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Sunday, June 2 |
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6:00 PM |
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Conference Registration |
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8:00 PM |
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Welcome Reception and Dinner |
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Monday, June 3 |
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7:30 AM |
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Breakfast |
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8:20 AM |
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Welcome and Opening Remarks
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SESSION I |
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Bolts and Nuts and Beyond Chairs: Belinda Parker and Isabelle Marie
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8:30 AM |
1 |
Interferon epsilon -a novel cytokine in ovarian cancer Zoe Marks, Niamh Mangan, Michelle Tate, Tony Matthews, David Bowtell, Paul Hertzog, and Nollaig Bourke |
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8:50 AM |
2 |
Membrane mechanics and dynamics selectively control JAK/STAT signaling by interferons Christophe Lamaze |
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9:10 AM |
3 |
Positive and negative regulation of interferon production and response Curt Horvath |
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9:30 AM |
4 |
The building blocks and their functional assembly of type I interferon signaling Gideon Schreiber |
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9:50 AM |
5 |
Acetylation vs Phosphorylation in STAT Activation, which one is more critical? Yueh Eugene Chinn |
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10:10 AM |
6 |
A new perspective of interferon signaling Ekaterini Platanitis, Duygu Demiroz, Katrin Fischer, Christophe Capelle, Anja Schneller, Markus Hartl, Thomas Gossenreiter, Mathias Müller, Maria Novatchkova, and Thomas Decker |
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10:30 AM |
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Robustness and information transfer within IL-6-induced JAK/STAT signalling Ulrike Billing, Tomasz Jetka, Lukas Nortmann, Nicole Wundrack, Michal Komorowski, Steffen Waldherr, Fred Schaper, and Anna Dittrich |
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10:45 AM |
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Coffee Break and Poster Viewing |
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SESSION II |
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The vagaries of interferons Chairs: Veronika Sexl and Yulia Nefedova |
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11:20 AM |
8 |
Tumor promoting function of Interferon-γ signaling in triple negative breast cancer Rumela Chakrabarti |
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11:40 AM |
9 |
SIRT2 regulates type I IFN-mediated responses by fine tuning STAT activity and transcription of ISGs Ewa M. Kosciuczuk, Swarna Mehrotra, Diana Saleiro, Athanasios Vasilopoulos, and Leonidas C. Platanias |
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12:00 PM |
10 |
Unconventional activities of interferons in the gastrointestinal tract Sergei Kotenko |
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12:20 PM |
11 |
IFNL4 in human cancers: genetics meets genomics and explains immunology Ludmila Prokunina-Olsson |
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12:40 PM |
12 |
Interferon-gamma: The Rogue One M. Raza Zaidi, Bo Zhou, Xuan Mo, and Sarah Preston |
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SESSION III |
Keynote Talk Chairs: Belinda Parker and Serge Fuchs |
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1:00 PM |
13 |
The IL-1/IL-1R family in carcinogenesis and tumor progression Alberto Mantovani |
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1:45 PM |
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Lunch and Informal Discussions |
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7:30 PM |
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Dinner and Informal Discussions Buses depart from the hotel lobby at 7:30 PM |
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Tuesday, June 4 |
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7:30 AM |
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Breakfast |
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8:20 AM |
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Housekeeping Notes
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SESSION IV |
Oncogenic and tumor suppressive cytokines- 1 Chairs: Eleanore Fish and Nathalie Britzen-Laurent
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8:30 AM |
14 |
Targeting the mitochondrial functions of STAT3 David Levy, Lara Brambilla, and Tanaya Lahiri |
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8:50 AM |
15 |
The role of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1/PCBP1) in EMT/metastasis Philip Howe |
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9:10 AM |
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T.N.T – The AC/DC tune of TYK2 Florian Grebien, Anzhelika Karjalainen, Caroline Lassnig, Sabine Macho-Maschler, Richard Moriggl, Mathias Müller, Stephen Shoebridge, Veronika Sexl, Birgit Strobl, and Katharina Wöss |
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9:30 AM |
17 |
Interferon activated protein ISGylation in cancer Dong-Er Zhang |
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9:50 AM |
18 |
STAT5A and STAT5B in hematopoietic and leukemic stem cells – between death and immortality Sebastian Kollmann, Michaela Prchal-Murphy, Barbara Maurer, Matthias Farlik, Eszter Doma, and Veronika Sexl |
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10:10 AM |
19 |
In vivo imaging of cytokine responses in blood cancers and Immunity Edwin Hawkins |
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10:30 AM |
20 |
The ERBB-STAT3 Axis drives tasmanian devil facial tumor disease Anna Orlova, Lindsay Kosack, Bettina Wingelhofer, Alexandra Popa, Benedikt Agerer, Bojan Vilagos, Peter Majek, Katja Parapatics, Alexander Lercher, Anna Ringler, Johanna Klughammer, Mark Smyth, Kseniya Khamina, Hatoon Baazim, Elvin de Araujo, David Rosa, Jisung Park, Gary Tin, Siawash Ahmar, Patrick Gunning, Christoph Bock, Hannah Siddle, Gregory Woods, Stefan Kubicek, Elizabeth Murchison, Keiryn Bennett, Richard Moriggl, and Andreas Bergthaler |
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10:45 AM |
21 |
Identification of novel interferon signaling targets for the treatment of Myeloproliferative Neoplasms Diana Saleiro and Leonidas Platanias |
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11:00 AM |
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Coffee Break and Poster Viewing |
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SESSION V |
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Oncogenic and tumor suppressive cytokines-2 Chairs: Ellen Pure and Iris Behrman |
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11:30 AM |
22 |
Macrophages, STAT1 and stress-induced extramedullary hematopoiesis Tanja Bulat, Riem Gawish, Mario Biaggio, Caroline Lassnig, Andrea Poelzl, Natalija Simonović, Veronika Sexl, Mathias Müller, and Birgit Strobl |
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11:50 AM |
23 |
Identification of long noncoding RNAs whose expression is regulated by both the UPR and TGF-b J. Alan Diehl |
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12:10 PM |
24 |
An IFN signature: Friend or foe Eleanor Fish |
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12:30 PM |
25 |
NETs promote myeloma cell survival in the bone marrow microenvironment Yulia Nefedova |
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12:50 PM |
26 |
SOCS-dependent regulation of hepatocarcinogenesis Md Gulam Musawwir Khan, Mehdi Yeganeh, Sheela Ramanathan, and Subburaj Ilangumaran |
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SESSION VI |
Keynote Talk Chair: Mathias Müller |
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1:10 PM |
27 |
Microbiota and Cancer Therapy Giorgio Trinchieri |
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1:50 PM |
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Lunch and Informal Discussions |
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7:30 PM |
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Dinner and Informal Discussions Buses depart from the hotel lobby at 7:30 PM |
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Wednesday, June 5 |
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7:30 AM |
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Breakfast |
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8:20 AM |
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Housekeeping Notes |
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SESSION VII |
Tumor microenvironment and immune therapies-1 Chairs: Stephanie Watowich and Rumela Chakrabarti
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8:30 AM |
28 |
TBA Chen Dong |
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8:50 AM |
29 |
Epigenetic regulation of anti-tumor immunity – the tale of two Ubiquitin Ligases Ze’ev Ronai |
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9:10 AM |
30 |
The interplay between ubiquitylation and glycosylation orchestrates immune checkpoint function and cytokine signaling Xinxin Song, Zhuan Zhou, Ziyi Fu, Ivet Bahar, Jeffery Brodsky, Leonidas Platanias, and Yong Wan |
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9:30 AM |
31 |
Myeloid-derived suppressor cells in cancer: targeting opportunities Dmitry Gabrilovich |
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9:50 AM |
32 |
Characterizing and targeting non-genetic vulnerabilities of acute leukemia biology Panagiotis Ntziachristos |
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10:10 AM |
33 |
Microenvironmental drivers of inflammation and tumorigenesis Maria Sibilia |
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10:30 AM |
34 |
USP12 promotes type-I interferon-induced inhibition of melanoma cancer growth Jin Liu, Yukang Yuan, Yibo Zuo, Ying Miao, Tingting Guo, Liting Zhang, and Hui Zheng |
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10:45 AM |
35 |
Modulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3 Florence Servais, Mélanie Kirchmeyer, Matthias Hamdorf, Nadège Minoungou, Stefan Rose-John, Stephanie Kreis, Claude Haan, and Iris Behrmann |
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11:00 AM |
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Coffee Break and Poster Viewing |
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SESSION VIII |
Tumor microenvironment and immune therapies-2 Chairs: Dong-Er Zhang and Diana Saleiro
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11:50 AM |
36 |
STAT3 anti-inflammatory activity in dendritic cells modulates immune-mediated adverse events during CTLA-4 blockade Yifan Zhou, Yusra Medik, Rachel Babcock, Taylor Chrisikos, Bhakti Patel, Kathryn Newton, Laura Serrudo, Xianxiu Wan, Haiyan Li, and Stephanie S Watowich |
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12:10 PM |
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Targeting myeloid cell inflammation to improve cancer therapy Ashleigh Poh and Matthias Ernst |
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12:30 PM |
38 |
A small molecule SUMOylation inhibitor activates both innate and adaptive anti-tumor immune responses and supports immune therapies Eric Lightcap, Pengfei Yu, Steve Grossman, Keli Song, Kristina Xega, Xingyue He, Pooja Shah, Erik Koenig, Akito Nakamura, Steve Langston, Mithun Khattar, Hisashi Imaichi, Hongru Zhang, Zhen Lu, Gary Shapiro, Sai Pulukuri, Serge Fuchs, and Dennis Huszar |
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12:45 PM |
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Concomitant Type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production Yuanyuan Tong, Luyang Zhou, Limin Yang, Panpan Guo, F. Xiao-Feng Qin, and Jianghuai Liu |
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1:00 PM |
40 |
bile acid receptor TGR5 in cancer Yan-Dong Wang and Wei-Dong Chen |
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1:15 PM |
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Lunch and Informal Discussions |
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3:30 PM |
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City Tour Buses depart from hotel lobby at 3:30 PM |
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7:30 PM |
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Dinner and Informal Discussions Please note that buses do not pick-up at the hotel prior to dinner. Dinner proceeds right after the tour |
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Thursday, June 6 |
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7:30 AM |
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Breakfast |
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8:20 AM |
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Housekeeping Notes |
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SESSION IX |
Cytokines and metastatic disease-1 Chairs: Birgit Strobl and Sabine Werner |
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8:30 AM |
41 |
Stroma-dependent regulation of primary tumors and metastasis Ellen Puré |
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8:50 AM |
42 |
Mesenchymal causalities in tissue homeostasis, inflammation and cancer George Kollias |
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9:10 AM |
43 |
Activin promotes epithelial carcinogenesis through fibroblast reprogramming Michael Cangkrama and Sabine Werner |
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9:30 AM |
44 |
PTPN2 deletion in T cells promotes anti-tumour immunity Tony Tiganis |
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9:50 AM |
45 |
STAT2 comes out of the shadows to promote colorectal cancer Ana Gamero, Kevin Kotredes, Tess Cremers, John Swain, Lauren Womer, Kamyar Esmaeili, and Bojana Gligorijevic |
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10:10 AM |
46 |
Tumour microenvironmental cytokines direct metastatic dissemination of breast cancer Andreas Möller |
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10:30 AM |
47 |
TLR Agonists, ATF3 and cancer therapy Bryan Williams |
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10:50 AM |
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Coffee Break and Poster Viewing |
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SESSION X |
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Cytokines and metastatic disease-2 Chairs: Ana Gamero and Mila Prokunina-Olsson
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11:30 AM |
48 |
Lymph node homing of immune cells and metastasizing tumor cells arriving via afferent lymphatics Reinhold Förster |
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11:50 AM |
49 |
IFNs as key players in cancer dormancy and bone metastasis Katie Owen, Jamie Gearing, Damien Zanker, Paul Hertzog, Chris Hovens, Peter Croucher, and Belinda Parker |
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12:10 PM |
50 |
TBA Leonidas Platanias |
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12:30 PM |
51 |
Type I interferons protect normal cells from reprogramming by tumor-derived extracellular vesicles Serge Fuchs |
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12:50 PM |
52 |
Type I Interferon mediated regulation of liver colorectal cancer metastatic spreading Ngoc Lan Tran, Valentina Buttiglione, Lorena MariaFerreira, Andrea Monestiroli, Claudio Fagioli, Antonello Spinelli, Paolo Marra, Luca Guidotti, and Giovanni Sitia |
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1:05 PM |
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Concluding Remarks |
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1:15 PM |
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Lunch and Informal Discussions |
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8:00 PM |
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Farewell Dinner |
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Friday, June 7 |
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7:30 AM |
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Breakfast |
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Departure |
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POSTERS |
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Response towards IL-6 trans- and IL-6 classic signalling is determined by the ratio of IL-6 receptor α to gp130 expression Heike Reeh, Nadine Rudolph, Ulrike Billing, Heinrich Huber, Rolf Findeisen, Fred Schaper, and Anna Dittrich |
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Stat5a and Stat5b – more than identical twins for leukemia progression Veronika Sexl, Barbara Maurer, Sebastian Kollmann, Klara Klein, Michaela Prchal-Murphy, Andrea Hölbl-Kovacic, and Richard Moriggl |
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55 |
The pro-inflammatory cytokine OSM contributes to breast cancer progression by activating OSMR in both the cancer and the stromal compartment Angela Araujo, Andrea Abaurrea, Ricardo Rezola, Paloma Bragado, Arkaitz Carracedo, Fernando Calvo, Nicholas Coleman, Clare Isacke, Charles Lawrie, and Maria Caffarel |
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56 |
Aberrant glycosylation of the interferon gamma receptor alpha chain inhibits the response to IFN-gamma in colorectal carcinoma cells Julia Straube, Hai Yang, Elisabeth Naschberger, Christian Pilarsky, Michael Stürzl, and Nathalie Britzen-Laurent |
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57 |
Loss of IFN-gamma pathway gene expression in tumor cells as mechanism of immune escape of colorectal carcinoma. Nathalie Britzen-Laurent, Julia Straube, Philipp Tripal, Jan Christoph, Maximilian Waldner, Christoph Becker, Elisabeth Naschberger, Roland Croner, Sergey Grivennikov, Susanne Merkel, and Michael Stürzl |
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58 |
Understanding the role of Interleukin-11 in chemotherapy resistance Suad Abdirahman, Riley Metcalfe, Adele Preaudet, Lotta Burstroem, Paul Nguyen, Oliver Sieber, Michael Griffin, and Tracy Putoczki |
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59 |
Epigenomics and Single-cell Sequencing Define a Jak-Stat Dependent Developmental Hierarchy in Langerhans Cell Histiocytosis Matthias Farlik, Florian Halbritter, Christoph Bock, and Caroline Hutter |
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60 |
Generation of immortal murine hematopoietic stem/progenitor cell lines from transgenic mice to study the JAK-STAT Pathway Tania Brandstoetter, Eszter Doma, Isabella Mayer, Barbara Maurer, and Veronika Sexl |
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61 |
High levels of plasma interleukin-17A is associated to neurodegenerative Langerhans cell histiocytosis complications Alexandre Belot, Mohamad Bachar ISMAIL, Selma Olsson Åkefeldt, Magda Lourda, Désirée Gavhed, Maurizio Aricò, Jan-Inge Henter, Christine Delprat, and Hélène Valentin |
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62 |
Pro-tumourigenic role of AIM2 innate immune DNA sensor in gastric cancer. Virginie Deswaerte and Brendan Jenkins |
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63 |
Suppressive role for STAT1 in inflammation and hematopoiesis Isabelle Marié, Lara Brambilla, and David Levy |
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64 |
PTPN2 deletion in T cells promotes anti-tumour immunity Tony Tiganis |
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65 |
Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling Magdalena Banach-Orłowska, Renata Wyszyńska, Małgorzata Maksymowicz, and Marta Miączyńska |
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66 |
An Interferon Gamma-response gene signature associates with T-cell activation in Invasive Breast Cancer Daniel Harari, Ron Rotkopf, and Gideon Schreiber |
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67 |
Immune modulation and therapeutic synergy of the chimeric, oncolytic virus VSV-GP with immuno therapies Philipp Mueller |
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68 |
IL-2 induces expression of PD-1 and Tim-3 in the ex vivo expanded CD8+ T cells without affecting their ex vivo stimulation with respective antigens Pavla Taborska, Hana Svobodova, Dmitry Stakheev, Zuzana Strizova, Michal Podrazil, Jirina Bartunkova, and Daniel Smrz |