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33 |
Combining RAS and TEAD inhibitors eliminates cholangiocarcinomaEleni C Kesikiadou, Weronika Kowalczyk, Leticia Sansores-Garcia, Hanne Hillen, Leen van Huffel, and Georg Halder
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34 |
Epigenetic rewiring of hepatocytes by Eed loss changes hepatocyte identity, liver damage, and fibrosisJames Griffin1, Yousra Ajouaou1, Sade Chaffatt2, and Kirsten C Sadler1
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35 |
Spatiotemporal Quantification of Disease Biomarkers in the MASLD Spectrum Using Longitudinal Micro-CT Imaging Rallia-Iliana Velliou, Aigli-Ioanna Legaki, Aikaterini Avdi , Martha-Eliza Papadopoulou, Stamatina Gkika, Athanasios Tsiatouras, Eirini Giannousi, Grigorios Papadopoulos, Polyxeni Nikolakopoulou, and Antonios Chatzigeorgiou
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Adipocyte-specific LUBAC deficiency promotes sex-dependent MASLD via adipose tissue-liver crosstalkXimena Hildebrandt
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37 |
Transcriptomic signatures of rodent liver aging reveal increased infiltration of specific subsets of immune cellsRomain Donne1, Tea Shavlakadze1, Kun Xiong2, Corissa McEwen1, Abhilash Gadi1, Matthew Wakai1, Hunter Salmon1, Jacob Treinish3, Elias Pavlopoulos2, Shuo Li4, Nicole Nigron4, Min Ni4, Yi Wei2, Yu Bai2, and David J. Glass1
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38 |
Replication Stress Stratifies HCC Aggressiveness and Predicts ATR Inhibitor SensitivityJing Fang1, Qiyuan He1, Long Pan3, Joana Araujo1, Maelle Cadiou1, Romain Donne2, Isabelle Galy-Fauroux1, Irene Portoles-Plaza1, Amaia Lujambio2, Jessica Zucman-Rosssi3, Jean-Pierre Couty1, Sandra Rebouissou3, Séverine Celton-Morizur1, and Chantal Desdouets1
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39 |
Linear ubiquitination protects from liver disease in response to obesity Armel Hyoubi1, Ximena Hildebrandt2,3, Önay Veli2,3, Ali Abdallah2, Julian Rodefeld3,4, Liane Gardeweg2,3, Anne Hoffman4, Matthias Blüher5,4, Philip Antczak2,3,6, and Nieves Peltzer1,2,3
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40 |
vascular control of MASH progression Michele D'Antonio1, Monica Giannotta1, Elisa Bono2, Pietro Delfino2, Leonardo Giustini2, Chiara Laura2, Micol Ravà2, Chiara Perucchini1,2, Matteo Iannacone2,3, and Donato Inverso1,3
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41 |
The role of the liver microenvironment in Ras driven tumorigenesisElena Zoppolato, Hasse Mol, Ana Alguero Nadal, Weronika Kowalczyk, Ivan Moya, and Georg Halder
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42 |
Protective role of COX-2 expression in hepatocytes during obstructive cholestasis and intrahepatic cholestasis of pregnancyMarina Fuertes-Agudo1,2, Rocio Brea3, Maria Luque-Tevar1,2, Carme Cucarella1,2, María Celeste Capitani4, Alexia Grass4, Matías Ezequiel Fusini5, Agustín Lahoz6, Marina López Nogueroles6, María Teresa Ronco44, Águeda González-Rodríguez3,8, Lisardo Boscá3,7, Daniel E Francés4, and Marta Casado1,2
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Lactococcus lactis subspecies cremoris, mitigates metabolic disease and induces hepatoprotection by driving changes in the metabolome between the gut and liver.Camilo Anthony G Gacasan1, Jaclyn Weinberg2, Crystal Naudin1, Stefi Barbian1, Dean Jones2, and Rheinallt Jones1
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Charting single-cell metabolism co-evolution during liver metastasisYingcheng Wu and Qiang Gao
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45 |
Genomic insights into FGF21-mediated therapeutic effects in MASLD from 396 patient liver biopsiesJürgen Borlak and Shifang Tang
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The Mevalonate Pathway Orchestrates CoQ10 and Selenoprotein Translation to Promote Ferroptosis Resistance and Tumor Progression in HCCYijing Chen1,2,3, Derek Lee1,2,3, Kenneth Kin Leung Kwan1,2,3, Mengjie Wu1,2, Gengchao Wang1,2, Misty Shuo Zhang1,2,3, Haijing Deng1,2, Jacinth Wing Sum Cheu1,2,3, Mandy Ho Ying Lau1,2,3, Cerise Yuen Ki Chan1,2,3, Zher Yee Ooi1,2, Yibing Wu1,2, Macus Hao Ran Bao1,2,3, Regina Cheuk-Lam Lo1,2, Irene Oi-Lin Ng1,2, Chun-Ming Wong1,2, and Carmen Chak Lui Wong1,2,3,4,5
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Loss of BRCA2 Sensitizes Hepatocellular Carcinoma to PARP Inhibition with OlaparibSalah Adlat, Chunmiao Cao, Dingzi Yin, Markcus A Lee, and Kirk J Wangensteen
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48 |
Embryonic Liver Innervation Regulates Glucose Metabolism and Contributes to Alagille Syndrome DefectsElisabeth Verboven1, Noémi Van Hul1, Csaba Adori3, Luke Adam Noon4, Jingyan He1, Marcel Maximilian Reichow1, Simona Hankeova1, Saskia Van Vliet1, Bettina Semsch1, Ewa Ellis2, Björn Fischler2, and Emma Rachel Andersson1
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NEURL1B is required for mitotic spindle organization during liver regeneration and tumorigenesisDingzi Yin, Alexandra M Vazquez Salgado, Markcus A Lee, and Kirk J Wangensteen
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50 |
Identification of Serum Amyloid A-expressing hepatocyte populations as new acute inflammatory driver in alcohol-associated hepatitisAlicia Martínez-Álvarez1, Aina Rill3, Jordi Gratacós-Ginès5, Laia Aguilar-Corominas1,2, Queralt Herms5, Javier Vicente-Mora1, Àlex Guillamón-Thiery1, Raquel Ferrer-Lorente4, Silvia Ariño4, Celia Martínez-Sánchez1, Xènia Almodòvar1, Martina Pérez-Guasch5, Ana Belén Rubio1, Pau Sancho-Bru4, Ramón Bataller5, Pere Ginès5, Mar Coll1,2, and Elisa Pose5
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51 |
Understanding mechanisms of biliary fibrosis using periportal liver assembloidsArmin Niksic1, Aleksandra Sljukic1, Anna Dowbaj1, Haochen Yang2, Matthias Artzt2, Cedric Lars Florian Landerer3, Fabian Rost1, Javier Bregante1, Heather Harrington2, Marino Zerial1, and Meritxell Huch 1
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52 |
Regulation of essential hepatocyte functions and identity by super-enhancers in health and diseaseTao Lin1, Chenjun Huang1, Chenhao Tong1, Wentao Xu2, Roman Liebe3, Matthias Ebert4,5,6, Steven Dooley1, and Honglei Weng1
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53 |
TGF-β serves as a critical signaling determinant of liver progenitor cell fate and functionChenhao Tong1,2, Tao Lin1, Han Wang3, Seddik Hammad1, Matthias P Ebert4,5,6, Huiguo Ding7, Steven Dooley1, and Hong-Lei Weng1
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54 |
ECM1 as Tumor Suppressor in Hepatocellular Carcinoma through Inhibition of the Integrin-FAK-YAP axisSai Wang, Ye Yao, Chenhao Tong, Vincent Rieger, Huihui Zou, Honglei Weng, Matthias P. A. Ebert, and Steven Dooley
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55 |
A Digital Twin Model Reveals Mechanisms of Liver Fibrosis PatterningSeddik Hammad1, Jieling Zhao2, Dirk Drasdo2, and Steven Dooley1
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56 |
PhenoForge: Phenotype-driven forging of optimized small molecule-based compounds to target mitosis in cancerAthina Anastasia Moschopoulou1,2, Melanie Henning1,2, Yuliia Skliarenko1,2, Benedikt Wagner3,4, Dirk Floetgen3,4, Juliander Reiner3,4, Elke Rist1,2, Stefan Zwirner1, Omelyan Trompak1,2, Svenja Schuette1,2, Oliver HIhn2,8, Simone Blaess8, Clemens Hinterleitner1,2, Marco Seehawer1,2, Dominik Sonanini1,2,7,8, Luana D'Artista1,2, Tatu Pantsar5, Thales Kronenberger3, Mohamed Ali Jarboui11, Thomas Muerdter9, Bettina Weigelin2,8, Matthias Schwab2,9,10, Antti Poso5, Karsten Boldt11, Michael Forster3,4, Wolfgang Albrecht1,3,6, Stefan Laufer3,4, and Lars Zender1,2,7
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57 |
Spatial-temporal analysis of human-correlated genetically engineered mouse models reveals extensive heterogeneity of hepatocellular carcinoma that is associated with genetic drivers and exacerbated by a high fat dietFiona Chalmers1, Stephanie May1, Anastasia Georgakopoulou1, George Skalka1, Megan Quince1, Danis Thomas1, Kyi Lai Yin Swe1, Toshiyasu Suzuki1, Colin Nixon1, Clara Mullen1, Ciara Curran1, Sara Gohar1, Miryam Müller1, Ramanuj DasGupta1, and Thomas G Bird1,
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58 |
Therapeutic targeting of cancer associated fibroblasts may allow for microenvironmental remodelling of immunotherapy resistant hepatocellular carcinoma Jack Dishington, Erik Ramon-Gil, and Jack Leslie
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59 |
MASH selects against antigenic Hepatocellular carcinomaAnthony Lozano and Amaia Lujambio
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60 |
Pharmaceutical Development and Individual Case Studies for Skepinone-L, a Highly Potent and Selective p38a Inhibitor for the treatment of Advanced Hepatocellular CarcinomaMichael Forster1,2, Stefan Laufer2, Wolfgang Albrecht3, Ulrich Lauer1,3, Daniel Dauch3, Ramona Rudalska3, and Lars Zender1,3
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Deep Learning–Driven HCC Morphologic Index from H&E Predicts Survival and Reveals Distinct Clinical and Molecular PhenotypesTyler M Yasaka1,2,3,4,5, Po-Yuan Chen5, Satdarshan P Monga1,2,4,5,6, and Yu-Chiao Chiu4,5,6
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Hepatic impairment studies for drugs with known hepatobiliary excretion - considerations for dose selection Galina Bernstein
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Ectopic Wnt/β-Catenin Signaling Drives Cyclin-D1 Expression During Early Liver RegenerationTyler M Yasaka1,2,3,4, Brandon M Lehrich1,2,3,4, Silvia Liu1,2,4, and Satdarshan P Monga1,2,4,5
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64 |
The Mevalonate Pathway Orchestrates CoQ10 and Selenoprotein Translation to Promote Ferroptosis Resistance and Tumor Progression in HCCYILING CHEN, Derek Lee, Kenneth Kin Leung Kwan , Mengjie Wu, Gengchao Wang, Misty Shuo Zhang, Haijing Deng , Jacinth Wing Sum Cheu, Mandy Ho Ying Lau, Cerise Yuen Ki Chan, Zher Yee Ooi, Yibing Wu, Macus Hao Ran Bao, Regina Cheuk-Lam LO , Irene Oi-Lin Ng , Chun-Ming Wong , and Carmen Chak-Lui Wong
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