GENERAL INFORMATION

Accommodations

The conference participants will be staying at the Aldemar: Knossos Royal Village (A' class), which is located in Hersonissos, 25 km from the airport.

Breakfast

Breakfast will be served at your hotel during the hours scheduled in this program.

Conference Venue

The Aldemar: Knossos Royal Village Conference Center is located at the hotel.

Oral Presentations

An LCD projector and an overhead projector will be available for the oral presentations. Speakers are asked to bring their USB flash drive or CD to the conference reception desk at least 30 minutes prior to the session. The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

Posters

Posters should be mounted Monday morning, May 29, on the designated boards and dismounted at the end of the meeting. The dimensions of the boards are 90W x 150H cm. Adhesive tape for mounting the posters on the boards will be available at the poster area.

Welcome Reception and Banquet

Badges are required for admission.

Tour to Knossos and Museum

Busses for the island tour will be leaving from the hotel on Tuesday, May 30 at 2:30 p.m. Accompanying persons will also be picked up at the hotel front lobby at that time. Badges are required for participation.

Lunches

Lunches will be served at the indicated times to all registered participants and registered accompanying persons in the hotel. Badges are required for admission.

Sunday, May 28
5:00 - 8:00 PM		Open Registration
8:00 PM		Welcome Reception/Dinner
Monday, May 29
8:30 AM		Welcome and Opening Remarks
Session I.		Transcription Factors and Signals for the Osteoimmune System: Part 1
9:00 AM	1	Control of cell migration by RANKL J Penninger
9:30 AM	2	Schnurri-3: a key regulator of postnatal skeletal remodeling DC Jones, M Wein, and LH Glimcher
10:00 AM	3	Regulation of ectodomain shedding of RANKL S Tanaka, A Hikita, I Yana, M Seiki, K Nakamura
10:30 AM	4	Regulation of Osteoclast Differentiation and Maturation Y Choi
11:00 AM		Coffee Break & Poster Session
Session II		Transcription Factors and Signals for Osteoclasts
11:30 AM	5	Molecular and cellular pathways in modeled arthritis E Douni
12:00 Noon	6	Tumor necrosis factor and the osteoclast S Teitelbaum
12:30 PM	7	Conditional mutagenesis reveals that nfatc1 is required for osteoclast differentiation in vivo AO Aliprantis, NC Walsh, KP McHugh, E Gravallese, and LH Glimcher
12:45 PM	8	The inositol polyphosphate 4-phosphatase type II, a novel modulator of osteoclast differentiation J Vacher, M Ferron, and M Pata
1:00 PM	9	ID Helix-loop-helix proteins negatively regulate trance-mediated osteoclasts differentiation N Kim, J Lee, K Kim, JH Kim, H Mi Jin, HK Choi, SH Lee, Y Yokota, SY Lee, and Y Choi
1:15 PM	10	Osteoclastgenesis is regulated by cyclin-dependent kinase 4/6 Y Murakami, H Takayanagi, N Miyasaka, and H Kohsaka
1:30 PM	11	Signaling pathways mediated by the G protein subunit Gsa are involved in regulation of B lymphopoiesis by osteoblasts JY Wu, LE Purton, S Rodda, AP McMahon, DT Scadden, and HM Kronenberg
1:45 PM	12	Osteoblasts express members of the NOD family of intracellular pattern recognition receptors that could mediate cell death and inflammation associated with osteomyelitis I Marriott
2:00 PM	13	Cooperative regulation of bone formation by NFAT and Osterix T Koga, K Nakashima, and H Takayanagi
2:15 PM		Lunch
8:00 PM		Dinner at a Local Greek Tavern
	The bus for the tavern will depart from the hotel at 7:30 PM
Tuesday, May 30
Session III		Bone Metabolism, Hematopoiesis and Immune responses
9:00 AM	14	Immunologic Regulation of Bone Cell Development M Horowitz
9:30 AM	15	PTH signaling and hematopoiesis H Kronenberg
10:00 AM	16	Regulation of Hematopoietic Stem Cells in the Osteoblastic Niche F Arai
10:30 AM	17	The chemokine CXCL12 and regulation of HSC and B lymphocyte development in the bone marrow niche T Nagasawa
11:00 AM		Coffee Break, Poster Viewing, and Poster Award Selection
1:30 PM		Lunch
2:30 PM		Tour to Knossos Archaeological site & Archaeological Museum of Heraklion
The bus for the museum will depart from the hotel at 2:30 PM
8:00 PM		Dinner at a local Greek Tavern
Wednesday, May 31
Session IV		Cytokines regulating the crosstalk between bone and the immune system
9:00 AM	18	Identification of osteoclast precursor cells and the role of osteoclasts in anabolic responses to parathyroid hormone J Lorenzo
9:30 AM	19	Inhibition of osteoclastogenesis by interleukins, lectins and lymphocytes M Gillespie
10:00 AM	20	Interaction with estrogen receptors as treatment of arthritis and osteoporosis H Carlsten
10:30 AM	21	Functions of AP-1(Fos/Jun)in inflammatory diseases E Wagner
11:00 AM		Coffee Break
Session V		Costimulation in the immune system and bone
11:30 AM	22	Novel signaling pathways and therapeutic targets in osteoclasts H Takayanagi
12:00 Noon	23	TREM receptors in osteoimmunology M Colona
12:30 PM	24	Ligands for TREM2, a regulator of osteoclastogenesis, are expressed on both macrophages and preosteoclasts MC Nakamura, MB Humphrey, J Hammerman, MR Daws, EC Niemi, LL Lanier, and WE Seaman
12:45 PM	25	An immunoreceptor-like pathway in neutrophils, macrophages and osteoclasts A Mocsai, MB Humphrey, CL Abram, Z Jakus , Z Kertesz, LL Lanier, MC Nakamura, and CA Lowell
1:00 PM	26	NK cells express RANKL and support osteoclast formation in vitro S Owen, L Danks, M Feldmann, F Brennan, and NJ Horwood
1:15 PM	27	CD4+ T cells induction of bone destruction during inflammation requires TNFa and not RANKL and is antagonized by IFNg acting in a STAT-1 independent manner via T-bet MP Quinones, C Estrada, F Jimenez, HG Martinez, M Dudley, OW, RL Reddick, SK Ahuja, and SS Ahuja
1:30 PM	28	B-Lymphocytes are not required for estrogen-mediated effects on bone mineral density M Lindberg, C Jochems, A Kallkopf, S Windahl, K Pettersson, J Inzunza, J-Å Gustafsson, L Svensson, R Holmdahl, C Ohlsson, and H Carlsten
1:40 PM	29	ALPHA/BETA-T cells do not modulate estrogen deficiency-induced bone loss in rats RG Erben and K Mildner
1:50 PM	30	The inhibitor of T cell costimulation CTLA-4IG prevents the loss of trabecular and cortical bone loss induced by ovariectomy. Evidence that T-cell activation is required for overiectomy to induce bone loss F Grassi, Y Gao, M Terauchi, M Ryan, K Page, X Yang, N Weitzmann, and R Pacifici
2:00 PM		Discussion for Abstract #28, 29, 30
2:10 PM		Lunch
8:00 PM		Dinner at Knossos Royal Village
Thursday, June 1
Session VI		Factors regulating the crosstalk between bone and the immune system
9:00 AM	31	Regulation of osteoclastogenesis by inflammatory cytokines and SOCS A Yoshimura, Y Minoda, H Takaki, and M Ohishi
9:30 AM	32	Role of IKK subunits in osteoclast function and inflammation-induced bone loss M Karin
Session VII		Osteoimmune diseases
10:00 AM	33	The role of cell-matrix interactions in osteoclast differentiation and activation S Goldring
10:30 AM	34	Molecular mechanisms of solid tumor metastases to bone T Guise
11:00 AM		Coffee Break
Session VIII		Novel Therapies
11:30 PM	35	Targeting osteoporosis, inflammation and bone resorption by vaccination against cytokines MF Bachmann, G Jennings, and G Spohn
12:00 Noon	36	RANKL Inhibition: From Mice to Men (and Women) D Zack
12:30 PM	37	Apoptotic Osteocytes Induce the Production of pro-inflammatory osteoclastogenic cytokines G Kogianni, V Mann, and BS Noble
12:45 PM	38	Hyaluronic acid inhibits osteoclast differentiation through toll-like receptor 4 HJ Kim, EJ Chang, J Ha, HJ Kim, J Ryu, UH Kim, ZH Lee, HM Kim, DE Fisher, and HH Kim
1:00 PM	39	Altered osteogenic properties of bone marrow stromal cells from multiple myeloma patients G Brunetti, S Colucci, G Mori, A Oranger, R Rizzi, S Capalbo, V Liso, and M Grano
1:15 PM	40	Novel human RANKL mRNAS are expressed in cell types associated with inflammatory bone loss NC Walsh, AR Pettit, CA Manning, JF Wang, SR Goldring, KP McHugh, and EM Gravallese
1:30 PM	41	Shwachman-Diamond syndrome is associated with neutropenia and low-turnover primary osteoporosis S Toiviainen-Salo, M Mäyränpää, N Richards, P Durie, L Ellis, J Rommens, WG Cole, E Savilahti, and O Mäkitie
1:45 PM	42	A neutralizing antibody to sclerostin can increase bone strength and help reduce inflammation induced bone loss M Robinson, D Marshall, K Greenslade, H Kirby, P Stephens, C Paszty, and A Moore
2:00 PM	43	Molecular and clinical analysis of 200 autosomal recessive osteopetrotic (ARO) patients C Sobacchi, A Pangrazio, M Helfrich, FP Coxon, PL Poliani, L Susani, F Rucci, P Vezzoni, A Villa, and A Frattini
2:15 PM		Concluding Remarks
2:30 PM		Lunch
8:00 PM		Gala Dinner at Aldemar: Knossos Royal Village

Friday, June 2
7:30 AM	Breakfast
	Departure

POSTERS
	44	24P3 released from bone enhance progenitor and mature hematopietic cells in bone marrow of transgenic mice D Costa, R Biticchi, R Tasso, Pennesi, S Negrini, F Descalzi Cancedda, S Garofalo, R Cancedda, and S Tavella
	45	Association of tumor necrosis factor -a\ G-238A and G-308A promotor polymorphisms with ankylosing spondylitisin Taiwan MY Shiau, MK Lo, CP Chang, TP Yang, KT Ho, KJ Tsai, and YH Chang
	46	Bone formation animal models Y Yu, J-L Yang, B Niechoda, WR Walsh
	47	Bone phenotype of IL-7 transgenic mice D Salopek, V Katavic, and V Marusic
	48	Cytokine expression profile of porcine osteoblasts as determined by flow cytometry W Sipos, D Krenbek, M Rauner, and P Pietschmann
	49	Development of bone phenotype in generalised lymphoproliferative disorder IK Lukic, N Kovacic, D Grcevic, V Katavic, A Lukic, S Ivcevic, and A Marusic
	50	Distribution of the bone morphogenic protein-4 polymophism in Russian adult women KA Maslova, MYu Krylov, EE Mikhailov, VA Myakotkin, and LI Benevolenskaya
	51	Environmental effects on bone matrix and immune function Zs Valkusz, B Hegedűs, M Radács, Gy Nagyéri, J Gardi, A Juhász, A Petri, and M Gálfi
	52	FAS/FAS ligand system is important both for apoptosis and differentiation of murine osteoblasts and osteoclasts N Kovacic, IK Lukic, D Grcevic, V Katavic, P Croucher, and A Marusic
	53	Features of mandible formation in adult rats after thymectomy VI Luzin and OV Andrieieva
	54	Hepatocyte growth factor inhibits BMP-inuced osteoblastogenesis T Standal, N Abildgaard, UM Fagerli, B Stordal, A Waage, M Borset, and A Sundan
	55	Heterogeneous expression of HLA class I in Ewing’s Sarcoma cell lines and patients A de Hooge, G Alblas, S Santos, E Jordanova, A Mulder, C Melief, P Hogendoorn, and A Lankester
	56	Histological examination of the periodontal tissues in a mouse model periodontal disease DM Wong, V Tam, R Lam, L Tatarczuch, CN Pagel, RN Pike, NM O’Brien-Simpson, and EJ Mackie
	57	Identification of RhoGTPases and RhoGEFs up regulated during RANKL-stimulated osteoclastogenesis A Blangy, N Morrison, H Brazier, S Stephens, P Fort, and S Ory
	58	IL-23 upregulates RANKL expression from CD4+T cells in IL-1Ra-/- mouse model JH Ju, ML Cho, YM Moon, S Heon Lee, YO Jung, HJ Ko, and HY Kim
	59	IL-4, IL-10 and CTLA-4 gene polymorphisms in Taiwanese patients with ankylosing spodylitis KT Ho, YH Chang, and CM Chen
	60	Interleukin-1 is a mediator of TNF-induced cartilage and bone damage J Zwerina, K Polzer, J Gasser, L Joosten, G Kollias, J Smolen, W van den Berg, K Redlich, and G Schett
	61	Interleukin-18 induces the production of Vascular Endothelial Growth Factor (VEGF) in rheumatoid arthritis synovial fibroblasts via AP-1 dependent pathways YO Jung, ML Cho, JH Ju,YM Moon, SH Lee, HJ Ko, and HY Kim
	62	Interleukin-6 and osteoprotegerin systems profiles in an apparently healthy population I Pantsulaia, S Trofimov, E Kobyliansky, and G Livshits
	63	Investigating the relationship between bone and immune systems S Corneau, S Y Smith, and L LeSauteur
	64	IP-10 mediates bone erosion in collagen-induced arthritis H Bok Kwak, H Ha, HN Kim, JH Lee, D Yang, HH Kim, YW Song, and Z Hee Lee
	65	Osteoclast differentiation, survival and morphology in vitro co-culture system V Nicolin, P Narducci, B Martinelli, and G Zauli
	66	Peroxynitrite-modified collagen-II induced synthesis of NO and other inflammatory mediators in chondrogenically differentiated mesenchymal progenitor cells: implications for cartilage damage and repair in the diseased human joint M Whiteman, JS Armstrong, and JT Schantz
	67	Phenotypic and functional characteristics of immune cells in severe post-menopausal osteoporotic women : preliminary results. V Breuil, M Ticchioni, J Testa, A Wakkach, JP Breittmaier, CH Roux, C Blin- Wakkach, A Bernard, L Euller-Ziegler, and GF Carle
	68	RANKL and OPG regulate pro-inflammatory cytokine production in mice K Maruyama, H Yasuda, and K Matsuo
	69	RANKL-mediated upregulation of oscar expression is dependent on IKKa M Chaisson and W Dougall
	70	Regulation of human osteoclast development by LILRB4 in vitro Y Mori, M Inui, S Tsuji, A Nakamura, and T Takai
	71	Regulation of Mouse Osteoprotegerin Gene Expression by Glucocorticoids T Kondo, R Kitazawa, and S Kitazawa
	72	Regulation of Osteoclast differentiation and function by CAMK and CREB pathway A Suematsu, K Sato, and H Takayanagi
	73	Risk Factors of osteoporosis in Systemic Lupus Erythematosus (SLE) - an Observational Study K Almehed, H Forsblad, EG Kvist, C Ohlsson, and H Carlsten
	74	STAT3 and NF-kB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model, IL-1 receptor antagonist-deficient mice ML Cho, YO Jung, JH Ju, HJ Ko, SH Lee, YM Moon, HY Kim
	75	Suppression of Osteoclastogenisis by activated T-lymphocytes does not depend on the mode of their activation D Grčević, IK Lukić, N Kovačić, S Ivčević, V Katavić, and A Marušić
	76	The bisphosphonate induces the inflammatory cytokines but inhibits the osteoclastogenesis from the human peripheral blood mononuclear cells (PBMCS) in vitro W Park, SR Kwon, and JY Shin
	77	The extrinsic regulation of hematopoietic stem cell function SR Mayack and AJ Wagers
	78	Time-Dependent RANKL and OPG gene expression in calvarie- and bone marrow-derived osteoblasts in mouse and rat M Rauner, E Kallay, M Winzer, and P Pietschmann
	79	TLR-2, 3, 4 modulate the osteoclastogenic activity of RA FLS via RANKL activation S Heon Lee, KW Kim, ML Cho, JH Ju, YO Jung, HJ Ko, and HY Kim
	80	TRANCE-induced Schlafen2 is a positive regulator of osteoclastogenesis NK Lee, HK Choi, HJ Yoo, and SY Lee
	81	Hepatocyte growth factor can substitute for macrophage colony stimulating factor in RANKL induced osteoclatogenesis IE Adamopoulos, Xia Zhidao, YS Lau, GG Russell, and NA Athanasou
	82	Estrogen deficiency induces bone loss in mice lacking the ITAM adapter proteins, DAP12 or FcRγ Y Wu, J Torchia, A Mocsai, CA Lowell, LL Lanier, MC Nakamura, and MB Humphrey
	83	HMGB1 is a bone and immune-active cytokine JP Bidwell, J Yang, R Shah, M Charoonpatrapong, and AG Robling
	84	Murine dentritic cells differentiate in vivo into functional osteoclasts C Blin-Wakkach, A Wakkach, R Dacquin, P Jurdic, and GF Carle
	85	Differential cytokine gene expression in the pagetic osteoblast J Cornish, B Matthews, U Bava, KE Callon, M Black, S Song, GD Gamble, IR Reid, and D Naot
	86	RANKL inhibition with RANK-fc prevents bone loss but does not affect immune status in a mouse collagen-induced arthritis (CIA) model WC Dougall, A Armstrong, D Alcorn, A Brewer, J Tocker, and M Chaisson
	87	The RANKL inhibitor denosumab increases bmd in postmenopausal women with osteopenia or osteoporosis with no alterations in measured parameters of immune function LA Fitzpatrick, PD Miller, EM Lewiecki, A Wang, Y Liu, DJ Zack, and SB Cohen
	88	Dietary intervention, does vitamin D intake have anti tumour necrosis factor properties? L Førli, Ø Bjørtuft, and J Boe
	89	Continuous PTH treatment causes bone loss through a bidirectional cross-talk between stromal cells and T cells Y Gao, M Terauchi, F Grassi, MR Ryan, K Page, X Yang, MN Weitzmann, and R Pacifici
	90	Deficiency of the specific immune system enhances bone healing in-vivo MS Gaston, BS Noble, and AHRW Simpson
	91	Oxidized low density lipoproteins induce RANKL production by resting Human T cells. LS Graham, F Parhami, and RB Effros
	92	The extracellular matrix proteins, fibronectin and vitronectin, have a biphasic effect on osteoclastogenesis and alter the expression of important osteoclastic markers A Gramoun, DP Trebec, N Azizi, and MF Manolson
	93	Heparin Sulphate binding VEGF isoforms selectively enhance endochondral bone formation and regulate the bone marrow hematopoietic stem cell niche S Bartunkova, C Maes, K Haigh, A Chan, L Liontos, I Stockmans, K Moermans, R Van Looveren, A Nagy, G Carmeliet, and JJ Haigh
	94	Protective properties of dexamethasone in experimental postmenopausal osteoporosis C Jochems, A Kallkopf, M Lindberg, C Ohlsson, and H Carlsten
	95	Raloxifene is a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis C Jochems, A Kallkopf, M Lindberg, C Ohlsson, and H Carlsten
	96	Actions of C-type lectins on bone metabolism V Kartsogiannis, A Nakamura, H Zhou, C Gange, C Ly, NA Sims, TJ Martin, Kong WahNg, JMW Quinn,and MTGillespie
	97	Mechanisms of shn3-mediated inhibition of osteoblast function MN Wein, DC Jones, M Oukka, and LH Glimcher
	98	RANKL inhibition with rank-fc inhibits osteoclast activity at doses that do not affect host immune responses to influenza infection RE Miller, D Branstetter, J Jones, L Cowan, and WC Dougall
	99	Targeting both osteoclast and osteoblast more effectively recudes prostate cancer growth in bone than either alone KS Mohammad, R Vessella, E Corey, and TA Guise
	100	Novel role for the immunomodulatory protein PLCγ2 in the regulation of bone homeostasis R Faccio and D Mao
	101	Rats overexpressing soluble opg from a prenatal stage exhibit a high bone mass phenotype but no alterations in the development of lymphoid organs or in innate immune response M Stolina, D Dwyer, MS Ominsky, T Corbin, DJ Zack, G Van, B Bolon, J McCabe, and PJ Kostenuik
	102	DC-STAMP play a role in osteoclast and macrophage giant cell fusion and dendritic cell cross presentation T Miyamoto, Y Toyama, and T Suda
	103	Pathway analysis during osteoblastic/adipocitic differentiation of human bone marrow-derived mesenchymal stem cells for the identification of osteoporosis therapeutic targets F Zolezzi, S Fenu, C Villa, R Calogero, and P Tarroni
	104	LTbR-signaling is not required for earliest lymph node developement MFR Vondenhoff and RE Mebius
	105	TIRC7, a new marker identifying a subset of CD25lowFoxp3+CD4+ regulatory T cells A Wakkach, S Augier, J Breittmayer, C Blin-Wakkach, and GF Carle
	106	Osteoclastic differentiation in two murine cell clones: Expression of neuronal oxide synthase (NOS) isoform and TNF-related apoptosis induced ligand (TRAIL) in osteoclastogenesis V Nicolin, P Narducci, and G Zauli