International Conference on Cytokine Signaling in Cancer

Program

Sunday, May 24

     

6:00 PM

 

Conference Registration

     

8:00 PM

 

Welcome Reception/Dinner

Monday, May 25

     

7:30 AM

 

Breakfast

     

8:25 AM

 

Welcome and opening remarks

     

Session I

 

Inflammatory Cytokines in Cancer

Chairs: Iris Behrman and Hallgeir Rui

     

8:30 AM

1

Inflammation, macrophage polarization and cancer

Alberto Mantovani

9:15 AM

2

Novel Technologies to Target STAT3: Transition into the Clinic

Hua Yu

9:40 AM

3

Tumor elicited inflammation and cytokines in tumor progression

Sergei Grivennikov

10:30 AM

4

The Interleukin-11/gp130/Stat3 signaling cascade serves as a therapeutically targetable rheostat during regeneration and tumorigenesis of the gastrointestinal epithelium

Matthias Ernst, Tracy Putoczki, Michael Buchert and Toby Phesse

     

10:45 AM

 

Coffee break and poster viewing

     

Session II

 

Mechanisms of molecular regulation

Chairs: Yu Hua and Mathias Ernst

     

12:00 PM

5

MicroRNAs as modulators of cytokine responses in cancer

Iris Behrmann, Susanne Reinsbach, Martina Schmitt, Petr Nazarov, Demetra Philippidou, Florence Servais, Matthias Hamdorf, Laurent Vallar, Christiane Margue and Stephanie Kreis

12:25 PM

6

TTP-dependent mRNA decay guards immune homeostasis: implications for inflammation and cancer

Pavel Kovarik

12:50 PM

7

Modulation of the innate immune response by BTB-ZF transcriptional regulator PLZF

Bryan Williams, Anthony Sadler and Dakang Xu

1:15 PM

8

Post-Transcriptional Regulation of Cytokine Signaling by AU-Rich and GU-Rich Elements

MaiLee  Moua, Amanda Zeisels, Paul Bohjanen and Irina St. Louis

     

1:30 PM

 

Lunch/Informal Discussions

     

7:30 PM

 

Dinner/Informal Discussions at a local Greek Restaurant

Meet at the hotel lobby at 7:30 PM

Tuesday, May 26

     

7:30 AM

 

Breakfast

     

Session III

 

Interferon signaling in cancer

Chairs: Nikola Baschuk and Fred Schaper

     

8:30 AM

9

Functional plasticity in type I interferon signaling

Gideon Schreiber

8:55 AM

10

ISG15 Deconjugating Enzyme USP18/UBP43 in IFN signaling, Blood Stem Cells, and Cancer

Kei-Ichiro Arimoto, Sayuri Miyauchi, Junbao Fan, Christopher Burkart and Dong-Er Zhang

9:20 AM

11

Canonical and non-canonical Tyk2 functions in cytokine signalling and cancer

Agnieszka Witalisz-Siepracka, Michaela Prchal-Murphy, Karoline Bednarik, Eva-Maria Putz, Dagmar Gotthardt, Kartin Meissl, Nicole Leitner, Dagmar Stoiber-Skaguchi, Veronika Sexl, Mathias Müller and Birgit Strobl

9:45 AM

12

STAT1 isoforms in cytokine signalling and tumour surveillance

Mathias Parrini, Christian Semper, Nicole Leitner, Caroline Lassnig, Agnieszka Witalisz-Siepracka, Sebastian Wienerroither, Ana Puga, Katrin Meissl, Pavel Kovarik, Veronika Sexl, Thomas Decker, Mathias Müller and Birgit Strobl

10:10 AM

13

Tumor microenvironment downregulates IFNAR1 in the lymphoid immune cells to promote development and progression of colorectal cancer

Kanstantsin Katlinski, Christopher Carbone, Sabyasachi  Bhattacharya, Melanie  Girondo, Hallgeir  Rui and Serge Fuchs

     

10:25 AM

 

Coffee break and poster viewing

     

Session IV

 

Anti-tumorigenic signaling and transactivation

Chairs: Marja Nevalainen and Belinda Parker

     

11:00 AM

14

Activities of Stat1 in absence of its tyrosine phosphorylation

Eva Maria Putz, Andrea Majoros, Dagmar Gotthardt, Mathias Müller, Veronika Sexl and Thomas Decker

11:25 AM

15

IFN-signaling pathways and their roles in malignancies

Leonidas Platanias

11:50 AM

16

Cytokine-induced tumor suppression: a GRIM lesson

Dhan Kalvakolanu, Sudhakar Kalakonda and Shreeram Nallar

12:15 PM

17

ISG15, a balancing factor between autoimmunity and antiviral protection

Scott Speer, Zhi Li, Mathilde Vinet, Béatrice Payelle-Brogard, Sofija Buta, Dusan Bogunovic and Sandra Pellegrini

12:40 PM

18

Gene cooperativity in a mouse model of childhood precursor B cell malignancy

Dagmar Stoiber

1:05 PM

19

A novel recombinant interferon sIFN-I elicits potent signaling and anti-tumor effect

Kangjian Zhang, Xiaofei Yin, Yuanqing Yang, Rongbing Guo, Guanwen Wei, Dacheng Wang and Xinyuan Liu

     

1:20 PM

 

Lunch/Informal Discussions

     

7:30 PM

 

Dinner/Informal Discussions at a local Greek Restaurant

Buses depart from the hotel lobby at 7:30 PM

Wednesday, May 27

     

7:30 AM

 

Breakfast

     

Session V

 

Alteration of cytokine signaling in cancer

Chairs: Yu Hua and Pavel Kovarik

     

8:30 AM

20

Elimination of the IFNAR1 chain of Type 1 interferons as a mechanism to overcome cell senescence and anti-tumor immunity

Serge Fuchs

8:55 AM

21

Mechanistic, therapeutic and prognostic insights into the role of tumour induced type I IFNs in metastatic disease

Jay Rautela, Nikola Baschuk, Paul Hertzog, Sandra O'Toole and Belinda Parker

9:20 AM

22

Prolactin receptor signaling in human breast cancer – new insights through novel models

Hallgeir Rui

9:55 AM

23

Murine models of disease dependent or independent of B cell intrinsic STAT3 expression

Alexei Petrenko, Sandeep Reddy, Hui-Chen Foreman, Ozula Sioux, Gee Ho Park, Valeria Poli, Laurie Krug and Nancy Reich

10:20 AM

24

STAT2 in Type I IFN Signaling and Cancer

Ana Gamero

10:45 AM

25

Erythropoietin – far beyond erythropoiesis

Drorit Neumann

     

11:10 AM

 

Coffee break

     

Session VI

 

JAK-STAT pathways in cancer

Chairs: Birgit Strobl and Sergei Grivennikov

     

11:30 AM

26

Mechanisms of STAT3 action in cancer

David Levy

11:55 AM

27

Oncogenic kinase ALK uses IL-2-type signaling pathways to transform target CD4+ T cells by multiple mechanisms.

Mariusz Wasik

12:20 PM

28

Regulation of Interferon pathways and signatures in cancers

Paul Hertzog, Belinda Parker, Ross Chapman, Helen Cumming, Sam Forster and Nollaig Bourke

12:45 PM

29

Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem Cell Properties in Prostate Cancer Cells

Pooja Talati, Lei  Gu, Elyse Ellsworth, Melanie Girondo, Marco Trerotola, David  Hoang, Benjamin Leiby, Ayush Dagvadorj, Peter McCue, Costas  Lallas, Edouard Trabulsi, Leonard  Gomella, Andrew Aplin, Lucia Languino, Alessandro Fatatis, Hallgeir Rui and Marja Nevalainen

1:10 PM

30

Illuminating STAT5 Biology in Cancers Through Gain or Loss of Function

Richard Moriggl

1:35 PM

31

Molecular mechanism of constitutive membrane binding of the multi-site docking protein Gab1 in Jak2-V617F expressing cells

Hannes Bongartz, Wiebke Hessenkemper, Alexandra Wolf, Rene Eulenfeld, Philip Simister, Iris Behrmann, Jan Tavernier, Stephan Feller, Claude Haan and Fred Schaper

     

1:50 PM

 

Lunch/Informal Discussions

     

3:00 PM

 

City Tour (depart from the hotel lobby at 3:00PM)

     

7:30 PM

 

Dinner/Informal Discussions at a local Greek Restaurant

Please note buses do not pick-up at the hotel prior to dinner.

Dinner proceeds right after the tour

Thursday, May 28

     

7:30 AM

 

Breakfast

     

Session VII

 

Cytokines signaling and anti-cancer therapies-I

Chairs: Drorit Neumann and Richard Moriggl

     

8:30 AM

32

The CypA/Jak2 Complex as a Therapeutic Target in Breast Cancer

Charles Clevenger

8:55 AM

33

Interferon-induced Necroptosis: Mechanism and Potential for Anti-tumor Therapy

Roshan Thapa, Shok Nogusa, Gregory Adams and Siddharth Balachandran

9:20 AM

34

Heterodimeric IL-15: structure, function and clinical development for cancer immunotherapy

George Pavlakis, Cristina Bergamaschi, Sin-Man Ng, Stephanie Chen, Jenifer Bear, Candido Alicea, Bethany Nagy, Raymond Sowder, Elena Chertova and Barbara K. Felber

9:45 AM

35

Therapeutic effect of Toll-like receptor- 2 agonist on lung cancer by reciprocal regulation of anti or pro-tumour cytokine productions in mice

Damo Xu and Dong Li

     

10:00 AM

 

Coffee break and poster viewing

     

Session VIII

 

Cytokines signaling and anti-cancer therapies-II

Chairs: Geir Hetland and Deborah Vestal

     

11:00 AM

36

CML: the role of cytokines in the TKI era

Jessica Altman

11:25 AM

37

Strategy of an oncolytic virus harboring two antitumor cytokines that completely eradicate xenograft tumors

Xin-Yuan Liu, Liang Chu and Kang-Jian  Zhang

11:50 AM

38

Common gamma chain (γc) expression controls lymphomagenesis via regulation of γc cytokine signaling

Changwan Hong

     

12:20 PM

 

Roundtable discussion and closing remarks

     

1:00 PM

 

Lunch/Informal Discussions

     

8:00 PM

 

Farewell Dinner

Friday, May 29

     

7:30 AM

 

Breakfast

     

9:00 AM

 

Departure

POSTERS

39

Circulating endothelial-derived microparticles level and incidence of hepatocellular carcinoma in patients with Child-Pugh class A liver cirrhosis.

Jolanta Zuwala-Jagiello, Monika Pazgan-Simon and Krzysztof Simon

40

Cytokine measurements in the APCMin+/- mouse model for intestinal tumors (Familial Adenomatous Polyposis), treated with Andosan – an extract of the immunomodulating and antitumor mushroom Agaricus blazei Murill

Geir Hetland, Dag Eide and Jan Paulsen

41

Cytokine senescence: IFNgamma-induced TGFbeta/SMAD signaling causes oxidative DNA damage via Nox4

Sona Hubackova, Alena Kucerova, Georg Michlits, Lenka Kyjacova, Milan Reinis, Olexander Korolov, Jiri Bartek and Zdenek Hodny

42

Analysis of immune cell infiltration and secreted factors in non-small cell lung cancer tumors

Nada Hradilova, Ondrej Palata, Lenka Sadilkova, Dagmar Mysikova, Hana Mrazkova, Robert Lischke, Radek Spisek, Irena Adkins

43

Cytokine’s levels after laparoscopic and open colectomies for cancer: A matched case control study

Dimitrios Tsamis and George Theodoropoulos

44

Development of novel inhibitors of STAT-mediated transcription

Iryna Kolosenko, Sander Busker, Jianping Liu, Martin Haraldsson, Thomas Lundbäck, Dan Grandér and Katja Pokrovskaja Tamm

45

Exposure to multi-walled carbon nanotubes affects intercellular communication and may depend on interleukin-1

Yke Jildouw Arnoldussen, Kristine Haugen Anmarkrud, Mayes Kasem, Vidar Skaug, Ron Apte, Edward Leithe, Aage Haugen and Shanbeh Zienolddiny

46

Functional study of TYK2 splicing variants

Zhi Li, Frédérique Michel and Sandra  Pellegrini

47

Gab1: SHP2 complex formation in Jak2-V617F expressing cells is crucial for constitutive MAPK activation

Hannes Bongartz, Katharina Mandel, Alexandra Wolf, Rene Eulenfeld, Stephan Feller and Fred Schaper

48

Guanylate-Binding Proteins (GBPs) as regulators of the cytoskeleton

Deborah Vestal, Angela Messmer-Blust, Suzan Wadi and Sujata Balasubramanian

49

Identification of age-related circulating factors in cigarette smoke-induced carcinogenesis

Moon Jung Back, Zhicheng Fu, Ji Min Jang, Han Gyeol  Kim, Hye Hyeon  Cha and Dae Kyong  Kim

50

IL-27 regulates angiogenesis via a STAT1-dominant pathway

Joana Lopes de Melo, Sebastian Nielsen, Anna-Kathrine Pedersen, Steen Dissing  and Katerina Tritsaris

51

Implication of combined PD-L1/PD-1 signaling blockade with Cytokine-induced killer cells as a synergistic immunotherapy for metastatic unresectable cancers

Congqi Dai and Jin Li

52

In vitro generation of ovarian tumor associated macrophages (ov-TAMs) can be stimulated to produce a phenotype that increases cancer cell invasion

Michael Bradaric, Alyssa Johnson, Mohammed Habis, Nadia Ismail, Ernst Lengyel and Iris Romero

53

Preconditioning prevent neuroinflammation induced p53, c-myc and Hsp70 gene over-expression.

Pushpa Gandi Sangaran, Abolhassan  Ahmadiani and Zahurin Mohamed Mohamed

54

Prediction and identification of antigenic epitopes in Eg95 of Echinococcus granulosus

Xi Lan, Wenyan Cao, Xiaoan Hu, Hui Zhao, Fengbo Zhang, Qian Wang, Shanshan Peng, Hao Wen, Jianbing Ding and Xiumin Ma

55

Structure function relationship of Interferon receptor

Nanaocha Sharma

56

The role of STAT1β in IL-27-regulated angiogenesis

Nina Mørup, Joana Lopes de Melo, Ulrik Kirk Hansen and Katerina Tritsaris

57

Tumour cell secreted immunoregulatory cytokines associated with prostate cancer bone metastasis

Nikola Baschuk, Alex Spurling, Katie Owen, Jai Rautela and Belinda Parker

58

Type I interferon activates PFKFB3-driven glycolysis to promote anti-viral defense in macrophages

Hui Jiang, Man Sun, Er-guang Li and Jianghuai Liu

59

Type I interferons contribute to cell senescence induced by DNA damage and oncogene activation

Yuliya Katlinskaya, Qiujing Yu and Serge Fuchs