7th International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems

Preliminary Program

Sunday, June 3

     

6:00 PM

 

Conference Registration

     

8:00 PM

 

Welcome Reception and Dinner

     

Monday, June 4

     
 

8:00 AM

 

Breakfast

     
 

9:00 AM

 

Welcome and Opening Remarks

     
 

SESSION I

 

Bone Marrow Niches

Chairs: TBA

 

9:15 AM

1

Regulation of immune cell bias by aging HSC niches

Paul Frenette

 

9:45 AM

2

Bone marrow niches, inflammatory hematopoiesis and osteoclasts

Claudine Blin-Wakkach

 

10:15 AM

3

The role of MyoD Family Inhibitor (Mdfi) in the maintenance of hematopoietic stem cells and lineage commitment

Jeremy  Houser, Marta Onopuik, Vasyl Nesin, Leo Tsiokas, and Mary Beth Humphrey

 

10:30 AM

4

Macrophages are key effectors of neurogenic heterotopic ossification following spinal cord injuries

Jean-Pierre Levesque

     
 

11:00 AM

 

Coffee Break and Poster Viewing

     
 

SESSION II

 

Bone and Tumor Microenvironment

Chairs: TBA

 

12:00 PM

5

The bone marrow stromal niche: An instigator and a therapeutic target of hematological myeloid malignancies

Stavroula Kousteni

 

12:30 PM

6

Using accelerator mass spectrometry to study bone metastasis and tumor microenvironment

Gabriela Loots

 

1:00 PM

7

Regulation of Macrophage-Osteoclast Polarization

Yihong Wan

     
 

1:30 PM

 

Lunch and Informal Discussions

     
 

7:30 PM

 

Dinner and Informal Discussions

     
         

Tuesday, June 5

     

8:00 AM

 

Breakfast

     

SESSION III

 

Osteoclast Differentiation

Chairs: TBA

9:00 AM

8

MicroRNAs control osteoclastogenesis and bone remodeling

Baohong Zhao

9:30 AM

9

A combination of key transcription factors defines the chromatin landscape during RANKL-induced osteoclastogenesis

Sakae Tanaka

10:00 AM

10

STAT1/3 signaling in osteoclastogenesis and the process of corticalisation

Natalie Sims

10:30 AM

11

The C-type lectin receptor Mincle controls osteoclast-induced bone remodeling by sensing necrotic osteocytes

Darja Andreev, Barbara Killy, Maria Faas, Ulrike Harre, Wolfgang Baum, Gerhard Krönke, Roland Lang, Georg Schett, and Aline Bozec

     

10:45 AM

 

Coffee Break and Poster Viewing

     

SESSION IV

 

Osteoimmunology and Joint Disease

Chairs: TBA

11:45 AM

12

The role of the IL-23/IL-17 immune pathway in structural damage in inflammatory arthritis

Erik Lubberts

12:15 PM

13

NK cells have distinct roles in the joint and gut pathology of ankylosing spondylitis

Lynett Danks, Sarah Wythe, Adel Ersek, Thibault Griseri, Fiona McCann, and Nicole Horwood

12:45 PM

14

Bone-damaging T cells and host defense

Hiroshi Takayanagi

     

1:15 PM

 

Lunch and Informal Discussions

     

7:30 PM

 

Dinner and Informal Discussions

Wednesday, June 6

     

8:00 AM

 

Breakfast

     

SESSION V

 

New Concepts

Chairs: TBA

9:00 AM

15

Novel mechanisms in Innate Immunity

Richard Flavell

9:30 AM

16

Osteoblast production of SLIT3 controls skeletal CD31hiEMCNhi vascular endothelium and bone formation

Ren Xu, Baohong Zhao, Jason Butler, Laurie Glimcher, and Matthew Greenblatt

9:45 AM

17

Targeting fundamental aging mechanisms to treat osteoporosis

Sundeep Khosla

     

10:15 AM

 

Coffee Break and Poster Viewing

     

SESSION VI

 

Microbiota and Bone

Chairs: TBA

11:15 AM

18

The microbiota, a novel regulator of bone health and disease.

Roberto Pacifici

11:45 AM

19

IGF-1: connecting microbiome and bone

Julia Charles

12:15 PM

20

Diabetes increases IL-17 to alter the oral microbiome and increase periodontal bone loss

Dana Graves

12:45 PM

21

The microbiome influences bone strength and tissue material properties

Christopher Hernandez

     

1:15 PM

 

Lunch and Informal Discussions

     

3:30 PM

 

City Tour

     

7:30 PM

 

Dinner and Informal Discussions

     

Thursday, June 7

     

8:00 AM

 

Breakfast

     

SESSION VII

New Developments in Innate Immunity

Chairs: TBA

9:00 AM

22

Development and ageing of vascular niches in bone

Anjali Kusumbe

9:30 AM

23

Autophagy in bone marrow-resident immune cells

Anna Katharina Simon

10:00 AM

24

Origins of Osteoclasts

Frederic Geissmann

10:30 AM

25

TBD

     

11:00 AM

 

Coffee Break and Poster Viewing

     

SESSION VIII

Short Talks

Chairs: TBA

11:45 AM

26

The glucocorticoid receptor (GR) in stromal cells reduces inflammation in arthritis by steroid treatment, whereas GR in immune cells reduces osteophyte formation

Jan Tuckermann, Mascha Koenen, Stephan Culemann, Sabine Vettorazzi, Wolfgang Baum, Gerhard Krönke, and Ulrike Baschant

12:00 PM

27

PTH improved immunodeficiency through osteoblast activation

Asuka Terashima, Kazuo Okamoto, and Hiroshi Takayanagi

12:15 PM

28

Bifunctional role of Ostm1 in osteoclast maturation

Monica Pata and Jean Vacher

12:30 PM

29

miR-146a a key player in bone metabolism

Victoria Saferding, Melanie Hofmann, Julia Brunner, Mihaela Militaru, Antonia Puchner, Silvia Hayer, Melanie Timmen, Richard Stange, Josef Smolen, and Stephan Blüml

12:45 PM

30

Targeted depletion of mature B cells induces bone loss in young mice 

Albert  Kolomansky, Naamit  Deshet-Unger, Alina  Ostrovsky, Nathalie  Ben-Califa, Sahar  Hiram-Bab, Tamar  Liron, Howard  Oster, Moshe  Mittelman, and Drorit Neumann

1:00 PM

31

LIGHT/TNFSF14 deficiency impairs basal bone remodeling

Giacomina Brunetti, Sara Bortolotti, Giuseppina Storlino, Graziana Colaianni, Paolo Pignataro, Lindsay Ward Kavanagh, Carl Ware, Janne Reseland, Silvia Colucci, and Maria Grano

1:15 PM

32

Why do sex hormones control bone loss?

Josef Penninger

     

1:45 PM

 

Closing Remarks

     

1:50 PM

 

Lunch and Informal Discussions

     

8:00 PM

 

Farewell Dinner

     

Friday, June 8

     

8:00 AM

 

Breakfast

     

10:00 AM

 

Departure

POSTERS

33

Association of Mitochondrial DNA Copy Number with Disease Activity in Rheumatoid Arthritis

Jihyung Yoo, Mi-kyoung Lim, Donghyuk Sheen, and Soon Kim

34

The stability of rheumatoid factor and anti-ccp antibody in archived samples of blood

35

Serum exosomal microRNA-1915-3p is correlated with disease activity of rheumatoid arthritis

Jihyung Yoo, Mi-Kyoung Lim, Jukyoung Song, and Soon Ae Kim

36

Efficacy of Human Monoclonal Antibody (Denosumab) On Bone Mineral Density in Postmenopausal Osteoporosis

Corina Galesanu

37

Corylifol C inhibits RANKL-induced osteoclast differentiation

Jung Yun Kang, Inik Chang, and Dong Min Shin

38

Diagnostic and prognostic value of presepsin as marker of post-operative orthopaedic joint prosthesis infection

Emanuela Galliera, Monica Marazzi, Filippo Randelli, Marco Brioschi, Lorenzo Drago, Carlo Romanò, Giuseppe Banfi, Luca Massaccesi, Calogero Crapanzano, Franca Morelli, and Massimiliano Corsi Romanelli

39

Development of a fluorescence-based osteoclast fusion assay

András Erdélyi, Dániel Csete, Edina Simon, Áron Pánczél, Simon Nagy, GergÅ‘ Bordács, Kristóf Csorba, Zoltán Jakus, and Attila Mócsai

40

Targeting fundamental aging mechanisms to treat osteoporosis

Sundeep Khosla

41

Plasma High-Resolution Metabolomics identifies unique Metabolites and Metabolic Pathways associated with Bone Health and the Gut Microbiome

Moriah Bellissimo, Thomas Ziegler, Roberto Pacifici, and Jessica Alvarez

42

Host defense system against bacterial infection by the osteoimmune crosstalk

Masayuki Tsukasaki, Noriko Komatsu, Warunee Pluemsakunthai, Toshihiko Suzuki, and Hiroshi Takayanagi

43

Hypoxia-sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Osteoclast Precursors and Suppresses Osteoclastogenesis

Koichi Murata, Chikashi Terao, Hiromu Ito, Koichiro Ohmura, Tsuneyo Mimori, Shuichi Matsuda, Kyung-Hyun Park-Min, and Lionel Ivashkiv

44

Blocking of OCL activity reverses systemic inflammation and reduces myeloid skewing in inflammatory bowel disease

Lidia báñez, Agathe Boucoiran, Matthieu Rouleau, Claudine Blin-Wakkach, and Abdelilah Wakkach

45

RANKL, a Disease Modifier in inflammatory Arthritis

Maria Papadaki, Vagelis Rinotas, Foteini Violitzi, Martina Samiotaki, George Panayotou, and Eleni Douni

46

Bone Marrow Adipose Tissue (BMAT) in modeled Osteoporosis

Vagelis Rinotas, Efthymios Tzortzis, Panagiota Siatra, Anthi Kolokotroni, Maria Papadaki, and Eleni Douni

47

Role of innate immune signaling adapter protein DAP12 in high fat diet induced osteoarthritis in mice

Evangelia Kalaitzoglou, Erika Barboza, Yao Fu, Jacquelyn Herron, Josiah Flaming, Elise Donovan, Adrian Filiberti, Timothy Griffin, and Mary Beth Humphrey

48

TRPC1 ion channel regulates calcium sensing receptor and PTH receptor responses

Marta Onopuik, Bonnie Eby, Vasyl Nesin, Peter Ngo, Maria Luisa Brandi, Wenhan Chang, Kai Lau, Leonidas Tsiokas, and Mary Beth Humphrey

49

Non-clonal elevation of serum immunoglobulin total free light chains is predictive of hip fracture in both women and men

Shreyasee Amin, Elizabeth Atkinson, Sara Achenbach, Angela Dispenzieri, Robert Kyle, and S. Vincent Rajkumar

50

Pasteurized Akkermansia muciniphila induces bone-loss in the femur of gonadal intact mice.

Lina Lawenius, Julia Scheffler, Petra Henning, Karin Gustafsson, Karin Nilsson, Hannah Colldén, Ulrika Islander, Willem de Vos, Patrice Cani, Hubert Plovier, Claes Ohlsson, and Klara Sjögren

51

New Approach for Cell Sorting and FACS Analysis on Osteoclasts

Maria-Bernadette Madel, Lidia Ibáñez, Matthieu Rouleau, Abdelilah Wakkach, and Claudine Blin-Wakkach

52

Vector-mediated TCIRG1 expression rescues resorptive capacity of osteoclasts derived from autosomal recessive osteopetrosis patients

Valentina Capo, Sara Penna, Elena Draghici, Lucia Sergi Sergi, Eleonora Palagano, Erika Zonari, Francesca Ficara, Cristina Sobacchi, Bernhard Gentner, and Anna Villa

53

Phosphorylation of S122 in ERα is dispensable for the physiological regulation of the Skeleton or the Immune System in Female Mice

Karin Gustafsson, Helen Farman, Petra Henning, Vikte Lionikaite, Sofia Movéare-Skrtic, Klara Sjögren, Annica Andersson, Ulrika Islander, Angelina Bernardi, Claes Ohlsson, and Marie Lagerquist

54

Mutations in the Neuroblastoma Amplified Sequence gene in a family affected by Acrofrontofacionasal Dysostosis type 1

Eleonora Palagano, Giulia Zuccarini, Paolo Prontera, Stefano Mantero, Ciro Menale, Antonella Forlino, Paolo Uva, Paolo Vezzoni, Anna Villa, Giorgio Merlo, and Cristina Sobacchi

55

Chondrogenically primed paediatric MSCs are immunomodulatory and do not exhibit immunogenic properties in vitro in an inflammatory micro-environment

Virginia Palomares Cabeza, Janneke Witte-Bouma, Eppo Wolvius, Pieter Brama, Martin Hoogduijn, and Eric Farrell

56

Autophagy and Immune Aging

Hanlin Zhang

57

Pasteurella multocida toxin manipulates the osteoclast metabolism

Sushmita Chakraborty, Bianca Kloos, Florian Uhle, and Katharina Kubatzky

58

Osteoporosis in murine lupus

Jauquline Nordqvist, Marie Lagerqvist, Louise Grahnemo, Ulrika Islander, and Hans Carlsten

59

Which cytokines affect periarticular bone loss?

Cecilia Engdahl, Julia Scheffler, Karin Gustafsson, Louise Grahnemo, and Marie Lagerqvist

60

Longitudinal intravital imaging of the bone marrow (LIMB) - A window to bone regeneration and cellular dynamics in bone tissue

Jonathan Stefanowski, David Reismann, Robert Günther, Asylkhan Rakhymzhan, Romano Matthys, Reto Nützi, Sandra Zehentmeier, Katharina Schmidt-Bleek, Georg Petkau, Hyun-Dong Chang, Sandra Naundorf, York Winter, Fritz Melchers, Georg Duda, Raluca Niesner, and Anja Hauser

61

Role of interleukin-9 on Synovial Regulatory T cells in Rheumatoid Arthritis

Sushmita Chakraborty, Ranjan Gupta, Rinkee Kumari, and Dipendra Kumar Mitra

62

Modulation of arthritis by type 2 innate lymphoid cells

Yasunori Omata

63

Preconditioning mesenchymal stem cells with factors secreted from macrophages regulates their osteogenic potential

Gema Vallés, Francisco Mancebo, Fatima Bensiamar, Nuria Vilaboa, and Laura Saldaña

64

Immunomodulatory properties of mesenchymal stem cells primed with factors secreted from macrophages

Laura Saldaña, Fátima Bensiamar, Francisco Mancebo, Gema Vallés, and Nuria Vilaboa

65

Lentiviral-mediated gene transfer of TCIRG1 to correct osteoclast function in Autosomal Recessive Osteopetrosis

Sara Penna, Valentina Capo, Elena Draghici, Lucia Sergi Sergi, Eleonora Palagano, Erika Zonari, Francesca Ficara, Cristina Sobacchi, Bernhard Gentner, and Anna Villa

66

Phosphatidylserine exposure regulates osteoclast fusion and bone homeostasis

Brenda Krishnacoumar, Carina Scherbel, Natacha Ipseiz, Martin Stenzel, Christina Böhm, Magdalena Czubala, Philip Taylor, Karl Kunzelmann, Martin Herrmann, Georg Schett, and Gerhard Krönke

67

Inhibitory effects of Puerariae radix extract on RANKL-mediated osteoclastogenesis

Keun Ha Park, Dong Ryun Gu, Su Hyun Jin, Youn Chul Kim, and Seoung Hoon Lee

68

Alpha-Enolase expressed on the surfaces of monocytes and macrophages induces robust synovial inflammation in rheumatoid arthritis.

Jae Seung Kang

69

Development of anti-inflammatory strategies for implant materials

Hala Al-Khoury, Adrian Hautmann, Frank Erdmann, Guoying Zhou, and Thomas Groth

70

Dickkopf-1 (Dkk1) plays distinct pathogenic roles in estrogen-deficiency vs. glucocorticoid-induced bone loss

Juliane Colditz, Sylvia Thiele, Ulrike Baschant, Lorenz Hofbauer, and Martina Rauner

71

Impact of the immune system on the development of osteochondromas

Marie Wehenkel, Spencer Richardson, Peter Vogel, and Maureen McGargill

72

The Influence of L-Arginine Availability on Osteoclastogenesis

Julia Brunner, Melanie Hofmann, Victoria Saferding, Alexander Lercher, Birgit Niederreiter, Paul Cheng, Gernot Schabbauer, and Stephan Blüml

73

Transcriptomic characterization of inflammatory and physiological osteoclasts emphasizes CX3CR1 as a marker of inflammatory osteoclasts

Maria-Bernadette Madel, Lidia Ibáñez, Antoine Boutin, Christophe Hue, Matthieu Rouleau, Isabelle Duroux-Richard, Florence Apparailly, Gilles Chiocchia, Henri-Jean Garchon, Abdelilah Wakkach, and Claudine Blin-Wakkach

74

Effects of glucocorticoid excess on the osteohematopoietic niche

Ulrike Baschant, Holger Henneicke, Martina Rauner, and Lorenz Hofbauer

75

Sustained effects of acute neonatal antibiotics on bone quantity and quality

Damian Genetos and Melanie Gareau

76

Glucocorticoid treatment does not decrease bone mass in Wif1 knockout mice

Julius Mühleisen, Michael Stock, Ann-Kristin Picke, Peng Liu, Baruch Frenkel, and Jan Tuckermann

77

Immune modulating scaffolds for bone tissue engineering

Olwyn Mahon, David Browe, Pierluca Pitacco, Tomas Gonzalez-Fernandez, Daniel Kelly, and Aisling Dunne

78

Fine tuning of calcium oscillations by ITAM receptors is essential for RANKL-induced osteoclast differentiation

Hiroyuki Okada, Hiroshi Kajiya, Jun Hirose, Takumi Matsumoto, Koji Okabe, Takeshi Miyamoto, and Sakae Tanaka