2nd International Conference on Tissue Repair, Regeneration, and Fibrosis

Preliminary Program

Wednesday, June 13


6:00 PM


Conference Registration


8:00 PM


Welcome Reception and Dinner


Thursday, June 14


7:30 AM




8:25 AM


Welcome & Opening Remarks
Tom Wynn




Cell types, mechanisms, and therapeutic targets in lung repair and fibrosis

Chair: Robert Martinez

8:30 AM


Fibroblasts drive inflammation and monocyte recruitment in damaged tissue via an IL-1R1/JunD/CCL2 dependant signalling pathway

Lauren Davison, Ben Barksby, Jack Leslie, Saimir Luli, Fiona Oakley, Andrew Fisher, Derek Mann, and Lee Borthwick

8:55 AM


Understanding endotypes of progressive pulmonary fibrosis?

Gisli Jenkins

9:20 AM


The impact of aging on fibrosis

Melanie Königshoff

9:45 AM


CCN2-mediated activation of cancer-associated fibroblasts is required for metastasis and tumor neovascularization in a murine model of melanoma

James Hutchenreuther, Krista Vincent, Chris Norley, David Holdsworth, Lynne-Marie Postovit, and Andrew Leask


10:10 AM


Coffee Break and Poster Viewing



Cell types, mechanisms, and therapeutic targets in lung repair and fibrosis

Chair: Neil Henderson

11:10 AM


Novel mechanisms driving rapid progression in IPF

Cory Hogaboam

11:35 AM


Targeting the ADAM10-sEphrin-B2 pathway in lung injury and fibrosis

David Lagares

12:00 PM


SREBP2 drives late-phase TNF-α inflammatory circuitry in macrophages and suppresses tissue repair program

Anthony Kusnadi, Lionel Ivashkiv, Kyung-Hyun Park-Min, Sung-ho Park, Ruoxi Yuan, Tania Pannellini, Orla O'Shea, David Oliver, and Eugenia Giannopoulou

12:15 PM


Clinically validated markers of the extracellular matrix remodelling are modulated by anti-fibrotic compounds in a human lung fibrosis ex vivo model

Diana Julie Leeming, Jannie Sand, Christina Hesse, Sebastian Konzok, Katherina Sewald, Sarah Rønnow, Armin Braun, Morten Karsdal, Sarah Brockbank, and Simon Cruwys

12:30 PM


Inhibition of autotaxin reduces the desmoplastic response and decreases growth of pancreatic adenocarcinoma

Bryan Fuchs

12:55 PM


understanding heterogeneity in IPF and its pre-clinical translation

Andy Blanchard, Adam Taylor, Gisli Jenkins, and Morten Karsdal

1:20 PM


Mechanistic insights from clinical trials in fibrotic disorders

Joseph Arron

1:45 PM


Pharmacological inhibition of ROCK protects vascular integrity and ameliorates experimental pulmonary fibrosis

Masha Poyurovsky, Rigen Mo, Sarah Lucas, Rafael Depetris, Ji-In Kim, Kevin Liu, Ed Skucas, Xiao-Jiang Feng, Jack Gaffney, and Jeegar Patel


2:00 PM


Lunch and Informal Discussions


7:30 PM


Dinner and Informal Discussions


Friday, June 15


7:30 AM





Stem cells in Development, Repair, and Fibrosis

Chair: Randy Levinson

8:30 AM


Building and re-building the lung: insights from human lung development

Dawei Sun, Kyungtae Lim, Quitz Jeng, Marko Nikolic, Oriol Caritg, Jo-Anne Johnson, and Emma Rawlins

8:55 AM


Perivascular progenitors in fibrotic disease

Rafael Kramann

9:20 AM


Adult liver cholangiocytes, organoid cultures and tissue regeneration

Meritxell Huch

9:45 AM


Modelling non-alcoholic fatty liver disease using human pluripotent stem cells

Ludovic Vallier

10:10 AM


Lung stem cells and their dynamic niche during regeneration and repair

Joo-Hyeon Lee


10:25 AM


Coffee Break and Poster Viewing



Cell types, mechanisms, and therapeutic targets in liver regeneration and fibrosis

Chair: Ludovic Vallier

11:10 AM


Using single cell RNA sequencing to investigate mechanisms of liver fibrosis and repair\

Neil Henderson

11:35 AM


Evaluation of inflammatory mechanisms in nonalcoholic steatohepatitis (NASH)

Franklin Schlerman, Zhiyong Yang, Martin Dowty, Christopher Taylor, Gabriel Sholder, Nicole Bodycombe, Evanthia Pashos, Tom Wynn, and Robert Martinez

12:00 PM


The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis

Marina Nati, Antonios Chatzigeorgiou, Lan-Sun Chen, Ales Neuwirth, Jochen Hampe, Oliver Soehnlein, Kyoung-Jin Chung, and Triantafyllos Chavakis

12:15 PM


Regulation of tissue fibrosis by galectin-3 and evaluation of inhibitors as anti-fibrotic therapies

Alison Mackinnon, Fredrick Zetterberg, Neil Henderson, Anders Pederson, Ulf Nilsson Nilsson, Hakon Leffler, and Hans Schambye

12:30 PM


A high-throughput microfluidic organ-on-chip system for screening of therapeutics

Joseph Charest

12:55 PM


When liver regeneration fails: identifying cellular and molecular targets for therapy

Stuart Forbes

1:20 PM


Development of liver fibrosis in mice reflects a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction.

Michelle Boland, Stephanie Oldham, Boland Brandon, Silvia Guionaud, Jean-Martin Lapointe, Sarah Will, Christopher Rhodes, and James Trevaskis

1:45 PM


Non-invasive high resolution and global assessment of biological processes in progressive liver fibrosis

Anja Schmidt-Christensen, Julia Nilsson, Michael Gottschalk, René ´T Zandt, Rajmund Mokso, and Dan Holmberg


2:00 PM


Lunch and Informal Discussions


7:30 PM


Dinner and Informal Discussions


Saturday, June 16


7:30 AM





Imaging the matrix

Chair: Bryan Fuchs

8:30 AM


Live imaging inflammation and its consequences in wound healing and cancer

Paul Martin

8:55 AM


Imaging lesion repair in multiple sclerosis

Daniel Reich

9:20 AM


Control of the matrisome in tissue repair and cancer

Sabine Werner

9:45 AM


Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring

Dongsheng, Donovan, Simon, Anna, Juan, Pushkar, Darcy, Yuval Jiang, Correa Gallegos, Christ, Stefanska, Liu, Ramesh, Wagner, Rinkevich


10:00 AM


Coffee Break and Poster Viewing



Mechanisms of organ specific fibrosis

Chair: Lynne Murray

11:00 AM


Control of immune cell phenotype: an antifibrogenic strategy


11:25 AM


Macrophages in skin repair and fibrosis

Sabine Eming

11:50 AM


Identification of an IL-6 dependent CD64+ lung macrophage population driving fibrosis.

Emma Doran, Darren Ruane, Alexander Abbas, Patrick Caplazi, Claire Emson, and Joseph Arron

12:05 PM


REVERBalpha modifies pulmonary fibrosis through inhibition of myofibroblast differentiation

Alicja Nazgiewicz, Peter Cuningham, Peter Meijer, Monika Lodyga, Hannah Durrington, Paul Mercer, David Bechtold, Julie Gibbs, Andrew Loudon, Karen Piper Hanley, Boris Hinz, David Ray, and John Blaikley

12:20 PM


Kidney repair: mechanisms and trade-offs

Paola Romagnani

12:45 PM


Innate immune signaling driving fibrosis: novel therapeutic targets

John Varga

1:10 PM


A novel mouse model that spontaneously develops chronic inflammation and fibrosis

Julia Nilsson, Anja Schmidt-Christensen, Nina Fransén Pettersson, and Dan Holmberg

1:25 PM


Lack of fibrotic response to wounding in the adult spiny mouse, Acomys, permits the regeneration of many tissue types

Malcolm Maden, Yanfei Qui, Carl Pepine, Mohan Raizada, Ketan Patel, Robert Mitchell, Henry Hollin-Cooper, Aaron Sandoval, and Jason Brant


1:40 PM


Lunch and Informal Discussions


3:30 PM


City Tour


7:30 PM


Dinner and Informal Discussions


Sunday, June 17


7:30 AM





Inflammation and epigenetics in organ regeneration and fibrosis

Chair: Jason Rock

8:30 AM


Understanding skeletal muscle regeneration and decline with aging

Pura Muñoz-Cánoves

8:55 AM


Causes and effects of interstitial fibrosis in skeletal muscle

Marcela Low, Elena Groppa, Hesham Soliman, Chihkai Chang, and Fabio Rossi

9:20 AM


Type 3 inflammation in liver fibrosis and hepatocellular carcinoma (HCC)

Naglaa Shoukry

9:45 AM


The role of endothelial cells in driving tissue fibrosis

Maria Trojanowska

10:10 AM


Mechanisms of tubulointerstitial injury and fibrosis driven by discrete inflammatory signals in human kidney organoids

Dario Lemos


10:25 AM


Coffee Break and Poster Viewing



Inflammation and epigenetics in organ regeneration and fibrosis

Chair: Tom Wynn

11:00 AM


Significance of epigenetics in liver fibrosis

Jelena Mann

11:25 AM


Mesenchymal-immune cell crosstalk in lung fibrosis

Oliver Eickelberg

11:50 AM


Recruited monocytes and type 2 immunity promote adult lung regeneration

Jason Rock

12:15 PM


Injury and defective regeneration of the epithelial basement membrane in myofibroblast-mediated corneal fibrosis: A paradigm for fibrosis in other organs?

Steven Wilson

12:30 PM


The M problem in fibrosis: myofibroblasts, macrophages, matrix, and mechanics

Boris Hinz


12:55 PM


Closing Remarks


1:10 PM


Lunch and Informal Discussions


8:00 PM


Farewell Dinner


Monday, June 18


8:00 AM




10:00 AM





Long term restoration of fecal continence in a large animal model using BioSphincters TM

Khalil Bitar, Jaime Bohl, Riccardo Tamburrini, and Prabhash Dadhich


Osteoconductive microarchitecture realized by additive manufacturing

Franz Weber


The NOX1/4 inhibitor GKT-137831 reduces alpha-SMA and CCN2 protein overexpression and collagen gel contraction in lesional scleroderma fibroblasts

Andrew Leask, Hannah Murphy-Marshman, Xu Shiwen, Richard Stratton, and Katherine Quensel


Lysosomes and volumes of the inflamed lung

Petra Jacobson, Hans Lennart Persson, and Linda Vainikka


Efficacy of a hybrid system of hyaluronic acid and collagen loaded with prednisolone and TGF-β3 for cartilage regeneration in rats

Farhad Mohammadi, Nader Tanideh, Soliman Mohammadi Samani, and Fatemeh Ahmadi


A new highly selective 5-Hydroxytryptamine 2B (5-HT2B) Receptor Antagonist ameliorating Fibrosis in preclinical Models of Systemic Sclerosis

Christina Wenglén, Lars Pettersson, Helena Arozenius, and Gunilla Ekstrom


Wilms Tumor 1 - a cytokine-inducible component of normal and fibrotic connective tissue repair

David O'Gorman, John Luo, Emmy Sun, Trisiah Tugade, Ana Maria Pena Diaz, Bing Siang Gan, Ruby Grewal, and Nina Suh


TGF-beta1 alters the epigenetic signature of histone marks during myofibroblast differentiation

Timothy Hewitson, Belinda Wigg, Stephen Holt, and Edward Smith


Epithelial-Mesenchymal Homeostasis in lung organoids

Qi Tan, Giovanni Ligresti, Jeffrey Meridew, and Daniel Tschumperlin


the anti-fibrotic effects of CB2 receptor agonist, JWH 133 on lungs affected by nicotine.

Ewelina Wawryk-Gawda, Katarzyna Chłapek, Marta Lis-Sochocka, Patrycja Chylińska-Wrzos , Michał Zarobkiewicz, Mirosław Sławiński, Beata Budzyńska, Anna Boguszewska-Czubara , and Barbara Jodłowska-Jędrych


Collagen type IV degradation predicts mortality in the ECLIPSE COPD cohort

Sarah Rønnow, Lasse Langholm, Morten Karsdal, Ruth Tal-Singer, Bruce Miller, Jørgen Vestbo, Jannie Sand , and Diana Leeming


Characterizing nuclear translocation of beta-catenin in palmar fascia fibrosis

David O'Gorman, Kevin Ho, Ana Maria Pena Diaz, Nina Suh, Ruby Grewal, and Bing Siang Gan


Leukemia inhibitory factor induces cholangiocyte proliferation and corrects the impaired bile duct morphogenesis in sortilin-deficient mice following cholestatic liver injury

Einav Hubel, Roy Avraham, Elise Lavoie, Jonathan Dranoff, Oren Shibolet, and Isabel Zvibel


Development of multiple rodent models of non-alcoholic steatosis and steatohepatitis (NASH) – a profile of a rodent NASH-CRN score

Samuel Daniels, Diana Leeming, Maria Bruun, Sönke Detlefsen, Sara Hjuler, Morten Karsdal, Peter Hein, Sarah Brockbank, and Simon Cruwys


Evaluation of the Scar-in-a-Jar as an in vitro screening tool for anti-fibrotic therapies, using markers reflecting ECM remodelling

Sarah Rønnow, Sarah Brockbank, Simon Cruwys, Morten Karsdal, Diana Leeming, and Jannie Sand


The ratio between von Willebrand factor and platelet count is highly correlated to the severity of Non-alcoholic fatty liver disease (NAFLD) histological parameters and can identify patients with advanced fibrosis

Samuel Daniels, Diana Leeming, Lasse Langholm, Morten Karsdal, and Leon Adams


Collagen type III degradation is impaired in patients with IgA nephropathy and ANCA-associated vasculitis with high renal fibrotic burden

Federica Genovese, Nadja Sparding, Morten Karsdal, Veronika Satrapova, Doubravka Frausova, Lenka Bartonova, Eva Honsova, Dita Maixnerova, Vladimir Tesar, and Zdenka Hruskova


A novel biomarker of type VI collagen formation measured in serum and urine of patients with CKD reflects the level of fibrosis in the kidneys

Nadja Sparding, Federica Genovese, Morten Karsdal, Michaela Neprasova, Dita Maixnerova, Veronika Satrapova, Doubravka Frausova, Lenka Bartonova, Eva Honsova, Zdenka Hrušková, and Vladimír Tesař


Collagen is not just collagen – differential matrix expression induced by TGF-β and PDGFs

Alexander Reese-Petersen, Morten Karsdal, and Federica Genovese


 In search of the balance between increasing mesenchymal stem cell regenerative properties and potential risk of tumor transformation

Katarzyna Drela, Luiza Stanaszek, Zuzanna Kuczynska, Sylwia Sarzyńska, and Barbara Lukomska


A novel Macrocyclic Compound reduces fully developed Pulmonary Fibrosis in the Mouse Bleomycin Model

Snjezana Cuzic, Boska Hrvacic, Ines Glojnaric, Maja Antolic Klasnic, Dijana Pesic, Sanja Kostrun, and Martina Bosnar


predicting lung function decline in IPF using gene expression in peripheral blood mononuclear cells

guiquan JIA, Alexander Abbas, Margaret Neighbors, Joseph Arron, and Thirumalai Ramalingam


The impact of age, sex and dietary regiment on the skin wound healing in C57BL/6J (B6) mice.

Marta Kopcewicz, Katarzyna Walendzik, Joanna Bukowska, and Barbara Gawronska-Kozak


TGF-beta and IL-1 as yin and yang in fibrosis: Keratinocytes as coplayers with fibroblasts

Mikael Ivarsson, Anita Koskela von Sydow, Chris Janbaz, and Matilda Skoglund


Long term dietary (ex vivo) and culture conditions (in vitro) effect on functional features of dermal fibroblasts (DF)

Katarzyna Walendzik, Joanna Bukowska, Marta Kopcewicz, and Barbara Gawronska-Kozak


Actomyosin signalling via PAK1 controls mechanical signals toward the nucleus in liver fibrosis

Aoibheann Mullan, Katherine Martin, James Pritchett, Elliot Jokl, Lindsay Birchall, Kara Simpson, Sayyid Raza, Varinder Athwal, Sara Wickstrom, Neil Hanley, and Karen Piper Hanley


Control of fibroblast behaviour by Nrf2-mediated microRNA expression and the potential impact on wound repair and regeneration

Paul Hiebert, Mateusz Wietecha, Michael Cangkrama, Eric Haertel, Eleni Mavrogonatou, Michael Stumpe, Heiko Steenbock, Peter Angel, Jürgen Brinckmann, Dimitris Kletsas, Jörn Dengjel, and Sabine Werner


Calcium signaling and the immune response play important roles for spinal cord regeneration in zebrafish

Ivar Dehnisch Ellström


Histatin-1: a salivary peptide that promotes endothelial cell migration and angiogenesis

Pedro Torres


Immune profiling of human chronic wounds

Antonella Pellicoro, Georgios Krilis, and Jenna Cash


Characterising the resolution network in acute and age-impaired skin healing

Holly Rocliffe, Antonella Pellicoro, Jesmond Dalli, and Jenna Cash


Prostaglandin environment may favor collagen deposition in mare endometrium when challenged by neutrophil extracellular traps proteases

Maria Rebordão, Ana Amaral, Carina Fernandes, Karolina Lukasik, Anna Szóstek-Mioduchowska, António Galvão, Pedro Pinto-Bravo, Dariusz Skarzynski, and Graça Ferreira-Dias


Activated interferon signaling in cultured BMSC from myelofibrosis patients: core finding of a proteomic study

Maria Åström, Edvard Welander, Arvid Pourlotfi, Akram Abawi, Erik Ahlstrand, and Mikael Ivarsson


Noscapine inhibits elastase induced collagen transcription and prostaglandin secretion in mare endometrium

Ana Amaral, Carina Fernandes, Karolina Lukasik, Anna Szóstek-Mioduchowska, Maria Rebordão, Sofia Morazzo, Pedro Pinto-Bravo, Dariusz Skarzynski, and Graça Ferreira-Dias


The role of interleukin-24 in the pathomechanism of IBD-associated tissue remodeling

Apor Veres-Székely, Anna Ónody, Erna Sziksz, Domonkos Pap, Réka Rokonay, Rita Lippai, István Takács, Gábor Veres, Áron Cseh, Attila Szabó, and Ádám vannay


The Renin-Angiotensin-Aldosterone System inhibitors ameliorate hyperglycaemia induced tubulointerstitial fibrosis in Diabetic Kidney Disease

Agnes Molnar, Sandor Koszegi, Lilla Lenart, Judit Hodrea, Dora Balogh, Edgar Szkibinszkij, Laszlo Wagner, Adam Vannay, and Andrea Fekete


Increased modulation of inflammation and fibrosis in experimental Chagas disease cardiomyopathy by G-CSF-overexpression in mesenchymal stem cells

Daniela Silva, Bruno Souza, Juliana Vasconcelos, Carine Azevedo, Clarissa Valim, Bruno Paredes, Vinicius Rocha, Gisele Carvalho, Pamela Daltro, Simone Macambira, Carolina Nonaka, Ricardo Santos, and Milena Soares


Assays of evaluation of inflammasomes’ activity in alveolar macrophages in fibrotic lung diseases

Athina Trachalaki, Eliza Tzitoura, Eirini Vasarmidi, Eleni Bibaki, George Margaritopoulos, Nikolaos Tzanakis, and Katerina Antoniou


Upregulation of Retinoic Acid-Related Orphan Receptor-alpha (RORa) in pulmonary fibrosis

Eliza Tsitoura, Eleni Bibaki, Anastasios Koutsopoulos, Eleni Lagoudaki, Nikos Tzanakis, and Katerina Antoniou