GENERAL INFORMATION Accommodations The conference participants will be staying at the Aldemar: Knossos Royal Village (A' class), which is located in Hersonissos, 25 km from the airport. Please take a taxi from the airport to the hotel (~30 EURO). Arrival and Check-in It is expected that attendees will arrive/check-in on Saturday after 2:00 PM. Anyone arriving after 10:30 pm on Saturday must make alternative dinner arrangements. Breakfast Breakfast will be served at your hotel during the hours scheduled in this program. Conference Venue The Aldemar: Knossos Royal Village Conference Center is located at the hotel. Handicapped Accessibility The site is fully handicapped accessible. Oral Presentations An LCD projector and an overhead projector will be available for the oral presentations. Speakers are asked to bring their USB flash drive or CD to the conference reception desk at least 30 minutes prior to the session. The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A. Posters Posters should be mounted Saturday from 5:00 – 8:00 PM, June 13, on the designated boards and dismounted at the end of the meeting. The dimensions of the boards are 90W x 150H cm. Adhesive tape for mounting the posters on the boards will be available at the poster area. Welcome Reception and Gala Dinner Badges are required for admission. Tour to Knossos and Museum Buses for the city & archaeological tour will be leaving from the hotel on Wednesday, June 16 at 3:00 p.m. Participants be picked up at the hotel front lobby at that time. Badges are required for participation. Lunches Lunches will be served at the indicated times to all registered participants and registered accompanying persons in the hotel. Badges are required for admission. Dinners Three of the dinners will be served at local Greek Tavernas. Scheduled transportation to these events will be provided by Aegean Conferences. Vegetarian entrees are available only if the request is made in advance of the meeting. Internet, Phone, & Computer Wireless Internet access is located throughout the conference center free charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room. Other Information Animals are not permitted on site. All Aegean Conferences events are non-smoking.
Saturday, June 13
5:00 - 8:00 PM		Open Registration
8:00 PM		Welcome Reception/Dinner
Sunday, June 14
8:30 AM		Welcome and Opening Remarks A Altman
Session I		Intracellular Signaling I Chair. Amnon Altman
8:45 AM	1	SLAT/Def6 –a novel regulator of TCR-stimulated calcium signaling and T cell-mediated inflammation S Becart, C Charvet, A Balancio, and A Altman
9:15 AM	2	MALT1: A key player in lymphocyte activation and lymphoma development S Hailfinger, F Rebeaud, A Posevitz-Fejfar, M Tapernoux, E Iancu, N Rufer, N Fasel, and M Thome
9:45 AM	3	TNFR family costimulosomes: How OX40 cosignals T cells M Croft
10:15 AM	4	Requirement for mature T cells, type I interferon and Stat1 in negative T cell selection DC Otero, H Moro, Y Tanabe, and M David
10:30 AM	5	Calcium signaling triggered by NAADP in T cells determines cell shape and motility during immunological synapse formation M Nebel, R Fliegert, B Zhang, A Flügel, BVL Potter, and AH Guse
10:45 AM	6	Coronin 1-Mediated Regulation of Calcium Signaling in Leukocytes J Pieters, R Jayachandran, and P Mueller
11:00 AM		Coffee Break & Poster Session
Session II		Intracellular Signaling II Chair: Tomohiro Kurosaki
11:30 AM	7	Erk signaling in B lymphocytes T Kurosaki
12:00 Noon	8	High resolution map of Prostaglandin E2-dependent signaling networks in lymphoid cells NG Oberprieler, S Lemeer, ME Kalland, KM Torgersen, AJR Heck, and K Taskén
12:30 PM	9	Protein ubiquitination in immune regulation YC Liu
1:00 PM	10	Definition of a novel TCR 'inside-out' pathway involving N-SKAP1-C-RapL for LFA-1 activation on T-cells M Raab, H Wang, X Smith, Z Liu, K Strebhardt, JE Ladbury and CE Rudd
1:30 PM	11	Role of Vav1 GEF activity for TCR signal transduction and lymphocyte activation as target for novel immunosuppressants D Haubert and G Weckbecker
1:45 PM	12	Cav1.2 L-type calcium channel: a novel calcium pathway that regulates mast cell effector responses and survival Y Suzuki, T Inoue, K Hayama, T Yoshimaru, and C Ra
2:00 PM		Lunch
8:00 PM		Dinner at a Local Greek Tavern
	The bus for the tavern will depart from the hotel at 7:30 PM
Monday, June 15
Session III		Immune Regulation I Chair: Antonella Viola
8:30 AM	13	Signaling amplification at the immunological synapse B Molon, R Lucia Contento, and A Viola
9:00 AM	14	A unique pathway governs the development of innate-like Natural Killer T cells I Engel, K Hammond, B Sullivan, X He, I Taniuchi, D Kappes, and M Kronenberg
9:30 AM	15	Plasticity in the Th17 developmental program; implications for cytokine gene regulation CT Weaver
10:00 AM	16	Role of SLAT and Ca2+/NFAT signaling in CD4+ T cell-mediated inflammatory responses S Becart, AJ Canonigo-Balancio, C Charvet, and A Altman
10:15 AM	17	PTP1B has opposing regulatory functions in leukocytes and endothelial cells during allergic lung inflammation JM Cook-Mills, S Berdnikovs, and H Abdala-Valencia
10:30 AM	18	Role of ThPOK in γδ T cell development DJ Kappes, K Park, X He, and Y Li
10:45 AM		Coffe Break & Poster Session
Session IV		Immune Regulation II Chair: John Cambier
12:00 PM	19	Molecular underpinning of anergy and its disruption by innate immune signals JC Cambier, S Gauld, K Merrell, S O’Neill, L Van Dyk, and A Getahun
12:30 PM	20	Signals for activation and inhibition of natural killer cells D Liu, ME Peterson, YT Bryceson, T Meckel, G Vasiliver-Shamis, ML Dustin, and EO Long
1:00 PM	21	Thymic deletion and myeloid leukemia development in c-Cbl RING finger mutant mice WY Langdon, SA Dagger, and CBF Thien
1:30 PM	22	Immunosuppresive effects of TGF-beta require both Smad2 and Smad3 but not Foxp3-induction A Yoshimura, Y Wakabayashi, Y Sugiyama, and T Takimoto
2:00 PM		Lunch
8:00 PM		Dinner at a Local Greek Tavern
	The bus for the tavern will depart from the hotel at 7:30 PM
Tuesday, June 16
Session V		Kinases & Phosphatases Chair: Constantine Tsoukas
8:30 AM	23	Signaling through the inducible T cell kinase JA Grasis, DM Guimond, NR Cam, K Herman, P Magotti, JD Lambris, and CD Tsoukas
9:00 AM	24	Positive regulation of Itk PH domain function by the soluble "Third" messenger IP4 is required for thymocyte positive but not negative selection K Sauer
9:30 AM	25	Lck regulation in T cells: new insights into T cell antigen receptor triggering K Nika, C Soldani, M Salek, A Gray, R Etzensperger, P Polzella, A Viola, and O Acuto
10:00 AM	26	TCR signals mediated by the Src-family kinases Lck and Fyn RJ Salmond and R Zamoyska
10:15 AM	27	CD148 complements CD45 deficiency in T cells O Stepanek, T Kacerova, A Weiss, and T Brdicka
10:30 AM		Coffee Break & Poster Session
Session VI		Adapters Chair: Gary Koretzky
11:00 AM	28	The role of the amino terminal tyrosines of SLP-76 in in vivo function of innate and adaptive immune cells M Jordan, J Smith, L Lenox, T Kambayashi, K Nichols, and G Koretzky
11:30 AM	29	Regulatory interactions within the SLP-76-nucleated complex R Gonen, Y Bogin, D Beach and D Yablonski
11:45 AM	30	Multiple roles for TRAFs 3 and 5 in lymphocyte activation GA Bishop, P Xie, ZJ Kraus, and LL Stunz
12:15 PM	31	Role of the adapter 3BP2 in leukocyte and bone homeostasis M Deckert
12:30 PM	32	Regulation of T cell signaling and trafficking by the adapter proteins chat-hand CASL K Alexandropoulos, A Regelmann, and N Barash
12:45 PM	33	DOK in T cell activation J Nunes
1:00 PM	34	Transmembrane adaptors regulate CTLA-4 expression KL Inder, E Valk, CE Rudd, and H Schneider
1:15 PM	35	The preponderance of negative signaling contributes to the altered clonal expansion of T cells with aging T Fulop, J Lamoureux, and C Fortin
1:30 PM		Lunch
3:00 PM		Tour to Knossos Archaeological site & Archaeological Museum of Heraklion
The bus for the tour will depart from the hotel at 3:00 PM
8:00 PM		Dinner at a local Greek Tavern
Wednesday, June 17
Session VII		Imaging and Other Signaling Technologies Chair: Andrey Shaw
8:30 AM	36	Imaging T cell activation A. Shaw
9:00 AM	37	Spatiotemporal patterning as a regulator of T cell signaling KS Singleton, KT Roybal, Y Sun, NSC van Oers, and C Wülfing
9:30 AM	38	Mechanism for raft-based signal transduction as studied by single-molecule tracking KGN Suzuki and A Kusumi
10:00 AM	39	The Inositol Kinase ITPKb controls B cell development, activation and antibody responses AT Miller, DR Beisner, and MP Cooke
10:30 AM	40	IFNg secretion at the immunological synapse is controlled by Cdc42-dependent cytoskeleton remodeling K Chemin, S Guégan, F Miro, S Dogniaux, A Bohineust, and C Hivroz
10:45 AM	41	Ezrin sets the microtubule architecture at the immune synapse driving microcluster dynamics and the T-cell receptor signal extinction R Lasserre,S Charrin, C Cuche, F de Chaumont, T Duong, MI Thoulouze, A Danckaert, N Perrault, N Varin-Blank, JC Olivo-Marin, M Arpin, V di Bartolo, andA Alcover
11:00 AM		Coffee Break
Session VIII		Disease Implications Chair: Andrew Chan
11:30 PM	42	Control of T cell effector functions through cytoskeletal regulation A Chan, JH Yeh, Q Gong, and Q Ou
12:00 Noon	43	Phospholipase C-b3 deficiency predisposes to skin inflammation in a mast cell-dependent manner W Xiao, Y Tomimori, T Ando, Y Kawakami, and T Kawakami
12:30 PM	44	IL-17-mediated inhibition of natural killer cell cytotoxicity allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum Y Kawakami, Y Tomimori, K Yumoto, S Hasegawa, T Ando, Y Tagaya, S Crotty, and T Kawakami
12:45 PM	45	Genomic and genetic analysis to discover the Achilles heel of lymphoid malignancies LM Staudt
1:10 PM	46	Orphan receptor NR2F6 is a novel repressor of autoimmunity N Hermann-Kleiter, T Gruber, M Meisel, and G Baier
1:30 PM	47	Role of PKC-q in anti-tumor immunity A Anel, JI Aguiló, J Garaude, XX, J Pardo, and M Villalba
1:45 PM		Closing Remarks G Koretzky
1:55 PM		Lunch
8:00 PM		Gala Dinner at Aldemar: Knossos Royal Village

Thursday, June 18
7:30 AM	Breakfast
	Departures

POSTERS
Posters will remain on display for the entirety of the conference
	48	Novel methods and approaches for analysis of membrane rafts S Dutta, C Kennedy, and A Bamezai
	49	Integrin selective ligands signaling leukocyte activation, migration and death C Barja-Fidalgo, R Saldanha-Gama, JA Moraes, and R Zingali
	50	Dok-1 and Dok-2 expression influences T cell development G Besin, I Saaba , S Jananji, and P Duplay
	51	Human serum albumin binds to CD43 on T-cells and prevents apoptosis through activation of the AKT and ERK signaling pathways ME Bravo-Adame, G Pedraza-Alva, and Y Rosenstein
	52	Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors YT Bryceson, HG Ljunggren, and EO Long
	53	Activation of human valve interstitial cells by a viridians streptococci modulin induces chemotaxis of mononuclear cells JS Chia and CY Yeh
	54	Genomic and non-genomic intracellular pathways involved in thyroid hormone mediated T lymphoma cell proliferation GA Cremaschi, RN Farías, AJ Klecha, HA Sterle, AM Genaro, ML Barreiro Arcos
	55	Intracelullar signals involved in Zinc deficit-mediated T Lymphocyte apoptosis ML Barreiro Arcos, A Paulazzo, HA Sterle, AJ Klecha, AM Genaro, GA Cremaschi
	56	A new role for FAS in attenuating proliferation of memory/effector TCR-rechallenfed T cells by controlling NF‑kB signaling: implications for lymphadenopathy and autoimmunity L Daszkiewicz, A Ballesteros-Tato, C Vázquez Mateo, and D Balomenos
	57	NVL: Transmembrane adaptor protein involved in MHCII signalling P Draber, I Vonkova, T Kacerova, P Otahal, P Angelisova, V Horejsi, A Weiss, and T Brdicka
	58	Measurement of NFAT activation in primary antigen-experienced T cells derived from patients with chronic hiv infection or ovarian cancer using quantitative imaging cytometry M Connors, MR Simpson-Abelson, RB Bankert, H Minderman, SA Migueles, and TC George
	59	The histone deacetylase inhibitor, CBHA, inhibits matrix metalloproteinase-9 expression in THP-1 cells G Hsiao,*JR Sheu,YH Lin, and YC Chou
	60	Beta-2 integrin-mediated monocyte interactions and the role of Rho GTPase Rac2 in adhesion events V Kanagasundaram, G Toh, E Manserand AJ Ridley
	61	Low prednisolone doses stimulate growth in glucocorticoid-resistant acute lymphoblastic leukemia cells and this action is completely abolished by proteasome inhibition GI Lambrou, K Eleftheria, S Vlahopoulos, M Moschovi, E Zoumakis, and F Tzortzatou-Stathopoulou^1
	62	Leukocyte infiltration in the tumor microenvironment B Molonand A Viola
	63	Engagement of different NK cell receptors signals for recruitment of specific cytotoxic effector proteins to perforin granules SM Wood, M Meeths, CCS Chiang, JI Henter, HG Ljunggren, and YT Bryceson
	64	TLR-3, TLR-4 and TLR-9 agonists protect human monocytic cells against HIV-VPR-induced apoptosis: a critical role for calmodulin-dependant protein kinase-II and an anti apoptotic CIAP-2 Gene M Saxena, S Mishra, A Busca, and A Kumar
	65	Computational approach predicts common pathway utilization for acute lymphoblastic leukemia and rhabdomyosarcoma cells GI Lambrou, K Eleftheria, S Vlahopoulos, M Moschovi, E Zoumakis, and F Tzortzatou-Stathopoulou
	66	Cav1.2 L-type calcium channel mediates gold (III)-induced mast cell activation K Hayama, Y Suzuki, T Inoue, T Yoshimaru, and C Ra
	67	Lck regulation in T cells: new insights into T cell antigen receptor triggering K Nika, C Soldani, M Salek, A Gray, R Etzensperger, P Polzella, A Viola and O Acuto