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Friday, June 03 2022 |
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18:00 PM |
Conference Registration |
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20:00 PM |
Welcome Reception - Dinner |
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Saturday, June 04 2022 |
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8:30 AM |
Breakfast |
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9:00 AM |
Welcome - Opening Remarks Organizing committee |
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SESSION I |
Mesenchymal cells in Immunity |
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9:15 AM |
1 |
Lymphoid organ fibroblasts Burkhard Ludewig |
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9:45 AM |
2 |
Active Notch signaling is critical for lymph node fibroblast development and function Sanjiv A. Luther |
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10:15 AM |
3 |
Selected short talk: Notch signaling in lymph node fibroblasts shapes the T cell zone and regulates its functions Nagham Alouche |
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10:30 AM |
4 |
Selected short talk: Mesenchymal Osr1 cells orchestrate lymph node initiation Pedro Vallecillo Garcia, Glenda Comai, Claudia Giesecke-Thiel, Uta Höpken, Mickael Orgeur, and Sigmar Stricker |
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10:45 PM |
5 |
Selected short talk: Conserved stromal–immune cell interactions secure B cell follicle homeostasis Mechthild Lütge, Angelina De Martin, Yves Stanossek, Lucas Onder, Hung-Wei Cheng, Lisa Kurz, Charlotte Soneson, Mark Robinson, Sandro Stöckli, Burkhard Ludewig, and Natalia Pikor |
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11:00 AM |
Coffee break and poster viewing |
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11:30 AM |
6 |
Diverse spleen mesenchymal cell populations direct tissue homeostasis and immunity Scott Mueller |
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12:00 PM |
7 |
Stroma of lymphoid organs: from development to infection Christopher Mueller |
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12:30 PM |
8 |
Selected short talk: Impact of RANKL on the hematopoietic stem cells in the bone marrow and CD169+ macrophages in the spleen Alice Lavanant and Christopher Mueller |
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12:45 AM |
9 |
Selected short talk: Podoplanin maintains lymph node tissue integrity and is required for acute lymph node expansion Spyridon Makris, Yukti Gupta, Jesus Cantoral-Rebordinos, Victor Martinez, Charlotte de Winde, Harry Horsnell, Agnesska Benjamin, and Sophie Acton |
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13:00 PM |
10 |
Selected short talk: ZEB1+AML orchestrate the bone marrow immune suppressive microenvironment via Th17 and stromal CD40 up-regulation. Bassani Barbara, Claudio Tripodo, Paola Portararo, Laura Botti, Valeria Cancila, Antonio Curti, Marilena Ciciarello, Mario Colombo, and Sabina Sangaletti |
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13:15 PM |
Lunch |
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Sunday, June 05 2022 |
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8:30 AM |
Breakfast |
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SESSION II |
Mesenchymal cells in Inflammation and Fibrosis |
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9:00 AM |
11 |
ΤΒΑ Christopher Buckley |
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9:30 AM |
12 |
ΤΒΑ Fiona Oakley |
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10:00 AM |
13 |
Selected short talk: Cellular networks established during human development drive propensity for arthritic disease Mark Coles, Sarah Davidson, and Christopher Buckley |
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10:15 AM |
14 |
Selected short talk: Bimodal single cell transcriptomic and chromatin analysis reveals a distinct Synovial Fibroblasts transitioning from homeostasis to pathology in TNF-driven arthritis Maria Sakkou, Dimitris Konstantopoulos, Christos Tzaferis, Matthieu D Lavigne, Anastasios Liakos, Petros P Sfikakis, Meletios A Dimopoulos, Maria Fousteri, Marietta Armaka, and George Kollias |
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10:30 AM |
15 |
Selected short talk: Repurposing of a known antipsychotic drug to target arthritogenic synovial fibroblasts Dimitra Papadopoulou, Fani Roumelioti, Vasiliki Mavrikaki, Christos Tzaferis, Filippos Charalampous, Niki Karagianni, Maria Denis, Alexis Matralis, and George Kollias |
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10:45 AM |
16 |
Selected short talk: PI-16+ reticular cells in human palatine tonsils generate a distinct subepithelial niche for activated T and B cells Angelina De Martin, Yves Stanossek, Mechthild Lütge, Lucas Onder, Hung-Wei Cheng, Sandro Stöckli, Natalia Pikor, and Burkhard Ludewig |
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11:00 AM |
Coffee Break and Poster Viewing |
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11:30 PM |
17 |
Hepatic stellate in liver fibrosis and cancer Robert F. Schwabe |
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12:00 PM |
18 |
Core regulators of Fibroblast Polarization and Organ Damage Andreas Ramming |
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12:30 PM |
19 |
Selected short talk: Primed to resolve: the shoulder capsule informs a cellular basis for resolving inflammatory fibrosis Michael Ng, Steven Sansom, Moustafa Attar, Hamez Gacaferi, Caio McHaido, Sarah Davidson, Rowie Borst, Micon Garvilles, Ian Reekie, Dylan Windell, Ananya Bhalla, Kate Powell, Paul Klenerman, Andrew Titchener, Steve Gwilym, Chris Little, Jonathan Rees, Salma Chaudhury, Rajat Chaudhury, Amar Rangan, Phil Holland, Dominic Furniss, Kathrin Jansen, James Charlesworth, Andrew Carr, Derek Gilroy, Mark Coles, Christopher Buckley, and Stephanie Dakin |
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12:45 PM |
20 |
Selected short talk: Restoration of WT1/miR-769-5p axis by HDAC1-3 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells. Giulio Bontempi, Michela Terri, Cecilia Battistelli, Sabrina Garbo, Veronica Bordoni, Chiara Agrati, Sergio Valente, Clemens Zwergel, Antonello Mai, Alessandro Domenici, Paolo Menè, Marco Tripodi, and Raffaele Strippoli |
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13:00 PM |
Lunch |
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Monday, June 06 2022 |
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8:30 AM |
Breakfast |
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SESSION III |
Mesenchymal cells in cancer |
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9:00 AM |
21 |
Androgen and Notch signalling as negative determinants of CAF activation and evolution : at the interface between gene transcription and DNA stability Gian-Paolo Dotto |
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09:30 AM |
22 |
The peripheral adaptive immune mesenchyme in cancer Maria Tsoumakidou |
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10:00 AM |
23 |
Selected short talks: Tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer Julia Houthuijzen, Roebi de Bruijn, Anne-Paulien Drenth, Eline van der Burg, Ellen Wientjens, Mirjam Boelens, Marja Nieuwland, Iris de Rink, Frank van Diepen, Colinda Scheele, Sjoerd Klarenbeek, Ron Kerkhoven, and Jos Jonkers |
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10:15 AM |
24 |
Selected short talk: Stromal cell - neutrophil interactions are driving a pro-tumor microenvironment in multiple myeloma Madelon de Jong, Cathelijne Fokkema, Teddie van Heusden, Natalie Papazian, Michael Vermeulen, Sabrin Tahri, Pieter van de Woestijne, Mark van Duin, Annemiek Broijl, Pieter Sonneveld, and Tom Cupedo |
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10:30 AM |
Coffee Break and Poster Viewing |
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11:00 AM |
25 |
ΤΒΑ Raghu Kalluri |
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11:30AM |
26 |
CAF metabolism drives pro-tumorigenic remodelling of the tumour microenvironment Sara Zanivan |
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12:00 PM |
27 |
THE EMBO LECTURE: Caveolin-1-mediated mechanotransduction regulates tumor stiffness and fibrosis Miguel Angel del Pozo |
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12:30 PM |
28 |
Selected short talk: Human cancer-associated fibroblasts suppress T cells through a COX-2 mediated immune checkpoint Alfie Baker and Anne Fletcher |
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12:45 PM |
29 |
Selected short talk: HDAC1 pharmacological inhibition impairs mesothelial cells/ovarian cancer adhesive interactions impacting on beta1-integrin mediated cytoskeletal remodelling Michela Terri, Pilar Sandoval, Valeria de Turris, Claudia Montaldo, Flavia Trionfetti, Giulio Bontempi, Lucia Pascual-Anton, Cecilia Battistelli, Sergio Valente, Antonello Mai, Miguel del Pozo, Carlos Cabañas, Marco Tripodi, Henar Tomero-Sanz, and Manuel Lopez-Cabrera |
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13:00 PM |
30 |
Selected short talk: Interconnection of epithelial-mesenchymal transition and senescence in pancreatic neuroendocrine lesions Ioanna Angelioudaki, Agapi Kataki, Efthymios Koniaris, Alexandros Tzingounis, Alexandros Mitrousias, Loukas Stoupis, and Manousos Konstadoulakis |
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13:15 PM |
Lunch |
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Tuesday, June 07, 2022 |
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8:30 AM |
Breakfast |
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SESSION IV |
Mesenchymal cells in Homeostasis and Tissue Regeneration |
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9:30 AM |
31 |
Stromal lineages crosstalk in postnatal intestinal homeostasis and repair Lucie Peduto |
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10:00 AM |
32 |
Col6a1/CD201+ mesenchymal cells regulate intestinal morphogenesis and homeostasis Vasiliki Koliaraki |
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10:30 AM |
33 |
Selected short talk: Intestinal fibroblasts display transcriptional and spatial heterogeneity in the TnfΔΑRE model of ileitis. Lida Iliopoulou, Alejandro Prados, Christos Tzaferis, Dimitris Konstantopoulos, Vasiliki Koliaraki, and George Kollias |
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10:45 AM |
34 |
Selected short talk: Fetal/regenerative reprogramming of intestinal epithelium by fibroblast derived Neuregulin-1 Toni Lemmetyinen, Emma Viitala, Linnea Wartiovaara, Eva Domenech Moreno, Timothy Wang, and Saara Ollila |
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11:00 AM |
Coffee Break and Poster Viewing |
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11:30 PM |
35 |
Mammals rapidly heal wounds through fibrous connective tissue build up and tissue contraction/Rigid anatomies Yuval Rinkevich |
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12:00 PM |
36 |
Sphingolipids control Dermal Fibroblast Heterogeneity Giovanni D’Angelo |
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12:30 PM |
37 |
Fibroblast heterogeneity and versatility in skin homeostasis and wound repair Xiaoyan Sun |
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13:00 PM |
Round table “The future of mesenchymal research” |
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13:30 PM |
Lunch |
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20:00 PM |
Farewell Gala Dinner |
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Wednesday, June 08 2021 |
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8:00 AM |
Breakfast |
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Departure |
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