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Monday, September 23 |
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6:00 PM |
Conference Registration |
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8:00 PM |
Welcome Dinner / Reception |
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Tuesday, September 24 |
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7:30 AM |
Breakfast |
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8:30 AM |
Welcome and Opening Remarks - Costas Koumenis |
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SESSION I |
Tumor Immunology I: Interactions between immune system and vasculature/hematopoetic system Chair: Costas Koumenis |
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8:35 AM |
1 |
Anti-angiogenic immunotherapy Michele De Palma |
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9:00 AM |
2 |
Immunomodulation of the tumor microenvironment: From vessel destruction to vessel construction Yichao Hua, Vella Gerlanda, Florian Rambow, Junbin Qian, Oliver Burton, Susan Schlenner, Mélanie Guyot, Diether Lambrechts, Jean-Christophe Marine, and Gabriele Bergers |
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9:25 AM |
3 |
The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MyD88 degradation Luca Busino |
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9:50 AM |
4 |
Complement: a master manipulator of the tumor microenvironment and emerging target for cancer immunotherapy Dimitrios Mastellos and John Lambris |
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10:15 AM |
Coffee Break and Poster Viewing |
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SESSION II |
Tumor stroma and its impact on tumor response to treatment Chair: Clare Isacke |
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11:00 AM |
5 |
Targeting the tumour stroma to limit breast cancer metastasis Clare Isacke |
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11:25 AM |
6 |
Altering the tumor stroma by eliminating or reducing cancer-associated fibroblasts using CAR T cells Steven Albelda and Ellen Pure |
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11:50 PM |
7 |
Inhibition of stromal HIF2 reduces tumor-associated macrophage infiltration and polarization and improves survival in pancreatic cancer Cullen Taniguchi |
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12:15 |
8 |
Exploring the lung adenocarcinoma tumor-stroma crosstalk at the single cell level Gina Bouchard, Loukia Karacosta, Weiruo Zhang, Amato Giaccia, and Sylvia Plevritis |
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12:30 PM |
9 |
Why don’t we get more cancer? The critical role of extracellular matrix and microenvironment in malignancy and dormancy Mina Bissell (Keynote) |
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1:30 PM |
Lunch and informal discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Wednesday, September 25 |
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7:30 AM |
Breakfast |
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SESSION III |
Tumor Immunology II: Impact of immune system and stroma on metastasis and therapy Chair: Quynh-Thu Le |
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8:30 AM |
10 |
Immune effector monocyte - neutrophil cooperation regulates the metastatic microenvironment in breast cancer Zena Werb (Keynote), Catharina Hagerling, and Hugo Gonzalez |
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9:30 AM |
11 |
Galectin-1 intensifies immunosuppression in head and neck cancer by boosting myeloid derived suppressive cell (MDSC) expansion Dhanya Nambiar, Todd Aguilera, Hongbin Cao, Joshua Bloomstein, Dadi Jiang, Albert Koong, Amato Giaccia, and Quynh Thu Le |
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9:55 AM |
12 |
Cooperative Immune-mediated Mechanisms of the HDAC Inhibitor Entinostat , an IL-15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy Sofia Gameiro and Jeffrey Schlom |
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10:20 AM |
13 |
Ligand mediated activation of B-Cell Maturation Antigen signaling boosts protein translation machinery to sustain the growth of multiple myeloma Yu Rebecca Miao, Can Cenik, Kazue Mizuno, Anh Diep, Dadi Jiang, Michaela Liedtke, Kaushik Thakkar, Grace Li, Hongjuan Zhao, and Amato Giaccia |
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10:45 AM |
Coffee Break and Poster Viewing |
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SESSION IV |
Tumor Hypoxia: Mechanisms contributing to tumor aggressiveness Chair: Erinn Rankin |
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11:30 AM |
14 |
The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling Amato Giaccia |
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11:55 PM |
15 |
Hypoxia-induced SETX links replication stress with the unfolded protein response Ester Hammond |
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12:20 PM |
16 |
Cancer associated mesothelial cells promote chemoresistance by enhancing stemness of ovarian cancer cells. Jin Qian, Suchitra Natarajan, and Erinn Rankin |
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12:45 PM |
17 |
Phosphorylation-dependent protein interactions mediate productive binding of HIF-1α to chromatin and inhibition of cancer cell apoptosis under hypoxia George Simos |
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1:10 PM |
18 |
Hypoxia increases GAS6/AXL signaling and its metastatic potential in hepatocellular carcinoma which can be reduced by a soluble AXL receptor Anne Ernst, Kaushik Thakkar, Erinn Rankin, and Amato Giaccia |
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1:25 PM |
Lunch and informal discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Thursday, September 26 |
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7:30 AM |
Breakfast |
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SESSION V |
The Unfolded Protein Response and Integrated Stress Response in cancer Chair: Marianne Koritzinsky |
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8:30 AM |
19 |
Targeting endoplasmic reticulum ROS metabolism in pancreas cancer Marianne Koritzinsky |
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8:55 AM |
20 |
Host ATF4 is a master regulator of tumor growth and metastasis Ioannis Verginadis, Brett Bell, Sravya Koduri, Nektaria Maria Leli, Frank Chinga, Sandra Ryeom, Ellen Pure, and Constantinos Koumenis |
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9:20 AM |
21 |
The PERK/JAK/STAT3 axis of the unfolded protein response induces CEBPD expression to regulate proteostasis and cell survival in cancer cells Namratha Sheshadri, Dipak Poria, Shikha Sharan, and Esta Sterneck |
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9:45 AM |
22 |
The Adaptive Trait of the Integrated Stress Response Promotes KRAS Lung Tumorigenesis Nour Ghaddar, Shuo Wang, Jothilatha Krishnamoorthy, Cedric Darini, Nicolas Ahson, Bethany Woodvine, John Le Quesne, Helmut Popper, Ivan Topisirovic, Ola Larsson, and Antonis Koromilas |
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10:00 AM |
23 |
Mechanisms of vulnerability of cancer cells to endoplasmic reticulum dysfunction and potential therapeutics Bo-Jhih Guan, Ahmad Khalil, Ivan Topisirovic, Ola Larsson, and Maria Hatzoglou |
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10:15 AM |
Coffee Break and Poster Viewing |
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SESSION VI |
Autophagy, mitochondrial and lysosomal stress Chair: Eileen White |
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11:15 AM |
24 |
Control of Cancer Metabolism and an Anti-cancer Immune Response by Autophagy Eileen White |
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11:40 AM |
25 |
ULK1 regulates mitochondrial and ER turnover, oxygen metaobolism, hypoxia tolerance, and is a therapeutic target in pancreatic cancer Dan Cojocari, Trevor McKee, Mark Zaidi, Ravi Vellanki, Rob Cairns, Marianne Koritzinsky, and Bradly Wouters |
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12:05 AM |
26 |
Chemotherapy and radiation induced autophagy and senescence as potential targets for chemosensitization and radiosensitization in cancer therapeutics David Gewirtz, Tareq Saleh, Liliya Tyutyunyk-Massey, Nipa Patel, Valerie Carpenter, and Fereshteh Ahmadinejad |
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12:30 PM |
27 |
Identification and characterization of lysosome vulnerabilities in VHL-inactivated renal cell carcinoma Sandra Turcotte, Nadia Bouhamdani, and Mathieu Johnson |
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12:45 PM |
28 |
3D-model to study the influence of microenvironment on FH-deficient cells Christina Schmidt, Ana Henriques da Costa, Efterpi Nikitopoulou, Alison McGuigan, and Christian Frezza |
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SESSION VII |
Meet the expert - Alexia Zaromytidou |
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1:00 PM |
29 |
The ins and outs of publishing in Nature Cancer and the Nature journals Alexia Zaromytidou |
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1:30 PM |
Lunch and informal discussions |
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3:30 PM |
City Tour |
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7:30 PM |
Dinner and Informal Discussions |
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Friday, September 27 |
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7:30 AM |
Breakfast |
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SESSION VIII |
Oncogenic stress, tumor metabolism and targeting metabolic vulnerabilities Chair: Thales Papagiannakopoulous |
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8:30 AM |
30 |
Uncovering Metabolic Bottlenecks in Lung Cancer Thales Papagiannakopoulos |
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8:55 AM |
31 |
Dysregulated protein synthesis and metabolic plasticity in neoplasia. Ivan Topisirovic |
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9:20 AM |
32 |
Blocking increased purine synthesis in high ASS1 expressing tumors promotes response to immunotherapy Ayelet Erez |
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9:45 AM |
33 |
Stage-Specific Roles of Rb Constrain Tumor Progression, Lineage Fidelity, and Metastasis David Feldser |
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10:10 AM |
34 |
Sweetening up NRF2 Viraj Sanghvi, Josef Leibold, Marco Mina, Zhuoning Li, Matthew Miele, Elisa de Stanchina, Agnes Viale, Scott Lowe, Giovanni Ciriello, Ronald Hendrickson, and Hans-Guido Wendel |
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10:25 AM |
35 |
A gain-of-function p53 mutant oncogene promotes cell fate plasticity and myeloid leukemia through the pluripotency factor Foxh1 Eva Loizou, Ana Banito, Geulah Livshits, Yu-Jui Ho, Richard Koche, Francisco Sánchez-Rivera, Mayle Allison, Chi-Chao Chen, Kinalis Savvas, Frederik Bagger, Edward Kastenhuber, Benjamin Durham, and Scott Lowe |
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10:40 |
36 |
Investigating αKG derivatives in preventing metabolic adaptation in tumorigenesis Houda Abla, Giulia Leone, Manuela Sollazzo, Alessandra Locatelli, Giuseppe Gasparre, Luisa Iommarini, and Anna Maria Porcelli |
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10:55 AM |
Coffee Break and Poster Viewing |
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SESSION IX |
Translational and clinical approaches leveraging the TME Chair: Ester Hammond |
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11:55 PM |
37 |
Gut microbiota modulate T cells and impact cancer therapies Andrea Facciabene |
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12:20 PM |
38 |
Hyperthermia: the optimal treatment to overcome radiation resistant hypoxia Michael Horsman, Brita Sorensen, Jens Overgaard, and Pernille Elming |
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12:45 PM |
39 |
Optimization of Clinical Trials in Precision Oncology Apostolia Tsimberidou |
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1:05 PM |
40 |
Cellular and molecular interrogation of pancreatic cancer cells suggests opportunity for carbon ion over photon irradiation Todd Aguilera |
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1:20 PM |
Closing remarks - Ester Hammond |
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1:30 PM |
Lunch and informal discussions |
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8:00 PM |
Farewell Dinner |
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Saturday, September 28 |
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8:00 AM |
Breakfast |
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10:00 AM |
Departure |
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POSTERS |
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40 |
TGF-β1 secreted by pancreatic stellate cells promotes stemness and tumorigenicity in pancreatic ductal adenocarcinoma through L1CAM downregulation enza lonardo |
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41 |
IKBKE phosphorylates MAP3K8 for maintaining constitutive MEK and ERK activations in transformed cells Serkan Göktuna |
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42 |
Microengineering the tumor stroma to quantify patient-derived cancer and immune cell interactions Nidhi Menon |
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43 |
Molecular mechanism of oxidative stress-mediated mast cell selective ablation: A new therapeutic strategy to intervene with detrimental functions of mast cells in cancer Aida Paivandy, Jens Eriksson, Fabio Melo, Mikael Sellin, and Gunnar Pejler |
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44 |
Evaluation of a novel hypoxia activated prodrug strategy in colorectal cancer cells Omar Hussain, Roger Phillips, Simon Allison, Henrik Johansson, and Daniel Pedersen |
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45 |
Impact of mitochondrial complex III inhibitors on cell proliferation and metabolic conversion rates in PC3 prostate cancer cells cultivated in the presence of 21% O2 and 1.5 % O2 Floriana Di Paola, Klaus Failing, and Sybille Mazurek |
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46 |
Lactate as a signaling molecule in the tumor microenvironment Martina Koncošová, Jaroslav Zelenka, and Tomáš Ruml |
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47 |
Cancer-associated fibroblasts of head and neck squamous cell carcinoma stimulate expression of cancer cell markers in normal epithelial cells Jana Šáchová, Michal Kolář, Václav Pačes, Čestmír Vlček, Lukáš Lacina, Karel Smetana Jr., and Jan Plzák |
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48 |
Cryopreservation of Colon Tumoroids in Multiwell Platforms Ana Almeida, Marie-Ann Ewart, and Colin Wilde |
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49 |
Mitochondrial respiratory function mediated by external succinate in prostate cancer cells. Ana Carolina Sant'Anna-Silva, Helmut Klocker, Eskil Elmer, Andras Meszaros, and Erich Gnaiger |
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50 |
Mitochondrial complex I-driven regulation of the hypoxic response in cancer cells Nikkitha Umesh Ganesh, Luisa Iommarini, Renaud Vatrinet, Laura Benedetta Amato, Monica De Luise, Giulia Girolimetti, Lara Gibellini, Rene Gunther Feichtinger, Silvia Vidali, Andrea Cossarizza, Barbara Kofler, Ilaria Malanchi, Anna Maria Porcelli, Ivana Kurelac, and Giuseppe Gasparre |
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51 |
Tumor Micro-environmental Resonance Effect on Tumor Growth Modeled by Correlated Colored Gaussian Noises Ibrahim Muawiyya Idris |
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52 |
HIF2 deletion in CAFs reduces tumor-associated macrophage recruitment and polarization in pancreatic cancer Daniel Lin, Cullen Taniguchi, Yanqing Huang, Meifang Yu, Jessica Molkentine, Amit Deorukhkar, and Tara Fujimoto |
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53 |
Expression heterogeneity of cancer-associated fibroblasts in basal-cell carcinoma at single cell resolution Jiří Novotný, Šárka Kocourková, Miluše Hradilová, Barbora Dvořánková, Karel Smetana, Michal Kolář, Lukáš Lacina, and Václav Pačes |
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54 |
Smoothened-dependent and independent pathways in mammalian non-canonical Hedgehog signalling: Insight to novel cancer therapy Ishaku Adamu and Maikel Peppelenbosch |
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55 |
Effects of different nutrient conditions on mitochondrial dynamics and function in ovarian cancer cell lines. Nicole Bezuidenhout and Maria Shoshan |
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56 |
FAM13A gene influences on the proliferation and metastatic potential of lung cancer cells Iwona Ziółkowska-Suchanek, Marta Podralska, Agnieszka Dzikiewicz-Krawczyk, Magdalena Żurawek, Katarzyna Iżykowska, and Natalia Rozwadowska |
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57 |
Genetic variants in H2AFX gene and susceptibility to lung cancer in the Polish population. Marta Podralska, Magdalena Żurawek, Katarzyna Iżykowska, Agnieszka Dzikiewicz-Krawczyk, Piotr Gabryel, Wojciech Dyszkiewicz, and Iwona Ziółkowska-Suchanek |
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58 |
Quantitative analysis of acyl-carnitines and acyl-coenzymes in cancer cells Maheshwor Thapa and Guido Dallmann |
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59 |
Patient-derived organoids as a potential model to predict response to PD-1/PD-L1 checkpoint inhibitors Filomena de Nigris |
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60 |
Radiation effects on mesenchymal stem cells in a model of fibrosarcoma Tariq Aabed, Debayan Mukherjee, Matthew Fisher, Gillian Tozer, and Chryso Kanthou |
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61 |
The Role of the Heat Shock Response in the Tumor Immune Microenvironment Kathryn Hockemeyer, Nikos Kourtis, Theodore Sakellaropoulos, Igor Dolgalev, Kleopatra Avrampou, Aristotelis Tsirigos, and Iannis Aifantis |
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62 |
Mitochondrial alterations associated to cisplatin resistance in ovarian cancer Luca Zampieri, Debora Grasso, Tania Capeloa, and Pierre Sonveaux |
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63 |
Ketogenic diet targets melanoma independent of the underlying metabolic signature and BRAF status Daniela Weber, Sepideh Aminzadeh-Gohari, Anna Redtenbacher, Luca Catalano, René Feichtinger, Peter Kölblinger, Johann Bauer, Michael Emberger, Roland Lang, and Barbara Kofler |
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64 |
Inducible IFN-alpha gene therapy inhibits glioblastoma multiforme growth in a new syngeneic mouse model Filippo Birocchi, Melania Cusimano, Anna Ranghetti, Tiziano Di Tomaso, Federico Rossari, Barbara Costa, Peter Angel, Nadia Coltella, and Luigi Naldini |
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65 |
Understanding the contribution of genetic Dock4 deletion and radiotherapy on glioblastoma blood vessel abnormalities and whether it has an effect on the efficacy of treatments Anastasia Widyadari, Teklu Egnuni, Michael Grant, Susan Short, Aruna Chakrabarty, Laura Heskin, Gary Shaw, Valerie Spiers, Heiko Wurdak, Mihaela Lorger, and Georgia Mavria |
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66 |
Induction of the glycerophospholipid / triacylglycerol biosynthesis pathway enzyme AGPAT2 by HIF-1, increases survival and etoposide resistance of cancer cells under hypoxia. Eleni-Anastasia Triantafyllou, Eleni Georgatsou, Ilias Mylonis, George Simos, and Efrosyni Paraskeva |
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67 |
Tobacco specific nitrosamines (TSNAs) repattern energy metabolism in human lung adenocarcinoma. Saharnaz Sarlak, Calude Lalou, Benoît Rousseau, Julien Izotte, Elodie Dumon , Hamid Reza Rezvani, Walid Mahfouf, Stéphane Claverol, Marc Bonneu, Didier Lacombe, Nivea Dias Amoedo, and Rodrigue Rossignol |
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68 |
Inhibition of fatty acid synthase as a new therapeutic strategy to eradicate cancer stem cells in HER2-positive gastric cancer Lorenzo Castagnoli, Filippo Pietrantonio, Elena Fasano, Simona Faraci, Serena Saggio, Silvia Giordano, Simona Corso, Claudio Vernieri, Matteo Dugo, Elda Tagliabue, and Serenella Pupa |
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69 |
The distinctive metabolic environment of the bone marrow niche drives leukemia chemoresistance Nick van Gastel, Jessica Spinelli, Azeem Sharda, Amir Schajnovitz, Ninib Baryawno, Catherine Rhee, Toshihiko Oki, Eliane Grace, Heather Soled, Charles Vidoudez, Sunia Trauger, Marcia Haigis, and David Scadden |
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70 |
Hypoxia drives the assembly of the multi-enzyme purinosome complex Cyrielle Doigneaux, Anthony Pedley, Ishna Mistry, Stephen Benkovic, and Ali Tavassoli |