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Sunday, September 17 |
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6:00 PM |
Conference Registration |
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8:00 PM |
Welcome Reception and Dinner |
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Monday, September 18 |
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8:00 AM |
Breakfast |
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8:55 AM |
Welcome and Opening Remarks |
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SESSION I |
Basic mechanisms of immune function Chairs: Melanie Greter and Daniel Campbell |
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9:00 AM |
1 |
Circulating CD4+ T cells with unique functional properties that are related to epidermal Trm Daniel Campbell, Iris Gratz, Maria Klicznik, Thomas Duhen, and Barbara Hoellbacher |
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9:30 AM |
2 |
TGF-b and tissue macrophages Xueyang Yu, Anne Buttgereit, Iva Lelios, Dilay Cansever, Burkhard Becher, and Melanie Greter |
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10:00 AM |
3 |
Targeting targeted treatment in Lupus George Tsokos |
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10:30 AM |
4 |
Specialization of Tregs in Th1 responses Katharina Littringer, Nikolas Rakebrandt, Xiaobei Zhou, Michelle Schorer, Tamas Dolowschiak, Mark Robinson, and Nicole Joller |
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10:45 AM |
Coffee Break and Poster Session |
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SESSION II |
Innate and adaptive control of autoimmunity Chairs: Jessica Hamerman and Jeff Bluestone |
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11:15 AM |
5 |
Manipulating Tregs to control tolerance in autoimmunity and cancer Jeffrey Bluestone |
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11:45 AM |
6 |
Dysregulated TLR7 signaling drives anemia via development of novel hemophagocytes Holly Akilesh, Matthew Buechler, Jeffrey Duggan, William Hahn, Xizhang Sun, Griffin Gessay, Elizabeth Whalen, Michael Mason, Keith Elkon, Adam Lacy-Hulbert, Marion Pepper, and Jessica Hamerman |
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12:15 PM |
7 |
Autoreactive T cells in narcoleptic patients Federica Sallusto |
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12:45 PM |
8 |
Butyrophilin (BTN) molecules control γδ T cells in tissue epithelia David Rhodes, Neil McCarthy, and Matthias Eberl |
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1:00 PM |
9 |
Ecoimmunity, self tolerance as a dynamic a predator prey equilibrium Uri Nevo |
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1:15 PM |
Lunch and Informal Discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Tuesday, September 19 |
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8:00 AM |
Breakfast |
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SESSION III |
Immunoregulatory Mechanisms I Chairs: Carola Vinuesa and Antonio Lanzavecchia |
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9:00 AM |
10 |
Antibody diversification by somatic mutations and DNA transposition Antonio Lanzavecchia |
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9:30 AM |
11 |
Role of TFH-derived dopamine in human germinal centres Ilenia Papa, David Saliba, Maurilio Ponzoni, Pablo Canete, Paula Gonzalez-Figueroa, Sonia Bustamante, Salvatore Valvo, Rebecca Sweet, Michelle Grimbaldeston, Michael Meyer-Hermann, Michael Dustin, Claudio Doglioni, and Carola Vinuesa |
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10:00 AM |
12 |
Developing therapies based on Epstein-Barr virus’s ability to predispose for Multiple Sclerosis Iryna Shanina, citlali Marquez, and Marc Horwitz |
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10:30 AM |
13 |
IL-10 producing CCR6+T-cells are a distinct population of B-helper T-cells that play a pathogenic role in systemic lupus erythematosus Federica Facciotti, Paola Larghi, Nicola Gagliani, Sergio Abrignani, Pierluigi Meroni, Richard Flavell, and Jens Geginat |
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10:45 AM |
Coffee Break and Poster Session |
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SESSION IV |
Immunoregulatory Mechanisms II Chairs: Mark Travis and Shimon Sakaguchi |
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11:45 AM |
14 |
TCR signaling, Treg, and autoimmunity Shimon Sakaguchi |
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12:15 PM |
15 |
Regulation of the intestinal immune response by integrins and TGF-beta Mark Travis |
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12:45 PM |
16 |
Unexpected role(s) for IRF5 risk variants in SLE disease onset Betsy Barnes, Dan Li, Bharati Matta, and Su Song |
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1:00 PM |
17 |
Publishing: Myths and legends Zoltan Fehervari |
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1:30 PM |
Lunch and Informal Discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Wednesday, September 20 |
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8:00 AM |
Breakfast |
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SESSION V |
Targeting Autoimmunity Chairs: Steve Miller and Sergio Lira |
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9:00 AM |
18 |
Tolerogenic regulation of activated diabetogenic CD4+ and CD8+ T cells via Treg induction using antigen-associated PLG nanoparticles Stephen Miller, Suchitra Prasad, Tobias Neef, Dan Xu, Joseph Podojil, Daniel Getts, and Lonnie Shea |
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9:30 AM |
19 |
Regulation of CNS inflammation by astrocytes Francisco Quintana |
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10:00 AM |
20 |
Development of a novel animal model to study colitis Sergio Lira |
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10:30 AM |
21 |
Pancreatic nerve electrostimulation inhibits recent onset autoimmune diabetes Philippe Blancou |
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10:45 AM |
Coffee Break |
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SESSION VI |
T cell function and dysfunction Chairs: Lucy Walker and James Moon |
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11:15 AM |
22 |
Tolerance in the self antigen-specific CD4+ T cell repertoire James Moon, Francois Legoux, and Zimeng Zhang |
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11:45 AM |
23 |
Regulation of Tregs in the central nervous system Thomas Korn |
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12:15 PM |
24 |
Understanding and manipulating Treg homeostasis Lucy Walker |
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12:45 PM |
25 |
Tissue-resident memory T cells as therapeutic targets Simone Park, Susan Christo, Julia Prier, Clara Castellucci, Erica Wynne-Jones, Francis Carbone, Scott Mueller, and Laura Mackay |
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1:15 PM |
26 |
Narcolepsy: selective autoimmune destruction of a subpopulation of sleep-regulating neurons Raphaël Bernard-Valnet, Xuan-Hung Nguyen, Clémence Quériault, Lidia Yshii, Jan Bauer, Yves Dauvilliers, Christelle Peyron, and Roland Liblau |
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1:30 PM |
Lunch and Informal Discussions |
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3:30 PM |
City Tour |
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7:30 PM |
Dinner and Informal Discussions |
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Thursday, September 21 |
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8:00 AM |
Breakfast |
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SESSION VII |
Immune Tolerance I Chairs: David Scott and Burkhard Becher |
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9:00 AM |
27 |
Four shades of engineered regulatory T cells and killers David Scott |
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9:30 AM |
28 |
T-cell-derived GM-CSF mediates graft-vs-host disease but is dispensable for graft-vs-leukemia effect Burkhard Becher |
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10:00 AM |
29 |
Fate-mapping of GM-CSF in inflammation Juliana Komuczki, Bettina Schreiner, Marija Banovic, Pawel Pelczar, and Burkhard Becher |
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10:15 AM |
30 |
Apoptotic cell induced AhR activity is required for immunologic tolerance and suppression of lupus Rahul Shinde, Kebria Hezaveh, Lara Utsch, Andreas Kloetgen, Ankur Chakravarthy, Tiago Da Silva Medina, Marie Jo Halaby, Reema Deol, Aristotelis Trisigos, David Munn, Michael Madaio, Zahi Touma, Joan Wither, Daniel De Carvalho, and Tracy McGaha |
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10:30 AM |
Coffee Break and Poster Session |
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SESSION VIII |
Immune Tolerance II Chairs: Ari Waisman and Jen Gommerman |
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11:30 AM |
31 |
Human dendritic cells: From development to functions Florent Ginhoux |
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12:00 PM |
32 |
Th17 and IL-17 in CNS diseases Ari Waisman |
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12:30 PM |
33 |
Recirculating intestinal IgA-producing cells regulate neuroinflammation Jennifer Gommerman |
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1:00 PM |
34 |
Thymus-derived Treg cell development is regulated by C-type-lectin–mediated BIC/miRNA155 expression Raquel Sanchez-Diaz, Rafael Blanco-Dominguez, Katerina Tsilingiri, Beatriz Linillos-Pradillo, Hortensia de la Fuente, Francisco Sanchez-Madrid, Maria L Toribio, Rinako Nakawaga, and Pilar Martin |
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1:15 PM |
Closing Remarks |
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1:20 PM |
Lunch and Informal Discussions |
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8:00 PM |
Farewell Dinner |
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Friday, September 22 |
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8:00 AM |
Breakfast |
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10:00 AM |
Departure |
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POSTERS |
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35 |
Role of diabetes in the Etiology of Laryngeal cancer Alexandre Didier and Roberto Menicagli |
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36 |
Sex-dependent treatment of chronic EAE with partial MHC class II constructs Gil Benedek, Priya Chaudhary, Roberto Meza-Romero, Evan Calkins, Gail Kent, Halina Offner, Dennis Bourdette, and Arthur Vandenbark |
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37 |
Mining helminth secretions for new classes of immune suppressing drugs Taylor Smallwood, Richard Clark, Jason Mulvenna, Johan Rosengren, and John Miles |
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38 |
Recombinant Fc hexamers show great potential for replacement of IVIG for treatment of autoimmune diseases Bonnie Lewis, Donald Branch, Rolf Spirig, and Fabian Käsermann |
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39 |
Granzyme B in Autoimmune Skin Diseases: A Key Player in Reduced Barrier Function and Blistering David Granville, Valverio Russo, Theo Klein, Darielle Lim, Nick Carr, Matthew Zeglinski, Richard Crawford, and Christopher Overall |
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40 |
The Lys63-deubiquitination of Smad7 by CYLD is required for T cell homeostasis and Smad-dependent TGF-β signaling Yilang Tang, Sonja Reissig, and Ari Waisman |
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41 |
Increased number of GITR positive regulatory T cells by an anti-GITR antibody prevents diabetes in NOD mice Luigi Cari, Pia Montanucci, Giuseppe Basta, Erika Ricci, Maria Petrillo, Jun Shimizu, Teresa Pescara, Riccardo Calafiore, Carlo Riccardi, and Giuseppe Nocentini |
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42 |
Therapeutic contribution of administration of coenzyme Q10, ω-3-polyunsaturated fatty acids and their mixture on skeletal muscle mitochondria functions and on the plasmatic level of γ-tocopherol studied in experimental arthritis Katarína Bauerová, Jarmila Kucharská, Silvester Poništ, Lukáš Slovák, Ľudmila Pašková, Oľga Vančová, Danica Mihalová, and Anna Gvozdjáková |
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43 |
Targeting islet-specific CD8 T cells in Type 1 Diabetes Dimitri Kakabadse, Mark Lewis, Sigal Fishman, Evy Leenheer, Joanne Davies, Gidion Gross, and Susan Wong |
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44 |
Endocytic regulation of IL-17 cytokines in stromal cells Cristina Ottone, Ash Maroof, Alex MacPherson, and Stevan Shaw |
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45 |
Sex differences in the effect of vitamin D on inflammatory heart disease: protective in women but damaging in men Katelyn Bruno, Jessica Mathews, Leslie Cooper, Erika Douglass, Michael Coronado, and DeLisa Fairweather |
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46 |
Sex differences in soluble ST2 predict heart failure during myocarditis and DCM in patients and mice Katelyn Bruno, Leslie Cooper, Michael Coronado, Jessica Mathews, Anneliese Hill, Erika Douglass, and DeLisa Fairweather |
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47 |
Regulation of focal adhesion assembly and Lamellopodia Dynamics with WNT signaling ligands in Rheumatoid Arthritis Aigul Sharip, Altynai Adilbayeva, Yergali Bexeitov, and Jeanette Kunz |
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48 |
CD40-pathway activation in ectopic lymphoid structure (ELS)-resident B cells contributes to disease pathology in primary Sjögren’s syndrome Grazyna Wieczorek, Marc Bigaud, Sabina Pfister, Sebastian Hoersch, Katriona McMichael, Catherine Afatsawo, Meike Hamburger, Celine Texier, Celine Cojean, Maurane Henry, and James Rush |
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49 |
Learning SLE pathological mechanisms from multi 'omics profiles Sabina Pfister, Nicholas Kelley, Thomas Schlitt, Anita Fernandez, Marc Sultan, Maroof Hasan, Anis Mir, and James Rush |
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50 |
Role of the transcriptional silencer Ets-2 in the pathogenesis of autoimmune diseases Ioannis Panagoulias, Ioanna Aggeletopoulou, Panagiota Davoulou, Vily Panoutsakopoulou, and Athanasia Mouzaki |
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51 |
Treatment of dendritic cells with dexamethasone and MPLA induces a transcriptional profile that promotes regulation of immune responses Juan Aguillon, Paulina Garcia-Gonzalez, Katina Schinnerling, Jaxaira Maggi, Lilian Soto, Oscar Neira, Ahmed Medhi, Hendrik Nel, Diego Catalan, Ricardo Verdugo, and Ranjeny Thomas |
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52 |
Intima-media tickness in patients with antiphospolipid sindrome in Bulagrian population. Nikolay Stoilov, Vladimira Boyadzhieva, Rasho Rashkov, and Stefan Stefanov |
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53 |
Multiple Sclerosis (MS): Nanoformulation of the biologic "LIF" to re-establish endogenous reparative homeostasis in the CNS Su Metcalfe |
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54 |
The Foxo3/Eomes axis regulates CD4 T cell differentiation and susceptibility to autoimmunity Michael Michieletto, caroline Stienne, and Anne Dejean |
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55 |
Extracellular hsa-miR-Chr8:96 as a unique biomarker for diagnosis of autoimmune myocarditis patients Rafael Blanco-Dominguez, Raquel Sánchez-Díaz, Beatriz Linillos-Pradillo, Francisco Sánchez-Madrid, and Pilar Martin |
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56 |
Suppression of autoreactive T and B lymphocytes by selective therapy in humanized murine SCID models of autoimmunity Silviya Bradyanova, Nikolina Mihaylova, Petroslav Chipinski, and Andrey Tchorbanov |
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57 |
T cell activation and differentiation Antal Nagy, Douglas Pinheiro, Maria Klicznik, Gertrude Achatz, Iris Gratz, Raimund Holly, and Abul Abbas |
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58 |
Alleviation of Chronic Inflammation by a novel Ganoderic analogue via dual HO-1/Nrf-2 and NF-κB inhibitory pathway against Complete fruend’s adjuvant induced arthritis Vikas Kumar and P Malairajan |
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59 |
Foxo1 inactivation is essential for effector T cell activation Jenna Sullivan and Daniel Campbell |
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60 |
Helminth-derived extracellular vesicles - a novel therapeutic for inflammation? Gillian Coakley, Jana McCaskill, Jessica Borger, Fabio Simbari, Henry McSorley, Amy Buck, and Rick Maizels |
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61 |
Acute exposure of green synthesized ZnO nanoparticles of Prosopis cineraria Linn damage spatial cognitive behavior in albino mice via up regulation of oxidative stress and acetylcholinesterase Ekta Yadav and Amita Verma |
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62 |
IFNγ controls the monocyte to phagocyte transition during tissue inflammation Ana Amorim, Dunja Mrdjen , Vinko Tosevski, Melanie Greter, Florent Ginhoux, and Burkhard Becher |