Saturday June 1, 2024

Start

Finish

18:00

19:30

Conference Registration

19:30

22:30

Welcome Reception / Dinner

Sunday June 2, 2024

Start

Finish

Presenter

Title

8:00

8:10

Mathias Müller

Introductory remarks

(Session 1) One Health: lessons from other diseases and species

Ana Gamero & Jun Gui

8:10

8:30

Lopa Mishra

Aldehydes alter TGF-beta signaling and induce obesity and cancer

8:30

8:50

Mathias Müller

TYK's 2 Sides in Steady-State Immunity and Fungal Skin Infection

8:50

9:10

Richard Moriggl

Targeting Horizontal Cancer in Tasmanian Devils as a Dying Species Due to Core Cancer Pathway Action with Immune Escape

9:10

9:30

Jennifer Lenz

STING agonist immunotherapy in dogs with solid tumors

9:30

9:50

Daniel Harari

Type I Interferon Accelerates Tumor Progression in a Mouse Model of Chronic Lymphocytic Leukemia

9:50

10:10

Eleanor Fish

Lessons learned from interferons and viruses

10:10

10:30

Matthew Atherton

Comparative studies of osteopontin as a candidate immune suppressor in histiocytic sarcoma

10:30

10:50

Noula Shembade

The role of type I IFN in the regulation of KSHV infection

10:50

11:10

Coffee break

(Session 2) Microenvironment and metabolism

Eleanore Fish & Jennifer Lenz

11:10

11:30

Ellen Puré

Targeting stroma to normalize the tumor microenvironment

11:30

11:50

Xi Chen

Stressing Out Immune-Cold Triple-negative Breast Cancers

11:50

12:10

Belinda Parker

Restoring cytokine signalling in bone metastases to enhance therapeutic sensitivity

12:10

12:30

Haiyan Liu

Multifaceted Function of IL-37 in the Tumor Microenvironment

12:30

12:50

Jun Gui

The crosstalk between FGF21 and T cell lipid metabolism in the tumor microenvironment

12:50

13:10

Christoforos Thomas

Defining the estrogen signaling in breast tumor microenvironment

13:10

13:30

Jason Pitarresi

Tumor-secreted PTHrP drives pancreatic cancer cachexia

13:30

13:50

Tracy McGuha

The microbiome and regulation of immunity in pancreatic cancer

13:50

14:50

Lunch and informal discussions

14:50

16:00

Poster Session #1

19:30

Dinner and informal discussions

Monday June 3, 2024

Start

Finish

Presenter

Title

8:00

8:10

Houskeeping notes

 (Session 3) Senescence & adverse effects

Ellen Purè & Lisa Mielke

8:10

8:30

Stephanie Watowich

Understanding host-microbiome communication affecting checkpoint blockade response and toxicity

8:30

8:50

Marcus Ruscetti

Applying lessons learned from senescence-mediated cytokine signaling mechanisms to cancer therapy

8:50

9:10

Ross Dickins

Therapeutics targeting the CD80:PD-L1 duplex modulate T cell immunity

9:10

9:30

Costas Koumenis

Role of Interferon pathways in sparing normal intestinal tissue during FLASH radiotherapy for PDAC

9:30

9:50

Francesca Cicarelli

Interplay between genetics and inflammation in the initiation of oesophageal cancer

9:50

10:10

Pancho Barriga

9p21.3 coordinates cell intrinsic and cell extrinsic tumor suppression

10:10

10:30

M. Raza Zaidi

Role of Interferon-gamma-induced glycosylation in melanoma

10:30

10:50

Oleg Demidov

The differential effect of classical senolytics on SASP cytokine secretion

10:50

11:10

Coffee break

(Session 4) Immunology and immunotherapy

Donna Senger & Margaret Chou

11:10

11:30

Andreas Behren

Mechanisms of resistance against gd T cell mediated tumour cell killing

11:30

11:50

Lisa Mielke

Cytokines and Intraepithelial Lymphocyte Function in Colorectal Cancer

11:50

12:10

Ian Parish

Engineering CAR T cell differentiation to improve anti-tumour efficacy

12:10

12:30

Tony Tiganis

Targeting JAK/STAT phosphatases in CAR T cell therapy

12:30

12:50

Evgeniy Eruslanov

Human tumor-associated myeloid cells in the regulation of anti-tumor antibody efficacy

12:50

13:10

Jadwiga Jablonska

Stat3 deficient neutrophils hinder the growth and dissemination of tumors

13:10

13:30

Santiago Gonzales

The lymph node microenvironment regulates the antitumoral response of NK cells against B cell lymphoma

13:30

13:50

Donna Senger

Role of the dual function cytokine IL-33 in glioma progression and control

13:50

14:50

Lunch and informal discussions

14:50

16:00

Poster Session #2

19:30

Dinner and informal discussions

Tuesday June 4, 2024

Start

Finish

Presenter

Title

8:00

8:10

Houskeeping notes

(Session 5) Pathogenesis

 Jadwiga Jablonska & Anna Bielawska

8:10

8:30

Isaac Witz

Metastatic Microenvironment of Melanoma Brain Metastasis

8:30

8:50

Mikhail Nikiforov

Intracellular GTP gradients is a major mechanism regulating G-proteins activity in cancer

8:50

9:10

Cechi Chen

KLF5 transcription factor promotes breast cancer through multiple cytokines

9:10

9:30

J. Alan Diehl

Ubiquitin-dependent degradation of cyclin D3 is a barrier for myeloproliferative neoplasms

9:30

9:50

Andres Blanco

Forward genetic screening incolorectal cancer organoids identifies novel regulators of metastasis

9:50

10:10

Katherine Borden

 Disrupted RNA metabolism in Cancer

10:10

10:30

Bryan Willams

Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis

10:30

10:50

Margaret Chou

Jekyll or Hyde: Leveraging the Ubiquitin-specific protease 6 (USP6) Oncogene for Therapeutic Benefit

10:50

11:10

Coffee break

(Session 6) Synthetic biology and therapeutics

Stephanie Watowich &Katherine Borden

11:10

11:30

Hua Yu

CRISPR to target oncogenic fusion gene with precision and efficiency in vitro and in vivo

11:30

11:50

Leonidas Platanias

Targeting elements of the interferon pathway in the treatment of malignancies

11:50

12:10

Roberta Mazzieri

A novel monocyte-based cell therapy for the tumour targeted delivery of IFN-alpha

12:10

12:30

Marcin Kortylewski

Oligonucleotide-based glioma immunotherapy: the Goldilock’s dilemma

12:30

12:50

Serge Fuchs

Cytokine-based approaches to normalizing the tumor microenvironment

12:50

13:10

Rebecca Guerra

Therapeutic potential of natriuretic peptide cytokines

13:10

13:30

Yi Fan

Endothelial cell-derived cytokines and cancer immunotherapy

13:30

13:50

I. Caroline Le Poole

Cytokine release differentiates responses to CAR T cells or BiTEs targeting melanoma

13:50

15:00

Lunch and informal discussions

15:00

Ancient Corinth Tour

19:30

Dinner and informal discussions

Wednesday June 5, 2024

Start

Finish

Presenter

Title

8:00

8:10

Houskeeping notes

(Session 7) Inter/intracellular communications

Elena Voronov & Hua Yu

8:10

8:30

Wei Guo

The role of exosomes in immune suppression and tumor progression

8:30

8:50

Angel Lopez

The differential expression of cytokine receptor subunits controls cancer cells fate

8:50

9:10

Daniel Gough

The role of tumour intrinsic inflammasome mutations in lung adenocarcinoma

9:10

9:30

Christophe Lamaz

Control of interferon JAK/STAT signaling by membrane dynamics and mechanics

9:30

9:50

Olli Silvennoinen

Molecular basis of JAK activation guiding their therapeutic targeting

9:50

10:10

Anreas Möller

Impact of cancer-derived cytokines and extracellular vesicles on anti-tumour immune responses

10:10

10:30

Antonis Koromilas

STAT1 function in mutant KRAS cancer

10:30

10:50

Vladimir Spiegelman

Mechanisms of extracellular vesicles-mediated neuroblastoma metastasis

10:50

11:10

Coffee break

(Session 8) Inflammation and cancer

Francesca Cicarelli & Lopa Mishra

11:10

11:30

Thomas Decker

A new look at macrophage activation 

11:30

11:50

Igor Astsaturov

The role of dietary carbohydrates and insulin in hepatic inflammation

11:50

12:10

Matthias Ernst

Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within IL-6 family cytokines

12:10

12:30

Ana Gamero

Inflammatory role of STAT2 in Hepatocellular Carcinoma

12:30

12:50

Elena Voronov

Inhibition of IL-1 beta-induced inflammation improves prognosis of CRC-bearing mice

12:50

13:10

Julien Mari

Cytokines and T lymphocytes inchronic inflammation associated cancers

13:10

13:30

Yan Liu

Inflammatory stress drives the progression of p53 mutant clonal hematopoiesis to myelodysplastic syndromes

13:30

13:50

George N Pavlakis 

Increasing the metabolic fitness of TILs by IL15 to treat tumors and metastatic disease

13:50

14:00

Serge Fuchs

Final remarks

14:00

Lunch and discussions

19:30

Farewell Dinner and Travel Awards

Belinda Parker and Leon Platanias

Thursday June 6, 2024

8:00

Breakfast

12:00

Departure