Sunday, May 19

5:00 – 8:00 PM

Open Registration

8:00 PM

Welcome Reception

Monday, May 20

7:00 AM

Breakfast

8:00 AM – 2:00 PM Registration

8:10 AM

Introductory remarks

Antonios G. Mikos

Keynote Speaker

8:15 AM

1

The continued maturation of tissue engineering.

P.C. Johnson

8:45 AM

Break

Session I: Cells

Chair: Arnold I. Caplan

Invited Lecture

9:00 AM

2

Mesenchymal stem cells and their use in tissue engineering skeletal constructs.

A.I. Caplan

Oral Presentations

9:30 AM

3

Microenvironment, stem properties and therapeutical potential of marrow derived mesenchymal cells.

R. Quarto, A. Daga, M. Mastrogiacomo, A. Muraglia, G. Bianchi, G. Corte and R. Cancedda

9:45 AM

4

Biofabricated coralline biomaterials as scaffolds for ex-vivo bone bioengineering.

R. Vago and L. Gottlib-Abramovitch

10:00 AM

5

Liver tissue engineering within alginate scaffolds: The effect of cell seeding on hepatocyte function.

M. Dvir-Ginzber, I. Gamlieli-Bonstein, R. Glicklis, R. Agbaria, S. Cohen

10:15 AM

6

In vitro culture of primary human adipocytes following various storage techniques and conditions.

M.B. Lyles, G. Taylor, S. Prstojevich, B. Ferguson, E. Mosby, R. Johnson and C. McArthur

10:30 AM

Break

Oral/Poster Presentations

10:35 AM

7

Characterization of spore-like cells isolated from adult kidney.

A. Koutrouvelis, J. Nichols, T. Varma, H. Saito, R. Mlchak, and J. Cortiella

10:40 AM

8

A Comparison of the Efficacy and Efficiency of Osteoblasts and Bone-Marrow-Derived Mesencymal Stem Cells in Cranial Bone Tissue.

J-Th.Schantz, T.C. Lim, KM Wong, M. Brinkmann, Ch. Lam, S.H. Teoh, D.W. Hutmacher

10:45 AM

9

A Comparison of the Efficacy and Efficiency of Osteoblasts and Bone-Marrow-Derived Mesencymal Stem Cells in Cranial Bone Tissue.

C.X.F. Lam, M. Brinkmann, K.M. Wong, M.L. Ng, S.H. Teoh, D.W. Hutmacher, J.T. Schantz

10:50 AM

10

Response of murine osteoblasts and porous hydroxyapatite (HA) scaffolds to two-step, slow freezing, and vitrification processes.

B.L. Liu, J. McGrath, L. McCabe and M. Crimp

10:55 AM

11

Culturing and characterization of human periodontal ligament fibroblasts.

A.M. Chou, V. Sae-Lim, D.W. Hutmacher, T.M. Lim

11:00 AM

Coffee Break

Session II: Genes, Growth Factors, and Other Biomolecules

Chair: A. Harri Reddi

Invited Lecture

11:30 AM

12

Morphogenesis and tissue engineering: Signals, stem cells and scaffolding.

A. Hari Reddi

Oral Presentations

12:00 Noon

13

Genomics in Tissue Engineering.

A.N. Economides

12:15 PM

14

Gene Therapy and Tissue Engineering based on muscle derived stem cells: Potential for musculoskeletal tissue regeneration.

J. Huard

12:30 PM

15

Biomechanical Strategies for of Articular Cartilage Regeneration.

K. Athanasiou

12:45 PM

16

Controlled localized delivery of insulin like growth factor I (IGF I) induces new bone formation: the significance of release kinetics.

L. Meinel, V. Luginbüh, B. Rechenberg, H.P. Merkle

1:00 PM

Break

Oral/Poster Presentations

1:05 PM

17

Mechanical strain affects bone-specific gene expression in engineered smooth muscle tissues.

J. Nikolovski and D.J. Mooney

1:10 PM

18

Expression of MRNA encoding for hard tissue associated proteins in periodontal ligament and gingival fibroblast.

Y.F. Zhou, A.M. Chou, V. Sae-Lim, D.W. Hutmacher, T.M. Lim

1:15 PM

19

The pharmacokinetics of IL-1 receptor antagonist delivered via controlled release PLGA microspheres.

G. Lavi, R.N. Apte, C. Dinarello,  S. Cohen

1:20 PM

20

Physically crosslinked Dextran Hydrogels: Degradation, protein release and extension to tissue engineering.

G.W. Bos, S. de Jong, C. van Nostrum, and W. Hennink

1:25 PM

21

Effects of surface coating of titanium on human bone cell performance.

A.Bruinink, A. Jaschko, D. Scharnweber, B. Müller, H. Worch

1:30 PM

21A

Chondral and Osseous Tissue Engineering.

N. Ashammakhi, C. Gaissmaeir,M.  Kellomäki, J. Fritz, M. Ninkovic, P. Ebbesen, G. Kristensen, E. Arnaud, H. Petite, E. Toft, P. Törmälä, T. Välimaa, T. Waris

1:35 PM

Lunch

8:30 PM

Dinner at a local Greek Taverna in Myconos Center

The bus will depart from the “Royal Myconian Hotel” at 6:00 PM

Tuesday, May 21

7:00 AM

Breakfast

Session III: Scaffolds, Carriers, and Other Delivery Vehicles

Co-Chairs: Dirk W. Grijpma and Antonios G. Mikos

Invited Lecture

8:30 AM

22

Biodegadable elastomeric scaffolds for tissue engineering.

D.W. Grijpma, Q. Hou, A.P. Pêgo and J. Feijen

Oral Presentations

9:00 AM

23

The Added Value of Synthetic Polymers in Tissue Engineering.

A.G. Mikos

9:15 AM

24

Lipids: An alternative to polymers for protein delivery.

A. Göpferich, W. Vogelhuber , A. Lucke ,A. Maschke

9:30 AM

25

In Vitro and in vivo behaviour of bioreconstructive P(L/D)LA (96/4) knitted scaffolds.

M. Kellomäki, T. Kulmala, V. Ellä, S. Länsman, N. Ashammakhi, T. Waris, P. Törmälä

9:45 AM

26

Novel Nanophase Ceramic/Polymer Composites for Bone Tissue Engineering.

R.W. Siegel, A.J. Dulgar, and R. Bizios

10:00 AM

27

Design of biodegradable implants for hard-tissue engineering.

E. Schacht, G. Jackers ,R. Cornelissen

10:15 AM

Break

Oral/Poster Presentations

10:20 AM

28

A versatile 3-dimensional polymeric inorganic scaffold for in vitro and in vivo  tissue engineering applications.

M.B. Lyles, J. Martell, B. McAllister, E.J.Boland, and R.G. LeBaron.

10:25 AM

29

Preliminary studies on human periodontal ligament fibroblasts and Alveolar Osteoblasts cultured on foil-scaffold  constructs.

A.M. Chou, V. Sae-Lim, Y.F. Zhou, J.T. Schantz, D.W. Hutmacher, T.M. Lim

10:30 AM

30

Ultra thin poly (e-caprolactone) films for tissue engineering applications.

A.S. Htay, S.H. Teoh, D.W. Hutmacher

10:35 AM

31

In vivo cartilage regeneration using 3D poly (e-caprolactone) scaffolds.

K.W. Ng, C. Kaps, A. Haisch, M. Sittinger, D.W. Hutmacher

10:40 AM

32

Current-conducting polymer/nanophase composites for bone tissue engineering.

R. Bizios, P.R. Supronowicz, S.H. Huang, P.M. Ajayan, B.P. Arulanandam, and D.W. Metzger

10:45 AM

33

Polymers for surface modification of biomaterials.

E. Schacht, G. Snellings

10:50 AM

34

The use of a polymer in the treatment of bone defects.

Luc W. J. Huys; Etienne H. Schacht ; Eddy W. Van Hecke

10:55 AM

Coffee break

Session IV: Angiogenesis; Vasculogenesis

Chair: Yasuhiko Tabata

Invited Lecture

11:30 AM

35

Angiogenesis based on growth factor release and its role in tissue engineering.

Y. Tabata

Oral Presentations

12:00 Noon

36

Vascular Potential of Adult Stem Cells.

K.K. Hirschi

12:15 PM

37

TEBV : The importance of the extra cellular Matrix in the self assembly approach.

F.A. Auger

12:30 PM

38

Vascularization of 3-Dimentional Scaffolds.

S.F Badylak, F. Ling, R. Record, and J. Hodde

12:45 PM

39

Normal functioning of endoplasmic reticulum is essential for angiogenesis.

J.A. Martínez, V.N. Katiyar, and D.K. Banerjee

1:00 PM

Break

Oral/Poster Presentations

1:05 PM

40

ECM Scaffold for Myocardial Reconstruction.

S.F. Badylak, R. Matheny, J. Obermiller, L.A. Geddes

1:10 PM

41

Engineering cardiac muscle tissue under microgravity within 3D polysaccharide scaffolds.

M. Shachar, T. Dvir, J. Leor, S. Cohen

1:15 PM

42

The first organic biomatrix with preserved native vascular network and a wide range of applications in tissue engineering.

T. Kofidis,  A. Haverich, H. Mertsching

1:20 PM

43

Restoration of blood flow by implantation of VEGF loaded biomatrices.

T. Kofidis, A. Metzakis, D. Nolt, A. Haverich.

1:25 PM

44

A novel multifunctional bioreactor - New prospects in tissue engineering and angiogenesis research.

T. Kofidis, P. Akhyari, A. Lenz, J. Boublik, B. Wachsmann, A. Haverich

1:30 PM

Lunch

Wednesday, May 22

7:00 AM

Breakfast

8:30 AM – 1:30 PM Delos Tour

1:30 PM

Lunch

Session V: Functional Design/ Assessment

Chair: David J.  Mooney

Invited Lecture

3:00 PM

45

Design of vascular networks for engineered tissues.

D. Mooney

Oral Presentations

3:30 PM

46

Cartilage repair by autologous chondrocyte implantation: maintenance of the chondrogenic potential of the expanded cells through a controlled and sustained expression of SOX9.

B. Dozin, M. Malpeli and R. Cancedda

3:45 PM

47

Self-Organization and Contractility of Skeletal and Cardiac Muscle Tissue In Culture.

R.G. Dennis

4:00 PM

48

Patient-oriented maxillo-facial tissue-engineering.

A. Letic-Gavrilovic

4:15 PM

49

Collagen meniscus implants (CMI): Tissue engineering approach to meniscus reconstruction.

W.G. Rodkey, J.R. Steadman

4:30 PM

Break

Oral/Poster Presentations

4:35 PM

50

Molecular design of biodegradable polymers for tissue engineering.

F. Rypácek, D. Kubies, L. Machová, V. Proks,  andS. Popelka

4:40 PM

51

Process development of acellular dermal matrix (ADM)  for soft tissue augmentation.

R-N. Chen, Y-T. Tsai, H-O.Ho, and M-T Sheu

4:45 PM

52

Preliminary study of Invitro Production of Skin Substitute using Polycaprolactone Based Membrane as Epidermal Substrate.

H.L. Khor, K.W. Ng, A.S. Htay, J-T. Shantz, S.H. Teoh, D.W. Hutmacher,

4:50 PM

53

A new bioreactor system to produce three-dimensional cartilage implants.

P. Czermak, D. Nehring,  S. Gokorsch, I. Wilcke

4:55 PM

54

Fluid flow increases mineralized matrix deposition in three-dimensional perfusion culture of marrow stromal osteoblasts in a dose-dependent manner.

V.I. Sikavitsas, G.N. Bancroft, J. van den Dolder, J.A. Jansen, and A.G. Mikos

5:00 PM

Coffee break

Session VI: Immunology/Biocompatibility

Chair: John D. Lambris

Invited Lecture

5:30 PM

55

Design of a complement inhibitor and its therapeutic potential to control biomaterial mediated complement  activation and inflammation.

J.D. Lambris, A. Sahu, A. Soulika, D. Morikis.

Oral Presentations

6:00 PM

56

Immune Response to Acellular Xenogeneic Scaffolds.

S.F. Badylak, D. Metzger, G. vanSeventer

6:15 PM

57

Macrophage-Mediated Proteolytic Degradation Of Tissues.

Z.S. Galis

6:30 PM

58

The evaluation of natural and synthetic 3D matrices as suitable dermal substrates.

K.W. Ng, H.L. Khor, H.N. Achuth, X.M. Mo, S.H. Teoh, T.C. Lim, D.W. Hutmacher

6:45 PM

59

A clinically established hemostatic scaffold (TISSUE FLEECE®) as biomatrix in tissue and organ engineering research.

T.Kofidis T, P. Akhyari, B. Wachsmann, K. Mueller-Stahl, J. Boublik, H. Mertsching, A. Haverich

7:00 PM

Break

Oral/Poster Presentations

7:05 PM

60

Tissue Engineering of Patient Specific Bone Grafts by Using Medical Imaging, Computational Modelling, Bioresorbable Scaffolds and Osteoblast-like Cells.

D.W. Hutmacher, Chou Ning, T.C. Lim, J.-Th. Schantz

7:10 PM

61

Standardization of skin culture for treatment of chronic ulcers and burned patients in Medellín Colombia.

C. Chamorro, M. Arango, L. Restrepo

7:15 PM

62

Cell culture substratum made of a tissue section induces unique cell behaviors.

T. Takezawa, T. Takenouchi, K. Imai, T. Takahashi, and K. Hashizume,

7:20 PM

63

Bone Marrow Derived Cells To Promote Alveolar Bone Regeneration By Tissue Engineering.

M.K. Marei, S.R. Nouh, M.M. Fata, M.A. El-Demellawy

7:25 PM

64

Preperation and evaluation of the post-surgical adhesion prevention opportunity of hyaluronate-based polymer.

S-W. Tsai, J-F. Fang, C-L. Yang, L-T. Su, B-H. Tsai, and J-H. Chen

7:30 PM

65

Thymosine beta 4 promotes wound repair and hair regeneration via a seven amino acid acting binding sequence.

D. Philp, B. Scheremeta, M. Elkin, and H.K. Kleinman

7:35 PM

66

Films of silk fibroin/collagen blends as substrata for mammalian cell culture.

G. Catapano, G. Cascardo, B. Cirillo B, C. Cassinelli

7:40 PM

Poster Session

8:30 PM

Dinner

Thursday, May 23

7:00 AM

Breakfast

Session VII: Product Development – Reaching the Application of Scientific Discovery

Co-Chairs: David S. Smith and Kiki B. Hellman

Oral Presentations

9:00 AM

67

K.B. Hellman

9:30 AM

68

Tissue Engineering -- Product development and public expectations.

D. Smith

10:00 AM

69

Product development in Europe: Regulatory hurdles.

F.J.C. van Strien

10:30 AM

70

WTEC Panel Report on Tissue Engineering.

L.V. McIntire

11:00 AM

Coffee break

Session VIII: Current Challenges and Future Directions

Chair: Robert M. Nerem

Oral Presentations

11:30 AM

Session I Report

11:35 AM

Session II Report

11:40 AM

Session III Report

11:45 AM

Session IV Report

11:50 AM

Session V Report

11:55 AM

Session VI Report

12 Noon

Session VII Report

12:05 PM

Break

12:10 PM

Discussion Session

Rapporteur

Robert M. Nerem

12:55 PM

Symposium Report

1:25 PM

Concluding Remarks

Kiki B. Hellman

1:30 PM

Lunch

8:00 PM

Gala Dinner