GENERAL INFORMATION Accommodations The conference participants will be staying on June 24, at the Residence Georgio, Athens, Chalkokondili 14 & 28^th, October str., 10677 - Athens – Greece and from June 25 - 29 at the AKS Porto Heli Hotel (4 star), which is located in Eastern Peloponnese. Directions to Residence Georgio, Athens from the airport 1) By taxi € 25-35, approximately 45 minutes 2) by bus to Syntagma Square (€ 3.20) and metro to Omonia (€ 0.80), approximately one hour 3) by Metro (€ 6.00), approximately 45 minutes (you have to change metro line from Syntagma to Omonia) See also http://www.residencegeorgio.com/location.html All destinations of metro (except Airport) cost € 0.80 per way Minimum fare for taxi € 2.65 Breakfast Breakfast on June 25 will be served at the Residence Georgio and from June 26 - 29 at the AKS Porto Heli Hotel during the hours scheduled in this program. Conference Venue AKS Porto Heli Conference Centre is located at the hotel. Oral Presentations An LCD projector will be available for the oral presentations. Speakers are asked to bring their USB flash drive or CD to the conference reception desk at least 30 minutes prior to the session. The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A. Posters Posters should be mounted Tuesday morning, June 26, on the designated boards and dismounted at the end of the meeting. The dimensions of the boards are 140 cm wide x 100 cm high. Adhesive tape for mounting the posters on the boards will be available at the poster area. Internet Internet will be available for participants during the meeting hours free of charge. Tour to Epidaurus The tour to Epidaurus will take place on the Monday June 25 during the trip from Athens to Porto Heli. Busses for the tour will be leaving from the hotel on at 7:30 a.m. Badges are required for participation.
	Sunday, June 24
5:00 - 8:00 PM			Open Registration
8:00 PM			Welcome Dinner
Monday, June 25
1:30 PM			Lunch
Session I			Genotypes and Phenotypes in Mammalian Systems Chair: S Subramaniam
3:00 PM		1	Modifier genes: simple traits and complex systems, in sickness and in health J Nadeau
3:45 PM		2	Epistasis and systems properties in chromosome substitution strains H Shao, L Burrage, D Sinasac, A Hill, C Croniger, K Jepsen, K Broman, E Lander, and J Nadeau
4:30 PM		3	Initial large-scale genomic approaches for finding sleep-wake regulatory genes and networks FW Turek
5:15 PM			Coffee Break
Session II			Pathways, Networks and Phenotypes Chair: E Liu
5:45 PM		4	The Fat Story: A systems approach to pathways and networks involved in lipid metabolism in macrophage activation S Subramaniam and the LIPID MAPS Glue Grant Consortium
6:30 PM		5	Molecular mechanisms and pathways controlling ectodermal organ formation M Bei, V Gupta, and A Datta
7:15 PM		6	Systems biology and systems medicine: a view from the National Heart, Lung and Blood Institute AM Michelson
7:45 PM			Dinner
Tuesday, June 26
Session III			Transcriptional Networks and Eukaryotic Biology Chair: K White
8:30 AM		7	Whole-genome cartography of estrogen receptor a binding sites E Liu, V Vega, J Thomsen, G Borque, and L ChinYo
9:15 AM		8	Functional genomic analysis of temporal-spatial control of cellular morphogenesis A Kiger
10:00 AM		9	Analysis of individual expression variation reveals a post-transcriptional network A Dudley
10:45 AM		10	Expression variability from a tetracycline-inducible positive feedback network in mammalian cells D Longo, A Hoffmann, and J Hasty
11:15 AM			Coffee Break & Poster Session
Session IV			Biological Information and Interactions Chair: R Germain
12:00 Noon		11	Biological information and the extraction of biological information from genetic interaction data DJ Galas, GW Carter, and T Galitski
12:45 PM		12	Identification of biological functions of nested feed-forward motifs by building “just-right” size models using an iterative model-experiment-model-experiment approach R Iyengar, NJ Eundamrong, and J Cijiang He
1:30 PM		13	Synergy and connectivity in microbial metabolic networks J Lehar
2:00 PM		14	Signalign: prediction and alignment of biochemical pathways using protein structural information S Hariharaputran, T Töpel, T Oberwahrenbrock, and R Hofestädt
2:30 PM			Lunch
8:00 PM			Dinner
Wednesday, June 27
Session V			Biological Models and phenotypes Chair: D Galas
8:30 AM		15	Multi-scale computational models in pulmonary physiology MH Tawhai, AJ Swan, and NJ Warren
9:15 AM		16	An extended software suite for spatially-resolved, multiscale modeling and biological prediction M Meier-Schellersheim, X Xu, B Angermann, E Kunkel, T Jin, A Wise, F Klauschen, F Zhang, and RN Germain
10:00 AM		17	Multiscale models for biological engineering YN Kaznessis
10:30 AM		18	A novel latent gene construct approach for modeling biological pathways in complex diseases: An application to folate (one carbon) metabolism in the frailty syndrome NL Nock, AM Matteini, LP Fried, S Stabler, RC Elston, and MD Fallin
11:00 AM			Coffee Break & Poster Session
Session VI			Pathways, Networks, and Models of Physiological Function Chair: H Lewin
12:00 Noon		19	Complement: From behind the scenes into the spotlight JD Lambris
12:45 PM		20	Modeling angiogenesis gene regulation network in an in vitro angiogenesis co-culture system T Wei, Y Chen, F Lawrence, HR Qian, L Yan, TP Burkholder, JJ Starling, JM Yingling, and J Shou
1:30 PM		21	Systems biology of the NF-κB transcriptional program in innate immunity C-A Lim, F Yao^,, J George, H Xu, K P Chiu, W-K Sung^,, L Lipovich, V B Vega, J Chen, A Shahab, X D Zhao, M Hibberd, C-L Wei, B Lim, H-H Ng^,, Y Ruan, and K-C Chin
2:00 PM		22	Interacting traits forge a path to bone fragility KJ Jepsen, B Hu, MA Cordova, SM Tommasini, C Price, HW Courtland, and JH Nadeau
2:30 PM			Lunch
4:00 PM			Tour to Spetses
8:00 PM			Dinner
Thursday, June 28
Session VII			Pathways, Networks and Pathology Chair: JD Lambris
8:30 AM		23	Why do good clones go bad? HA Lewin, RE Everts, SL Smith, A Razzak, P Chavatte-Palmer, I Hue, CA Green, R Oliveira, SL Rodriguez-Zas, JP Renard^, XC Tian, and X Yang
9:15 AM		24	Systems analysis of human mitochondrial disorders V Mootha
10:00 AM		25	Human insulin-resistance and thiazolidinedione insulin-sensitization in skeletal muscle A Hsiao, G Hsiao, DS Sears, JM Olefsky, and S Subramaniam
10:30 AM		26	A systematic evaluation of an F2 mouse cross predisposed to obesity and mammary tumor development fed varying levels of dietary fat RR Gordon, KW Hunter, P Sørensen, and P Pomp
11:00 AM			Coffee Break
Session VIII			Measurement and Integration in Biological Systems Chair: A Dudley
12:00 Noon		27	Biological large scale integration S Quake
12:45 PM		28	Synthetic ecosystems, codes and lab evolution G Church
1:30 PM		29	Sequencing based interrogation of functional elements on human genome CL Wei and Y Ruan
2:00 PM		30	Integrated analysis of the Drosophila segmentation network identifies a biomarker for human kidney cancer KP White
2:30 PM			Lunch
8:00 PM			Gala Dinner
Friday, June 29
7:30 AM			Breakfast
			Departure
POSTERS
		31	The Coagulation Network: Structure, Function and Evolution of Complexity K Brohi, MJ Cohen, MT Ganter, AP Arkin , and JF Pittet
		32	Integrative and comparative genomics to target potential pathways for a functional body weight qtl in poultry CP Cabrera, CS Haley and DJ de Koning
		33	Mining Biological Networks for Unknown Pathways A Cakmak and G Ozsoyoglu
		34	Growing functional modules from a seed protein by integrating gene expression and protein interaction data K Dimitrakopoulou, IAMaraziotis, and A Bezerianos
		35	Success and Failure in DNA Microarray Meta Analysis - A Case Study H Goessling, H Herzel, and M Futschik
		36	Inference of cooporative control of cell cycle related genes in yeast using modeling of transcriptional control TT Vu and J Vohradsky
		37	Modeling stochastic gene expression under repression GCP Innocentini and JEM Hornos
		38	Annotating proteins via biological network analysis M Kirac and G Ozsoyoglu