7th International Conference on Autoimmunity: Mechanisms and Novel Treatments

Preliminary Program

Tuesday, September 29

 

 

 

6:00 PM

 

Conference Registration

 

 

 

8:00 PM

 

Welcome Reception/Dinner

 

 

 

Wednesday, September 30

7:30 AM

 

Breakfast

 

 

 

9:00 AM

 

Welcome and Opening Remarks

 

 

 

Session I

 

Tolerance I

Chairs: Steve Miller, Steve Levin

9:05 AM

1

Protein modifications in the etiology of autoimmune disease

Mark Mamula, Mei-Ling Yang, Kevan Herold and Li Wen

9:35 AM

2

Mechanistic study of ODS: an immunomodulatory drug with proven human efficacy

Steven D Levin, Le Son Tran, David T Crowe, Kyle A Serikawa, Garry L Redlich, Donald C Foster, and Ian S Frazer

10:05 AM

3

MARCO-targeting carboxylated PLG nanoparticles promote therapeutic tolerance induction and suppression of inflammatory monocytes

Stephen Miller, Zoe Hunter, Derrick McCarthy, Christopher Harp, Rachael Terry, Suchitra Prasad, Woon-Teck Yap, Nichoas King, Lonnie Shea and Daniel Getts

10:35 AM

4

TBA

Francesco Quintana

11:05 AM

5

Proteolysis-induced defects in B7-H4-mediated negative co-stimulation: the roadmap for the development of Novel biomarker and perspective treatments of Type 1 diabetes-associated autoimmunity

Alexei Savinov, Ilian Radichev, Christina Amatya and Maryam Salehi

 

 

 

11:20 AM

 

Coffee Break & Poster Viewing

 

 

 

Session II

 

Inflammation I

 

 

Chairs: Hilde Cheroutre, Vassili Soumelis

12:00 PM

6

Thymic stromal lymphopoietin in human allergy and autoimmunity: physiopathological links and underlying mechanisms

Vassili Soumelis

12:30 PM

7

Immune tolerance at the Mucosal front line: AT cell's perspective

Magdalena Baudewijn, Sofia Mayans, Florence Lambolez, Mohammed Husain, Yujun Huang, Ichiro Taniuchi and Hilde Cheroutre

1:00 PM

8

Local perturbation of lymph nodes alters the extent and specificity of systemic tolerance

Lisa Tostanoski, Yu-Chieh Chiu, Joshua Gammon, Thomas Simon, Jonathan Bromberg and Christopher Jewell

1:15 PM

9

Type 1 interferon biology in human and mouse Type 1 Diabetes

Sindhu Avrizhagen, Benjamin Looney, Sally Yuan, Clayton Mathews, Chang Quing Xia and Michael Clare-Salzler

 

 

 

1:30 PM

 

Lunch/Informal Discussions

 

 

 

7:30 PM

 

Dinner/Informal Discussions at a local Greek Restaurant

 

 

 

Thursday, October 1

 

 

 

7:30 AM

 

Breakfast

 

 

 

Session III

 

Myeloid Cells

Chairs: Burkhard Becher, Rick Maizels

9:00 AM

10

Targeting Microglia Using the Transcription Factor Sall1

Melanie Greter, Iva Lelios, Xueyang Yu, Burkhard Becher, Ruichi Nishinakamura, and Anne Buttgereit

9:30 AM

11

Type 2 immunity to Helminth Parasites: Regulation, regulators and effectors

Rick M Maizels, Kara J. Filbey, Yvonne Harcus, Christopher J C Johnston, Danielle J Smyth, James P Hewitson, Katherine A Smith and Henry J McSorley

10:00 AM

12

GM-CSF in autoimmunity and immunopathology

Burkhard Becher, Andrew Croxford, Sabine Spath, Margit Lanzinger, Sonia Tugues, and Ana Amorin

10:30 AM

13

GM-CSF driven expansion of myeloid cells elicits CNS inflammation and neurological deficits

Sabine Spath, Bettina Schreiner, Juliana Komuczki, Pawel Pelczar and Burkhard Becher

 

 

 

11:00 AM

 

Coffee Break & Poster Viewing

 

 

 

Session IV

 

Tolerance II

Chairs: Lucy Walker, Dan Campbell

11:30 AM

14

Control of CD8+ T cell responses by the signaling adaptor BCAP

Daniel J Campbell

12:00 PM

15

Generation and maintenance of peripheral regulatory T cells

Abul Abbas, Iris Gratz and Michael Rosenblum

12:30 PM

16

Coordinated regulation of T and B cells responses by the CTLA-4 pathway

Lucy SK Walker

1:00 PM

17

Working with pharma to transform your discoveries into medicines

Jennifer Bell

 

 

 

1:15 PM

 

Lunch/Informal Discussions

 

 

 

7:30 PM

 

Dinner/Informal Discussions at a local Greek Restaurant

 

 

 

Friday, October 2

 

 

 

7:30 AM

 

Breakfast

 

 

 

Session V

 

Tolerance III

Chairs: Steven Ziegler, Sergio Lira

9:00 AM

18

TBA

Steven Ziegler

9:30 AM

19

Understanding the impact of flux through the cholesterol biosynthesis pathway in host defense

Steven J Bensinger

10:00 AM

20

A relapsing-remmiting model of  inflammatory bowel disease

Sergio A Lira

10:30 AM

21

Cellular sources of IL-6 in CNS autoimmunity

Thomas Korn

 

 

 

11:00 AM

 

Coffee Break and Poster Session

 

 

 

Session VI

 

 

1:00 PM

22

Publishing in Nature Immunology – an editorial perspective

Ioana Visan

 

 

 

1:30 PM

 

Lunch and Informal Discussions

 

 

 

3:30 PM

 

City Tour

 

 

 

7:30 PM

 

Dinner and Informal Discussion

 

 

 

Saturday, October 3

 

 

 

7:30 AM

 

Breakfast

 

 

 

Session VII

 

Inflammation II

Chairs: Mitch Kronenberg, Ari Waisman

9:00 AM

23

Pathogenic Th2 (Tpath2) cells in airway inflammation

Toshinori Nakayama, Yusuke Endo, Kenta Shinoda and Kiyoshi Hirahara

9:30 AM

24

Genetic programming of functional subsets of innate-like NKT cells in the thymus

Mitchell Kronenberg

10:00 AM

25

The role of IL-17 in CNS diseases

Tommy Regen, Nir Yogev, Ilgiz Mufazalov, Judith Hauptmann and Ari Waisman

10:30 AM

26

Natural CD4+CD25+T regulatory cells (nTreg) cultured with antigen and Th2 cytokines, suppress induction of EAE

Suzanne Hodgkinson, Giang Tran, Catherine Robinson, Paul Wilcox, Rachael Hall and Bruce Hall

10:45 AM

27

Semaphorin 3a/PlexinA4/Neuropilin-1 form a functional B7-H4 receptor complex

Joseph Podojil, Ming-Yi Chiang, William Burke, David Liebenson, Roumen Balabanov, Dario Vignali and Stephen Miller

 

 

 

11:00 AM

 

Coffee Break & Poster Viewing

 

 

 

Session VIII

 

Therapy

Chairs: Frank Nestle, Sergio Quezada

11:30 AM

28

TBA

Frank Nestle

12:00 PM

29

Immune Regulation at the Tumour Site

Sergio A. Quezada

12:30 PM

30

Disentangling the roles of IL-2 in immune activation and immune suppression

Jason Fontenot

1:00 PM

 

 

 

 

1:15 PM

31

Towards the clonotype analysis of alopecia areata-specific, intralesional human CD8+ T-lymphocytes

Marta Bertolini, Youhei Uchida, Quingquing Zhou, Alfredo Rossi, Klaus Dornmair and Ralf Paus

 

Closing Remarks

 

 

 

1:30 PM

 

Lunch and Informal Discussions

 

 

 

8:00 PM

 

Farewell Dinner

 

 

 

Sunday, October 4

 

 

 

7:30 AM

 

Breakfast

Departure

 

 

         

 

 

POSTERS

 

 

 

32

Autoantibodies as biomarkers of neurolupus

Ivana Stiborova, Vlastimil Kral and Stanislava Blazickova

33

B cell subsets immunophenotyping in patients after splenectomy

Vlastimil Kral, Jitka Pohorska, Eva Jilkova, Jarmila Zizkova, Dalibor Jilek and Josef Richter

34

Dendritic cell homeostasis and functions in autoimmunity revealed by critical requirement of non-canonical NFkB

Dunja Mrdjen, Florian Mair and Burkhard Becher

35

Describing the role of GM-CSF in autoimmune inflammation using novel transgenic mouse strains

Juliana Komuczki Komuczki, Sabine Spath, Pawel Pelczar and Burkhard Becher

36

Differential expression of autophagic genes in adipose tissue in short term of high fat diet

Carla Nuñez, Rafaela Marineli, Joseane Morari, Natalia Ribeiro, Guilherme Prado, Andressa Baseggio and Mário Maróstica

37

Do human γδ T cells contribute to hair biology and pathology?

Youhei Uchida, Marta Bertolini, Takuro Kanekura, Alfredo Rossi and Ralf Paus

38

Elevated MVP levels in patients with Rheumatoid Arthritis

Dionysia Marinou, Maria Mavrouli, Athanasios Tsakris and John Routsias

39

Inflammation skews B cells to an immunoregulatory phenotype in Juvenile inflammatory myopathies

Christopher Piper, Meredyth Wilkinson, Juvenile Dermatomyositis Research Group (JDRG), Lucy Wedderburn, Claudia Mauri and Kiran Nistala

40

Molecular mechanisms of pemphigoid disease elicitation by dipeptidyl peptidase-IV inhibitors

Iosifina Doxastaki, Christian Sadik and Detlef Zillikens

41

NMDA receptor antibody positive encephalitis as a complication of herpes simplex encephalitis: Poor response to immunotherapy and serious long-term deficits

Alison Christy and Colin Roberts

42

Parasitic infestations protection from autoimmunity in EAE is mediated by IL-5 activation of antigen specific CD4+CD25+Treg

Suzanne Hodgkinson, Giang Tran, Dent Lindsay, Catherine Robinson, Paul Wilcox and Bruce Hall

43

Preclinical characterization of JAK1/JAK2 inhibitors for treatment of type 1 diabetes

Prerak Trivedi, Kate Graham, Stacey Fynch, Misty Jenkins, Nicholas Scott, Thoams Kay and Helen Thomas

44

Role of EBI2 in Experimental Autoimmune Encephalomyelitis

Florian Wanke, Andrew Croxford, André  Heinen, Sonja  Moos, Stephanie  Firmenich, Yilang  Tang, Khalad  Karram, Denise  Tischner, Sonja  Sonja Reißig, Sonja Lacher, Ilgiz  Mufazalov, Tanja  Kuhlmann, Nina  Wettschureck, Andreas  Sailer, Klaus  Rajewsky, Stefano  Casola, Ari  Waisman and Florian Kurschus

45

Serum calprotectin (S100A8/9, MRP8/14) in patients with rheumatoid arthritis: its relation with clinical, laboratory and ultrasound parameters of disease activity

Jana Hurnakova, Jakub Zavada, Petra Hanova, Hana Hulejova, Martin Klein, Herman Mann, Olga Sleglova, Marta Olejarova, Sarka Forejtova, Olga Ruzickova, Jiri Vencovsky, Karel Pavelka and Ladislav Senolt

46

The effect of dichloroacetate on certain glycolytic enzymes and on the signature transcription factors of Th1, Th2, Th17 and Treg in human alloreactive CD4+ T-cells

Maria Sounidaki, Theodoros Eleftheriadis, Georgios Pissas and Ioannis Stefanidis

47

TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis

Xin Chen and Joost Oppenheim

48

Unraveling the genetic causes of severe autoinflammation and autoimmunity in the gut

Nina Serwas, Aydan Kansu, Elisabeth Salzer, Cecilia Dominguez Conde, Rico Ardy, Elisangela Santos-Valente, Zarife Kulo─člu, Arzu Demir, Aytac Yaman, Laura Gamez Diaz, Bodo Grimbacher, Reha Artan, Ersin Sayar, Arzu Ensari, Richard Flavell and Kaan Boztug

49

Vitamin D influences TREM-2 receptor expression in pulmonary sarcoidosis

Milan Buc, Maria Bucova, Magda Suchankova, Elena Tibenska, Ivan Majer, Eva Tedlova and Helena Novosadova