs |
8:55 AM |
21 |
Mechanistic, therapeutic and prognostic insights into the role of tumour induced type I IFNs in metastatic disease Jay Rautela, Nikola Baschuk, Paul Hertzog, Sandra O'Toole and Belinda Parker |
9:20 AM |
22 |
Prolactin receptor signaling in human breast cancer – new insights through novel models Hallgeir Rui |
9:55 AM |
23 |
Murine models of disease dependent or independent of B cell intrinsic STAT3 expression Alexei Petrenko, Sandeep Reddy, Hui-Chen Foreman, Ozula Sioux, Gee Ho Park, Valeria Poli, Laurie Krug and Nancy Reich |
10:20 AM |
24 |
STAT2 in Type I IFN Signaling and Cancer Ana Gamero |
10:45 AM |
25 |
Erythropoietin – far beyond erythropoiesis Drorit Neumann |
11:10 AM |
Coffee break |
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Session VI |
JAK-STAT pathways in cancer Chairs: Birgit Strobl and Sergei Grivennikov |
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11:30 AM |
26 |
Mechanisms of STAT3 action in cancer David Levy |
11:55 AM |
27 |
Oncogenic kinase ALK uses IL-2-type signaling pathways to transform target CD4+ T cells by multiple mechanisms. Mariusz Wasik |
12:20 PM |
28 |
Regulation of Interferon pathways and signatures in cancers Paul Hertzog, Belinda Parker, Ross Chapman, Helen Cumming, Sam Forster and Nollaig Bourke |
12:45 PM |
29 |
Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem Cell Properties in Prostate Cancer Cells Pooja Talati, Lei Gu, Elyse Ellsworth, Melanie Girondo, Marco Trerotola, David Hoang, Benjamin Leiby, Ayush Dagvadorj, Peter McCue, Costas Lallas, Edouard Trabulsi, Leonard Gomella, Andrew Aplin, Lucia Languino, Alessandro Fatatis, Hallgeir Rui and Marja Nevalainen |
1:10 PM |
30 |
Illuminating STAT5 Biology in Cancers Through Gain or Loss of Function Richard Moriggl |
1:35 PM |
31 |
Molecular mechanism of constitutive membrane binding of the multi-site docking protein Gab1 in Jak2-V617F expressing cells Hannes Bongartz, Wiebke Hessenkemper, Alexandra Wolf, Rene Eulenfeld, Philip Simister, Iris Behrmann, Jan Tavernier, Stephan Feller, Claude Haan and Fred Schaper |
1:50 PM |
Lunch/Informal Discussions |
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3:00 PM |
City Tour (depart from the hotel lobby at 3:00PM) |
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7:30 PM |
Dinner/Informal Discussions at a local Greek Restaurant Please note buses do not pick-up at the hotel prior to dinner. Dinner proceeds right after the tour |
7:30 AM |
Breakfast |
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Session VII |
Cytokines signaling and anti-cancer therapies-I Chairs: Drorit Neumann and Richard Moriggl |
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8:30 AM |
32 |
The CypA/Jak2 Complex as a Therapeutic Target in Breast Cancer Charles Clevenger |
8:55 AM |
33 |
Interferon-induced Necroptosis: Mechanism and Potential for Anti-tumor Therapy Roshan Thapa, Shok Nogusa, Gregory Adams and Siddharth Balachandran |
9:20 AM |
34 |
Heterodimeric IL-15: structure, function and clinical development for cancer immunotherapy George Pavlakis, Cristina Bergamaschi, Sin-Man Ng, Stephanie Chen, Jenifer Bear, Candido Alicea, Bethany Nagy, Raymond Sowder, Elena Chertova and Barbara K. Felber |
9:45 AM |
35 |
Therapeutic effect of Toll-like receptor- 2 agonist on lung cancer by reciprocal regulation of anti or pro-tumour cytokine productions in mice Damo Xu and Dong Li |
10:00 AM |
Coffee break and poster viewing |
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Session VIII |
Cytokines signaling and anti-cancer therapies-II Chairs: Geir Hetland and Deborah Vestal |
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11:00 AM |
36 |
CML: the role of cytokines in the TKI era Jessica Altman |
11:25 AM |
37 |
Strategy of an oncolytic virus harboring two antitumor cytokines that completely eradicate xenograft tumors Xin-Yuan Liu, Liang Chu and Kang-Jian Zhang |
11:50 AM |
38 |
Common gamma chain (γc) expression controls lymphomagenesis via regulation of γc cytokine signaling Changwan Hong |
12:20 PM |
Roundtable discussion and closing remarks |
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1:00 PM |
Lunch/Informal Discussions |
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8:00 PM |
Farewell Dinner |
7:30 AM |
Breakfast |
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9:00 AM |
Departure |
POSTERS
39 |
Circulating endothelial-derived microparticles level and incidence of hepatocellular carcinoma in patients with Child-Pugh class A liver cirrhosis. Jolanta Zuwala-Jagiello, Monika Pazgan-Simon and Krzysztof Simon |
40 |
Cytokine measurements in the APCMin+/- mouse model for intestinal tumors (Familial Adenomatous Polyposis), treated with Andosan – an extract of the immunomodulating and antitumor mushroom Agaricus blazei Murill Geir Hetland, Dag Eide and Jan Paulsen |
41 |
Cytokine senescence: IFNgamma-induced TGFbeta/SMAD signaling causes oxidative DNA damage via Nox4 Sona Hubackova, Alena Kucerova, Georg Michlits, Lenka Kyjacova, Milan Reinis, Olexander Korolov, Jiri Bartek and Zdenek Hodny |
42 |
Analysis of immune cell infiltration and secreted factors in non-small cell lung cancer tumors Nada Hradilova, Ondrej Palata, Lenka Sadilkova, Dagmar Mysikova, Hana Mrazkova, Robert Lischke, Radek Spisek, Irena Adkins |
43 |
Cytokine’s levels after laparoscopic and open colectomies for cancer: A matched case control study Dimitrios Tsamis and George Theodoropoulos |
44 |
Development of novel inhibitors of STAT-mediated transcription Iryna Kolosenko, Sander Busker, Jianping Liu, Martin Haraldsson, Thomas Lundbäck, Dan Grandér and Katja Pokrovskaja Tamm |
45 |
Exposure to multi-walled carbon nanotubes affects intercellular communication and may depend on interleukin-1 Yke Jildouw Arnoldussen, Kristine Haugen Anmarkrud, Mayes Kasem, Vidar Skaug, Ron Apte, Edward Leithe, Aage Haugen and Shanbeh Zienolddiny |
46 |
Functional study of TYK2 splicing variants Zhi Li, Frédérique Michel and Sandra Pellegrini |
47 |
Gab1: SHP2 complex formation in Jak2-V617F expressing cells is crucial for constitutive MAPK activation Hannes Bongartz, Katharina Mandel, Alexandra Wolf, Rene Eulenfeld, Stephan Feller and Fred Schaper |
48 |
Guanylate-Binding Proteins (GBPs) as regulators of the cytoskeleton Deborah Vestal, Angela Messmer-Blust, Suzan Wadi and Sujata Balasubramanian |
49 |
Identification of age-related circulating factors in cigarette smoke-induced carcinogenesis Moon Jung Back, Zhicheng Fu, Ji Min Jang, Han Gyeol Kim, Hye Hyeon Cha and Dae Kyong Kim |
50 |
IL-27 regulates angiogenesis via a STAT1-dominant pathway Joana Lopes de Melo, Sebastian Nielsen, Anna-Kathrine Pedersen, Steen Dissing and Katerina Tritsaris |
51 |
Implication of combined PD-L1/PD-1 signaling blockade with Cytokine-induced killer cells as a synergistic immunotherapy for metastatic unresectable cancers Congqi Dai and Jin Li |
52 |
In vitro generation of ovarian tumor associated macrophages (ov-TAMs) can be stimulated to produce a phenotype that increases cancer cell invasion Michael Bradaric, Alyssa Johnson, Mohammed Habis, Nadia Ismail, Ernst Lengyel and Iris Romero |
53 |
Preconditioning prevent neuroinflammation induced p53, c-myc and Hsp70 gene over-expression. Pushpa Gandi Sangaran, Abolhassan Ahmadiani and Zahurin Mohamed Mohamed |
54 |
Prediction and identification of antigenic epitopes in Eg95 of Echinococcus granulosus Xi Lan, Wenyan Cao, Xiaoan Hu, Hui Zhao, Fengbo Zhang, Qian Wang, Shanshan Peng, Hao Wen, Jianbing Ding and Xiumin Ma |
55 |
Structure function relationship of Interferon receptor Nanaocha Sharma |
56 |
The role of STAT1β in IL-27-regulated angiogenesis Nina Mørup, Joana Lopes de Melo, Ulrik Kirk Hansen and Katerina Tritsaris |
57 |
Tumour cell secreted immunoregulatory cytokines associated with prostate cancer bone metastasis Nikola Baschuk, Alex Spurling, Katie Owen, Jai Rautela and Belinda Parker |
58 |
Type I interferon activates PFKFB3-driven glycolysis to promote anti-viral defense in macrophages Hui Jiang, Man Sun, Er-guang Li and Jianghuai Liu |
59 |
Type I interferons contribute to cell senescence induced by DNA damage and oncogene activation Yuliya Katlinskaya, Qiujing Yu and Serge Fuchs |