GENERAL INFORMATION
Accommodations
All participants will be staying at the Royal Myconian Hotel, which is located in Elia Beach, 12 km from Mykonos Center, Mykonos Airport, and Port.
Arrival and Check-in
It is expected that attendees will arrive/check-in on Sunday after 2:00 PM. Anyone arriving after 10:30 pm on Sunday must make alternative dinner arrangements.
Conference Venue
The Royal Myconian Conference Center is located at the hotel.
Posters
Posters should be mounted Sunday, Septemer 21 between 7:00 – 8:00 PM or the following morning before the conference session, on the designated boards and dismounted at the closing of the conference. The dimensions of the boards are 90 cm wide X 120 cm high. Adhesive tape for mounting the posters on the boards will be available at the poster area.
Oral Presentations
Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session. The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.
Delos Tour
Buses for the city tour will depart from the hotel front lobby on Tuesday, September 24 at 2:30 pm. Badges are required for participation.
Breakfast for registered participants and registered accompanying persons will be served at the Royal Myconian Hotel main restaurant during the hours scheduled in this program.
Lunches/Informal Discussions
Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant. Badges are required for admission.
Dinners/Informal Discussions
Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting. Please contact info@aegeanconferences.org.
Internet, Phone, & Computer
Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.
Certificate of Participation
A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session.
Other Information
Animals are not permitted on site.
Badges are required for admission to all events.
All Aegean Conferences events are non-smoking.
No Photographs and Recording Devices
Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations.
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Sunday, September 21 |
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6:00 PM – 8:00 PM |
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Conference Registration |
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8:00 PM |
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Welcome Reception Dinner/Informal Discussions |
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Monday, September 22 |
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7:30 AM |
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Breakfast |
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9:00 AM |
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Welcome / Opening Remarks |
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Session I |
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Tumor-stroma interactions |
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Chairs: Ester Hammond and Adrian Harris |
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9:05 AM |
1 |
Inflammation and cancer: Good cells behaving badly |
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Lisa Coussens |
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9:30 AM |
2 |
Diverse populations of macrophages promote metastasis |
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Jeffrey W Pollard |
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9:55 AM |
3 |
The dynamic interplay between extrinsic and intrinsic force regulates cancer progression |
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Valerie Weaver |
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10:20 AM |
4 |
TBA |
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Raghu Kalluri |
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10:45 AM |
5 |
Activin promotes Human Papilloma Virus (HPV) 8-induced skin tumorigenesis through alterations in T cells and macrophages |
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Maria Antsiferova, Aleksandra Piwko-Czuchra, Katharina Birkner, Sigrun Smola, Daniel Hohl, and Sabine Werner |
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10:55 AM |
6 |
Connective tissue growth factor (CTGF) as a therapeutic stromal target in ovarian cancer |
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Kim Moran-Jones, Rajmohan Murali, David K Chang, Carol W Wong, Sue S Spong, Neville F Hacker, and Goli Samimi |
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11:05 AM |
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Coffee Break & Poster Viewing |
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Session II |
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Microenvironment effects from tumor initiation to metastasis |
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Chairs: Lisa Coussens and Amit Maity |
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12:00 PM |
7 |
Regulation of metastasis by scaffolding proteins and lateral receptor activation under hypoxia conditions |
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Erinn B Rankin, Katherine Fuh, Laura Castellini, Kartik Viswanathan, Elizabeth Finger, Anh Diep, Edward LaGory, David Lindgren, Håkan Axelson, Yu Miao, Mihalis Kariolis, Adam Krieg, and Amato J Giaccia |
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12:25 PM |
8 |
MTDH-SND1 interaction is essential for the expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors |
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Yibin Kang |
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12:50 PM |
9 |
Matrix remodelling during tumour progression |
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Janine T Erler |
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1:15 PM |
10 |
Hypoxia-regulated miRNAs in glioma-initiating cells |
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Xiao Fan Wang, and Jing Hu |
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1:40 PM |
11 |
Lysyl hydroxylase-2 driven collagen cross-linking and lung cancer metastasis |
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Masahiko Terajima, Yulong Chen, Yanan Yang, Li Sun, Jonathan Kurie, and Mitsuo Yamauchi |
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1:50 PM |
12 |
Cellular adhesion molecules mediate tumour-host interactions and facilitate brain metastasis |
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Manuel S Soto and Nicola R Sibson |
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2:00 PM |
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Lunch / Informal Discussions |
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7:30 PM |
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Dinner / Informal Discussions at a local Greek Taverna Buses depart from the hotel lobby at 7:30 PM |
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Tuesday, September 23 |
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7:30 AM |
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Breakfast |
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Session III |
The hypoxic microenvironment: HIF-dependent and HIF-independent pathways |
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Chairs: Maho Niwa and Nicholas Denko |
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8:30 AM |
13 |
Oxygen sensing in pericytes |
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Volker H Haase |
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8:55 AM |
14 |
Intertwined regulation of angiogenesis and immunemodulation in cancer progression and resistance |
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L Rivera, K Lu, J Varner, D Meyronet, and Gabriele Bergers |
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9:20 AM |
15 |
TBA |
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Lorenz Poellinger |
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9:55 AM |
16 |
The PI3K/mTOR Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1αPhosphorylation |
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George J Cerniglia, Souvik Dey, Shannon M Gallagher-Colombo, Natalie Daurio, Stephen Tuttle, Theresa M Busch, Alexander Lin, Tatiana V Esipova, Sergei A Vinogradov, Constantinos Koumenis, and Amit Maity |
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10:10 AM |
17 |
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER |
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Twan G van den Beucken, Elizabeth Koch, Kenneth Chu, Rajesha Rupaimoole, Peggy Prickaerts, Michiel Adriaens, Jan Willem Voncken, Adrian L Harris, Francesca M Buffa, Syed Haider, Maud HW Starmans, Cindy Q Yao, Mircea Ivan, Cristina Ivan, Chad V Pecot, Paul C Boutros, Anil K Sood, Marianne Koritzinsky, and Bradly G Wouters |
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10:35 AM |
18 |
Next generation sequencing of hypoxic tumors reveals alternative splicing as a way to regulate microenvironment |
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Lauren K Brady, Vladimir M Popov, and Constantinos Koumenis |
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11:00 AM |
19 |
Hypoxia-mediated loss of PHD1 function leads to metabolic transformation and chemoresistance, independently of hypoxia-inducible factors (HIFs) |
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Giulio Laurenti, Gavin McNee, Tatiana Volpari, Deborah S Williams, Christian Ludwig, and Daniel A Tennant |
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11:10 AM |
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Coffee Break |
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Session IV |
Tumor metabolism |
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Chairs: Lenka Munoz and Gabriele Bergers |
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11:45 AM |
20 |
Rare Insights Into Cancer Biology |
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Patrick J Pollard, Ming Yang, Huizhong Su, Julie Adam, and Tomoyoshi Soga |
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12:10 PM |
21 |
Translation makes an impact: Tailor-made protein expression for metabolism, cancer and disease |
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Davide Ruggero |
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12:35 PM |
22 |
Hypoxic Regulation of glutamine metabolism is necessary for the growth of model tumors |
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Ramon C Sun, Ioanna Papandreou, Adam Richardson, and Nicholas Denko |
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1:00 PM |
23 |
Functions of metabolic reprogramming in cancer |
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Dimitrios Anastasiou |
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1:25 PM |
24 |
Glycogen metabolism in hypoxia as a target for cancer therapy |
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Adrian L Harris |
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1:50 PM |
25 |
Deregulation of lipid droplet dynamics impacts cellular metabolism and tumor growth |
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Ioanna Papandreou, Shiva Raghuvanshi, and Nicholas Denko |
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2:00 PM |
26 |
Targeting AMP-Kinase to modulate tumour radio-resistance and its microenvironment |
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Theodoros Tsakiridis |
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2:10 PM |
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Lunch / Informal Discussions |
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7:30 PM |
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Dinner / Informal Discussions at a local Greek Taverna Buses depart from the hotel lobby at 7:30 PM |
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Wednesday, September 24 |
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7:30 AM |
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Breakfast |
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Session V |
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Stress resistance mechanisms I: Unfolded Protein Response and Integrated Stress Response |
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Chairs: Ioanna Papandreou and Jay Dorsey |
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9:00 AM |
27 |
Regulation of protein folding in the hypoxic tumor microenvironment |
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Marianne Koritzinsky |
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9:25 AM |
28 |
Targeting the IRE1α-XBP1 pathway for cancer therapy |
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Dadi Jiang, Muthu Alagappan, Zhifen Yang, Paul Johannet, Connor Lynch, Quynh T Le, Amato J Giaccia, Nicholas C Denko, Michael Hay, Maho Niwa, and Albert C Koong |
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9:50 AM |
29 |
The Paradox of PERK in Tumorigenesis |
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J Alan Diehl |
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10:15 AM |
30 |
A tale of two distinct mechanisms for IRE1 RNase and implications for the Cancer treatment |
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Arvin B Tam, Albert Koong, and Maho Niwa |
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10:40 AM |
31 |
Inhibition of the IRE1α-XBP1 pathway: a new approach to targeting the tumour microenvironment |
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Michael P Hay, Dadi Jiang, Margaret Kozak, Maho Niwa, and Albert C Koong |
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11:05 AM |
32 |
“The Hallmarks of Cancer” and tumor hypoxia: selective targeting of hypoxic cancer cells with the hypoxia-activated prodrug (HAP) TH-302 |
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Charles P Hart |
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11:30 AM |
33 |
Antimyeloma in vitro activity of 15-deoxy-delta 12,14-prostaglandin J2 is associated with endoplasmic reticulum stress |
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Ana P Demasi, Marcelo H Napimoga, Elizabeth F Martinez, Adriana S Duarte, Marcelo Sperandio, Ney S Araujo, and Vera C Araujo |
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11:55 PM |
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Lunch / Informal Discussions |
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2:30 PM |
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Tour to Delos |
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The busses for the boat tour will depart from the hotel at 2:30 AM
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7:30 PM |
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Dinner / Informal Discussions at the Royal Myconian Hotel |
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Thursday, September 25 |
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7:30 AM |
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Breakfast |
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Session VI |
Stress resistance mechanisms II: Autophagy, and cell death/survival decisions |
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Chairs: Marianne Koritzinsky and Patrick Pollard |
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9:00 AM |
34 |
Autophagy inhibition in cancer therapy: Progress and unanswered questions |
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Ravi Amaravadi |
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9:25 AM |
35 |
TBA |
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Andrew Thorburn |
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9:50 AM |
36 |
Hypoxia-induced p53-dependent apoptosis is reliant on transactivation of clinically relevant target genes including negative regulators of AKT |
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Ester Hammond |
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10:15 AM |
37 |
MK2 signaling in glioma: role and targeting |
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Lenka Munoz |
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10:40 AM |
38 |
Poor prognosis of constitutive γ-H2AX expressing triple negative breast cancers is associated with telomere dysfunction |
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Paul N Span |
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11:05 AM |
39 |
Blocking hypoxia-induced autophagy restores natural killer cell-mediated anti-tumor immune response |
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Joanna Baginska, Elodie Viry, Guy Berchem, Muhammad Zaeem Noman, Anais Oudin, Simone Niclou, Salem Chouaib, and Bassam Janji |
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11:15 AM |
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Coffee Break & Poster Viewing |
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Session VII |
Imaging and targeting the Tumor Microenvironment in clinical modalities |
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Chairs: Amato Giaccia and Costas Koumenis |
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12:00 PM |
40 |
RadVax - Immune Activation of T-cells with Ablative radiotherapy & Immune Checkpoint inhibitors |
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Stephen M Hahn, Robert Vonderheide, Amit Maity, John Wherry, and Andy Minn |
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12:25 PM |
41 |
Precision medicine in oncology: The MD Anderson Cancer Center experience |
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Apostolia-Maria Tsimberidou |
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12:50 PM |
42 |
Imaging cancer heterogeneity with multispectral optoacoustic mesoscopy |
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Vasilis Ntziachristos |
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1:15 PM |
43 |
Circulating glioma tumor cells: detection and potential implications |
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MF Cooke, D Saxenna, M Xu, D Steinmetz, X Xu, M Alonso-Basanta, G Kao, S Hahn, R Lustig, and Jay Dorsey |
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1:35 PM |
44 |
Clinical implications of cancer stem cells in oral cancer metastasis and targeted therapies |
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Petros Papagerakis, Li Zheng, Vincenzo Desiderio, Margarite Matossian, Luigi Mele, Li Zheng, Gianpaolo Papaccio, Mark Prince, and Silvana Papagerakis |
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1:45 PM |
45 |
Depression, biomarkers of inflammation in the serum and tumor microenvironment, and survival in advanced Cancer patients |
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Jennifer L Steel, KH Kim, M Antoni, L Butterfield, L Burke, F Penedo, DA Geller, JW Marsh, and A Tsung |
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2:00 PM |
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Closing Remarks |
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2:15 PM |
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Lunch / Informal Discussions |
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8:00 PM |
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Farewell Dinner |
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Friday, September 26 |
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7:30 AM |
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Breakfast |
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Departure |
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POSTERS |
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46 |
ATRA liposomes targeting to the tumor microenvironment for improved therapeutic efficacies |
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Yuhong Xu, Lieyi Wu, Xiaofei Si, and Anjie Zhen |
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47 |
Beyond pH regulation: A role of CA IX in focal adhesion during cell spreading and migration |
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Eliska Svastova, L Csaderova, M Debreova, P Radvak, M Stano, M Vrestiakova, S Pastorekova, and J Kopacek |
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48 |
Blockage of hypoxia inducible factor: A comparison between the effect of Silymarin, PX-478 and Celecoxib on tumor growth in mouse model of melanoma |
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Jamshid Hajati, Nasim Kheshtchin, Afshin Namdar, and Morteza Hafezi |
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49 |
Blockage of hypoxia inducible factor: A comparison between the effect of Silymarin, PX-478 and Celecoxib on tumor growth in mouse model of melanoma |
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Jamshid Hajati, Nasim Kheshtchin, Afshin Namdar, and Morteza Hafezi |
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50 |
Cluster analysis of single-cell calcium traces as a tool for analyzing heterogeneous cell populations |
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Anna M Lipp, Christian Paar, Kata Juhasz, Christoph Ogris, Paul Eckerstorfer, Roland Thuenauer, Jan Hesse, Hannes Stockinger, Gerhard J Schütz, Ulrich Bodenhofer, Zsolt Balogi, and Alois Sonnleitner |
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51 |
Expression of HIF-1α and CAIX in relation to hypoxia and metastasis in human cervical carcinoma xenografts |
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Christine Ellingsen, Lise M K Andersen, Kanthi Galappathi, and Einar K Rofstad |
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52 |
Fenofibrate as a novel therapeutic adjuvant for targeting glioma stem cells |
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Isabelle M Germano and Emanuela Binello |
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53 |
HAUSP regulates hypoxia-induced epithelial-mesenchymal transition and gene transcription through deubiquitination of HIF-1a and induction of specific chromatin modification |
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Han-Tsang Wu, Yi-Chih Kuo, Chi-Hung Huang, Shu-Chun Teng, and Kou-Juey Wu |
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54 |
Hypoxia and PHD2&3 regulate cancer-associated fibroblast and remodelling of the tumour microenvironment |
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Chris D Madsen, Jesper T Pedersen, Lukram Babloo Singh, Freja Venning, Thomas R Cox, Erik Sahai, and Janine T Erler |
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55 |
Hypoxia enhances cytotoxicity of wedelolactone to breast cancer cells |
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Petr Benes, Tereza Nehybova, Lucia Knopfova, and Jan Smarda |
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56 |
Hypoxia leads to tamoxifen resistance |
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Denise A Chan, Merce Padro, Louie J Raymond, Brian V Lananna, and Jen-Tsan Chi |
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57 |
Immunotherapy with Mycobacterium indicus pranii (MIP) results in activation of anti tumor immune response and reduction of regulatory T cells in tumor milieu of treated mice |
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Pawan Kumar, and Sangeeta Bhaskar |
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58 |
In vivo PET detection of lung metastasis by targeting endothelial VCAM-1 |
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Stavros Melemenidis, Veerle Kersemans, Bart Cornelissen, Ruth Muschel, and Nicola Sibson |
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59 |
In vivo tumor-targeting strategy of nanoparticles using bioorthogonal copper-free click chemistry |
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Heebeom Koo, Sangmin Lee, and Kwangmeyung Kim |
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60 |
Inhibitory effect of succinyl macrolactin A on angiogenesis and tumor growth is mediated through suppression of mTOR activity and HSP90 expression |
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Mi-Yeong Kim, Youra Kang, Jaya Gautam, and Jung-Ae Kim |
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61 |
Mesenchymal stem cells are affecting glioblastoma as part of the tumour microenvironment |
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Tamara T Lah, Helena Motaln, Johannes Schuchhard, Karol Stec, Barbara Breznik, and Henning Ulrich |
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62 |
Modulation of immune cells with programmed biomaterials in tumor microenvironments for enhanced anti-tumor Immunity |
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Yong Taik Lim |
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63 |
Molecular MRI for the detection of tumour angiogenesis |
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Stavros Melemenidis, Andrew Jefferson, Neil Ruparelia, Danny Allen, Alastair Hamilton, James Larkin, Francisco Perez-Balderas, Sean Smart, Jin Xie, Ruth Muschel, Xiaoyuan Chen, Robin Choudhury, and Nicola Sibson |
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64 |
New role of JNKs as suppressors of pancreatic neoplasia |
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Tobias Leibfritz, Roger J Davis, and Jens T Siveke |
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65 |
Nitroimidazole radiosensitizers: can we teach old dogs new tricks? |
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Michael P Hay, Jingli Wang, Cho Rong Hong, Muriel Bonnet, Ralph Stevenson, Robert F Anderson, Frederik B Pruijn, Kevin O Hicks, and William R Wilson |
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66 |
Notch triggers myeloid reprogramming in murine pancreatic cancer |
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Florian Neff, David G Kirsch, Dieter Saur, Roland Schmid, Mathias F Heikenwälder, and Jens T Siveke |
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67 |
Nuclear Cathepsin D acts as a co-regulator of TRPS1-mediated transcription repression in breast cancer: effect on the transcription of genes modulating the tumor micro-environment |
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Anne-Sophie Emmanuelle Bach, Danielle Derocq, Valérie Laurent-Matha, Salwa Sebti, Béatrice Orsetti, Charles Theillet, Laëtitia Linarès, Céline Gongora, Sophie Pattingre, Guillaume Meurice, Frank Kaiser, Christian Gespach, and Emmanuelle Liaudet-Coopman |
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68 |
Perineural Microenvironment: GDNF secreted by M2 macrophages induces perineural invasion in Pancreatic Ductal Adenocarcinoma |
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Moran Amit, Yoav Binenbaum, and Ziv Gil |
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69 |
Role of Sod2 in pancreatic carcinogenesis |
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Christin Ruoff, Henrik P Einwächter, and Roland M Schmid |
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70 |
Serum Amyloid A activates lymphocytes and inhibits melanoma cells proliferation |
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Luziane P Belle, Silvana Sandri, Franciele H Knebel, Renata Albuquerque, Silvya Stuchi Maria-Engler, and Ana Campa |
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71 |
S-adenosylmethionine (SAM) blocks osteosarcoma cells proliferation and invasion in vitro and tumor metastasis in vivo |
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Surabhi Parashar, David Cheishvili, Ani Arakelian, Zahid Hussain, Imrana Tanvir, Haseeb Ahmed Khan, Moshe Szyf, and Shafaat A Rabbani |
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72 |
The inhibition of tumor cell proliferation and motility by fibroblasts is both contact and soluble factor dependent |
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Twana Alkasalias, Emilie Flaberg, Vladimir Kashuba, Andrey Alekseenko, Tatiana Pavlova, Andrii Savchenko, Laszlo Szekely, George Klein, and Hayrettin Guven |
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73 |
The recurrence pattern following delayed breast reconstruction after mastectomy for breast cancer suggests a systemic effect of surgery on occult dormant micrometastases |
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Hanna Dillekås, Renate Vik, Martin Pilskog, Jörg Assmus, Geir Kleppe, and Oddbjørn Straume |
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74 |
The role of Rho/ROCK/MLC signaling in regulation of amoeboid phenotype, invasiveness and metastasis |
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Jan Kosla, Daniela Paňková, Jiří Plachý, Ondřej Tolde, Kristýna Bicanová, Michal Dvořák, Daniel Rösel, and Jan Brábek |
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75 |
Expression pattern of carbonic anhydrase IX in medullary thyroid carcinoma supports a role for RET-mediated activation of HIF pathway |
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Martina Takacova, Petra Bullova, Veronika Simko, Pavel Babal, Juraj Kopacek, Jaromir Pastorek, Seppo Parkkila, and Silvia Pastorekova |
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76 |
Carnosine as a potent inhibitor of the carbonic anhydrase IX-mediated extracellular acidosis |
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Veronika Simko, Zuzana Ditte, Peter Ditte, Martina Labudova, Filippo Iuliano, Miriam Zatovicova, Lucia Csaderova, Juraj Kopacek, Silvia Pastorekova and Jaromir Pastorek |
| 77 |
Proteome profiling of primary & metastatic exosome populations reveal known secreted modulators of the metastatic niche |
| 78 |
Exosomes: Purification and characterization of discrete membrane vesicles from the tumour secretome |