Each session consists of invited talks (20+5 for Q&A) and some w short talks (12+3 Q&A)
Day 1-Sunday, September 17
Conference Registration: 7:00-8:00pm Hotel Lobby
Welcome Reception and Dinner 8:00-10:30pm
Day 2-Monday, September 18
7:30am - Breakfast
9:00 Costas Koumenis, UPenn - Opening remarks
Session I (9:05 am- 10:45 am): Age-related changes in the TME and cancer cells
Chair: Costas Koumenis
9:05 Ashani Weeraratna, Johns Hopkins - Age Against the Machine: How the aging microenvironment drives tumor progression
9:30 Sheila Stewart, Washington Univ. - Age-related stromal changes drive breast cancer progression
9:55 Ravi Amaravadi, UPenn - Understanding the role of Mitochondria in Cancer and Ageing
10:20 Sandra McAllister, Harvard Univ. - Unraveling the Complexities of the Aging Breast Cancer Microenvironment for Improved Treatment Strategies
10:45 Coffee Break-Discussions & Poster Viewing (10:45 am-11:20 pm)
Session II (11:20am-1:30pm): The immune landscape of tumors, cancer cell plasticity & immune evasion
Chair: Sandra Ryeom
11:20 Malay Haldar, UPenn - Glutamine metabolism regulates dendritic cell distribution in the tumor microenvironment
11:45 Tim Padera, Harvard Univ. - The lymph node microenvironment induces cancer cell plasticity and evasion of anticancer immunity
12:10 Yi Fan, UPenn - Metabolic reprogramming of endothelial cells for cancer immunotherapy
12:35 Quynh Le, Stanford Univ. - NFE2L2 mutation enhances radioresistance in head & neck cancer by modulating intratumoral myeloid cells
1:00 Richard Groen, U Amsterdam - Investigating the bidirectional interaction of tumor cells and the bone marrow (BM) microenvironment.
1:15 James Schofield, Notre Dame - Enhanced Acod1 expression in cancer cells promotes immune evasion
1:30 pm Lunch/Informal Discussions
3:00pm Informal Discussions
7:30pm Dinner/Informal Discussions
Day 3-Tuesday, September 19
7:30am - Breakfast
Session III (8:30am- 10:40am) TME stress responses I: UPR and ISR
Chair: Ravi Amaravadi
8:30 Albert Koong, MDACC - IRE1a Regulates Ferroptosis through Regulation of Glutathione Synthesis: Implications for Cancer Therapy
8:55 Eric Chevet, INSERM - Endoplasmic Reticulum proteostasis in brain cancer
9:20 Christina Munoz-Pinedo, IDIBELL - Metabolic stress in the tumor microenvironment and the Integrated Stress Response
9:45 Xi Chen, Baylor Coll. Med. - Stressing Out Therapy-Resistant Cancers
10:10 David Soto-Pantoja, WFUSM - PKR-like endoplasmic reticulum kinase is a marker and target to enhance immune checkpoint therapy response
10:25 Lucie Malbeteau, U Toronto - PRDX4 loss triggers antitumor immune responses through DNA damage in pancreatic cancer
10:40 Coffee Break-Discussions & Poster Viewing (10:40 am-11:30 pm)
Session IV (11:30am-1:35pm): TME Stress responses II: Autophagy, differentiation & senescence
Chair: Ashi Weeraratna
11:30 Rushika Perera, UCSF - Identifying and disabling lysosome dependent adaptive programs in primary and metastatic pancreatic cancer
11:55 Jayanta Debnath, UCSF - Autophagy and metastatic differentiation
12:20 Ravi Amaravadi, UPenn - Understanding the role of Mitochondria in Cancer and Ageing
12:45 Pataje Prasanna, NCI - Therapy-Induced Senescence Landscape
1:10 David Gewirtz, VCU - Senescence and senolytic strategies to enhance the response to standard of care in preclinical cancer models
1:35 pm Lunch/Informal Discussions
3:00pm Informal Discussions
7:30 pm Dinner/Informal Discussions
Day 4-Wednesday, September 20
7:30am - Breakfast
Session V (8:30am -10:35am): Metabolism in primary and metastatic tumors
Chair: Yi Fan
8:30 Eileen White, NJCI/Rutgers - Metabolic alterations in tumor and host in cancer
8:55 Thales Papagiannakopoulos, NYU - Dissecting the crosstalk of nutrient sensing, stress response signalling and immune evasion
9:20 Davide Ruggero, UCSF - Selective remodeling of the translatome underlies ketogenesis and diet associated tumor growth
9:45 Jiangbin Ye, Stanford Univ. - Deciphering the Warburg effect: mitochondrial uncoupling reprograms cancer metabolism and epigenome to induce differentiation
10:10 Marcia Haigis, Harvard Univ. - Understanding the role of Mitochondria in Cancer and Ageing
Coffee Break-Discussions & Poster Viewing (10:35 am-11:15 am)
Session VI (11:15am-1:30pm) Tumor-stroma interactions
Chair: Ioannis Verginadis
11:15 Ruth Scherz-Shouval, Weizmann Inst. - Tumor-stroma coevolution
11:40 Sandra Ryeom, Columbia Univ. - Tumor innervation in cancer progression
12:05 Carla Kim, Harvard Univ. - Cell-cell interactions in regulation of lung homeostasis, disease and cancer
12:30 Gina Bouchard, Stanford Univ. - Tumor-stroma assembloids of lung adenocarcinoma reveal the spatial cell-cell "colocatome”
12:45 Monika Dzwigonska, Polish Acad. Sci. - Hypoxia shapes the chromatin accessibility changes in glioma reprogrammed microglial cells.
1:00 Krista Dalton, VCU - Exploring the relationship between metabolism and the epigenome in MYCN-amplified neuroblastoma
1:15 Katherine Wu, NYU - Dissecting the role of redox homeostasis and ferroptosis in lung adenocarcinoma
1:30 pm Lunch/Informal Discussions
3:30pm CULTURAL TOUR
7:30pm Dinner/Informal Discussions
Day 5-Thursday, September 21
7:30am - Breakfast
Session VII (8:30am- 10:10am) Tumor stem cells, cell-autonomous signaling
Chair: Maria Tsiarli
8:30 Seamus Martin, Trinity Coll. - Cell Stress, Cell Death and Inflammation: What doesn’t Kill you Makes you Stronger
8:55 Irfan Asangani, UPenn - Loss of PP2A activity drives prostate cancer progression and therapy resistance
9:20 Lenka Munoz, Univ of Sydney - Targeting lipid metabolic vulnerabilities in chemotherapy-tolerant persister cells
9:45 Yang Shi, Oxford Univ. - Chromatin regulation and cancer
Short Coffee break (10:10 am-10:25 am)
Session VIII (10:25am-11:15am) Latest developments in Radiotherapy-FLASH Radiation I
Chair: Michele Kim
10:25 Marie Catherine-Vozenin, U Geneva - Overcoming radiation resistance of tumors with FLASH?
10:50 Charles Limoli, UC Irvine - Elucidating the protective neurological mechanisms of hypofractionated FLASH radiotherapy in pediatric and adult mouse models
Coffee Break-Discussions & Poster Viewing (11:15 am-11:45 am)
Session IX (11:45am-1:40pm) Latest developments in Radiotherapy-FLASH Radiation II
Chair: Erato Stylianou-Makridou
11:45 Michele Kim, UPenn - Physics considerations for clinical translations of proton FLASH radiotherapy
12:10 Amit Maity, Univ. Utah - Effects of FLASH proton radiotherapy on bone/soft tissue and tumor growth using single dose and fractionated regimens
12:35 Costas Koumenis, UPenn - A surprising role for IFN signaling behind the FLASH sparing effect in normal intestinal tissues
1:00 Keith Cengel, UPenn - Investigating the Effects of FLASH Radiotherapy Using Large Animal Models: The Issue at Hand is the Tissue at Hand
1:25 Yiannis Verginadis, UPenn - FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease.
1:40 Sandra Ryeom, Columbia Univ. - Closing remarks
1:45pm Lunch/Informal Discussions
3:00pm Informal Discussions
7:30pm Farewell Dinner
Day 6–Friday, September 22
7:00am - Breakfast
Departure
All remaining abstracts have been accepted as a poster presentation