GENERAL INFORMATION Accommodations The conference participants will be staying at the Hilton Hotel (A' class), which is located in Ixia, 9 km from the airport. Participants are asked to take a taxi from the airport to the hotel. Conference Venue The Hilton Conference Center is located at the hotel. Oral Presentations An LCD projector will be available for the oral presentations. Speakers are asked to bring their USB flash drive or CD to the conference reception desk at least 30 minutes prior to the session. The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A. Posters Posters should be mounted Sunday June 8 from 5:00 – 8:00 PM on the designated boards and dismounted at the end of the meeting. The dimensions of the boards are 90W x 150H cm. Adhesive tape for mounting the posters on the boards will be available at the poster area. All Aegean Conferences events are non-smoking.
Sunday, June 8
5:00 - 8:00 PM		Open Registration
8:00 PM		Welcome Reception/Dinner
Monday, June 9
8:40 AM		Welcome and Opening Remarks J Lorenzo
Session I.		Niche and Soil Chair: J Lorenzo
9:00 AM	1	Normal and neoplastic stem cells IL Weissman
9:30 AM	2	Gsa mediated signalling determines the success of stem cell engraftment in bone marrow H Kronenberg
10:00 AM	3	Transforming growth factor beta (TGFb): role in cancer and bone TA Guise
10:30 AM		Coffee Break & Poster Viewing
Session II		Basic Concepts into osteoimmunology: Inflammatory Bone diseases Chair: S Goldring
12:00 Noon	4	Mechanisms of inflammatory joint remodeling G Schett
12:30 PM	5	Inflammatory arthritis: how well do rodents mimic the human disease? Lessons with RANKL inhibition DJ Zack
1:00 PM	6	The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis EM Schwarz
1:30 PM	7	Dendritic cells and the origin of osteoclasts: implications on osteoclastogenesis and bone loss AYT Teng
2:00 PM		Lunch
8:00 PM		Dinner at a local Greek Tavern
		The bus for the tavern will depart from the hotel at 7:30 PM
Tuesday, June 10
Session III		Basic Concepts into osteoimmunology: Osteoblasts Chair: M Horowitz
9:00 AM	8	Role of EBF2 in the stromal support of hematopoiesis M Kieslinger, G Dobreva, I Gyory, and R Grosschedl
9:30 AM	9	Regulation of bone formation and immune cell development by Schnurri proteins DC Jones and LH Glimcher
10:00 AM	10	Role of Wnt signaling in development of adipose tissues and bone OA MacDougald
10:30 AM	11	Regulation of osteoblasts and osteoclasts by osteocytes T Komori
11:00 AM	12	Megakaryocyte-bone cell interactions M Kacena
11:30 AM		Coffee Break
12:00 Noon		Poster Viewing & Poster Award Selection
1:30 PM		Lunch
3:00 PM		City Tour
The bus for the city tour will depart from the hotel at 3:00 PM
8:00 PM		Dinner at Local Greek Tavern
Wednesday, June 11
Session IV		Basic Concepts into osteoimmunology: Osteoclasts Chair: A Zallone
9:00 AM	13	αvβ3 Integrin and M-CSF; partners in the osteoclast W Zou, M Croke, FP Ross, and S Teitelbaum
9:30 AM	14	Inflammation and Innate Receptors-Influencing Each other In Osteoclastogenesis Y Wu, JC Charles, MB Humphrey, LL Lanier, and MC Nakamura
10:00 AM	15	TREM-2 in osteoclastogenesis M Cella, H Zhao, FP Ross, SL Teitelbaum, and M Colonna
10:30 AM	16	Regulation of RANK and TREM-2 expression and costimulation of RANK signaling by cytokines and inflammatory factors during human osteoclast differentiation LB Ivashkiv
11:00 AM		Coffee Break & Poster Viewing
Session V		Basic Concepts into osteoimmunology: Osteoclasts Chair: A Zallone
11:30 AM	17	Unexpected link between osteoclast and the immune system H Takayanagi
12:00 Noon	18	NFATc1 uncouples Osteoclastogenesis from inflammation in a mouse model of cherubism AO Aliprantis,Y Ueki, A Park, BR Olsen,and LH Glimcher
12:30 PM	19	Regulation of skeletal homeostasis by Bcl-2 family S Tanaka, T Akiyama, H Wakeyama, Y Nagase, M Iwasawa, Y Oshima, M Nakamura, Y Kadono, and K Nakamura
Session VI		Short Talks Chair: H Takayanagi
1:00 PM	20	SHIP1 associates with DAP12 and negatively reguates trem2/dap12 signaling in Osteoclasts Q Peng and MB Humphrey
1:15 PM	21	Sphingosine-1-phosphate promotes recirculation of osteoclast precursor monocytes and dynamically regulates bone mineral homeostasis M Ishii, JG Egen, F Klauschen, M Meier-Schellersheim, and RN Germain
1:30 PM	22	Molecular profiling reveals a higher similarity between osteoclasts and dendritic cells than between monocytes and osteoclasts A Gallois, G Despars, S Roche, J Lachuer, A Wierinckx, F Brunet, C Servet-Delprat,C Rabourdin-Combe, P Jurdic and M Mazzorana
1:45 PM	23	Identification of RANK mutations in patients with osteoclast-poor autosomal recessive osteopetrosis C Sobacchi, M M Guerrini, B Cassani, M Abinun, S S Kilic, A Pangrazio, D Moratto, E Mazzolari, J Clayton-Smith, P Orchard, F P Coxon, M Helfrich, J Crockett, LD Notarangelo, M Rogers, P Vezzoni, A Frattini, and A Villa
2:00 PM	24	VEGF induced b-catenin stabilization leads to bone marrow fibrosis and osteosclerotic/petrotic bone formation S Bartunkova, C Maes, S Goossens, B Drogat, L Coenegrachts, I Stockmans, K Moermans, O Nyabi, K Haigh, A Nagy, G Carmeliet, and JJ Haigh
2:15 PM	25	OsteOLINEAGE cells dynamically regulate hematopoietic stem cell fucntion in the context of diverse physiological conditions SR Mayack and AJ Wagers
2:30 PM		Lunch
8:00 PM		Dinner at a local Greek Tavern
		The bus for the tavern will depart from the hotel at 7:30 PM
Thursday, June 12
Session VII		Up and Coming Chair: J Penninger
9:00 AM	26	Osteoclast independent roles of RANKL and RANKJ Penninger
9:30 AM	27	Fra1 and “danger signals” in lung injury and bone fracture K Matsuo
10:00 AM	28	Activation of gd T cells by bisphosphonate drugs K Thompson
10:30 AM	29	Identification of cell cycle-arrested osteoclast precursors in vivo N Takahashi
11:00 AM	30	Regulation of ephrinB2/EphB4 signaling within the osteoblast lineage TJ Martin, EH Allan, S Pompolo, JHGooi, and NA Sims
11:30 AM		Coffee Break
Session VIII		Short Talks Chair: Y Choi
12:00 Noon	31	Deletion of sFRP4 in mice results in an increased bone mass phenotype G Sabatakos, H Saito, D Ebert, C Blanton, E Houghton, N Jaiswal, L Elenich, D Cody, A Houghton, RBaron, and R Hinkle
12:15 PM	32	High bone mass in intact and estrogen-deficient mice lacking IL-15 signaling S Djaafar, DD Pierroz, XX Zheng, SL Ferrari, and S Ferrari-Lacraz
12:30 PM	33	Adenosine and osteoporosis: adenosine A1 receptor blockade reverses bone loss in ovariectomized mice and deletion of adenosine A2A receptors leads to diminished bone density FM Kara, SB Doty, A Boskey, B Fredholm, and BN Cronstein
12:45 PM	34	IL-27/WSX-1 signaling inhibits RANKL-induced osteoclastogenesi s through STAT1 activation: a possible involvement in TLR4/MyD88- mediated inflammatory arthritis M Furukawa, H Takaishi, M Yoda, T Tohmonda, J Takito, S Sakai, M Matsumoto, and Y Toyama
1:00 PM	35	Activated CD4^+CD25^+ regulatory T cells suppress osteoclastogenesis and inhibit autoimmune arthritis in mice L Geboes, H Kelchtermans, T Mitera, D Huskens, G Leclercq, and P Matthys
1:15 PM	36	CD40 ligand prevents osteoclastogenesis induced by glucocorticoids W Yao, Z Cheng, A Pham, M Shanazari, RO Ritchie, LF Bonewald,and NE Lane
1:30 PM		Concluding remarks
2:00 PM		Lunch
8:00 PM		Gala Dinner
Friday, June 13
7:30 AM		Breakfast
		Departure
POSTERS
	37	RANKL/RANK controls the central fever response R Hanada, A Leibbrandt, C Pifl, and J Penninger
	38	A possible effect of CD27-CD70 interaction on osteoclast differentiation Y Xiao, J Song, AM Keller, TJ de Vries, T Schoenmaker, V Everts, and J Borst
	39	Soluble TRAIL enhanced bone destruction acting on Rank-ligand in estrogen dependent/independent human breast cancer cell lines V Nicolin and P Narducci
	40	Wnt5a secreted by osteoblasts regulate osteoclasts differentiation K Maeda, Y Kobayashi, A Ishihara, N Udagawa, I Takada, S Kato, M Nishita, Y Minami, K Marumo, and N Takahashi
	41	Characterization of a novel osteoclast population in rat long bones E Karlström, B Ek-Rylander, S Zenger, M Wendel, and G Andersson
	42	Stem cell antigen-1^+ (Sca-1^+) cell-based gene therapy with MODIFIED fibroblast growth factor 2 (FGF2) dramatically increases vertebral endosteal bone formation in mice S Hall, S Wang, S Chen, J Wergedal, S Mohan, and KH Lau
	43	Expression of Estrogen Receptor in osteoblasts of patients with adolescent idiopathic scoliosis (AIS) D Leboeuf, K Letellier, B Azeddine, G Grimard, S Parent, H Labelle, A Moreau, and F Moldovan
	44	Genome-wide transcriptional Profiling as an approach to characterize osteoimmunological crosstalk LM Havill and MC Mahaney
	45	CD4+CD25+Foxp3+Regulatory T cells suppress osteoclast commitment BR Lee, KH Seo, C Li, L Zhou, and Q-Sheng Mi
	46	The role of Tec family kinases in osteoclast differentiation M Shinohara, T Koga, K Okamoto, T Nakashima, H Inoue, K Arai, and H Takayanagi
	47	Cathepsin K regulated TH17 cell polarization through toll-like receptor 9 signaling in dendritic cells HJ Gober, M Asagiri, T Hirai,^, T Kunigami,^, K Okamoto, K Nishikawa, A Suematsu, M Hayashi, P Saftig, and H Takayanagi
	48	Effect of caspase 3 on bone metabolism H Amano, A Karakawa, M Okazaki, Y Fukawa, K Takahash, and S Yamada
	49	The role of the chemokine CXCL12 in induction of osteoclast activity and osteolytic bone disease in multiple myeloma P Diamond, SA Hampton-Smith, A Labrinidis, S K Martin, S Gronthos, L To, N Fujii, PO’Loughlin, A Evdokiou, and AC W Zannettino
	50	Induction of kinin B1 receptor in osteoarthritis is performed by vasoactive peptide endothelin-1 LH Attalah, D Deblois, É Rich, CA Manacu, Ns Newman, A Moreau, and F Moldovan
	51	Estrogen crosstalk with the melatonin signalling pathway in human osteoblasts derived from adolescent idiopathic scoliosis (AIS) patients L Kareen, A Bouziane, P Stefan, L Hubert, M Alain, and M Florina
	52	Defective bone structure and bone marrow microenvironment in the immunodeficient ada ko mouse AV Sauer, E Mrak, E Zacchi, R Jofra Hernandez, A Tabucchi, A Ambrosi, A Rubinacci, and A Aiuti
	53	Osteal tissue macrophages are critical for woven bone deposition in fracture healing KA Alexander, LJ Raggatt, MK Chang, ER Maylin, ACK Wu, AI Cassady, DA Hume, and AR Pettit
	54	Precursor & functional analyses of CD11C^+dendritic cells-associated osteoclastogenesis and bone loss M Alnaeeli and AYT Teng
	55	Dlk1/FA1 stimulates osteoclast formation via osteoblast dependent mechanism BM Abdallah, N Ditzel, GA Traustadottir, AF Schilling, M Amling and M Kassem
	56	DcR3 involvement in multiple myeloma bone disease G Brunetti, S Colucci, G Mori, A Oranger, M Centonze, R Rizzi, V Liso, and M Grano
	57	Addition of estrogen to corticosteroid treatment in experimental arthritis prevents osteoporosis and arthritis, possibly by induction of regulatory T-cells C Jochems, C Håkansson, M Lagerquist, C Ohlsson, and H Carlsten
	58	The role of the signaling adapters LAT and LAB in osteoclastogenesis JF Charles, G Whittaker, Y Wu, W Zhang, DW McVicar, and MC Nakamura
	59	Estrogen deficiency increases osteoclastogenesis upregulating T cells activity: a key mechanism in osteoporosis P D’Amelio, A Grimaldi, S Di Bella, MA Cristofaro, C Tamone, and G Isaia
	60	Reduced bone density in Bruton’s tyrosine kinase deficient patients: effect of B cells on osteoclast activity L Danks, S Workman, V Nicolaidou, B Grimbacher, BMJ Foxwell, and NJ Horwood
	61	Formation of osteoclast-like cells from peripheral blood from (osteopenic) chronic liver disease and periodontitis patients occurs without supplementation of M-CSF TJ de Vries, BJ Olivier^,, STS Tjoa, T Schoenmaker, RE Mebius, CJ Mulder, BG Loos, SW van der Merwe, and V Everts
	62	Identification and characterization of a novel loss-of-function missense mutation in the RANKL gene causes osteopetrosis in mice E Douni, E Makrinou, J Zwerina, JM Penninger, G Schett, and G Kollias
	63	The role of JAK1 in osteoclastogenesis regulation JI Ha, Y Lee, HJ Kim, SW Hyung, HJ Jung, SW Lee, and HH Kim
	64	Mesenchymal cells expressing Col1a2 is required for the estrogenic effects on bone and B cell lymphopoiesis C Håkansson, S Windahl, A Börjesson, C Jochems, H Carlsten, C Ohlsson, and MK Lagerquist
	65	Identification of primary target cells for the classical genomic effects of estrogen and raloxifene in bone C Håkansson, C Jochems, P van der Saag, C Ohlsson, H Carlsten, and MK Lagerquist
	66	Cell cycle-arrested quiescent osteoclast precursors (QOP) circulate to settle in the osteoclast niche A Muto^, T Mizoguchi, Y Kobayashi, T Noguchi, J M Penninger, N Udagawa, and N Takahashi
	67	Cell-cell communication between osteoclast precursors through ephrinA2-EphA2 interaction regulates bone homeostasis N Irie, Y Takada, and K Matsuo
	68	Comparison of direct osteoclastogenic potential on osteoclast precursor cells among proinflammatory cytokines JH Ju, JS Park, HJ Oh, YM Moon, CM Kang, ML Cho, HJ Ko, SH Lee, SH Park, HY Kim
	69	Long-term denosumab treatment of non-human primates had no observed effects on leukocyte subsets or T-cell-dependent immune responses M Stolina, MS Ominsky, J Schroeder, JE Atkinson, SY Smith, L LeSauteur, S Corneu, and PJ Kostenuik
	70	Negative regulation of human rank and trem2 expression by toll-like receptors JD Ji, KH Park-Min, and LB Ivashkiv
	71	Synovial fibroblasts promote osteoclastogenic activity by activation RANKL and differentiation of monocytes via TLR3 activation in RA KW Kim, ML Cho, HJ Oh, CM Kang, YM Moon, JS Park, HR Kim, HY Kim, and SH Lee
	72	Potential roles of osteoclastogenic cytokine - NF-κB signaling in methotrexate chemotherapy-induced osteoporosis T King, S MA, JC Cool, J Xu, BK Foster, and CJ Xian
	73	Expression of RANKL on the surface of peripheral blood cells D Krenbek, U Semrad, G Hofbauer, M Griesser, and PRM Willheim
	74	The TEC family tyrosine kinase BTK regulates RANKL-induced osteocalst maturation SH Lee, T Kim, D Jeong, N Kim, and Y Choi
	75	T-lymphocytes amplify the anabolic action of PTH through WNT10B signaling M Terauchi, Y Gao, MS Nanes, M Zayzafoon, TF Lane, MN Weitzmann, and R Pacifici
	76	Macrophages reside in mouse and human osteal tissues and regualte osteoblast mineralisation MK Chang , AR Pettit, KA Alexander, JS Kuliwaba, NL Fazzalari, K Schroder, VM Ripoll, DA Hume, and LJ Raggatt
	77	Osteoclast specific dicer deficiency suppress osteoclast differentiation and increase bone mass F Mizoguchi, Y Izu, T Hayata, H Hemmi, K Nakashima, T Nakamura, H Kohsaka, N Miyasaka, B Harfe, S Kato, Y Ezura, and M Noda
	78	The association between body composition and bone health: The European Prospective Investigation into Cancer-Norfolk study A Moayyeri, RN Luben, NJ Wareham, S Bingham, and KT Khaw
	79	A novel neutrophil-osteoclast signaling pathway is critically involved in the development of autoimmune arthritis Z Jakus and A Mocsai
	80	The interaction of alpha9 integrin with its ligands regulates the development of rheumatoid arthritis J Morimoto, M Kanayama, D Kurotaki, T Asano, Y Nakayama, K Ito, Y Saito, C Kimura, T Harada, LH Mei, J Uehara, T Miyazaki, T Uede, and S Kon
	81	Regulation of skeletal homeostasis by anti-apoptotic molecule Bcl-2 Y Nagase, M Iwasawa, T Akiyama, Y Kadono, Y Oshima, M Nakamura, T Yasui, T Miyamoto, K Nakamura, and T Sakae
	82	TLR9-ligand CpG inhibits BMP-2 induced differentiation of human Mesenchymal Stem cells NN Nørgaard, A Sundan, J Bohnhorst, and T Standal
	83	Regulation of human osteoclast precursor generation by Type II cytokines KH Park-Min, JD Ji, T Antoniv, MB Humphrey, M Nakamura, and LB Ivashkiv
	84	Bone metabolism in a RODENT model of ankylosing spondylitis M Rauner, D Stupphann, W Sipos, I Fert, S Glatigny, M Breban, and P Pietschmann
	85	Diagnostic implication of spontaneous osteoclastogenesis and IL-7 serum levels in bone metastases from non-small cell lung cancer I Roato, E Gorassini, L Buffoni, P Lyberis, E Ruffini, L Ciuffreda, and R Ferracini
	86	Running has a negative effect on bone metabolism and proinflammatory status in male aged rats W Sipos, M Rauner, M Skalicky, A Viidik, G Schett, K Redlich, S Lang, and P Pietschmann
	87	NIK mutation in ALY/ALY mice causes osteopetrosis and reduce RANKL induced osteoclastogenesis NS Soysa, CNRA Alles, AH Mian, HYasuda, E Jimi, H Shimokawa, K Aoki, and K Ohya
	88	RANKL/osteoprotegerin and markers of inflammation in association with bone deterioration in patients with inflammatory Bowel Disease N Turk, S Cuković-Cavka, M Korsic, ZTurk, and B Vucelić
	89	Contribution of multiple hematopoietic cells in the correction of grey-lethal osteopetrosis J Vacher, M Pata, and C Héraud
	90	MAYP/PSTPIP2 regulates macrophage and osteoclast development and function V Chitu, V Nacu, PJ Ferguson, J Charles, and ER Stanley
	91	The role of ITAM adapter in low calcium diet-induced bone loss Y Wu, LL Lanier, MB Humphrey, and MC Nakamura
	92	IL-6, COX-2 and VEGF expression during stress fracture healing CKA Wu, L Kidd, N Cowling, and MR Forwood
	93	Roles of injury-induced inflammatory response in the bony repair of the growth plate cartilage CJ Xian, FH Zhou, R Chung, M Scherer, and BK Foster
	94	Comprehensive analysis of the downstream effectors of transforming growth factor-beta in osteoclastogenesis T Yasui, Y Kadono, M Nakamura, Y Oshima, M Iwasawa, Y Nagase, K Nakamura, and S Tanaka
	95	Osteoclast-inducing property alteration attributable to optical isomers of beta-adrenergic agonists Y Fukawa, K Akiko, M Okazaki, K Miyamoto, H Amano, S Yamada, and M Yamamoto
	96	Functional analysis of Bcl-xL in osteoclasts by osteoclast-specific deletion of bcl-x gene in mice M Iwasawa, Y Nagase, Y Kadono, M Nakamura, T Yasui, T Nakamura, S Kato, K Nakamura, and S Tanaka