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GENERAL INFORMATION Accommodations The conference participants
will be staying at the Aldemar Paradise Village (A'
class), which is located in Kalithea, 20 km from
the airport and 6 kilometers from Rhodes harbour. Conference
Venue The Aldemar Conference Center is located at the hotel. Oral
Presentations An LCD projector
will be available for the oral presentations. Speakers are asked to bring their USB flash drive or CD to the
conference reception desk at least 30 minutes prior to the session. The allocated time for all presentations,
unless otherwise indicated, includes five minutes Q&A. Posters Posters
should be mounted Saturday afternoon, October 11, on the designated boards
and dismounted at the end of the meeting. The dimensions of the boards
are 170 cm wide x 110 cm high. Adhesive tape
for mounting the posters on the boards will be available at the poster area. Internet Internet will be available for participants during
the meeting hours free of charge. City Tour Busses for the city tour will be leaving from the
hotel on Tuesday, October 14 at 3:00 p.m.
Accompanying persons will also be picked up at the hotel front lobby at that
time. Badges are required for participation. All Aegean Conferences events are non-smoking. |
Saturday, October 11 |
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5:00 - 8:00 PM |
Open Registration |
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8:00 PM |
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Welcome Reception/Dinner |
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Sunday, October 12 |
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8:50
AM |
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Welcome and
Opening Remarks
M Busslinger |
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Session
I |
Basic molecular
processes in hematopoiesis Chair: A Tarakhovsky |
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9:00 AM |
1 |
The role of cohesins in gene
regulation and genome organization S Hadjur, L Williams, H Mira, AG Fisher, and M Merkenschlager |
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9:30 AM |
2 |
Regulation
of higher-order chromatin structure and gene expression by the nuclear matrix
component SATB2 I Pawlitzky, M Dautzenberg, S Vomstein,
J Skok, and R Grosschedl |
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10:00 AM |
3 |
Epigenetic control of antiviral immunity T Fang and A Tarakhovsky |
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10:30 AM |
4 |
Novel roles for microRNA-34 in B-cell
development DS Rao, RM O’Connell, A Chaudhuri, and D Baltimore |
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10:50 AM |
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Coffee Break & Poster
Viewing |
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Session
II |
Regulation
of antigen receptor assembly and diversity Chair: C Murre |
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11:30 AM |
5 |
The 3D structure of the immunoglobulin heavy chain locus S Jhunjhunwala, M Van Zelm, M Peak, S Cuthcin, T Koch, and C Murre |
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12:00 Noon |
6 |
Recombinase-dependent homologous
pairing of Ig alleles: A novel regulatory aspect of
allelic exclusion K Marszalek,
S Hewitt, J Tenthorey, G Salvagiotto, Y Ji, J Glysdael,
M Farrar, DG Schatz, M Busslinger, and
JA Skok |
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12:30 PM |
7 |
Subnuclear
localization and the initiation of TCRB allelic exclusion RJ
Schlimgen, KL Reddy, H Singh, and MS Krangel |
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1:00 PM |
8 |
Novel roles for NBS1 in alternative nonhomologous end goining of
V(D)J recombination intermediates L Deriano, TH Stracker, A Baker, JHJ Petrini,
and DB Roth |
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1:30 PM |
9 |
miR-181b negatively regulates activation induced deaminase
in B cells VG de Yébenes, L Belver, and AR Ramiro |
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1:50 PM |
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Lunch |
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8:00 PM |
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Dinner at a local Greek Tavern |
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The bus for the tavern will depart from
the hotel at 7:30 PM |
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Monday,
October 13
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Session
III |
Transcriptional
control of T-lymphopoiesis Chair: D Littman |
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9:00 AM |
10 |
Early T-cell
regulation of PU.1 expression and activity EV Rothenberg, M Zarnegar, M Morales Del Real, J Zhang, DD Scripture-Adams, C Georgescu, and H Bolouri |
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9:30 AM |
11 |
Transcriptional
regulation of the CD4:CD8 lineage decision T Egawa, M Chong, A Collins, and DR Littman |
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10:00 AM |
12 |
The molecular basis of the function of Foxp3-expressing regulatory T
cells M Ono and S Sakaguchi |
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10:30 AM |
13 |
Deviation
of CD4 single positive thymocytes into the natural Treg lineage G Wirnsberger, F Mair, J
Huehn, and L Klein |
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11:00 AM |
14 |
Distinct
roles for non-coding regulatory regions at the foxp3 locus in defining the
frequency of regulatory T cells Y Zheng, SZ Josefowicz, A Chaudhry, TT Chu, A Kas, and A Rudenksy |
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11:20 AM |
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Coffee
Break & Poster Viewing |
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Session
IV |
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T
cell signaling Chair: BJ Fowlkes |
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12:20 PM |
15 |
TCR
signaling, notch, gata3, and Zbtb7b promote CD4 T cell development BJ Fowlkes, L Wang, K Laky, and R Bosselut |
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12:40 PM |
16 |
Stage-dependent molecular changes in notch signaling regulate human t
cell development T
Taghon, I Van de Walle, G De Smet, M De Smedt, and J Plum |
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1:00 PM |
17 |
β-Catenin
acts downstream of αβTCR and determines the outcome of thymic
selection D Kovalovsky, Y Yu, M Dose, Z
Guo, M Mandal, and F Gounari |
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1:20 PM |
18 |
Phosphorylation of ikaros by
CK2 kinase regulates expression of the TDT gene
during T cell differentiation Z Gurel, T Ronni, S Ho, J Kuchar, KJ Payne, CW Turk, and S Dovat |
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1:40 PM |
19 |
Functional
analysis of the role of polarity determinants in lymphocyte development and
function F Sacirbegovic, J Oliaro,
V van Ham, V Vasioukhin, P Humbert,
and S Russell |
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2:00 PM |
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Lunch |
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8:00 PM |
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Dinner at Local Greek Tavern |
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The bus for the tavern will depart from
the hotel at 7:30 PM |
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Tuesday,
October 14 |
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Session V |
Inflammation Chair: M Busslinger |
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9:00 AM |
20 |
The transcription factor XBP1 regulates hepatic lipogenesis,
immunity and inflammation AH Lee, EF Scapa, DE Cohen, A Kaser, R Blumberg, and LH Glimcher |
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Session VI |
Early
hematopoiesis Chair: M Busslinger |
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9:30 AM |
21 |
Dormant and activated stem cells during homeostasis injury and
cancer M Essers, A Wilson,G Oser, and A Trumpp |
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10:00 AM |
22 |
The
role of the ubiquitin-proteasome system in
hematopoietic stem cell self-renewal and transformation I Aifantis |
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10:30 AM |
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Coffee Break & Poster Viewing |
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11:30 AM |
23 |
Wnt signals regulate critical developmental
steps in hematopoiesis FJT Staal ,T Luis, F Weerkamp, K Pike-Overzet, MRM Baert, BAE Naber, EEL Koster, EEF de Haas, and JJM van Dongen |
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11:50 AM |
24 |
Regulation of the T/B lineage fate choice
by hebalt D Wang, CL
Claus, M Braunstein, and MK Anderson |
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12:10 PM |
25 |
EBF
directed lineage commitment before expression of B220 or CD19 R Mansson, S Zandi, P Tsopogas, and M Sigvardsson |
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12:30 PM |
26 |
Priming
of the multi-potent HSC for lymphoid lineage transcription and
differentiation is controlled by Ikaros K Georgopoulos |
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1:00
PM |
Lunch |
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3:00 PM |
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City Tour |
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The bus for the city tour will depart from the hotel at 3:00 PM |
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Dinner at a local Greek Tavern |
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Wednesday, October 15 |
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Session
VII |
B-lymphopoiesis Chair: S Nutt |
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9:00 AM |
27 |
Role of IKK
mediated NFkB signaling in B cell development E Derudder, M
Schmidt-Supprian, E Cadera,
M Pasparakis, M Schlissel,
and K Rajewsky |
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9:30 AM |
28 |
Regulation of early B cell
development by IL-7 and Stat5 signaling
S
Malin, S McManus, A Delogu,
C Cobaleda, M Fuxa, L Hennighausen, A Strasser, and M Busslinger |
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10:00 AM |
29 |
Inhibition of
expression of surrogate light chains of the pre-BCR and other important proteins
during lymphocyte development through calmodulin
inhibition of E-proteins J Hauser, A
Wallenius, N Sveshnikova, J Saarikettu, and T Grundström |
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10:30 AM |
30 |
Controlling
germinal centre output D
Tarlinton, D Zotos, I Vikstrom, J Coquet, A
Strasser, D Godfrey, L Corcoran, M Busslinger, M Smyth, D Huang, and S Nutt |
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11:00 AM |
31 |
The control of lymphocyte
terminal differentiation S Nutt, S Carotta,
A Xin, G Belz, and A Kallies |
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11:20 AM |
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Coffee Break & Poster
Viewing |
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Session
VIII |
Lymphoid
tumors Chair: A Strasser |
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12:00 Noon |
32 |
The role of pro-survival Bcl-2 family members in tumour
development and sustaining tumour growth PN Kelly, JM Adams, and A Strasser |
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12:30 PM |
33 |
BLIMP1
is limiting for transformation in a mouse plasmacytoma
model LM Corcoran, K D’Costa, D Emslie, G Smythe, SL Nutt, A Karnowski, A Kallies, and D Metcalf |
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12:50 PM |
34 |
Loss
of E2A function is linked to human lymphoma pathogenesis S Mathas and M Janz |
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1:10 PM |
35 |
Molecular
genetics of diffuse large B-cell lymphoma R Dalla-Favera |
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1:40 PM |
36 |
Genomic
and genetic analysis to discover the Achilles heel of lymphoid malignancies LM Staudt |
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2:10 PM |
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Concluding
Remarks |
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2:30 PM |
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Lunch |
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8:00 PM |
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Gala
Dinner |
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Thursday,
October 16
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7:30 AM |
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Breakfast |
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Departure |
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POSTERS |
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37 |
HEB
upregulates CD3 and TCRb
and downregulates DELTEX-1 to allow progression of
T cell precursors through b-selection M Braunstein and MK Anderson |
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38 |
Dysregulation of apoptosis pathways in lupus patients
revealed by network analysis of dynamic gene expression data I Dozmorov, N Dominguez, J B Harley, J M Guthridge |
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39 |
CpG methylation of the IFNG gene
as a mechanism to induce immunosupression in tumor
Infiltrating lymphocytes PCJ Janson, P Marits, M Thörn, R Ohlsson, and O Winqvist |
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40 |
Acquisition of a
functional T cell receptor during T lymphocyte development is enforced by HEB
and E2A Transcription factors ME Jones and Y Zhuang |
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41 |
Micro-rnas in lymphoid lineage decisions: role in development
of plasmacytoid denritic
cells JJ Karrich, F Scheeren, H Schmidlin, W Dontje, M Nagasawa, He Spits,
and B Blom |
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42 |
V(D)J
recombination and nucleosome positioning HD Kondilis, RM Cobb, EM Oltz, and MS Krangel |
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43 |
Presenilin-dependent Notch signaling
influences fate determination of CD4 T cells by modulating TCR signal
strength K Laky, H Yamane, S Evans, J Hu-Li, WE Paul, and BJ Fowlkes |
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44 |
Therapeutic
targeting of circulating endothelial cells and VEGFR1+ progenitors for the
prevention of treatment relapse and metastasis E Naik, J M Adams, and A Strasser |
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45 |
A conserved gene regulatory network
orchestrating innate versus adaptive cell fate choice in the immune system CJ Spooner, J Cheng, and H Singh |
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46 |
Stem cell specific epigenetic priming and B
cell specific transcriptional activation at the mouse Cd19 locus K Walter and H Tagoh |
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47 |
Regulation of EBF levels by
IL-7 does not account for the critical role of IL-7 in B cell specification P Tsapogas, S Zandi, R Månsson, and M Sigvardsson |
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48 |
Notch in human T cell differentiation: an interplay with different ligands? I Van de Walle , G De Smet, M De Smedt, J
Plum, and T Taghon |
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49 |
Germinal
center maintenance mediated by IL21 acting on B cells D Zotos, J Coquet, A Light, A Kallies, L Corcoran, D Godfrey, M Smyth, S Nutt, and D Tarlinton |
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50 |
Transcription Factor 1 (TCF1) functions as
a molecular switch during T cell development MM Tiemessen, T Schonewille, MR Baert, T C
Luis, JJ van Dongen, and FJ Staal |
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51 |
Micro-RNA gene deregulation
following BCL6 rearrangement Associated with chromosome fragility RAF MacLeod, B Schneider, S Nagel, M Sherr, S
Chen, M Kaufmann, and HG Drexler |
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52 |
Further characterization of the
roles of Bcl11a and Bcl11b in homeostatic haematopoiesis P Li, SC Lee, M Ortiz, and P Liu |
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53 |
Ikaros
expression by B-1 cells questions its guide role in the lymphoid commitment AF Popi, AL Bacchi, S Schenkman, and M Mariano |
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54 |
Lymphoid and myeloid gene
expression during B-1 cell differention into
mononuclear phagocytes AF Popi, FLT Motta, RA Mortara, S Schenkman, JD Lopes, and M Mariano |