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GENERAL INFORMATION Accommodations The conference participants will be staying at the Minoa
Palace Hotel, which is located in Platanias, 24 km
from Chania International Airport and 12 km west of
Chania town center. Participants are kindly asked
to take a taxi to the conference venue (~25-30
EUR). Arrival and Check-in It is expected that attendees will
arrive/check-in on Sunday after 2:00 PM. Anyone arriving after 10:00 pm on
Sunday must make alternative dinner arrangements. Breakfast
Breakfast will be served at your
hotel during the hours scheduled in this program. Conference Venue The Oral Presentations An LCD projector and an overhead projector will be available for
the oral presentations.
Speakers are asked to bring their USB flash drive or CD to the
conference reception desk at least 30 minutes prior to the session. The allocated time for all presentations,
unless otherwise indicated, includes five minutes Q&A. Posters Posters should be mounted Sunday,
October 2, from 6:00 pm – 8:00 pm on the designated boards and dismounted at the end of the meeting.
The dimensions of the boards are 90 cm wide x 140 cm high. Adhesive tape for
mounting the posters on the boards will be available at the poster area. Welcome Reception and Gala Dinner Badges are required
for admission. City Tour Busses for the city tour
will be leaving from the hotel on Wednesday,
October 7 at 3:00 pm Accompanying persons will also be picked up at the hotel
front lobby at that time. Badges
are required for participation. Lunches Lunches will be served
at the indicated times to all registered participants and registered
accompanying persons in the hotel. Badges
are required for admission. Dinners/Informal
Discussions Three of the dinners/informal
discussion will be served. Vegetarian entrees are available only if the
request is made in advance of the meeting. Internet, Phone,
& Computer Wireless Internet access is located throughout the conference center free charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room. Other Information Animals are not permitted on site. All Aegean Conferences events are
non-smoking. |
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Sunday, October 4 |
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6:00 - 8:00 PM |
Open Registration |
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8:00 PM |
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Welcome
Reception/Dinner |
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Monday, October 5 |
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8:15 AM |
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Welcome and Opening Remarks
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Session
I |
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Innate
immunity and autoimmunity |
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Chairs: M Shlomchik |
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8:30 AM |
1 |
NKT-cell
activation for autoimmune diabetes prevention-silver bullet or Russian
roulette? DV
Serreze, J Driver, F Scheuplein, and YG Chen |
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9:00 AM |
2 |
T’s, B’s and DCs in
systemic autoimmunity M Shlomchik, R Herlands,
R Sweet, L Teichmann, J Giles, SR Christensen, R Flavell, SR Dillon, and M Harris |
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9:30 AM |
3 |
Environmental Triggers of Autoimmunity M
Monestier |
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10:00 AM |
4 |
The role of innate
immunity and gut flora in autoimmune diabetes development A
Chervonsky, CY Hu, MJ
Liu, J Peng, J Gordon, FS Wong, and L Wen |
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10:30 AM |
5 |
Meningeal
mast cells regulate CNS inflammatory cell influx and blood brain barrier
permeability in EAE BA
Sayed, AL Christy, ME Walker, and MA Brown |
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11:00 AM |
6 |
Microbiome in autoimmunity M
Atkinson |
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11:30 AM |
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Coffee Break |
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Session
II |
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Inflammation,
infections and enhancement versus prevention of autoimmunity |
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Chairs: M von Herrath |
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12:00 Noon |
7 |
Virus
infections and autoimmunity – good or bad? M von Herrath and C Filippi
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12:30 PM |
8 |
Is
there a role for Th17 cells in diabetes development? D Bending, J Phillips, H de La Pena, M Veldhoen, B Stockinger, C Uyttenhove, and ACooke |
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1:00 PM |
9 |
Role of NKT cells : from viral infection to TYPE 1 diabetes J Diana and A Lehuen |
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1:30 PM |
10 |
Analyses
of iNKT cell agonists that optimally protect from
Type 1 diabetes R Tohn, H Blumenfeld, D Ly, SA Porcelli, PB
Savage, and TL Delovitch |
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2:00 PM |
11 |
Myocarditis: the critical decisions N
Rose |
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2:30 PM |
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Lunch |
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8:00 PM |
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Dinner / Informal Discussions at a
local Greek Restaurant |
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The bus for the restaurant will depart from the
hotel at 7:30 PM |
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Tuesday, October 6
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Session
III |
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Antigen presenting cells in
autoimmunity |
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Chair: J Katz |
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8:30 AM |
12 |
A novel subset of dendritic cells, merocytic dendritic cells,
stimulate CD4+ and CD8+ islet-specific T cells in vivo
and precipitate type 1 diabetes in NOD mice JD Katz, JK Ondr, R Opoka,
and E Janssen |
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9:00 AM |
13 |
Indoleamine
2,3 dioxygenase (IDO) and immune privilege AL Mellor, BA Johnson III, PR Chandler, B Baban, MD Sharma, and DH Munn |
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9:30 AM |
14 |
Protein modifications to autoantigens in autoimmune disease S Connolly, H Doyle, ML Yang, and MJ Mamula |
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10:00 AM |
15 |
IgG and CD95 denotes a unique
population of human memory B cells that are uniquely driven to differentiate
into plasma cells by IL-21 and BAFF and are expanded rheumatoid arthritis
patients R Ettinger, S Kuchen, C
Hostage, M Wilson, R Goldbach-Mansky, and PE Lipsky |
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10:30 AM |
16 |
The
Inducible Costimulator ICOS is Required for the
Maintenance of Germinal Centers: in vivo Studies with a Novel Depleting
anti-ICOS Antibody R Herbst, G Carlesso, R Lemaire, D Taylor,
N Mittereder, E Kuta, T
Burwell, T Delaney, J Connor, J Zhu, H Dong, M Bowen, J Lin, C Gao, R Woods, Karnell, R
Ettinger, P Brohawn, Y
Yao, B Jallal, and AJ Coyle |
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11:00 AM |
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Coffee Break & Poster
Session |
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Session
V |
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Autoantigens,
Selection, and autoimmunity |
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Chair: S Miller |
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12:00 Noon |
17 |
Control of immune
tolerance by the Aire protein MS Anderson |
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12:30 PM |
18 |
Creating
autoimmunogenic determinants; the evidence so far Y
D Dai, A Quinn, K P Jensen, I Marrero, L S Wicker, and E E
Sercarz |
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1:00 PM |
19 |
SD Miller, D Turley, C. Smith, A. Martin, D Getts, S. Prasad, AP Kohm, H
Zhang, J Podojil, and X Luo |
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1:30 PM |
20 |
Identification of a new autoantigen in type 1 diabetes K
Haskins, B Stadinski, J Kappler,
and T Delong |
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2:00 PM |
21 |
Mechanisms
of impaired regulation in T1D A Long, A Schneider, M Rieck,
C Greenbaum, JH Buckner |
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2:30 PM |
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Lunch |
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8:00 PM |
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Dinner / Informal Discussions at a local Greek Restaurant |
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The bus for the restaurant will depart
from the hotel at 7:30 PM |
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Wednesday, October 7 |
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Session
V |
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Regulatory T cells and T cell
homeostasis in autoimmunity |
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Chair: D Farber |
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8:30 AM |
22 |
Molecular
mechanisms of regulatory T cell differentiation and function A
Chaudhry, D Rudra, T Egawa, MMW Chong, P Treuting,
DR Littman, and AY Rudensky |
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9:00 AM |
23 |
Immune
privilege, Tregs and
autoimmunity
RR Caspi, R Zhou, P Silver, R Horai Rajeev, A Shao, B Su, and CC Chan |
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9:30 AM |
24 |
The role of regulatory t
cells in autoimmunity M
Battaglia |
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10:00 AM |
25 |
Viral triggers of central nervous
system autoimmune disease J Goverman and Q Ji |
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10:30 AM |
26 |
Regulatory mechanisms AND
type 1 diabetes DAA Vignali, LW Collison,
M Bettini, and V Chaturvedi |
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11:00 AM |
27 |
Tissue-retentive
memory CD4 T cells DL Farber, JR. Teijaro,
C Page, L LeFrancois, and D Verhoeven |
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11:30 AM |
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Coffee
Break |
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Session
VI |
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Regulatory T cells and T cell
homeostasis in autoimmunity |
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Chairs: D Farber |
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12:00 Noon |
28 |
Homeostasis of human
memory T cells in islet transplantation E Bonifacio, P Monti,
A Heninger, A Theil, and R Paul |
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12:30 PM |
29 |
Common Mechanisms in Autoimmunity: An Expanding Role for Th40
cells D
Wagner |
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1:00 PM |
30 |
Rheumatic fever and rheumatic heart
disease: From pathogenesis to vaccine J Kalil and L Guilherme |
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1:30 PM |
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Lunch |
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3:00 PM |
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City Tour |
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The bus for the tour
will depart from the hotel at 3:00 PM |
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8:00 PM |
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Dinner / Informal Discussions at a local Greek Restaurant |
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Thursday, October 8 |
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Session
VII |
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Immunotherapies for
Autoimmunity |
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Chair: D Scott |
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8:30 AM |
31 |
Role of tregs
and Ig epitopes in B-cell
delivered Gene therapy for tolerance DW Scott |
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9:00 AM |
32 |
Targeting
regulatory T-cells in patients with rheumatoid arthritis MR Ehrenstein |
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9:30 AM |
33 |
The
use of T cell co-receptor blockade for the reversal of Type 1 diabetes R Tisch, Z Yi, and B Wang |
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10:00 AM |
34 |
Recombinant
T-Cell receptor ligands: Mechanism of activity and
application toward autoimmune therapy GG Burrows, YK Chou, J Huan, R Meza-Romero, S Andrew, A Buenafe, T Proctor, S Sinha, S Subramanian, J Mooney, DN Bourdette, H Offner, and AA Vandenbark |
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10:15 AM |
35 |
AIRE activated tissue
specific genes have histone modifications
associated with inactive chromatin T Org, A Rebane, K Kisand, M Laan, U Haljasorg, R Andreson, and P Peterson |
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10:30 AM |
36 |
Regulatory T cells
insufficiency in patients with alopecia areata A Arakawa, M Ono, H Fujii,
A Kitoh, M Nakamura, S Sakaguchi,
and Y Miyachi |
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10:45 AM |
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Coffee Break & Poster Session |
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Session
VIII |
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Chair: |
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11:30 AM |
37 |
Inflammation-induced
antibody polyreactivity A clue to the origin of rheumatoid factor? JD
Dimitrov and TL Vassilev |
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11:45 AM |
38 |
AHR
ligand induced human regulatory T cells R Gandhi, FJ Quintana, M Farez, A Laroni, D
Kumar, and HL Weiner |
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12:00 Noon |
39 |
Targeting
B cell function in Type 1 Diabetes JW
Thomas, RA Henry, and PL Kendall |
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12:15 PM |
40 |
MCS-18, a novel natural product
isolated from Helleborus purpurascens,
inhibits dendritic cell activation and prevents
autoimmunity as shown in vivo using the NOD model E Zinser, L Littmann, S Rössner, F Kerek, Y Resheq, C Seifarth, and A Steinkasserer |
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12:30 PM |
41 |
Keynote Speaker: TGF-b, Regulatory T cells, and immune suppression RA
Flavell |
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1:30 PM |
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Closing
Remarks |
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1:45 PM |
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Lunch |
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8:00 PM |
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Farewell Dinner |
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Friday, October 9
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7:30 AM |
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Breakfast |
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Posters
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42 |
Autoimmune mechaisms in Chronic obstructive pulmonary Disease MT Borchers, GT Motz, BL Eppert, B Wortham, and J Flury |
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43 |
Unifying theory for the mechanism
of action of IVIG for the treatment of autoimmune diseases DR
Branch |
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44 |
Analysis
of peripheral tolerance in Adascid patients treated
with enzyme replacement or gene therapy I Brigida, AV Sauer, S Selleri, S Scaramuzza, A
Ripamonti, N Carriglio, M Casiraghi, F Ferrua, MG Roncarolo, and A Aiuti |
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45 |
Aging Worsens Sjögren's syndrome
like keratoconjunctivitis in CD25KO mice CS De Paiva, C Hwang, JD Pitcher III, SB Pangelinan, E Rahimy, W
Chen, WJ Farley, JY Niederkorn, ME Stern, D-Q Li, and SC Pflugfelder |
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46 |
Thymus and activation
regulated chemokine (TARC/CCL17) in serum during
and after pregnancy in patients with systemic lupus erythematosus
and in cord blood from their neonates U Holmlund, K Bremme,
and E Sverremark-Ekström |
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47 |
Diversity of TCRS on
natural FOXP3 T cells in mice lacking AIRE expression D
Daniely, J Kern, A Cebula,
and L Ignatowicz |
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48 |
FCγ–receptor
antagonist SM101 is effective in the therapy of autoimmune disease animal
models U Jacob |
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49 |
Plasma monocyte chemotactic
protein-1 levels correlated with pulmonary hypertension in patients with
systemic sclerosis HS Kim, MK Park, HY Kim, and SH Park |
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50 |
Anti-DNA
antibodies in Systemic lupus erythematosus – never
ending story? V Král, I Stiborová,
S Blažíčková, and L Cebecauer |
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51 |
Aire deficiency results in decreased expression
of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes M Laan, K Kisand, V Kont, K Möll, L Tserel, HS
Scott, and P Peterson |
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52 |
Long-term follow-up of
lymphocyte subpopulations and intracellular cytokine production in patients
with anca-associated vasculitis
treated with RITUXIMAB H
Mareckova, Z Hruskova, E Jancova, R Rysava, and V Tesar |
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53 |
MicroRNA
regulation of TH17 development MP
Mycko, M Marasiewicz, A Machlanska,
M Cichalewska, B Szymanska,
H Cwilinska, and KW Selmaj |
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54 |
Distinctive and co-operative role of
TYPE 1 and TYPE 2 interferons in the immunopathogenesis of Th1 and Th17 cells in Experimental
Autoimmune Encephalomyelitis R
Naves, SP Singh, P De Sarno, RC Axtell, L Steinman,
and C Raman |
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55 |
CD5
Sets Threshold for Activation and Anergy in T-cells C
Raman, CS Sestero, D McGuire, and P De Sarno |
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56 |
Exceptional conformational
plasticity of a dodecameric
self-peptide bound by the HLA-B*2705 antigen A Ziegler, P Kumar, R Misselwitz,
A Vahedi-Faridi, J José Crangolini, W Saenger, JA López de Castro, and B Uchanska-Ziegler |
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57 |
Inuslin-producing
cells derived from human tissue stem cells: susceptibility to immune
responses directed against beta cells L Anker-Kitai and S Efrat
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58 |
Genome-wide
identification and characterization of novel genes encoding potential
cytokines with modulatory effects on Th cells W Han, P Wang, Y Zhang, W
Fu, X Guo, T Li, T Shi, and D Ma |