GENERAL INFORMATION

Accommodations

The conference participants will be staying at the Minoa Palace Hotel (A' class), which is located in Platanias, 24 km from Chania International Airport and 12 km west of Chania town center. Participants are kindly asked to take a taxi from the airport to the hotel

.

Conference Venue

The Minoa Palace Conference Center is located at the hotel. 

 

Oral Presentations

An LCD projector will be available for the oral presentations. Speakers are asked to bring their USB flash drive or CD to the conference reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

 

Posters

Posters should be mounted Monday, June 16, from 5:00 pm – 8:00 pm on the designated boards and dismounted at the end of the meeting. The dimensions of the boards are 90 cm wide x 140 cm high. Adhesive tape for mounting the posters on the boards will be available at the poster area.

 

Internet

Internet will be available for participants during the meeting hours free of charge.

 

All Aegean Conferences events are non-smoking.

 

 





Monday, June 16

 

5:00 - 8:00 PM

Open Registration

8:00 PM

 

Welcome Reception/Dinner

 

 

 

Tuesday, June 17

 

 

 

8:30 AM

 

Welcome and Introductory Remarks

J Nadeau

 

 

 

Session I

Cancer Pathways and Networks

Chair: J Nadeau

 

 

 

8:30 AM

1

Transgenerational gene interactions and susceptibility to inherited disease

J Nadeau

9:00 AM

2

Protein-based profiling of liver cancer using multi-linear regression and Boolean models

LG Alexopoulos, J Saez-Rodriguez, B Cosgrove, DA Lauffenburger, and PK Sorger

9:30 AM

3

Drugging the Cancer Epigenome

Y Qiang

10:00 AM

4

Determination of complex reaction mechanisms

J Ross

10:35 AM

5

Signaling across cell Bounderies: genetic analysis of the PTEN pathway in the breast tumor microenvironment

MC Ostrowski, C Cantemir, A Trimboli, F Li, J Wallace, and G Leone

 

 

 

10:45 AM

 

Coffee Break & Poster Viewing

 

 

 

 

Session II

Chair: V Cheung

 

 

 

11:45 AM

6

Genetics of human gene expression

R Nayak, D Smirnov, M Morley, T Weber, RS Spielman, and VG Cheung

12:15 PM

7

Computational analysis of biological networks

M Koyuturk, J Pandey, S Subramaniam, and A Grama

12:45 PM

8

Systems biology of the cell cycle

L Alberghina

1:15 PM

9

Correlation of chromatin modification and genetic regulation

S Jones, G Robertson, M Bilenky, A Tam, Y Zhao, T Zeng, N Thiessen, T Cezard, A Fejes, E Wederell, R Cullum, M Krzywinski, I Birol, M Hirst, P Hoodless, and M Marra

1:45 PM

10

Spatial and temporal control of MAPK signaling during periodic morphogenesis

Z Hilioti, W Sabbagh, Jr, S Paliwal, A Bergmann, M Goncalves, L Bardwell, and A Levchenko

 

 

 

2:00 PM

 

Lunch

 

 

 

8:00 PM

 

Dinner at a local Greek Tavern

The bus for the tavern will depart from the hotel at 7:30 PM

 

 

 

Wednesday, June 18

 

 

Session III

Metabolic Disease Networks

Chair: A Attie

 

 

 

8:30 AM

11

A gene expression network model of type 2 diabetes establishes a relationship between cell cycle regulation in islets and diabetes susceptibility

MP Keller, YJ Choi, P Wang, DB Davis, ME Rabaglia, AT Oler, DS Stapleton, C Argmann, KL Schueler, S Edwards, HA Steinberg, EC Neto, R Klienhanz, S Turner, MK Hellerstein, EE Schadt, BS Yandell, C Kendziorski, and AD Attie

9:00 AM

12

Metabolomic: a global biochemical approach to the study of human disease and drug effects

R Kaddurah-Daouk

9:30 AM

13

Integrating gene expression, sequence and proteomics data to identify disease biomarkers

S Horvath, JE Aten, and AJ Lusis

10:00 AM

14

Insulin signaling, adipose tissue and metabolic syndrome

CR Kahn

10:30 AM

15

The genetic architecture of diet-induced obesity

DA Buchner, LC Burrage, AE Hill, EJ Vazquez, M Rosca, P Solinas, S Yazbek, H Shao, ES Lander, CL Hoppel, and JH Nadeau

 

 

 

10:45 AM

 

Coffee Break & Poster Viewing

 

 

Session IV

Chair: H Lewin

 

 

 

11:30 AM

16

Lipid maps approach to lipidomics

EA Dennis

12:15 PM

17

Multi-tissue profiling of human insulin resistance and pharmacological insulin sensitization

G Hsiao, A Hsiao, J Chapman, PD Miles, JG Yu, CH Courtney, J Neels, JL Resnik, J Wilkes, D Thapar, JM Ofrecio, S Subramaniam, and DD Sears

12:45 PM

18

A modularized model of apoptosis

HA Harrington, KHo, Sk Ghosh, KC Tung , CY Kao, and B Aguda

1:15 PM

19

Network analysis identifies affected biological processes in type 2 diabetes models

M Liu, A Liberzon, SW Kong, WR Lai, PJ Park, IS Kohane, and S Kasif

1:45 PM

20

DGAT1: a diet-regulated quantitative trait locus that affects hepatic lipid deposition

R Oliveira, JJ Loor, NA Janovick Guretzky, JK Drackley, and HA Lewin

 

 

 

2:00 PM

 

Lunch

 

 

 

8:00 PM

 

Dinner at Local Greek Tavern

 

The bus for the tavern will depart from the hotel at 7:30 PM

 

Thursday, June 19

 

 

 

Session V

Organs, Pathways and Stem cells

Chairs: S Subramaniam

 

 

 

8:30 AM

21

The systems biology cycle for pathways and networks: modeling and experimentation

MR Maurya, S Bornheimer, M Farquhar, and S Subramaniam

9:00 AM

22

Transcription factor -mediated global epigenetic remodeling to induced pluripotent stem cells

K Plath, R Sridharan, J Tchieu, MJ Mason, Q Zhou, W Lowry, N Maherali, and K Hochedlinger

9:30 AM

23

Localization of transcription factors in embryonic stem cells

X Chen, H Xu, P Yuan, F Fang, M Huss, V Vega, E Wong, Y Orlov, W Zhang, J Jiang, YH Loh, HC Yeo, ZX Yeo, V Narang, K Govindarajan, B Leong, A Shahab, Y Ruan, G Bourque, WK Sung, N Clarke, CL Wei, and HH Ng

10:00 AM

24

NHLBI programs and resources in genomics, proteomics & other emerging areas

P Qasba

10:30 AM

25

A complex systems approach to modeling stem cell decision-making

JD Halley, DA Winkler, and FR Burden

 

 

 

10:45 AM

 

Coffee Break

 

 

 

Session VI

 

Chair: P Hunter

 

 

 

11:15 AM

26

A framework for computational physiology

PJ Hunter

11:45 AM

27

Systems biology of kidney development

S Nigam

12:15 PM

28

Learning global transcriptional dynamics with the inferelator and cMonkey

A Madar, P Waltman, T Kacmarczyk, V Thorsson, N Baliga, D Reiss, and R Bonneau

1:45 PM

29

Transcriptional networks in development and disease

KP White

1:15 PM

30

Disease-associated transcription factor modules

M Wiesinger, P Perco, J Söllner, A Lukas, and B Mayer

 

 

 

1:30 PM

 

Lunch

 

 

 

3:00 PM

 

City Tour

The bus for the city tour will depart from the hotel at 3:00 PM

 

 

 

8:00 PM

 

Dinner at a local Greek Tavern

 

 

 

Friday, June 20

 

 

 

Session VII

Inflammation, immunity, microbes and the environment

Chair: J Lambris

 

 

 

8:30 AM

31

Evasion strategies of microorganisms

J Lambris

9:00 AM

32

Core diversity profile of human skin microbiome in health and disease

EA Grice, TC Scharschmidt, HH Kong, AC Young, NISC Comparative Sequencing Program, S Conlan, RW Blakesley, GG Bouffard, ML Turner, ED Green, and JA Segre

9:30 AM

33

Microbial community proteogenomics

J Banfield, V Denef, N VerBerkmoes, P Wilmes, G Dick, C Belnap, D Goltsman, R A Andersson, S Simmons, C Pan, B Baker, C Sun, M Wilkins, S Singer, G Tyson, M Shah, M Thelen, and R Hettich

10:00 AM

34

A predictive model fortranscriptional control of physiology in a free living cell

NS Baliga

10:30 AM

35

Modeling interactions of heterogeneous genetic perturbations

GW Carter and T Galitski

 

 

 

10:45 AM

 

Coffee Break & Poster Viewing

 

 

Session VIII

Inflammation, immunity, microbes and the environment

Chair: M Kellis

 

 

 

11:45 AM

36

Interrogating dynamic phenotypes using a high-throughput single cell microfluidic platform

RJ Taylor, D Falconnet, A Niemisto, S Ramsey, I Shmulevich, T Galitski, and C Hansen

12:15 PM

37

Integrative analysis for tnfa-nfkb signaling pathway

LWK Cheung and M Visvanathan

12:45 PM

38

Hepatitis C virus infection protein network

L Tafforeau, B de Chassey, V Navratil, M S Hiet, A Aublin, S Agaugué, G Meiffren, F Pradezynski, BF Faria, T Chantier, M Le Breton, J Pellet, N Davoust-Nataf, P E Mangeot, A Chaboud, F Penin, Y Jacob, PO Vidalain, M Vidal, P André, C Rabourdin-Combe, and V Lotteau

1:00 PM

39

Pathological iron loading among patients with thalassemia: solving the clinical mystery with systems medicine

JL Miller

1:15 PM

40

VelociGene®: an integrated suite of high throughput, customizable genome engineering technologies for analysis of gene function and drug target discovery and development

AN Economides

1:30 PM

41

Regulatory genomics of drosophila and mammalian species

M Kellis

 

 

 

2:00 PM

 

Concluding Remarks

 

 

 

2:15 PM

 

Lunch

 

 

 

8:00 PM

 

Gala Dinner

 

 

 

Saturday, June 21

 

 

 

7:30 AM

 

Breakfast

 

 

Departure

 

 

 

POSTERS

 

42

Pathway enrichment analysis reveals that IL-17 pathway modulation is more closely related to psoriasis disease resolution with effective therapy than IFNg

M Suárez-Farińas, L Zaba, J Fuentes-Duculan, I Cardinale, P Gilleaudeau, M Sullivan-Whalen, and J Krueguer

 

43

Computational synthetic biology

YN Kaznessis

 

44

A dependency graph approach for analyzing differential gene expression data of B-cell lymphomas

I Mühlberger, P Perco, A Bernthaler, R Fechete, A Lukas, and B Mayer

 

45

Neostasis as a therapeutically vulnerable homogeneous component of robust cancer systems

H Warenius and L Kyritsi

 

46

Predicting targets and risk genes for long-QT syndrome side effects

SI Berger, A Ma’ayan, and R Iyengar

 

47

CASIMIR, A coordination action focusing on database interoperability and financial sustainability; a step formward

V Aidinis, C Chandras, M Zouberakis, and the CASIMIR consortium

 

48

Integrated dynamics of the regulatory network controlling cell division in Caulobacter

P Brazhnik, S Li, and JJ Tyson

 

49

A comprehensive map of molecular interactions in RB/E2F pathway

L Calzone, A Gelay, A Zinovyev, F Radvanyi, and E Barillot

 

50

Gene expression responses to endoplasmic reticulum (ER) stress in humans

BA Dombroski, WM Ankener, K Chapman, KG Ewens, and RS Spielman 

 

51

Detection of mRNA transcripts for the ESCRT machinery in Entamoeba histolytica

I López-Reyes, C Bańuelos-Barrón, and E Orozco

 

52

Cell networks in the pituitary structure, function, development

M Cassou, N Courtois, N Chauvet, C Lafont, F Molino, P Mollard, J Drouin, I Robinson, and R Smallwood

 

53

Feedback regulation in gene expression and gradient sensing in the yeast pheromone mark pathway

S Paliwal, Z Hilioti, P Iglesias, and A Levchenko

 

54

Deconvolution of functional association network modules involced in mircrobial iron homeostasis

R Quatrini, F Lazo, C Oporto, J Ugarte, G Rivera, H Ososrio, and DS Holmes

 

55

Systems analysis of endosomal transport using phenotypic screening and genetic interactions in yeast

NR Quenneville, M Davey, R White, K Bryan, and E Conibear,

 

56

Relational genomic data analysis as an approach to study oldactory endophenotypes of schizophrenia

L Rioux, M Levy, SJ Kanes,, RW Williams, and J Nissanov

 

57

Putative metabolic regulators in nutrient signalling and adaptation: a comparative case study through gene-metabolite correlation networks for plants and humans as two evolutionary distant biological systems

NN Rudovich and VJ Nikiforova

 

58

Mutagenic analysis of Type I restriction-modification system EcoR124I

E Šišáková, A Guzanová, and M Weiserová

 

59

Potential role of EF-TU in regulation and cell signalling during morphological and biochemical differentiation in streptomycetes

J Weiser, M Holub, Š Nezbedová, LD Nguyen, and S Bezoušková

 

60

Analysis of the proteomic profile modulated by the antitumoral peptide CIGB-300

AR Ulloa, Y Perera, J Gil, Y Ramos, LC Serra, L Betancourt, A Sánchez, LJ González, V Besada, BE Acevedo, D Alonso, DE Gomez, and SE Perea

 

61

Pathways analysis of the proteins encoded by the genes protecting against Huntington’s disease mutation identified in a drugable genome-wide RNA intereference screen

E Gonzalez Couto, A Caricasole, F Heitz, GC Terstappen, and A Kremer

 

62

Cue-signal analysis of U937 cells: a model for inflammation

CW Espelin, A Goldsipe, JS Rodriguez, P Sorger, D Lauffenburger, D de Graaf, and B Hendriks