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19-May |
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Start |
Finish |
Presenter |
Title |
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19:00 |
Conference Registration |
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20:00 |
Welcome Reception and Dinner |
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20-May |
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Start |
Finish |
Presenter |
Title |
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7:30 |
Breakfast |
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8:20 |
8:30 |
Leonidas Platanias |
Introductory remarks |
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(1) Pro-oncogenic mechanisms |
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Chairs: Lopa Mishra & Diana Saleiro |
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8:30 |
8:55 |
Marcus Peter |
Novel tumor promoting roles of CD95/Fas in breast cancer |
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8:55 |
9:20 |
Lopa Mishra |
TGF-beta-ALDH2 axis controls Obesity driven Cancer |
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9:20 |
9:45 |
Phil Howe |
The role of lincRNA Platr18 in TGFbeta-mediated breast cancer progression |
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9:45 |
10:10 |
Tony Tiganis |
PTPs and STATs in Cancer Immunotherapy |
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10:10 |
10:30 |
Julien Marie |
Activation of TGFbeta pathway in tumors |
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10:30 |
11:00 |
Coffee and Posters Viewing |
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(2) Fundamentals and unexpected angles |
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Chairs: Jadwiga Jablonska & Elena Voronov |
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11:00 |
11:25 |
Angel Lopez |
Cytokine receptor Stoichiometry regulates cell signalling and function |
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11:25 |
11:50 |
Thomas Decker |
Structural Rearrangements of Chromatin during Transcriptional Activation of Interferon-Induced Genes |
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11:50 |
12:15 |
Ludmila Prokunina-Olsson |
Exploring shared immune mechanisms in cancer and COVID-19 |
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12:15 |
12:40 |
Gideon Schreiber |
SARS-CoV-2: variant predictions and antiviral drug design are enabled by in vitro evolution |
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12:40 |
13:05 |
Eleanor Fish |
IFNs-α, COVID-19 and cancer |
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13:05 |
13:25 |
Santiago Gonzalez |
IL-1alpha promotes melanoma metastasis in the lymphatic compartment |
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13:25 |
13:45 |
Oleg Demidov |
Effects of PPM1D-driven clonal hematopoiesis on anti-tumor immunity |
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13:45 |
15:00 |
Lunch and Informal Discussions |
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15:00 |
19:30 |
Informal Discussions |
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19:30 |
Dinner and discussions |
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21-May |
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Start |
Finish |
Presenter |
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7:30 |
Breakfast |
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8:20 |
8:30 |
Housekeeping notes |
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(3) Inflammation & Cancer- 1 |
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Chairs: Eleanor Fish & Ana Gamero |
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8:30 |
8:55 |
Sergei Grivennikov |
Cytokines and microbiota in inflammation, cancer progression and metastasis |
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8:55 |
9:20 |
J. Alan Diehl |
Activation of cyclin D1-NF-kB and inactivation of PTEN drives development of endometrial carcinoma |
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9:20 |
9:45 |
Andrew Brooks |
Growth Hormone Receptor (GHR) signalling in melanoma progression and immune evasion. |
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9:45 |
10:10 |
Ana Gamero |
Pro-inflammatory activity of STAT2 in the gastrointestinal tract |
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10:10 |
10:30 |
Sebastian Kollmann |
STAT5A/B in Hematopoietic and Leukemic Stem Cells – Between Death and Immortality |
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10:30 |
11:30 |
Coffee and Poster Viewing |
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(4) Inflammation & Cancer- 2 |
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Chairs: Katherine Borden & Iris Behrman |
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11:30 |
11:55 |
M.Raza Zaidi |
IFN-gamma promotes melanoma progression and metastases |
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11:55 |
12:20 |
Tanja Bulat |
Myeloid STAT1 regulates hematopoiesis in the spleen during infection and inflammation |
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12:20 |
12:55 |
Elena Voronov |
The role of tumor-related and microenvironment IL-1alpha in TNBC progression |
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12:55 |
13:20 |
Iris Behrman |
IL-6 signaling in liver (cancer) cells: involvement of non-coding RNAs |
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13:20 |
13:45 |
Fred Schaper |
Role of SOCS3 and SHP2 for the Robustness and Information Transfer within IL-6 Signalling |
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13:45 |
15:00 |
Lunch and Informal Discussions |
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15:00 |
19:30 |
City Tour and discussions |
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19:30 |
Dinner and discussions |
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22-May |
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Start |
Finish |
Presenter |
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7:30 |
Breakfast |
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8:20 |
8:30 |
Housekeeping notes |
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(5) Tumor microenvironment and immune responses-1 |
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Chairs: Stephanie Watowich & Anna Bielawska |
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8:30 |
8:55 |
Bryan Williams |
Co-opting the innate and adaptive immune system for potent antitumor activity and antiviral immunity |
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8:55 |
9:20 |
Malay Haldar |
IFN generate a distinct subset of activated dendritic cells in the tumor microenvironment |
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9:20 |
9:45 |
Jadwiga Jablonska |
Interferon-deficiency modulates granulopoiesis and neutrophil activity in cancer |
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9:45 |
10:10 |
Andreas Behren |
BTN2A1 is highly expressed on cancer cells and essential for the activation of γδ-T cells |
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10:10 |
10:30 |
Matthias Ernst |
Interleukin-11 as a therapeutic target to control oncogenic Stat3 signaling |
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10:30 |
11:00 |
Coffee and Poster Viewing |
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(6) Tumor microenvironment and immune responses-2 |
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Chairs: Veronika Sexl & Tanja Bulat |
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11:00 |
11:25 |
Serge Fuchs |
Inactivation of the Type I IFN pathway in the intratumoral cytotoxic T lymphocytes |
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11:25 |
11:50 |
Andreas Möller |
The role of cytokines bound to extracellular vesicles in cancer and metastasis |
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11:50 |
12:15 |
Richard Moriggl |
Towards an understanding of the STAT5BN642H driver mutation in blood cancers and how to eliminate it |
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12:15 |
12:40 |
Brendan Jenkins |
The diverse oncogenic impact of STAT3 in cancer |
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12:40 |
13:05 |
Daniel Gough |
STAT3 deletion increases metastatic dissemination of Small Cell Lung Cancer |
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13:05 |
13:25 |
Giovanni Sitia |
Sensing of IFNα by liver sinusoidal endothelial cells shapes a vascular antimetastatic barrier |
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13:25 |
13:45 |
Belinda Parker |
TBA |
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13:45 |
15:30 |
Lunch and Informal Discussions |
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15:30 |
19:30 |
Informal Discussions |
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19:30 |
Dinner and discussions |
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23-May |
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Start |
Finish |
Presenter |
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7:30 |
Breakfast |
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8:20 |
8:30 |
Housekeeping notes |
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(7) Pathogenesis and therapies-1 |
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Chairs: Hua Yu & Natalia Bednarz-Knoll |
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8:30 |
8:55 |
Hallgeir Rui |
Prolactin-humanized NSG mice for improved in vivo modeling of human cancer and tissues |
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8:55 |
9:20 |
Ze'ev Ronai |
Melanoma addiction to GCDH |
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9:20 |
9:45 |
Veronika Sexl |
STAT3 and STAT5 gain-of-function mutations in hematopoietic malignancies |
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9:45 |
10:10 |
Hua Yu |
STAT3: from fundamental discoveries to clinical translation |
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10:10 |
10:30 |
Diana Saleiro |
ULK1 as a novel therapeutic target in melanoma |
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10:30 |
11:00 |
Coffee and Poster Viewing |
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(8) Pathogenesis and therapies-2 |
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Chairs: Bryan Williams & Mila Prokunina-Olsson |
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11:00 |
11:25 |
Sergei Kotenko |
Development of targetable IFN-based anticancer therapeutics |
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11:25 |
11:50 |
Stephanie Watowich |
Mechanisms of immune toxicity in checkpoint blockade therapy |
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11:50 |
12:15 |
Katherine Borden |
Cancer cells hijack RNA processing to transform cell architecture inside and out |
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12:15 |
12:40 |
Leonidas Platanias |
Interferon signaling circuits as targets in the treatment of malignancies |
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12:40 |
13:00 |
Marcin Kortylewski |
Oligonucleotide STAT3 and NF-kB targeting for therapy of leukemia and immunomodulation |
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13:00 |
13:20 |
Katie Owen |
Loss of tumour-intrinsic IFN-I signalling predicts and facilitates bone metastases in advanced prostate cancer |
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13:20 |
13:40 |
George Pavlakis |
Clinical Development of heterodimeric IL-15 for Cancer Immunotherapy |
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13:40 |
13:45 |
Serge Fuchs |
Concluding remarks |
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13:45 |
15:00 |
Lunch and Informal discussions |
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15:00 |
19:30 |
Informal discussions |
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19:30 |
Farewell Dinner |
Leonidas Platanias - Travel awards presentation |
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24-May |
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Start |
Finish |
Presenter |
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7:30 |
Breakfast |
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Departure |
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All remaining abstracts have been accepted for poster presentation |
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