Aegean Conferences

2nd International Conference of Liver Pathobiology: From Bench to Bedside

Program

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General Information

No details.

Monday, October 06

06:30 PM - 07:30 PM

Conference Registration

07:30 PM - 10:00 PM

Welcome Reception and Dinner

Tuesday, October 07

08:00 AM - 08:50 AM

Breakfast

08:50 AM - 09:00 AM

Welcome and Opening Remarks - Robert Schwabe

Novel approaches to model and dissect liver disease

Chairs: Keren Bahar Halpern and Kirsten Sadler Edepli

09:00 AM - 09:30 AM

TBA - Neil Henderson
Neil Henderson

09:30 AM - 10:00 AM

TBA - Takenori Takebe
Takenori Takebe

10:00 AM - 10:30 AM

A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liver
Keren Bahar Halpern, Oran Yakubovsky, and Shalev Itzkovitz

10:30 AM - 11:00 AM

Epigenetic Disordering by UHRF1 overexpression Drives Stemness and Senescence Escape in HCC
Elena Magnani¹, Filippo Macchi¹, Tijana Randic¹, and Kirsten C. Sadler^1,²

11:00 AM - 11:45 AM

Coffee Break and Poster Viewing (Odd Numbers)

Novel approaches to model and dissect liver disease

Chairs: Keren Bahar Halpern and Kirsten Sadler Edepli

11:45 AM - 12:15 PM

TBA - Fotios Sampaziotis
Fotios Sampaziotis

12:15 PM - 12:30 PM

Identifying hepatocellular carcinoma immunotherapy targets using population-level clinical data
Kelly Wong and Hao Zhu

12:30 PM - 12:45 PM

Combined stem cell and predictive models reveal flavin cofactors as targets in metabolic liver dysfunction
Julian Weihs and Milad Rezvani

12:45 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:00 PM

Informal Discussions

07:30 PM - 11:00 PM

Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Wednesday, October 08

08:00 AM - 09:00 AM

Breakfast

Cell-cell communication and tissue biology in the liver

Chairs: Valerie Chew and Jan Tchorz

09:00 AM - 09:30 AM

TBA - Georg Halder
Georg Halder

09:30 AM - 10:00 AM

Dynamic cell heterogeneity in homeostasis and chronic liver disease
Jan S Tchorz

10:00 AM - 10:30 AM

Building Architecture and Complexity in Tissue-Derived Liver Organoids
Anna M. Dowbaj, Aleksandra Sljukic, Armin Niksic, and Meritxell Huch

10:30 AM - 11:00 AM

The ontogeny and therapeutic targeting of immunosuppressive neutrophils in hepatocellular carcinoma.
Derek Mann and Erik Ramon Gil

11:00 AM - 11:45 AM

Coffee Break and Poster Viewing (Even Numbers)

Cell-cell communication and tissue biology in the liver

Chairs: Valerie Chew and Jan Tchorz

11:45 AM - 12:15 PM

TBA - Robert Schwartz
Robert Schwartz

12:15 PM - 12:45 PM

The role of transport in metabolism and liver disease – what goes in must go out
Rebecca Haeusler

12:45 PM - 01:00 PM

Platelets hijack neutrophils for pro-tumour polarisation in MASH-HCC
Erik Ramon Gil, Daniel Geh, Derek A Mann, and Jack Leslie

01:00 PM - 01:15 PM

Applying machine learning to identify modulators of immune cell function for targeted therapy in hepatocellular carcinoma
Nurul Jannah M Nasir², John F Ouyang¹, Owen J. L. Rackham¹, and Valerie Chew²

01:15 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:00 PM

Informal Discussions

07:30 PM - 11:00 PM

Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Thursday, October 09

08:00 AM - 09:00 AM

Breakfast

Metabolic liver disease

Chairs: Rebecca Haeusler and Yasuko Iwakiri

09:00 AM - 09:30 AM

DeLIVERing in vivo CRISPR screens to study hepatic cell-cell interactions
Martin Guilliams and Aimée Bugler-Lamb

09:30 AM - 10:00 AM

Control of Obesity and Inflammation Driven Liver Cancer by the Dr. Jekyll and Mr Hyde Site-specific Actions of NRF2
Michael Karin

10:00 AM - 10:30 AM

TBA - Viraj Sanghvi
Viraj Sanghvi

10:30 AM - 11:45 AM

Coffee Break and Poster Viewing (Odd Numbers)

Metabolic liver disease

Chairs: Rebecca Haeusler and Yasuko Iwakiri

11:45 AM - 12:15 PM

The hepatic lymphatic system in cholestatic liver disease: Mechanisms and therapeutic potential
Yasuko Iwakiri

12:15 PM - 12:45 PM

In utero next-generation single-cell lineage tracing reveals hepatic mesenchymal cell lineages
Emma R Andersson¹, Jingyan He¹, Agustin Corbat¹, Sergey Isaev², Sandra de Haan¹, Lenka Belicova¹, Jia Sun¹, Johan Lorentz¹, Robert Tonoian¹, Noemi Van Hul¹, Jonas Frisén¹, Michael Ratz¹, Igor Adameyko^2,³, Enikö Lazar⁴, Joakim Lundeberg⁴, and Raphael Mauron⁴

12:45 PM - 01:00 PM

Perivascular macrophages increase in adipose tissue during metabolic dysfunction-associated fatty liver disease and contribute to local angiogenesis
Laia Aguilar-Corominas^1,², Celia Martínez-Sánchez², Javier Vicente-Mora^1,², Alicia Martínez-Álvarez², Hilmar Berger³, Xènia Almodovar², Alicia Jurado⁴, Yiliam Fundora⁵, Ainitze Ibarzábal⁵, Ana De Hollanda⁵, Josep Vidal⁵, Anna Soria⁵, Isaac Almendros⁴, Pau Sancho-Bru², Frank Tacke³, Pere Ginès^1,^2,⁵, Isabel Graupera^2,⁵, and Mar Coll^1,²

01:00 PM - 01:15 PM

Linear ubiquitination prevents MASLD by preserving adipose tissue integrity during obesity
Nieves Peltzer^1,², Ximena Hildebrandt², Hyoubi Armel¹, Julia Zinngrebe⁴, Julian Rodefeld², Anne Hoffmann³, Philipp Antczak², Matthias Blueher³, and Pamela Fischer-Posovszky⁴

01:15 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 08:00 PM

Archaeological Tour of Knossos and the Museum (Buses Depart Hotel Lobby)

08:00 PM - 11:00 PM

Dinner and Informal Discussions (Buses do not return to the hotel prior to dinner)

Friday, October 10

08:00 AM - 09:00 AM

Breakfast

Hepatic carcinogenesis and novel therapeutic strategies

Chairs: Jessica Zucman-Rossi and Carmen Wong

09:00 AM - 09:30 AM

TBA - Scott Lowe
Scott Lowe

09:30 AM - 10:00 AM

A Decision Point between cell death and transdifferentiation in carcinogenesis
Tomdde, Luedde

10:00 AM - 10:30 AM

TBA - Lars Zender
Lars Zender

10:30 AM - 11:00 AM

TBA - Valerie Chew
Valerie Chew

11:00 AM - 11:45 AM

Coffee Break and Poster Viewing (Even Numbers)

Hepatic carcinogenesis and novel therapeutic strategies

Chairs: Jessica Zucman-Rossi and Carmen Wong

11:45 AM - 12:15 PM

Targeting tumor-stroma crosstalk in cholangiocarcinoma
Robert Schwabe

12:15 PM - 12:45 PM

TBA - Mathias Heikenwälder
Mathias Heikenwälder

12:45 PM - 01:15 PM

TBA - Jessica Zucman-Rossi
Jessica Zucman-Rossi

01:15 PM - 01:45 PM

The Gut Microbiome Controls Liver Tumors via the Vagus Nerve
Tim Greten

01:45 PM - 02:00 PM

Prognostic and Mechanistic Role of the cGAS-STING Pathway in Hepatocellular Carcinoma Pathogenesis
Maëlle Cadiou¹, Irene Portoles-Plaza², Jing Fang², Long Pan², Joana Araujo², Solenne Marmier², Isabelle Galy-Fauroux², Jean-Pierre Couty², Jessica Zucman-Rossi², Séverine Celton-Morizur², and Chantal Desdouets²

02:00 PM - 02:15 PM

Multiomic analyses demonstrate hepatocyte SOX9 loss exacerbates fibrosis and HCC development in the DEN-CCl4 mouse model
Elliot Jokl¹, Syed Murtuza Baker¹, Sokratia Georgaka¹, Kara Simpson¹, Rosa Sanchez Alvarez¹, Nigel Hammond¹, Chris Mysko^1,², Varinder Athwal^1,², Richard Hubner^1,³, and Karen Piper Hanley¹

02:15 PM - 02:20 PM

Closing Remarks

02:15 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:00 PM

Informal Discussions

07:30 PM - 11:00 PM

Farewell Dinner

Saturday, October 11

08:00 AM - 10:00 AM

Breakfast

10:00 AM - 12:00 PM

Departure