Friday, September 16

6:00 PM

Conference Registration

8:00 PM

Welcome Reception/Dinner

Saturday, September 17

7:30 AM

Breakfast

SESSION I

Immune mediated diseases I

Chairs: Dominique Baeten

9:00 AM

1

Characterization of pathogenic B cells in rheumatoid arthritis

Dominique Baeten

9:30 AM

2

Plasmacytoid dendritic cells drive acute exacerbations of asthma by heightening type 2 inflammation in the airways

Evangelos Andreakos

10:00 AM

3

Initiation and Regulation of Immune Responses by Human Dendritic Cell Subsets

Eynav Klechevsky

10:30 AM

4

High Density Lipoproteins selectively promote the survival of Human Regulatory T-cells.

Claire Chougnet, Sean Davidson, Cesar Rueda, Maria Moreno-Fernandez, and Ana  Rodríguez-Perea

10:45 AM

5

Pro-resolving lipid mediators D-series Resolvins and Maresin 1 are critical in modulating T cell responses: implications for modulation of chronic inflammation

Valerio Chiurchiu, Alessandro  Leuti, Jesmond  Dalli, Anders Jacobsson, Luca  Battistini, Mauro Maccarrone, and Charles Serhan

11:00 AM

Coffee Break/Poster Viewing

SESSION II

Immunity to pathogens

Chairs: Vincenzo Barnaba

11:30 AM

6

The impact of persistent infections upon T cell repertoire, T cell differentiation and immune aging

Janko Nikolich-Žugich

12:00 PM

7

IFITM3 prevents influenza virus-induced immunopathology

Adolfo Garcia-Sastre

12:30 PM

8

Immunological tolerance by maintaining naïveness in human autoreactive T cells

Vincenzo Barnaba

1:00 PM

9

Targeting EBV positive cancers with affinity enhanced T cell receptors

Yide Wong, Emma Gostick, Martine Lomax, Annelise Vuidepot, Emma Baston, William Shingler, Namir Hassan, Joseph Dukes, Corey Smith, Rajiv Khanna, Kristin Ladell, David Coles, Andrew Sewell, Scott Burrows, Bent Jakobsen, David Price, and John Miles

1:15 PM

10

Ex vivo determination of stem cell transplantation graft-versus-HIV reservoir effects

Louise Hogan, Kristen Hobbs, Emily Hanhauser, Christine Palmer, Marisol Romero-Tejeda, Yvonne Robles, Stephanie Jost, Daniel Kuritzkes, Ritz Jerome, and Timothy Henrich

1:30 PM

Lunch and Informal Discussions

7:30 PM

Dinner and Informal Discussions

Sunday, September 18

7:30 AM

Breakfast

SESSION III

Cancer immunology and immunotherapy

Chairs: Stephen Schoenberger

9:00 AM

11

Immune Checkpoint Blockade in Cancer Therapy: Insights, Opportunities, and Prospects for Cures

Jim Allison

9:45 AM

12

Preclinical development of personalized immunotherapy of HNSCC

Aaron Miller, Milad Bahmanof, Luise  Sternberg, Bjoern Peters, Pandurangan Vijayanand, Ezra Cohen, and Stephen Schoenberger

10:15 AM

13

Development of heterodimeric IL-15 for cancer immunotherapy

George Pavlakis, Cristina Bergamaschi, Sinnie Sin  Man Ng, Antonio Valentin, Dionysios Watson, Bethany Nagy, Xintao Hu, Candido Alicea, Shawn Jensen, Bernard Fox, Eirini Moysi, Constantinos Petrovas, Shakti Singh, Jenifer Bear, and Barbara Felber

10:45 AM

14

Genetic engineering for T cell therapies

Carl June

11:30 AM

Coffee Break/Poster Viewing

SESSION IV

Mucosal Immunology -Gut/lung immunology

Chairs: Maria Rescigno

12:00 PM

15

Broadly neutralizing antibodies and a new mechanism of diversification

Antonio Lanzavecchia

12:30 PM

16

Role of the immune system in colorectal cancer treatment

Maria Rescigno

1:00 PM

17

IL-1 family cytokines regulate group 2 innate lymphoid cell function and plasticity, a consequence of which has biological relevance in exacerbations of COPD 

Alison Humbles

1:30 PM

18

The surfactant protein A receptor SP-R210 (Myo18A/CD245) impairs resolution of influenza A virus pneumonia by alveolar macrophages

Zissis Chroneos

1:45 PM

19

Mechanisms of activation of human skin group 2 innate lymphoid cells

Maryam Salimi, Luzheng Xue, Graham Ogg, Linda Stöger, Ian Pavord, Paul Klenerman, Clare Hardman, Helen Jolin, David Cousins, and Andrew McKenzie

2:00 PM

Lunch and Informal Discussions

7:30 PM

Dinner and Informal Discussions

Monday, September 19

7:30 AM

Breakfast

SESSION V

Immune mediated disease II

Chairs: Peter Katsikis

9:00 AM

20

T cell functions in autoimmunity and immunodeficiencies

Federica Sallusto

9:30 AM

21

IL-33 and Alzheimer’s Disease

Eddy Liew

10:00 AM

22

Novel insights into APDS immune defects

Peter Katsikis

10:30 AM

23

A LAG-3/PD-L1 bispecific antibody inhibits tumour growth in two syngeneic colon carcinoma models

Matthew Kraman, Katarzyna  Kmiecik, Natalie Allen, David Weismann, Mustapha Faroudi, Carlo Zimarino, Mateusz Wydro, and Jacqueline Doody

10:45 AM

24

T cell receptor oligoclonality and functional specialization of FOXP3 regulatory T cells in human autoimmune inflammation

Gerdien Mijnheer and Femke van Wijk

11:00 AM

Coffee Break/Poster Viewing

SESSION VI

Systems immunology of humans: vaccination and infection

Chairs: Bali Pulendran

11:30 AM

25

Systems approaches highlight the many facets of interferons in infections and in vaccine mediated protection

Malika Aid, Khader Ghneim, Steve Deeks, Michael Lederman, and Rafick Pierre Sekaly

12:00 PM

26

systems-based approaches to vaccine development

Bali Pulendran

12:30 PM

27

Reverse Vaccinology 2.0: human immunology instructs vaccine antigen design

Oretta Finco and Rino Rappuoli

1:00 PM

28

Systems analysis of protective immune responses to RTS,S malaria vaccination in humans

Dmitri Kazmin, Helder Nakaya, Matthew Johnson, Robbert van der Most, Robert van den Berg, Ripley Ballou, Erik Jongert, Ulrike Wille-Reece, Christian Ockenhouse, Alan Aderem, Daniel Zak, Jerald Sadoff, Jenny Henrdiks, Jens Wrammert, Rafi Ahmed, Eva Lee, and Bali Pulendran

1:15 PM

29

Vitamin D Induces a Type 1 Regulatory T cell (Tr1)-like Phenotype In Human CCR6+ T Cells And Promotes Their Migration To an Inflammatory Environment

Wendy Dankers, Jan Piet van Hamburg, Nadine Davelaar, Patrick Asmawidjaja, Ke-xin Wen, Hans van Leeuwen, Edgar Colin, and Erik Lubberts

1:30 PM

Lunch and Informal Discussions

3:00 PM

City Tour

7:30 PM

Dinner and Informal Discussions

Tuesday, September 20

7:30 AM

Breakfast

SESSION VII

Systems immunology of humans: nature versus nurture

Chairs: Monika Wolkers

9:00 AM

30

The Milieu Intérieur Consortium: taking a systems approach to immune monitoring and immunotherapy

Etienne Patin and Mathew Albert

9:30 AM

31

Immune System Development In Newborn Children Under Different Environmental Conditions

Petter Brodin

10:00 AM

32

Post-transcriptional regulation dictates T cell functionality to infection and tumors

Fiamma Salerno, Aurelie  Guislain, Benoit Nicolet, Julian Freen, and Monika Wolkers

10:30 AM

33

Defective Central Tolerance and the Gut Microbiota Regulate Development of Spontaneous Autoimmune Hepatitis in Mice

Konstantina Alexandropoulos and Erica Weinstein

10:45 AM

34

The cellular composition of the human immune system is shaped by age and cohabitation

Adrian Liston

11:00 AM

Coffee Break/Poster Viewing

SESSION VIII

Systems immunology of humans: transcriptomics and beyond

Chairs: Ken Ishii

11:30 AM

35

Immune isoforms: next generation transcriptomics reveals a complex isoform repertoire in human immune cells

Jacques Banchereau

12:00 PM

36

A literature derived immune inter-cellular communication network reveals novel interactions and disease relations

Ksenya Kveler, Amit Ziv-Kenet, Elina Starosvetsky, Yuval Kalugny, Yuri Gorelik, Gali  Shalev-Malul, Netta Aizenbud-Reshef, Tatiana Dubovik, John Campbell, Jan Rieckmann, Nuaman Asbeh, Doron Rimar, Felix Meissner, Jeff Wiser, and Shai Shen-Orr

12:30 PM

37

Serum miRNA linking human and mouse immunology

Ken Ishii

1:00 PM

38

Found In Translation: A statistical model for improving mouse to human translation for gene expression data

Rachelly Normand, Wenfei Du, Renaud Gaujoux, Elina Starosvetsky, Gali Shalev-Malul, Robert Tibshirani, and Shai Shen-Orr

1:15 PM

39

HLA class I-dependent targeting of myeloid leukemia by IL-10-engineered human CD4+ Tr1 cells

Grazia Locafaro, Grazia Andolfi, Fabio Russo, Barbara Camisa, Fabio Ciceri, Angelo Lombardo, Attilio Bondanza, Maria Grazia Roncarolo, and Silvia Gregori

1:30 PM

Lunch and Informal Discussions

8:00 PM

Farewell Dinner and Informal Discussions

Wednesday, September 21

7:30 AM

Breakfast

10:00 AM

Departure

POSTERS

40

Alterations in the expression of IL-4 and IFN-γ by iNKT cells in patients with chronic lymphocytic leukemia after stimulation with α-GalCer

Małgorzata Waldowska, Justyna  Woś, Agnieszka Bojarska-Junak, and Jacek Roliński

41

Lymphocytes obtained from ovarian cancer patients differentiate in vitro towards regulatory Tcells while being co-cultured with autologous dendritic cells.

Justyna Surówka, Iwona Wertel, Karolina Okła, Monika Bilska, and Jan  Kotarski

42

Effects of antigenic stimulation of the MyD88-independent signaling pathway of TLR4  in chronic lymphocytic leukemia cells (CD5 +/CD19 +) and normal B cells (CD19 +)

Magdalena Osiak, Natalia Pająk, and Halina Antosz

43

Comparison of gene expression of TRAF3, IRF7 and IL-18 in normal and chronic lymphocytic leukemia B cells

Natalia Pająk, Magdalena Osiak, and Halina Antosz

44

Differential subcellular localization and expression of SPNS2 (spinster homolog 2) in airway epithelia and alveolar macrophages in response to cigarette smoke and in chronic obstructive pulmonary disease (COPD) may contribute to macrophage phagocytic dysfunction

Hai  Tran, Rhys  Hamon, Miranda Ween, Greg Hodge, Eugene Roscioli, Jameel Barnawi, Paul Reynolds, Stuart Pitson, Rainer Haberberger, and Sandra Hodge

45

Cigarette smoke induced multiple inflammasome activation and anti-inflammatory effects of S1P and FTY720 suggest novel targets in chronic obstructive pulmonary disease

Hai Tran, Rhys Hamon, Eugene Roscioli, Miranda Ween, Greg Hodge, Hubertus Jersmann, Paul Reynolds, and Sandra Hodge

46

Primary gout, interleukin-1 β and urate transporter ABCG2

Blanka Stiburkova, Pavel Cepek, Lenka Petru, Katerina Pavelcova, Jakub Zavada, and Karel Pavelka

47

RORC Positive Th17, Th17/Th1, And Th17.1 Cells From The Blood Of Treatment Naïve RA Patients Differ In IL-17A But Are All Pathogenic When Co-Cultured With RA Synovial Fibroblasts

Sandra Paulissen, Jan Piet van Hamburg, Nadine Davelaar, Wendy  Dankers, Anne-Marie Otten-Mus, and Erik Lubberts

48

Regulation of CD20 expression by AKT-Forkhead signaling cascade influences the efficacy of immunotherapy with monoclonal antibodies.

Beata Pyrzynska, Michal Dwojak, Agnieszka Zagozdzon, Nina Miazek, Piotr Zapala, Kamil Bojarczuk, Malgorzata Bobrowicz, Jakub Golab, Abdessamad Zerrouqi, and Magdalena Winiarska

49

A novel combination of markers identifies tolerogenic DC-10 in vivo

Michela Comi, Matteo Villa, Matteo Floris, Alessandro Bulfone, Maria Grazia Roncarolo, and Silvia Gregori

50

Lack of CD200 molecule attenuates the severity of DSS induced colitis

Katarzyna Tonecka, Zofia Pilch, Elisabetta Manuali, Linde Meyaard, Jakub Golab, and Tomasz Rygiel

51

Role of the thiol-dependent antioxidant enzymes in NK cells

Radoslaw Zagozdzon, Marta Siernicka, Malgorzata Bajor, Malgorzata Firczuk, Jodie Goodridge, Jakub Golab, Karl-Johan Malmberg, and Magdalena Winiarska

52

Anit-CD200R antibody potentiates the antitumor effect of TLR7 agonist

Zofia  Pilch, Katarzyna  Tonecka, Jakub  Gołąb, and Tomasz  Rygiel

53

Transcription factors controlling MS4A1 expression are predictive of B-cell lymphomas response to anti-CD20 antibodies

Abdessamad  Zerrouqi, Beata Pyrzynska, Jakub Golab, and Magdalena Winiarska

54

ToxoGRA15II-polarized macrophages inhibit growth of hepatic carcinoma both in vitro and in vivo

Jilong Shen

55

Upregulated Tim-3/galectin-9 expressions in acute lung injury and liver damage in a murine malaria model

Fangli Lv, Jinfeng Liu, Siyu Xiao, and Shiguang Huang

56

Rogue Germinal Centre B cells: Unconventional lymphocytes released by FAS inactivation that drive IgE and autoantibody production

Danyal Butt and Robert Brink

57

Dissecting the complexity of the antigen specific CD4 T cell response against Typhoid Salmonella.

Giorgio Napolitani and Prathiba Kurupati

58

Mir193a expression pattern in lymph, spleen and brain samples and cell cultures of Experimental Autoimmune Encephalomyelitis induced mice

Saba Gharibi, Bahram Moghimi, Mohammad Mahmoudi, Mohammad Tahoori, Ensieh Shahvazian, Shima Dehghaniahmadabad, and Ehsan Farashahi

59

Variability in selected candidate genes for recurrent aphthous stomatitis: a pilot study

Simona Valova, Petra Borilova Linhartova, Jirina Bartova, Jitka Petanova, Pavel Kuklinek, Antonin Fassmann, and Lydie Izakovicova Holla

60

Molecular regulation of effector anti-viral CD8+ T cell formation controlled by microRNA-155 overexpression.

Jennifer Hope, Christopher Stairiker, Adam Fike, Alison Carey, Marjan van Meurs, Davy Van de Vijver, Inge Brouwers-Haspels, Laurine Rijsbergen, Donald Gracias, Joseph Fraietta, Yvonne Mueller, and Peter Katsikis

61

RNA transcriptome analysis of influenza A virus infected type 2 alveolar epithelial cells reveals a unique gene expression profile compared to bystander uninfected cells

Christopher Stairiker, Aidan Hancock, Alina Boesteanu, Elisa Monzon-Casanova, Sebastian Lukasiak, Yvonne Muller, Andrew Stubbs, Martin Turner, and Peter Katsikis