GENERAL INFORMATION

Accommodations

The conference participants will be staying at the Aldemar: Knossos Royal Village (A' class), which is located in Hersonissos, 25 km from the airport.

Breakfast

Breakfast will be served at your hotel during the hours scheduled in this program.

Conference Venue

The Aldemar: Knossos Royal Village Conference Center is located at the hotel.

Oral Presentations

An LCD projector and an overhead projector will be available for the oral presentations. Speakers are asked to bring their USB flash drive or CD to the conference reception desk at least 30 minutes prior to the session. The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

Posters

Posters should be mounted Monday morning, May 29, on the designated boards and dismounted at the end of the meeting. The dimensions of the boards are 90W x 150H cm. Adhesive tape for mounting the posters on the boards will be available at the poster area.

Welcome Reception and Banquet

Badges are required for admission.

Tour to Knossos and Museum

Busses for the island tour will be leaving from the hotel on Tuesday, May 30 at 2:30 p.m. Accompanying persons will also be picked up at the hotel front lobby at that time. Badges are required for participation.

Lunches

Lunches will be served at the indicated times to all registered participants and registered accompanying persons in the hotel. Badges are required for admission.

Sunday, May 28
5:00 - 8:00 PM		Open Registration
8:00 PM		Welcome Reception/Dinner
Monday, May 29
8:30 AM		Welcome and Opening Remarks
Session I.		Transcription Factors and Signals for the Osteoimmune System: Part 1
9:00 AM	1	Control of cell migration by RANKL J Penninger
9:30 AM	2	Schnurri-3: a key regulator of postnatal skeletal remodeling DC Jones, M Wein, and LH Glimcher
10:00 AM	3	Regulation of ectodomain shedding of RANKL S Tanaka, A Hikita, I Yana, M Seiki, K Nakamura
10:30 AM	4	Regulation of Osteoclast Differentiation and Maturation Y Choi
11:00 AM		Coffee Break & Poster Session
Session II		Transcription Factors and Signals for Osteoclasts
11:30 AM	5	Molecular and cellular pathways in modeled arthritis E Douni
12:00 Noon	6	Tumor necrosis factor and the osteoclast S Teitelbaum
12:30 PM	7	Conditional mutagenesis reveals that nfatc1 is required for osteoclast differentiation in vivo AO Aliprantis, NC Walsh, KP McHugh, E Gravallese, and LH Glimcher
12:45 PM	8	The inositol polyphosphate 4-phosphatase type II, a novel modulator of osteoclast differentiation J Vacher, M Ferron, and M Pata
1:00 PM	9	ID Helix-loop-helix proteins negatively regulate trance-mediated osteoclasts differentiation N Kim, J Lee, K Kim, JH Kim, H Mi Jin, HK Choi, SH Lee, Y Yokota, SY Lee, and Y Choi
1:15 PM	10	Osteoclastgenesis is regulated by cyclin-dependent kinase 4/6 Y Murakami, H Takayanagi, N Miyasaka, and H Kohsaka
1:30 PM	11	Signaling pathways mediated by the G protein subunit Gsa are involved in regulation of B lymphopoiesis by osteoblasts JY Wu, LE Purton, S Rodda, AP McMahon, DT Scadden, and HM Kronenberg
1:45 PM	12	Osteoblasts express members of the NOD family of intracellular pattern recognition receptors that could mediate cell death and inflammation associated with osteomyelitis I Marriott
2:00 PM	13	Cooperative regulation of bone formation by NFAT and Osterix T Koga, K Nakashima, and H Takayanagi
2:15 PM		Lunch
8:00 PM		Dinner at a Local Greek Tavern
	The bus for the tavern will depart from the hotel at 7:30 PM
Tuesday, May 30
Session III		Bone Metabolism, Hematopoiesis and Immune responses
9:00 AM	14	Immunologic Regulation of Bone Cell Development M Horowitz
9:30 AM	15	PTH signaling and hematopoiesis H Kronenberg
10:00 AM	16	Regulation of Hematopoietic Stem Cells in the Osteoblastic Niche F Arai
10:30 AM	17	The chemokine CXCL12 and regulation of HSC and B lymphocyte development in the bone marrow niche T Nagasawa
11:00 AM		Coffee Break, Poster Viewing, and Poster Award Selection
1:30 PM		Lunch
2:30 PM		Tour to Knossos Archaeological site & Archaeological Museum of Heraklion
The bus for the museum will depart from the hotel at 2:30 PM
8:00 PM		Dinner at a local Greek Tavern
Wednesday, May 31
Session IV		Cytokines regulating the crosstalk between bone and the immune system
9:00 AM	18	Identification of osteoclast precursor cells and the role of osteoclasts in anabolic responses to parathyroid hormone J Lorenzo
9:30 AM	19	Inhibition of osteoclastogenesis by interleukins, lectins and lymphocytes M Gillespie
10:00 AM	20	Interaction with estrogen receptors as treatment of arthritis and osteoporosis H Carlsten
10:30 AM	21	Functions of AP-1(Fos/Jun)in inflammatory diseases E Wagner
11:00 AM		Coffee Break
Session V		Costimulation in the immune system and bone
11:30 AM	22	Novel signaling pathways and therapeutic targets in osteoclasts H Takayanagi
12:00 Noon	23	TREM receptors in osteoimmunology M Colona
12:30 PM	24	Ligands for TREM2, a regulator of osteoclastogenesis, are expressed on both macrophages and preosteoclasts MC Nakamura, MB Humphrey, J Hammerman, MR Daws, EC Niemi, LL Lanier, and WE Seaman
12:45 PM	25	An immunoreceptor-like pathway in neutrophils, macrophages and osteoclasts A Mocsai, MB Humphrey, CL Abram, Z Jakus , Z Kertesz, LL Lanier, MC Nakamura, and CA Lowell
1:00 PM	26	NK cells express RANKL and support osteoclast formation in vitro S Owen, L Danks, M Feldmann, F Brennan, and NJ Horwood
1:15 PM	27	CD4+ T cells induction of bone destruction during inflammation requires TNFa and not RANKL and is antagonized by IFNg acting in a STAT-1 independent manner via T-bet MP Quinones, C Estrada, F Jimenez, HG Martinez, M Dudley, OW, RL Reddick, SK Ahuja, and SS Ahuja
1:30 PM	28	B-Lymphocytes are not required for estrogen-mediated effects on bone mineral density M Lindberg, C Jochems, A Kallkopf, S Windahl, K Pettersson, J Inzunza, J-Å Gustafsson, L Svensson, R Holmdahl, C Ohlsson, and H Carlsten
1:40 PM	29	ALPHA/BETA-T cells do not modulate estrogen deficiency-induced bone loss in rats RG Erben and K Mildner
1:50 PM	30	The inhibitor of T cell costimulation CTLA-4IG prevents the loss of trabecular and cortical bone loss induced by ovariectomy. Evidence that T-cell activation is required for overiectomy to induce bone loss F Grassi, Y Gao, M Terauchi, M Ryan, K Page, X Yang, N Weitzmann, and R Pacifici
2:00 PM		Discussion for Abstract #28, 29, 30
2:10 PM		Lunch
8:00 PM		Dinner at Knossos Royal Village
Thursday, June 1
Session VI		Factors regulating the crosstalk between bone and the immune system
9:00 AM	31	Regulation of osteoclastogenesis by inflammatory cytokines and SOCS A Yoshimura, Y Minoda, H Takaki, and M Ohishi
9:30 AM	32	Role of IKK subunits in osteoclast function and inflammation-induced bone loss M Karin
Session VII		Osteoimmune diseases
10:00 AM	33	The role of cell-matrix interactions in osteoclast differentiation and activation S Goldring
10:30 AM	34	Molecular mechanisms of solid tumor metastases to bone T Guise
11:00 AM		Coffee Break
Session VIII		Novel Therapies
11:30 PM	35	Targeting osteoporosis, inflammation and bone resorption by vaccination against cytokines MF Bachmann, G Jennings, and G Spohn
12:00 Noon	36	RANKL Inhibition: From Mice to Men (and Women) D Zack
12:30 PM	37	Apoptotic Osteocytes Induce the Production of pro-inflammatory osteoclastogenic cytokines G Kogianni, V Mann, and BS Noble
12:45 PM	38	Hyaluronic acid inhibits osteoclast differentiation through toll-like receptor 4 HJ Kim, EJ Chang, J Ha, HJ Kim, J Ryu, UH Kim, ZH Lee, HM Kim, DE Fisher, and HH Kim
1:00 PM	39	Altered osteogenic properties of bone marrow stromal cells from multiple myeloma patients G Brunetti, S Colucci, G Mori, A Oranger, R Rizzi, S Capalbo, V Liso, and M Grano
1:15 PM	40	Novel human RANKL mRNAS are expressed in cell types associated with inflammatory bone loss NC Walsh, AR Pettit, CA Manning, JF Wang, SR Goldring, KP McHugh, and EM Gravallese
1:30 PM	41	Shwachman-Diamond syndrome is associated with neutropenia and low-turnover primary osteoporosis