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Tuesday, May 28 |
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6:00 PM |
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Conference Registration |
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8:00 PM |
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Welcome Reception and Dinner |
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Wednesday, May 29 |
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7:30 AM |
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Breakfast |
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8:25 AM |
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Welcome and Opening Remarks |
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SESSION I |
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Adaptive Immunity Chair: Randy Levinson |
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8:30 AM |
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Mitochondrial integrity regulated by FABP5 is a cell-intrinsic checkpoint for Treg suppressive function Cameron Field, Francesc Baixauli, and Erika Pearce |
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9:00 AM |
2 |
Contribution of iron to intrinsic and extrinsic macrophage immunometabolism Alyssa Hasty |
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9:30 AM |
3 |
Airway macrophage metabolic reprogramming during lung fibrosis Patricia P Ogger, Poonam Ghai, Simone A Walker, Peter Saunders, Shaun Kingston, Philip L Molyneaux, Toby M Maher, Clare M Lloyd, and Adam Byrne |
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10:00 AM |
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Coffee Break and Poster Viewing |
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SESSION II |
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Short Talks Chairs: Tony Ferrante and Randy Levinson |
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10:30 AM |
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The source of dietary fat differentially shapes anti-cancer immunity in obesity Roisin Loftus, Lydia Dyck, Hannah Prendeville, and Lydia Lynch |
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10:45 AM |
5 |
Adipocytes acquire innate immune cell functions during bacterial infection George Caputa, Edward Pearce, and Erika Pearce |
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11:00 AM |
6 |
Immune checkpoint blockade restores obesity-associated defects in cancer immunosurveillance Lydia Dyck, Mathilde Raverdeau, Roisin Loftus, Alexandra Zaborowski, and Lydia Lynch |
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11:15 AM |
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Diet-induced obesity causes metabolic reprogramming and suppresses immunity in the tumor microenvironment Jefte Drijvers, Alison Ringel, Alessia Catozzi, Juan Carlos García-Cañaveras, Vikram Juneja, Shakchhi Joshi, Thao Nguyen, Haejin Yoon, Peter Sage, Martin LaFleur, Justin Trombley, Joshua Rabinowitz, Arlene Sharpe, and Marcia Haigis |
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11:30 AM |
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Del-1 regulates brown adipocyte progenitor proliferation via β3 integrin Kyoung-Jin Chung, Anke Witt, Marina Nati, Pallavi Subramanian, Janine Gebler, Antonios Chatzigeorgiou, George Hajishengallis, and Triantafyllos Chavakis |
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11:45 AM |
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Ghrelin exerts immunoregulatory roles through modulation of mitochondrial metabolism Felipe Silva, Cristhiane Aguiar, Jessica Pereira, Lauar Monteiro, Gustavo Davanzo, Leonardo Freitas, Aline Berti, Danilo Ferrucci, Hernandes Carvalho, Silvio Consonni, and Pedro Vieira |
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12:00 PM |
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Coffee Break |
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SESSION III |
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Short Talks Chairs: Tony Ferrante and Randy Levinson |
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12:15 PM |
10 |
Mechanisms of amino acid sensing in mouse embryonic stem cells and macrophages Marion Russier, Annette Gross, and Peter Murray |
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12:30 PM |
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AMPK regulation of iNKT cell function during obesity Cristhiane Aguiar, Gustavo Davanzo, Vitor Jaccomo, Felipe Correa Silva, Lauar Monteiro, Fernanda Terra, José Alves Filho, Niels Câmara, Alexandre Keller, and Pedro Moraes Vieira |
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12:45 PM |
12 |
Specific inhibition of the NLRP3 inflammasome abrogates the inflammatory effect of Warburg metabolism in cystic fibrosis neutrophils Oliver McElvaney, Zbigniew Zaslona, Katrin Becker-Flegler, Eva Palsson-McDermott, Erich Gulbins, Luke O'Neill, Emer Reeves, and Noel McElvaney |
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1:00 PM |
13 |
The function of CPT1a in alternative macrophage activation Nikki van Teijlingen Bakker and Edward Pearce |
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1:15 PM |
14 |
Immunometabolic crosstalk during infection-associated cachexia Hatoon Baazim, Martina Schweiger, Michael Moschinger, Haifeng Xu, Thomas Scherer, Alexandra Popa, Suchira Gallage, Sheikh Ali, Kseniya Khamina, Lindsay Kosack, Bojan Vilagos, Mark Smyth, Alexander Lercher, Joachim Friske, Doron Merkler, Thomas Helbich, Mathias Heikenwälder, Philipp Lang, Rudolf Zechner, and Andreas Bergthaler |
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1:30 PM |
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Lunch and Informal Discussions |
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7:30 PM |
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Dinner and Informal Discussions Buses depart from the hotel lobby at 7:30 PM |
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Thursday, May 30 |
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7:30 AM |
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Breakfast |
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SESSION IV |
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Hot Topics Chair: Triantafyllos Chavakis |
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8:30 AM |
15 |
Mechanisms that promote inflammation in human type 2 diabetes Barbara Nikolajczyk |
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9:00 AM |
16 |
Immune regulation at barrier surface David Artis |
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9:30 AM |
17 |
Are alterations in adipose tissue immunometabolism involved in the pathogenesis of metabolic dysfunction in people with obesity? Samuel Klein |
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10:00 AM |
18 |
Cell specific metabolic changes in response to respiratory viral infection Svetlana Rezincuic, Barry Shulkin, John Devincenzo, and Heather Smallwood |
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10:15 AM |
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Coffee Break and Poster Viewing |
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SESSION V |
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Organelles and Signaling Pathways in Inflammation Chair: Steve Shoelson |
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11:15 AM |
19 |
Inflammasome activation and lossof organismal stress-resilience in aging Vishwa Deep Dixit |
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11:45 PM |
20 |
Control aid inflammation by mitochondrial metabolism Michael Karin |
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12:15 PM |
21 |
Unraveling the role of organelle communication in shaping immunometabolism Angelika Rambold |
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12:45 PM |
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Lunch and Informal Discussions |
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7:30 PM |
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Dinner and Informal Discussions Buses depart from the hotel lobby at 7:30 PM |
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Friday, May 31 |
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7:30 AM |
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Breakfast |
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SESSION VI |
Innate Immunity Chair: Erika Pearce |
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8:30 AM |
22 |
Fueling the firestarters Mathilde Raverdeau, Ayano Kohlgruber, Aaron Douglas, and Lydia Lynch |
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9:00 AM |
23 |
Targeting NK-cells in obesity-associated insulin resistance Jens Bruening |
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9:30 AM |
24 |
Immunometabolic regulation of myelopoiesis in trained immunity Triantafyllos Chavakis |
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10:00 AM |
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Coffee Break and Poster Viewing |
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SESSION VII |
Co-morbidities of Obesity/Type 2 Diabetes Chair: Mark Febbraio |
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11:00 AM |
25 |
LC3-associated endocytosis (LANDO) in receptor recycling and Alzheimer’s Disease Douglas Green |
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11:30 AM |
26 |
Why uric acid is elevated in the metabolic syndrome and why it matters Steve Shoelson, Giulio Romeo, SunAh Ham, Maria Martins-Sandoz, Ai Harashima, Ok-Hee Kim, Byung-Chul Oh, and Jongsoon Lee |
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12:00 PM |
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Optimizing liver organoids for clinical applications Kristina Schoonjans |
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12:30 PM |
28 |
A metabolic checkpoint in cardiovascular disease Filip Swirski |
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1:00 PM |
29 |
Meta(anti)inflammation; a defective pentose phosphate pathway reduces inflammatory macrophage responses during hypercholesterolemia Jeroen Baardman, Sanne Verberk, Menno de Winther, and Jan Van den Bossche |
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1:15 PM |
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Lunch and Informal Discussions |
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3:00 PM |
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City Tour Buses depart from hotel lobby at 3:00 PM |
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7:30 PM |
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Dinner and Informal Discussions Please note that buses do not pick-up at the hotel prior to dinner. Dinner proceeds right after the tour |
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Saturday, June 1 |
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7:30 AM |
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Breakfast |
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SESSION VIII |
Peripheral Metabolism Chair: Vishwa Deep Dixit |
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8:30 AM |
30 |
Microbiota-mediated shaping of gut secretory IgA in systemic metabolism Fabio Grassi |
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9:00 AM |
31 |
Skeletal muscle secretory proteins: a link between regular physical activity and reduced disease risk in obesity? Martin Whithamand Mark Febbraio |
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9:30 AM |
32 |
Adipocytes secrete lipid particles that regulate macrophage differentiation and function Stephen Flaherty III, Ambar Grijalva, Xiaoyuan Xu, Eleanore Ables, and Anthony Ferrante Jr. |
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10:00 AM |
33 |
The role of adipose tissue-resident eosinophils in adipocyte metabolism and whole-body energy homeostasis Ting Li, James Hernandez, William LeSuer, Jun Liu, Adrian Vella, Elizabeth Jacobsen, and Eleanna De Filippis |
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10:15 AM |
34 |
S100A8/A9 controls body weight during obesity via its modulation of adaptive thermogenesis Isabel Zvibel, Irina Efimova, Keren Cohen, Alona Epshtein, Chen Varol, and Sigal Fishman |
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10:30 AM |
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Coffee Break and Poster Viewing |
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SESSION IX |
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Immune cell function in homeostasis and disease Chair: Sam Klein |
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11:30 AM |
35 |
Metabolic signals of pseudo-starvation drive human regulatory T cell transcriptional fitness Giuseppe Matarese, Veronica De Rosa, and Paola De Candia |
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12:00 PM |
36 |
An ex vivo system to study metabolism-driven T cell exhaustion in the tumor microenvironment Carlos Carmona-Fontaine |
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12:30 PM |
37 |
Sympathetic neuroimmunity for obesity Ana Domingos |
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1:00 PM |
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Closing Remarks |
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1:10 PM |
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Lunch and Informal Discussions |
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8:00 PM |
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Farewell Dinner |
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Sunday, June 2 |
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8:00 AM |
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Breakfast |
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Departure |
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POSTERS |
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38 |
LC3-associated endocytosis regulates inflammatory immune activation Douglas Green and Bradlee Heckmann |
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39 |
The role of lipid metabolism in macrophage function Heba Abdelmegeed, Alessandra Palladini, Michal Grzybek, Anupam Sinha, Andreas Petzold, Andreas Dahl, Peter Mirtschink, Nicola Zamboni, Ünal Coskun, Triantafyllos Chavakis, and Vasileia Alexaki |
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40 |
Soluble adenylate cyclase (ADCY10) promotes brown adipose tissue function Anupam Das, Ruben García-Martín, Anupam Sinha, Thomas Noll, Triantafyllos Chavakis, and Vasileia Ismini Alexaki |
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41 |
A pathway downstream of arginine metabolism that inhibits white adipogenesis Vasileia Ismini Alexaki, Peter Mirtschink, Anupam Sinha, Mirko Peitzsch, Georgia Fodelianaki, Andres Soto, Alessandra Palladini, Michal Grzybek, Alexander Rauch, Mathias Lesche, Andreas Petzold, Ünal Coskun, Nicola Zamboni, Andreas Dahl, Susanne Mandrup, Peter Murray, and Triantafyllos Chavakis |
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42 |
Lysophosphatidic acid alters glucose metabolism via NRF2 activation in microglia cells Lisha Joshi, Ioanna Plastira, Eva Bernhart, Chintan Koyani, Seth Hallström, Andelko Hrzenjak, Wolfgang Sattler, Tobias Madl, and Sarah Stryeck |
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43 |
COMMD10 regulates adipose tissue macrophage control of energy expenditure Shani Ben-Shlomo, Nathan Gluck, and Chen Varol |
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44 |
Pompe disease causes metabolic impairment and activation defects in both human and murine T cells Helena Costa Verdera, Umut Cagin, Philippe Veron, Priscilla Jean-Alphonse, Kuranda Klaudia, Peggy Sanatine, Laetitia van Wittenberghe , Pascal Laforet, and Federico Mingozzi |
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45 |
Glucose-dependent insulinotropic polypeptide (GIP) controls body weight under diet-induced obesity via its regulation of dendritic cell or endothelial cell activity Irina Efimova, Isabel Zvibel, Alona Epshtein, Sigal Fishman, and Chen Varol |
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46 |
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis Pallavi Subramanian, Alessandra Palladini, Sofia Gargani, Margarita Chatzimike, Anupam Sinha, Michal Grzybek, Mario Brosch, Ünal Coskun, Jochen Hampe, Dimitris Kontoyiannis, and Triantafyllos Chavakis |
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47 |
Lipid droplet formation drives pathogenic ILC2 responses in airway inflammation Schekufe Kharabi Masouleh |
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48 |
Rifampicin resistance conferring mutations in Mycobacterium tuberculosis modulate host macrophage metabolism through cell wall lipid changes Nicole Howard, Nancy Marin, Mushtaq Ahmed, Bruce Rosa, John Martin, Monika Bambouskova, Alexey Sergushichev, Ekaterina Loginicheva, Natalia Kurepina, Javier Rangel-Moreno, Liang Chen, Barry Kreiswirth, Robyn Klein, Jordi Torrelles, Joan-Miquel Balada-Llasat, Gaya Amarasinghe, Makedonka Mitreva, Fong-Fu Hsu, Maxim Artyomov, Barun Mathema, and Shabaana Khader |
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49 |
Combination therapy of pulsed-wave ultrasound hyperthermia and immunostimulant OK-432 enhances systemic antitumor immunity for cancer treatment Ting-Chuan Li, Chih-Chun Liu, Yan-Zhang Lee, Chi-Feng Chiang, Win-Li Lin, and Shi-Chuen Miaw |
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50 |
Transcriptional activity of Irf5 mediates metabolic adaptation of macrophages upon metabolic stress Lucie Orliaguet, Tina Ejlalmanesh, Raphaëlle Ballaire, Maria Kondili, Mano Matthew, Catherine Chollet, Jean-Baptiste Julla, Jean-François Gautier, Nicolas Venteclef, and Fawaz Alzaid |
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51 |
Phenotypically distinct alternatively-activated adipose tissue macrophages induced by helminth molecules differently impact metabolic homeostasis Hendrik van der Zande, Karin de Ruiter, Ruud Wilbers, Michael Gonzalez, Jordan Poles, Anna Zawistowska-Deniziak, Frank Otto, Arjen Schots, P'ng Loke, Maria Yazdanbakhsh, and Bruno Guigas |
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52 |
Abscisic acid and salicylic acid as potential endogenous immune regulators in animals SeoWoo Kim, Jens Staal, Jacob Pollier, Alain Goossens, and Rudi Beyaert |
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53 |
Characterisation of circulating inflammatory markers before and after bariatric surgery Valentina Greto, Niall Dempster, Tamara Pavić, Richard Gillies, Bruno Sgromo, Jeremy Tomlinson, Gordan Lauc, Alessandra Geremia, and Carolina Arancibia |
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54 |
Ameliorating mitochondrial dysfunction in Aging CD4+ T cells through extracellular delivery of viable mitochondria Colwyn Headley, Varun Dwivedi, Russell Ault, and Joanne Turner |
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55 |
Obesity potentiates TH2 immunopathology via dysregulation of PPAR Sagar Bapat, Alexander Marson, Ronald Evans, and Ye Zheng |
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56 |
Tripartite organelle communication shapes macrophage plasticity via itaconate metabolism Ev-Marie Schuster, Julia Zimmermann, Eirini Trompouki, Andrea Ballabio, and Angelika Rambold |
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57 |
Metabolic rewiring governs activation of human bronchial epithelial cells in response to the bacterial component flagellin Ivan Ramirez-Moral, Xiao Yu, Michel van Weeghel, Alex de Vos, Riekelt Houtkooper, Menno de Jong, and Tom van der Poll |
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58 |
The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis Marina Nati, Antonios Chatzigeorgiou, Lan-Sun Chen, Ales Neuwirth, Pallavi Subramanian, Jochen Hampe, Oliver Soehnlein, Kyoung-Jin Chung, and Triantafyllos Chavakis |
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59 |
Monocyte adherence influences the function and metabolic programming upon stimulation with lipopolysaccharide Natasja Otto, Ivan Ramirez-Moral, Jeroen van Heijst, Alex de Vos, and Tom van der Poll |
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60 |
Hypoxia-inducible factor (HIF)1α in macrophages, but not in neutrophils, is important for host defense during K. pneumoniae-induced pneumosepsis Natasja Otto, Jeroen van Heijst, Alex de Vos, and Tom van der Poll |
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61 |
Metabolic adaptations of CD4+ T cells as antigen presenting cells Jesús Osuna, Raquel García, Arantzazu Cruz-Adalia, Mónica Torres, and Esteban Veiga |
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62 |
The transcriptional co-regulator GPS2 is fundamental for adipose tissue metabolism, function and adaptation during obesity drareni karima, Raphaëlle Ballaire, Serena Barilla, Fawaz Alzaid, Mano Mathew, Eckardt Treuter, and Nicolas Venteclef |
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63 |
Molecular regulation of Th17 and Treg development by fatty acid metabolism Philipp Stüve, Tim Sparwasser, and Luciana Berod |
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64 |
Decreased human adipose tissue-resident eosinophils in obese subjects is associated with increased insulin resistance James Hernandez, Ting Li, Cassandra Rau, Mia Masuda, James Madura, Elizabeth Jacobsen, and Elena Anna De Filippis |
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65 |
Role of PPARβ on the metabolic activity and activation of the immunosuppressive mechanisms of MSCs Rafael Contreras, Roberto Elizondo-Vega, Maria Jose Paredes-Martinez, Noymar Luque, Farida Djouad, and Patricia Luz-Crawford |
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66 |
Leptin-treated macrophages present an inflammatory profile while maintaining m2-like features Lauar Monteiro, Felipe Silva, Cristhiane Aguiar, Gustavo Davanzo, Angela Castoldi, Silvio Consonni, and Pedro Moraes-Vieira |
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67 |
Metabolism governs the immunomodulatory effect of umbilical-cord derived mesenchymal stem cells on human T-Cells Noymar Luque-Campos, Rafael Contreras, Carolina Pradenas, María-José Paredes, Milenka Valdebenito, María-José Torres, Claudia Altamirano, Roberto Elizondo, Farida Djouad, and Patricia Luz-Crawford |
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68 |
Evidence for metabolic reprogramming of circulating neutrophils in Gram-negative sepsis Oliver McElvaney, Emer Reeves, and Noel McElvaney |
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69 |
Specific inhibition of the NLRP3 inflammasome abrogates the inflammatory effect of Warburg metabolism in cystic fibrosis neutrophils. Oliver McElvaney, Zbigniew Zaslona, Katrin Becker-Flegler, Eva Palsson-McDermott, Erich Gulbins, Luke O'Neill, Emer Reeves, and Noel McElvaney |
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70 |
Anti-tumor T cells - you are what you eat Susan Kaech |
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71 |
The role of immunometabolism in the pathogenesis of acne Olga Demina |
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72 |
Nutrient sensing mTORC1 and the control of splenic DCs function Diana Moreira, Elisabeth Littwitz-Salomon, Nadine Assmann, Natalia Munoz-Wolf, and David Finlay |
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73 |
Phenotypic and metabolic changes of resident intestinal lamina propria macrophages induced by high fat diet Angela Castoldi, Niels Olsen Camara, and Edward Pearce |
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74 |
Pathogenesis of obesity-driven non-alcoholic fatty liver disease (NAFLD) development is associated with Th17 metabolic switch and inflammatory hepatic Th17 cells Maria Moreno-Fernandez, Daniel Giles, Calvin Chan, Jarren Oates, Traci Stankiewicz, Rebekah Karns, Matthew Weirauch, Michael Helmrath, Thomas Inge, Hitesh Deshmukh, Nathan Salomonis, and Senad Divanovic |
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75 |
The ER-localised Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection Yao Lu, Ying Qiu, Bin Wei, and Hongyan Wang |
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76 |
Identifying metabolic immunomodulatory mediators of fasting and refeeding using a multi-omics approach Allison Meadows, Julian Griffin, and Michael Sack |
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77 |
Intermittent fasting improves metabolic abnormalities and rejuvenation of white adipose tissue in mice Hoon-Ki Sung, Ju Hee Lee, Eashita Das, Sammy Shi, Somayeh Shahrokhi, and Jae-Ryong Kim |
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78 |
Use of synbiotics (L. casei and fructans of A. Salmiana) as modulators of the expression of GPR41/43 (FFAR2/3) in children with overweight and obesity Portales Diana, Mariela Vega-Cárdenas, Olivia González-Acevedo, Fidel Martínez-Gutierrez, and Juan Vargas-Morales |
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79 |
Caloric-Restriction mediated adipose-immune crosstalk in humans: Insights from CALERIE-II Olga Spadaro, Alexander Predeus, Yun-Hee Youm, Maxim Artyomov, Sidorov Sviatoslav, and Vishwa Deep Dixit |
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80 |
Leptin modulates lymphocyte proliferation process in a dose-dependent manner Vinicius Diniz, Laiane Santos-Oliveira, Heloisa Alves, Tiago Lobato, Paola Domenech, Amanda Alecrim, Elaine Hatanaka, Sandro Hirabara, Rui Curi, and Renata Gorjão |
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81 |
Inhibition of glycolytic and oxidative metabolism with metformin and 2-deoxyglucose suppresses human CD4+ T cell inflammatory function Ying-Lin Stefanie Tan, Darren Dumlao, Angela Hadjipanayis, Yogeshwar Kelkar, Heng Liu, Mary Piotrowski, Nusrat Sharif, Thomas Wynn, and James Hall |
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82 |
Targeting Tr1 cells to treat disease Marcela Montes de Oca, Fabian de Labastida Rivera, Susanna Ng, Chelsea Edwards, Rachel Kuns, Ping Zhang, Agnieszka Kabat, Ramon Klein Geltink, Jude Uzonna, Edward Pearce, Geoffrey Hill, and Christian Engwerda |
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83 |
Intermittent Fasting (IF) prevents development of Diabetic Retinopathy (DR) by regulating low-grade inflammation through changes in metabolic flexibility Eleni Beli, Leni Moldovan, Yaqian Duan, Sergio Li Calzi, Carmella Evans-Molina, Julia V Busik, and Maria B Grant
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