Friday, June 26
|
|
|
|
5:00 - 8:00 PM
|
Open Registration
|
|
|
|
|
|
8:00 PM
|
|
Welcome
Reception/Dinner
|
|
|
|
|
|
Saturday, June 27
|
|
|
|
|
|
9:00 AM
|
|
Welcome and Opening Remarks
|
|
|
|
|
|
Session
I
|
|
Complement
Biology
|
|
|
|
Chairs: JP Atkinson, B Stevens
|
|
9:15 AM
|
1
|
Complement: from behind the scenes into the spotlight
J
Lambris
|
|
9:40 AM
|
2
|
Role of properdin in complement-dependent tissue injury
W Song
|
|
10:05 AM
|
3
|
The
role of the complement cascade in eliminating CNS synapses during
development and disease
B
Stevens, D Schafer, NJ Allen, GR Howell, LE Vasquez, NNouri,
JD Lambris, SWM John, and BA Barres
|
|
10:30 AM
|
4
|
What atypical hemolytic
uremic syndrome teaches us about age-related macular degeneration
JP Atkinson
|
|
|
|
|
|
10:55 AM
|
|
Coffee Break
|
|
|
|
|
|
Session
II
|
|
Complement Structural Biology
|
|
|
|
Chairs: W Song, P. Zipfel
|
|
11:25 AM
|
5
|
Structural
insights in the C3 convertase and its regulation
J Wu, YQ Wu, D Ricklin, S
Rooijakkers, M Ruyken, BJC Janssen, J van
Strijp, JD Lambris, and P Gros
|
|
11:50 AM
|
6
|
Solution
structures and macromolecular interactions of complement factor H with its ligands
SJ
Perkins
|
|
12:15 PM
|
7
|
Self-association of the
TYR402 and HIS402 allotypes of complement factor
H in the absence and presence of Zinc
R Nan, G Ward, J Gor,
I Lengyel, and SJ Perkins
|
|
12:25 PM
|
8
|
Complement factor H
related genes and age-related macular degeneration
N
Lauer, B Uzony, J Böhme,
C Skerka, BH Weber, M Opperman, TH Goodship,
P Charbel-Issa,
HP Scholl, F G Holz, and PF Zipfel
|
|
12:50 PM
|
9
|
Y402H polymorphism affects
MCRP binding and leads to a diminished complement control on the surface of
necrotic ARPE cells
N Lauer, A Hartmann, M
Mihlan, H Richter, F Sühnel, C Binder, C v. Strachwitz, C Skerka, and PF
Zipfel
|
|
1:00 PM
|
10
|
Glaucoma: what is the
role of complement?
J Danias and L Panagis
|
|
|
|
|
|
1:20 PM
|
|
Lunch
|
|
|
|
|
|
8:00 PM
|
|
Dinner at a Local Greek Tavern
|
|
The bus for the tavern will depart from the hotel
at 7:30 PM
|
Sunday, June 28
|
|
|
|
|
Session
III
|
|
Inflammation
|
|
|
|
Chairs: A Adamis, K Palczewski
|
|
9:00 AM
|
11
|
The
case for complement and inflammation in AMD: open questions
AP
Adamis
|
|
9:25 AM
|
12
|
The link between oxidation and inflammation
in age related macular degeneration
JG Hollyfield
|
|
9:50 AM
|
13
|
Macrophages play an indispensable role in
central nervous system repair
M
Schwartz, R Shechter, and A London
|
|
10:15 AM
|
14
|
Chemistry of vision and retinal disease
K Palczewski
|
|
|
|
|
|
10:40 AM
|
|
Coffe Break & Poster Session
|
|
|
|
|
|
Session
IV
|
|
Inflammation
|
|
|
|
Chairs: J Danias, DT Shima
|
|
11:10 AM
|
15
|
Association between chlamydia pneumoniae infection
and age-related macular degeneration
M
Kalayoglu
|
|
11:35 AM
|
16
|
Possible
role of bA3/A1-crystallin
in the properdin system
D
Sinha, JS Zigler, Jr., E Wawrousek,
and GA Lutty
|
|
12:00 Noon
|
17
|
Functional genomics of
complement activation in amd
AO Edwards, LA Hecker,
E Ryu, N Tosakulwong,
KH Baratz, W Brown, P Charbel
Issa, B Pollok-Kopp, KE Schmid-Kubista,
KR Bailey, and M Oppermann
|
|
12:25 PM
|
18
|
Endothelial
cell activation: a molecular link between complement and monocytes in age-related macular degeneration?
RF Mullins and JM Skeie
|
|
12:55 AM
|
19
|
Using
mouse models to dissect the links between inflammation and retinal neovascular disease
DT
Shima
|
|
|
|
|
|
1:20 PM
|
|
Lunch
|
|
|
|
|
|
8:00 PM
|
|
Dinner at a Local Greek Tavern
|
|
The bus for the tavern will depart
from the hotel at 7:30 PM
|
|
Monday, June 29
|
|
|
|
|
|
Session
V
|
|
Therapeutics
|
|
|
|
Chairs: MV Holers, D Ricklin
|
|
8:30 AM
|
20
|
Taming the double-edged
sword: Therapeutic interventions in the complement cascade
D Ricklin, P Magotti, H Qu, G Sfyroera, YQ Wu, and JD Lambris
|
|
8:55 AM
|
21
|
Development
and description of two potent targeted therapeutics that modulate the
alternative pathway of complement by either inhibition of factor B or
supplementation of factor H activity
MV
Holers, C Horvath, C Smith, H Akana,
I Mazsaroff, WJ Emlen,
and R Marians
|
|
9:15 AM
|
22
|
Phase I results of the complement
C3 inhibitor pot-4 in AMD
CG Francois, PJ Rosenfeld, J Slakter, S Bakri, D Boyer, S Kaushal, R Chace, H Hudson, P
Deschatelets, and F Grossi
|
|
9:30 AM
|
23
|
Phase 1 trial of
complement inhibition in neovascular AMD using an
anti –C5 pegylated aptamer
(ARC 1905)
S Patel and the Ophthotech
Study Team
|
|
9:45 AM
|
24
|
Complement
depletion with humanized cobra venom factor reduces tissue damage in a
mouse model for age-related macular degeneration
DC
Fritzinger, R Dean, K Wong,, R Halter, J Borlak,
W St. John, and CW Vogel
|
|
10:00 AM
|
25
|
A
targeted inhibitor of the alternative complement pathway reduces RPE injury
and angiogenesis in models of age-related macular degeneration
B Rohrer, Q Long, B Coughlin, B Renner ,
Y Huang, K Kunchithapautham, V Ferreira, M Pangburn, G Gilkeson, J
Thurman, and S Tomlinson
|
|
10:15 AM
|
26
|
Combination therapy for
age-related macular degeneration using verteporfin
and ranibizumab; pre-clinical assessment in the
CAM model
E Debefve, BPegaz, JP
Ballini, and H van den Bergh
|
|
|
|
|
|
10:30 AM
|
|
Coffee
Break
|
|
|
|
|
|
Session
VI
|
|
Therapeutics/Diagnostics
|
|
|
|
Chairs: T Iwata, JR Sparrow
|
|
11:00 AM
|
27
|
Suppression of drusen
formation by Compstatin (POT-4), a peptide
inhibitor of complement component C3 activation, on cynomolgus monkey with early-onset macular degeneration
T Iwata, Z-L Chi, T Yoshida, K Fujinami,
Y Miyake, A Mizota, MT Suzuki, K Terao, Y Yoshikawa,
JD Lambris, and P Olson
|
|
11:25 AM
|
28
|
Depletion of complement component C5 inhibits secondary cataracts
in mice
R Suetsugu-Maki, TP Fox, H Qu,
JD. Lambris and PA Tsonis
|
|
11:50 AM
|
29
|
Towards predicting individual risk
for age-related macular degeneration
JL Haines, K Spencer, LM Olson, P Gallins, WK Scott, N Schnetz-Boutaud,
A Agarwal, EA Postel, J
Kovach, S Schwartz, and MA Pericak-Vance
|
|
12:15 PM
|
30
|
Development
of fluorescence probes based on kistrin linked to
a photosensitizer to provide his selective
delivery
B Pegaz, E Debefve, JP Ballini,
and H van den Bergh
|
|
12:30 PM
|
31
|
Imaging of the
optic nerve with improved radio frequency coils for 3T MRI
J Rose, EP
Quigley, JS Anderson, S Kim, EK Jeong, E Minalga, R Merrill, D Parker, and R Hadley
|
|
12:45 PM
|
32
|
Activation of complement
by photooxidation products of the bisretinoids of RPE lipofuscin
JR Sparrow
|
|
|
|
|
|
1:10 PM
|
|
Lunch
|
|
|
|
|
|
2:45 PM
|
|
Tour to Knossos Archaeological site
& Archaeological Museum of Heraklion
|
|
The bus for the tour
will depart from the hotel at 2:45
PM
|
|
|
|
|
|
8:00 PM
|
|
Dinner at a local Greek Tavern
|
|
|
|
|
|
Tuesday, June 30
|
|
|
|
|
|
Session
VII
|
|
Angiogenesis/Animal
Models
|
|
|
|
Chairs: T Chavakis, SW Cousins
|
|
9:00 AM
|
33
|
Mechanism
studies of the racial differences in age related macular degeneration
R D’Amato and I Adini
|
|
9:25 AM
|
34
|
Novel aspects in the
regulation of hypoxia-driven retina angiogenesis: The contribution of the Dna repair response and the complement system
H Langer, M Economopoulou,
P Magotti, JD Lambris, and T Chavakis
|
|
9:50 AM
|
35
|
The alternative
complement cascade regulates pathological angiogenesis in the retina
KM Connor, N
Krah, R Dennison, K
Willett,
GL Stahl, and LEH Smith
|
|
10:10 AM
|
36
|
Retinal iron overload in Cp/Heph
mutant mice induces degeneration and inflammation with features of AMD
M Hadziahmetovic, P
Hahn, Y Song, JD Lambris, and J Dunaief
|
|
10:35 AM
|
37
|
Inflammation-mediated neurodegeneration:
models, mechanisms and interventions
JS Hong
|
|
|
|
|
|
11:00 AM
|
|
Coffee Break
|
|
|
|
|
|
Session
X
|
|
Animal
Models
|
|
|
|
Chairs: K
Del Rio-Tsonis, J Dunaief
|
|
11:30 PM
|
38
|
Up-regulation of
vascular endothelial growth factor after scatter retinal photocoagulation –
a possible cause for post-laser macular edema?
Y Ogura
|
|
11:50 PM
|
39
|
The role of complement
in retina regeneration
T
Haynes, A Tzekou, C Gomez, A Luz Madrigal, PA Tsonis, JD Lambris, and K Del Rio-Tsonis
|
|
12:15 PM
|
40
|
Macrophage
infiltration into neurosensory retina in
different mouse models for retinal disorders
SW
Cousins and G Malek
|
|
12:40 PM
|
41
|
Chronic oxidant exposure in
association with expression of C-reactive protein (CRP) induces thick basal
laminar deposits in mice
KG Csaky, CCChan, AJ Szala, and CZhang
|
|
|
|
|
|
1:05 PM
|
|
Closing
Remarks
|
|
|
|
|
|
1:30 PM
|
|
Lunch
|
|
|
|
|
|
8:00 PM
|
|
Gala Dinner at Aldemar: Knossos
Royal Village
|
|
|
|
|